Implications of hepatic cytochrome P450-related biotransformation processes in veterinary sciences

European Journal of Pharmacology

Volumn 585, Issue 2-3, 2008, Pages 502-509

  Fink Gremmels, Johanna ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

(Cat); (Cattle); (Dog); (Horse); (Pig); Cytochrome P450; Drug drug interaction in veterinary medicine

Indexed keywords

AMPHETAMINE; BERGAMOTTIN; BUFURALOL; CHLORAMPHENICOL; CHLORZOXAZONE; CIMETIDINE; CIPROFLOXACIN; CLOMIPRAMINE; COUMARIN; CYTOCHROME P450; DEXTROMETHORPHAN; DICLOFENAC; DIETHYLDITHIOCARBAMIC ACID; ENROFLOXACIN; IVERMECTIN; KETOCONAZOLE; LOPERAMIDE; MEPHENYTOIN; MIDAZOLAM; OFLOXACIN; ORBIFLOXACIN; PHENACETIN; PLEUROMUTILIN; QUINIDINE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TESTOSTERONE; THEOPHYLLINE; TOLBUTAMIDE; TRANSCRIPTION FACTOR; VALNEMULIN;

ANIMAL DISEASE; BIOTRANSFORMATION; BOVIDS; CARNIVORE; CAT; CATTLE; DOG; DOSE RESPONSE; DRUG DETERMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG TRANSPORT; ENZYME BLOOD LEVEL; HERBIVORE; HORSE; HUMAN; NONHUMAN; POLLUTANT; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SPECIES COMPARISON; SWINE; VETERINARY MEDICINE;

ANIMALS; BIOLOGICAL MARKERS; BIOTRANSFORMATION; CATS; CYTOCHROME P-450 ENZYME SYSTEM; DOGS; DRUG INTERACTIONS; ENVIRONMENTAL POLLUTANTS; HORSES; LIVER; POLYMORPHISM, GENETIC; RUMINANTS; SPECIES SPECIFICITY; SWINE; VETERINARY DRUGS;

EID: 43049181756     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.03.013     Document Type: Review

References (106)

1. Amsallem-Holtzman E., and Ben-Zvi Z. Drug metabolizing enzymes in the ostrich (Struthio camelus): comparison with the chicken and the rat. Comp. Biochem. Physiol. C. Pharmacol. Toxicol. Endocrinol. 116 (1997) 47-50
2. Anzenbacher P., Soucek P., Anzenbacherová E., Gut I., Hrubý K., Svoboda Z., and Květina J. Presence and activity of cytochrome P450 isoforms in minipig liver microsomes. Comparison with human liver samples. Drug Metab. Dispos. 26 (1998) 56-59
3. Anzenbacher P., Anzerbacherová E., Zuber R., Soucek P., and Guengerich F.P. Pig and minipig cytochromes P450. Drug Metab. Dispos. 30 (2002) 100-102
4. Atkins W.M., Wang R.W., and Lu A.Y. Allosteric behavior in cytochrome p450-dependent in vitro drug-drug interactions: a prospective based on conformational dynamics. Chem. Res. Toxicol. 14 (2001) 338-347
5. Baader M., Gnerre C., Stegeman J.J., and Meyer U.A. Transcriptional activation of cytochrome P450 CYP2C45 by drugs is mediated by the chicken xenobiotic receptor (CXR) interacting with a phenobarbital response enhancer unit. J. Biol. Chem. 277 (2002) 15647-15653
6. Blaisdell J., Goldstein J.A., and Bai S.A. Isolation of a new canine cytochrome P450 CDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression. Drug. Metab. Dispos. 26 (1998) 278-283
7. Bogaards J.J., Bertrand M., Jackson P., Oudshoorn M.J., Weaver R.J., van Bladeren P.J., and Walther B. Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man. Xenobiotica 30 (2000) 1131-1152
8. Byard J., Marshall D.E., Houghton E., and Gower D.B. Novel approaches to the purification and identification of cytochrome P450 enzymes in the equine. Biochem. Soc. Trans. 24 (1996) 208S
9. Bull, S., Fink-Gremmels, J. Valnemulin toxicity is associated with a low expression of CYP1A and CYP3A activity in pigs. manuscript in preparation.
10. Ceppa L., Dacasto M., Carletti M., Montesissa C., and Nebbia C. 'In vitro' interactions of monensin with hepatic xenobiotic metabolizing enzymes. Pharmacol. Res. 36 (1997) 249-254
11. Chauret N., Gauthier A., Martin J., and Nicoll-Griffith D.A. In vitro comparison of cytochrome P450-mediated metabolic activities in human, dog, cat, and horse. Drug. Metab. Dispos. 25 (1997) 1130-1136
12. Chirulli V., Marvasi L., Zaghini A., Fiorio R., Longo V., and Gervasi P.G. Inducibility of AhR-regulated CYP genes by beta-naphthoflavone in the liver, lung, kidney and heart of the pig. Toxicology 240 (2007) 25-37
13. Cortright K.A., and Craigmill A.L. Cytochrome P450-dependent metabolism of midazolam in hepatic microsomes from chickens, turkeys, pheasant and bobwhite quail. J. Vet. Pharmacol. Ther. 29 (2006) 469-476
14. Coulet M., Eeckhoutte C., and Galtier P. Ontogenic development of drug-metabolizing enzymes in male chicken liver. Can. J. Physiol. Pharmacol. 74 (1996) 32-37
15. Court M.H., Von Moltke L.L., Shader R.I., and Greenblatt D.J. Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species. Biopharm. Drug Dispos. 18 (1997) 213-226
16. Court M.H., Hay-Kraus B.L., Hill D.W., Kind A.J., and Greenblatt D.J. Propofol hydroxylation by dog liver microsomes: assay development and dog breed differences. Drug Metab. Dispos. 27 (1999) 1293-1299
17. Dacasto M., Eeckhoutte C., Capolongoa F., Dupuy J., Carletti M., Calléja C., Nebbia C., Alvinerie M., and Galtier P. Effect of breed and gender on bovine liver cytochrome P450 3A (CYP3A) expression and inter-species comparison with other domestic ruminants. Vet. Res. 36 (2005) 179-190
18. Donato M.T., Castell J.V., and Gomez-Lechon M.J. Characterization of drug metabolizing activities in pig hepatocytes for use in bioartificial liver devices: comparison with other hepatic cellular models. J. Hepatol. 31 (1999) 542-549
19. Dupuy J., Larrieu G., Braun J.P., Alvinerie M., and Galtier P. Differential effects of phenobarbital on the constitutive and inducible expression of P450 2B and 3A subfamilies in sheep tissues. Can. J. Physiol. Pharmacol. 79 (2001) 848-853
20. Edwards R.J., Boobis A.R., and Davies D.S. A strategy for investigating the CYP superfamily using targeted antibodies is a paradigm for functional genomic studies. Drug Metab. Dispos. 31 (2003) 476-480
21. Eguchi K., Nishibe Y., Baba T., and Ohno K. Quantitation of cytochrome P450 enzymes (CYP1A1/2, 2B11, 2C21 and 3A12) in dog liver microsomes by enzyme-linked immunosorbent assay. Xenobiotica 26 (1996) 755-763
22. Elsheikh H.A. A comparative study of some drug-metabolizing enzymes in lungs of Dromedary camels, desert sheep and Nubian goats. J. Vet. Pharmacol. Ther. 20 6 (1997) 496-498
23. Fink-Gremmels J., and van Miert A.S. Veterinary drugs: disposition, biotransformation and risk evaluation. Analyst 119 (1994) 2521-2528
24. Ershov E., Bellaiche M., Hanji V., Soback S., Gips M., and Shlosberg A. Interaction of fluoroquinolones and certain ionophores in broilers: effect on blood levels and hepatic cytochrome p450 monooxygenase activity. Drug Metabol. Drug Interact. 18 (2001) 209-219
25. Gillberg M., Skaanild M.T., and Friis C. Regulation of gender-dependent CYP2A expression in pigs: involvement of androgens and CAR. Basic Clin. Pharmacol. Toxicol. 98 (2006) 480-487
26. Goriya H.V., Kalia A., Bhavsar S.K., Joshi C.G., Rank D.N., and Thaker A.M. Comparative evaluation of phenobarbital-induced CYP3A and CYP2H1 gene expression by quantitative RT-PCR in Bantam, Bantamized White Leghorn and White Leghorn chicks. J. Vet. Sci. 6 (2005) 279-285
27. Graham R.A., Downey A., Mudra D., Krueger L., Carroll K., Chengelis C., Madan A., and Parkinson A. In vivo and in vitro induction of cytochrome P450 enzymes in beagle dogs. Drug Metab. Dispos. 30 (2002) 1206-1213
28. Greger D.L., and Blum J.W. Effects of dexamethasone on mRNA abundance of nuclear receptors and hepatic nuclear receptor target genes in neonatal calves. J. Anim. Physiol. Anim. Nutr. (Berl.) 91 (2007) 62-67
29. Guengerich F.P. Role of cytochrome P450 enzymes in drug-drug interactions. Adv. Pharmacol. 43 (1997) 7-35
30. Gupta R.P., and Abou-Donia M.B. Cytochrome P450 enzymes in chickens: characteristics and induction by xenobiotics. Comp. Biochem. Physiol. C. Pharmacol. Toxicol. Endocrinol. 121 (1998) 73-83
31. Gusson F., Carletti M., Albo A.G., Dacasto M., and Nebbia C. Comparison of hydrolytic and conjugative biotransformation pathways in horse, cattle, pig, broiler chick, rabbit and rat liver subcellullar fractions. Vet. Res. Commun. 30 (2006) 271-283
32. Handschin C., Podvinec M., Looser R., Amherd R., and Meyer U.A. Multiple enhancer units mediate drug induction of CYP2H1 by xenobiotic-sensing orphan nuclear receptor chicken xenobiotic receptor. Mol. Pharmacol. 60 (2001) 681-689
33. Handschin C., Podvinec M., Stöckli J., Hoffmann K., and Meyer U.A. Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans. Mol. Endocrinol. 15 (2001) 1571-1585
34. Hengstler J.G., Arand M., Herrero M.E., and Oesch F. Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility. Recent Results Cancer Res. 154 (1998) 47-85
35. Hosseinpour F., and Wikvall K. Porcine microsomal vitamin D(3) 25-hydroxylase (CYP2D25): catalytic properties, tissue distribution, and comparison with human CYP2D6. J. Biol. Chem. 275 (2000) 34650-34665
36. Ioannides C. Cytochrome p450 expression in the liver of food-producing animals. Curr. Drug Metab. 7 (2006) 335-348
37. Ingelman-Sundberg M., Sim S.C., Gomez A., and Rodriguez-Antona C. Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects. Pharmacol. Ther. 116 (2007) 496-526
38. Ishizuka M., Lee J.J., Masuda M., Akahori F., Kazusaka A., and Fujita S. CYP2D-related metabolism in animals of the Canoidea superfamily - species differences. Vet. Res. Commun. 30 (2006) 505-512
39. Kamimura H. Genetic polymorphism of cytochrome P450s in beagles: possible influence of CYP1A2 deficiency on toxicological evaluations. Arch. Toxicol. 80 (2006) 732-738
40. Kawalek J.C., and el Said K.R. Maturational development of drug-metabolizing enzymes in dogs. Am J Vet Res 51 (1990) 1742-1745
41. Kawalek J.C., and el Said K.R. Maturational development of drug-metabolizing enzymes in sheep. Am. J. Vet. Res. 51 (1990) 1736-1741
42. Kukanich B., Coetzee J.F., Gehring R., and Hubin M. Comparative disposition of pharmacologic markers for cytochrome P-450 mediated metabolism, glomerular filtration rate, and extracellular and total body fluid volume of Greyhound and Beagle dogs. J. Vet. Pharmacol. Ther. 30 (2007) 314-319
43. Kuroha M., Azumano A., Kuze Y., Shimoda M., and Kokue E. Effect of multiple dosing of ketoconazole on pharmacokinetics of midazolam, a cytochrome P-450 3A substrate in beagle dogs. Drug Metab. Dispos. 30 (2002) 63-68
44. Lamba J., Strom S., Venkataramanan R., Thummel K.E., Lin Y.S., Liu W., Cheng C., Lamba V., Watkins P.B., and Schuetz E. MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype. Clin. Pharmacol. Ther. 79 (2006) 325-338
45. Lainesse C., Frank D., Beaudry F., and Doucet M. Comparative oxidative metabolic profiles of clomipramine in cats, rats and dogs: preliminary results from an in vitro study. J. Vet. Pharmacol. Ther. 30 (2007) 387-393
46. Lakritz J., Winder B.S., Noorouz-Zadeh J., Huang T.L., Buckpitt A.R., Hammock B.D., and Plopper C.G. Hepatic and pulmonary enzyme activities in horses. Am. J. Vet. Res. 61 (2000) 52-57
47. Langsch A., and Bader A. Longterm stability of phase I and phase II enzymes of porcine liver cells in flat membrane bioreactors. Biotechnol. Bioeng. 76 (2001) 15-25
48. LeCluyse E.L. Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics. Chem. Biol. Interact. 134 (2001) 283-289
49. Lin Z., Lou Y., and Squires E.J. Molecular cloning, expression and functional characterization of the cytochrome P450 2A6 gene in pig liver. Anim. Genet. 35 (2004) 314-316
50. Lu C., and Li A.P. Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague-Dawley rat, minipig, and beagle dog. Chem. Biol. Interact. 134 (2001) 271-281
51. Mahmood I. Interspecies scaling: is a priori knowledge of cytochrome p450 isozymes involved in drug metabolism helpful in prediction of clearance in humans from animal data?. Drug Metabol. Drug Interact. 18 (2001) 135-147
52. Machala M., Neca J., Drábek P., Ulrich R., Sabatová V., Nezveda K., Raszyk J., and Gajdusková V. Effects of chronic exposure to PCBs on cytochrome P450 systems and steroidogenesis in liver and testis of bulls (Bos taurus). Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 120 (1998) 65-70
53. Machala M., Soucek P., Neca J., Ulrich R., Lamka J., Szotakova B., and Skalova L. Inter-species comparisons of hepatic cytochrome P450 enzyme levels in male ruminants. Arch. Toxicol. 77 (2003) 555-560
54. Mealey K.L., Bentjen S.A., Gay J.M., and Cantor G.H. Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene. Pharmacogenetics 11 (2001) 727-733
55. Monshouwer M., McLellan R.A., Delaporte E., Witkamp R.F., van Miert A.S., and Renton K.W. Differential effect of pentoxifylline on lipopolysaccharide-induced downregulation of cytochrome P450. Biochem. Pharmacol. 52 (1996) 1195-1200
56. Monshouwer M., Witkamp R.F., Nijmeijer S.M., Van Leengoed L.A., Vernooy H.C., Verheijden J.H., and Van Miert A.S. A lipopolysaccharide-induced acute phase response in the pig is associated with a decrease in hepatic cytochrome P450-mediated drug metabolism. J. Vet. Pharmacol. Ther. 19 (1996) 382-388
57. Monshouwer M., Van't Klooster G.A.E., Nijmeijer S.M., Witkamp R.F., and Van Miert A.S.J.P.A.M. Characterization of cytochrome P450 isoenzymes in primary cultures of pig hepatocytes. Toxicology in vitro 12 (1998) 715-723
58. Moore J.T., and Kliewer S.A. Use of the nuclear receptor PXR to predict drug interactions. Toxicology 153 (2000) 1-10
59. Myers M.J., Farrell D.E., Howard K.D., and Kawalek J.C. Identification of multiple constitutive and inducible hepatic cytochrome P450 enzymes in market weight swine. Drug Metab. Dispos. 29 (2001) 908-915
60. Nebbia C. Biotransformation enzymes as determinants of xenobiotic toxicity in domestic animals. Vet. J. 161 (2001) 238-252
61. Nebbia C., Ceppa L., Dacasto M., Carletti M., and Nachtmann C. Oxidative metabolism of monensin in rat liver microsomes and interactions with tiamulin and other chemotherapeutic agents: evidence for the involvement of cytochrome P-450 3A subfamily. Drug Metab. Dispos. 27 (1999) 1039-1044
62. Nebbia C., Ceppa L., Dacasto M., Nachtmann C., and Carletti M. Oxidative monensin metabolism and cytochrome P450 3A content and functions in liver microsomes from horses, pigs, broiler chicks, cattle and rats. J. Vet. Pharmacol. Ther. 24 (2001) 399-403
63. Nebbia C., Dacasto M., and Carletti M. Postnatal development of hepatic oxidative, hydrolytic and conjugative drug-metabolizing enzymes in female horses. Life Sci. 74 (2004) 1605-1619
64. Nebbia C., Dacasto M., Rossetto Giaccherino A., Giuliano Albo A., and Carletti M. Comparative expression of liver cytochrome P450-dependent monooxygenases in the horse and in other agricultural and laboratory species. Vet. J. 165 (2003) 53-64
65. Nelson D.R., Koymans L., Kamataki T., Stegeman J.J., Feyereisen R., Waxman D.J., Waterman M.R., Gotoh O., Coon M.J., Estabrook R.W., Gunsalus I.C., and Nebert D.W. P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics 6 (1996) 1-42
66. Nielsen K.K., Flinois J.P., Beaune P., and Brosen K. The biotransformation of clomipramine in vitro, identification of the cytochrome P450s responsible for the separate metabolic pathways. J. Pharmacol. Exp. Ther. 277 (1996) 1659-1664
67. Ohmori S., Shirakawa C., Motohashi K., Yoshida H., Abe H., Nakamura T., Horie T., Kitagawa H., Asaoka K., and Rikihisa T. Purification from liver microsomes from untreated Cynomolgus monkeys of cytochrome P450 closely related to human cytochrome P450 2B6. Mol. Pharmacol. 43 (1993) 183-190
68. Olkowski A., Gooneratne R., and Eason C. Cytochrome P450 enzyme activities in the Australian brushtail possum trichosurus vulpesula: a comparison with the rat, rabbit, sheep and chicken. Vet. Hum. Toxicol. 40 (1998) 70-76
69. Omura T., and Sato R. The carbon monoxide-binding pigment of liver microsomes. II. solubilization, purification, and properties. J. Biol. Chem. 239 (1964) 2379-2385
70. Pal D., and Mitra A.K. MDR- and CYP3A4-mediated drug-drug interactions. J. Neuroimmune Pharmacol. 1 (2006) 323-339
71. Paulson S.K., Engel L., Reitz B., Bolten S., Burton E.G., Maziasz T.J., Yan B., and Schoenhard G.L. Evidence for polymorphism in the canine metabolism of the cyclooxygenase 2 inhibitor, celecoxib. Drug Metab. Dispos. 27 (1999) 1133-1142
72. Pont A., Goldman E.S., Sugar A.M., Siiteri P.K., and Stevens D.A. Ketoconazole-induced increase in estradiol-testosterone ratio. Probable explanation for gynecomastia. Arch. Intern. Med. 145 (1985) 1429-1431
73. Ratz V., Laczay P., Mora Z., Csiko G., Monostori K., Vereczkey L., Lehel J., and Semjen G. Recent studies on the effects of tiamulin and monensin on hepatic cytochrome P450 activities in chickens and turkeys. J. Vet. Pharmacol. Ther. 20 (1997) 415-418
74. Raza H., Bhagwat S.V., and John A. Flavin-containing monooxygenase activity in camel tissues: comparison with rat and human liver enzymes. Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 139 (2004) 289-293
75. Regmi N.L., Abd El-Aty A.M., Kubota R., Shah S.S., and Shimoda M. Lack of inhibitory effects of several fluoroquinolones on cytochrome P-450 3A activities at clinical dosage in dogs. J. Vet. Pharmacol. Ther. 30 (2007) 37-42
76. Roussel F., Duignan D.B., Lawton M.P., Obach R.S., Strick C.A., and Tweedie D.J. Expression and characterization of canine cytochrome P450 2D15. Arch. Biochem. Biophys. 357 (1998) 27-36
77. Sahi J., Reyner E.L., Bauman J.N., Gueneva-Boucheva K., Burleigh J.E., and Thomas V.H. The effect of bergamottin on diazepam plasma levels and P450 enzymes in beagle dogs. Drug Metab. Dispos. 30 (2002) 135-140
78. Sakuma T., Shimojima T., Miwa K., and Kamataki T. Cloning CYP2D21 and CYP3A22 cDNAs from liver of miniature pigs. Drug Metab. Dispos. 32 (2004) 376-378
79. Schlezinger J.J., Keller J., Verbrugge L.A., and Stegeman J.J. 3,3',4,4'-Tetrachlorobiphenyl oxidation in fish, bird and reptile species: relationship to cytochrome P450 1A inactivation and reactive oxygen production. Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 125 (2000) 273-286
80. Shah S.S., Sanda S., Regmi N.L., Sasaki K., and Shimoda M. Characterization of cytochrome P450-mediated drug metabolism in cats. J. Vet. Pharmacol. Ther. 30 (2007) 422-428
81. Sharer J.E., Shipley L.A., Vandenbranden M.R., Binkley S.N., and Wrighton S.A. Comparisons of phase I and phase II in vitro hepatic enzyme activities of human, dog, rhesus monkey, and cynomolgus monkey. Drug Metab. Dispos. 23 (1995) 1231-1241
82. Shimada T., Tsumura F., Yamazaki H., Guengerich F.P., and Inoue K. Characterization of ( + / - )-bufuralol hydroxylation activities in liver microsomes of Japanese and Caucasian subjects genotyped for CYP2D6. Pharmacogenetics 11 (2001) 143-156
83. Skaanild M.T. Porcine cytochrome P450 and metabolism. Curr. Pharm. Des. 12 (2006) 1421-1427
84. Skaanild M.T., and Friis C. Characterization of the P450 system in Gottingen minipigs. Pharmacol. Toxicol. 80 Suppl. 2 (1997) 28-33
85. Skaanild M.T., and Friis C. Is cytochrome P450 CYP2D activity present in pig liver?. Pharmacol. Toxicol. 91 (2002) 198-203
86. Skaanild M.T., and Friis C. Porcine CYP2A polymorphisms and activity. Basic. Clin. Pharmacol. Toxicol. 97 (2005) 115-121
87. Smith T.L., Merry S.T., Harris D.L., Joe Ford J., Ike J., Archibong A.E., and Ramesh A. Species-specific testicular and hepatic microsomal metabolism of benzo(a)pyrene, an ubiquitous toxicant and endocrine disruptor. Toxicol. In Vitro 21 (2007) 753-758
88. Stoilov I., Jansson I., Sarfarazi M., and Schenkman J.B. Roles of cytochrome p450 in development. Drug Metabol. Drug Interact. 18 (2001) 33-55
89. Stupans I., Murray M., Kirlich A., Tuck K.L., and Hayball P.J. Inactivation of cytochrome P450 by the food-derived complex phenol oleuropein. Food Chem. Toxicol. 39 (2001) 1119-1124
90. Sureshkumar V., Venkateswaran K.V., and Jayasundar S. Interaction between enrofloxacin and monensin in broiler chickens. Vet. Hum. Toxicol. 46 (2004) 242-245
91. Szotakova B., Baliharova V., Lamka J., Nozinova E., Wsol V., Velik J., Machala M., Neca J., Soucek P., Susova S., and Skalova L. Comparison of in vitro activities of biotransformation enzymes in pig, cattle, goat and sheep. Res. Vet. Sci. 76 (2004) 43-51
92. Szucs G., Tamasi V., Laczay P., and Monostory K. Biochemical background of toxic interaction between tiamulin and monensin. Chem. Biol. Interact. 147 (2004) 151-161
93. Tanaka E., Narisawa C., Nakamura H., Sawa Y., Etoh H., Tadano K., Horie T., Ohkawa H., and Misawa S. Changes in the enzymatic activities of beagle liver during maturation as assessed both in vitro and in vivo. Xenobiotica 28 (1998) 795-802
94. Tanaka E., Taniguchi T., Sawa Y., Ohmori S., Kitada M., and Horie T. Trimethadione metabolism and microsomal monooxygenases in untreated and phenobarbital-treated rhesus monkeys. Comp. Biochem. Physiol. C. Pharmacol. Toxicol. Endocrinol. 120 (1998) 317-320
95. Tanaka N., Miyasho T., Shinkyo R., Sakaki T., and Yokota H. cDNA cloning and characterization of feline CYP1A1 and CYP1A2. Life Sci. 79 (2006) 2463-2473
96. Thomas J.H. Rapid birth-death evolution specific to xenobiotics cytochrome P450 genes in vertebrates. PloS Genetics 3 (2007) 702-728
97. Trepanier L.A. Cytochrome P450 and its role in veterinary drug interactions. Vet. Clin. North Am. Small Anim. Pract. 36 (2006) 975-985
98. Tydén E., Olsén L., Tallkvist J., Larsson P., and Tjälve H. CYP3A in horse intestines. Toxicol. Appl. Pharmacol. 201 (2004) 112-119
99. Vaclavikova R., Soucek P., Svobodova L., Anzenbacher P., Simek P., Guengerich F.P., and Gut I. Different in vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs, and minipigs. Drug Metab. Dispos. 32 (2004) 666-674
100. van't Klooster G.A., Blaauboer B.J., Noordhoek J., and van Miert A.S. Cytochrome P450 induction and metabolism of alkoxyresorufins, ethylmorphine and testosterone in cultured hepatocytes from goats, sheep and cattle. Biochem. Pharmacol. 46 (1993) 1781-1790
101. Witkamp R.F., Nijmeijer S.M., Csiko G., and van Miert A.S. Tiamulin selectively inhibits oxidative hepatic steroid and drug metabolism in vitro in the pig. J. Vet. Pharmacol. Ther. 17 (1994) 317-322
102. Wolkers H., Hammill M.O., and van Bavel B. Tissue-specific accumulation and lactational transfer of polychlorinated biphenyls, chlorinated pesticides, and brominated flame retardants in hooded seals (Cistophora cristata) from the Gulf of St. Lawrence: applications for monitoring. Environ. Pollut. 142 (2006) 476-486
103. Wolkers H., Corkeron P.J., Van Parijs S.M., Similä T., and Van Bavel B. Accumulation and transfer of contaminants in killer whales (Orcinus orca) from Norway: indications for contaminant metabolism. Environ. Toxicol. Chem. 26 (2007) 1582-1590
104. Yang C.S., Brady J.F., and Hong J.Y. Dietary effects on cytochromes P450, xenobiotic metabolism, and toxicity. Faseb J. 6 (1992) 737-744
105. Zeilmaker W.M., van 't Klooster G.A., Fink-Gremmels J., van Miert A.S., and Horbach G.J. cDNA and deduced amino acid sequence of a dwarf goat liver cytochrome P450 fragment belonging to the CYP2C gene subfamily. Biochem. Biophys. Res. Commun. 200 (1994) 120-125
106. Zweers-Zeilmaker W.M., Batzias J., Maas R.F., Horbach G.J., van Miert A.S., and Witkamp R.F. In vitro and in vivo oxidative biotransformation in the West-African dwarf goat (Caprus hircus aegagrus): substrate activities and effects of inducers. Xenobiotica 26 (1996) 1131-1141