Is cytochrome P450 CYP2D activity present in pig liver?

Pharmacology and Toxicology

Volumn 91, Issue 4, 2002, Pages 198-203

  Skaanild, Mette T ^a   Friis, Christian ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BUFURALOL; CYTOCHROME P450; CYTOCHROME P450 1A; CYTOCHROME P450 2A; CYTOCHROME P450 2B; CYTOCHROME P450 2D; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; DEBRISOQUINE; DEXTROMETHORPHAN; ENZYME INHIBITOR; ORPHENADRINE; RESVERATROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY DETECTION; ARTICLE; CATALYSIS; CELL ISOLATION; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SUBSTRATE; HYBRIDIZATION; IMMUNOBLOTTING; IMMUNOREGULATION; LIVER; LIVER MICROSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; STRAIN DIFFERENCE; SWINE;

ANIMALS; ANTIBODIES, MONOCLONAL; CYTOCHROME P-450 CYP2D6; DEBRISOQUIN; DEXTROMETHORPHAN; ETHANOLAMINES; FEMALE; MALE; MICROSOMES, LIVER; SUBSTRATE SPECIFICITY; SWINE; SWINE, MINIATURE;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A; SUS SCROFA;

EID: 0036800863     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0773.2002.t01-2-910403.x     Document Type: Article

References (22)

1. Alvan, G., B. Bechtel, L. Iselius, & U. Gundert-Remy: Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations. Eur. J. Clin. Pharmacol. 1990, 39, 533-537.
2. Chang, T. K. H., L. Yu, P. Maurel & D. J. Waxman: Enhanced cyclophosphamid and ifosfamide activation in primary human hepatocyte cultures: Response to cytochrome P-450 inducers and autooinduction by oxazaphosphorines. Cancer Res. 1997, 57, 1946-1954.
3. Chang, T. K. H. & H. H. Ko: Inhibition of rat hepatic microsomal CYP2B by resveratrol. FASEB 1999, 13(5), A811.
4. Cholerton, F. J. & J. R. Daly: The role of individual human cytochrome P450 in drug metabolism and clinical response. Trends Pharmacol. Sci. 1992, 13, 434-439.
5. Desille, M., L. Corcos, A. L. Helgoualch, B. Fremond, J. Campion, A. Goullouzo & B. Clement: Detoxifying activity in pig livers and hepatocytes intended for xenotherapy. Transplantation 1999, 68, 1437-1443.
6. Ekins, S., M. VandenBranden, B. J. Ring S. A. Wrighton: Examination of purported probes of human CYP2B6. Pharmacogenetics 1997, 7, 165-179.
7. Gelboin, H. V., K. W. Krausz, M. Shou, F. J. Gonzales & T. J. Yang: A monoclonal antibody inhibitory to human P450 2D6: A paradigm for use in combitorial determination of individual P450 role in specific drug tissue metabolism. Pharmacogenetics 1997, 7, 469-477.
8. Hanioka, N., H. Jinno, T. Tanaka-Kagawa, T. Nishimura & M. Ando: In vitro metabolism of chlorotriazines: Characterisation of simazine, atrazine, and propazine metabolism using liver microsomes from rats treated with various cytochrome P450 inducers. Toxicol. Appl. Pharmacol. 1999, 156, 195-205.
9. Horai, Y., M. Nakano, T. Ishizaki, K. Ishikawa, H. H. Zhou, B. J. Zhou, C. L. Liao & L. M. Zhang: Metropol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects: Japanese versus mainland Chinese. Clin. Pharmacol. Therap. 1989, 46, 198-207.
10. Jurima-Romet, M., W. L. Casley, C. A. Leblanc & M. Nowakowska: Evidence for the catalysis of dextromethorphan O-demethylation by a CYP2D6-like enzyme in pig liver. Toxicol. In Vitro 2000, 14, 253-263.
11. Kimonen, T., R. O. Juvonen, E. Alhava & M. Pasanen: The inhibition of CYP enzymes in mouse and human liver by pilocarpine. Brit. J. Pharmacol. 1995, 114, 832-836.
12. Krombach, T., D. Mathys, J. Gut, T. Castin & U. A. Meyer: High-performance liquid chromatographic assays for bufuralol 1′-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsoms and purified cytochrome P450 isoenzymes of human liver. Anal. Biochem. 1987, 162, 24-32.
13. Monshouwer, M., G. A. E. van't Klooster, S. M. Nijmeijer, R. F. Witkamp & A. S. J. P. A. M. van Miert: Characterisation of cytochrome P450 in primary cultures of pig hepatocytes. Toxicology in vitro 1998, 12, 715-723.
14. Nakamura, K., F. Goto, W. A. Ray, C. B. McAllister, E. Jacqz, G. R. Wilkinson & R. A. Branch: Interethnic differences in genetic polymorphism of debrisoquine and mephenytoin hydroxylation between Japanese and Caucasian populations. Clin. Pharmacol. Therap. 1985, 38, 402-408.
15. Reidy, G. F., I. Mehta & M. Murray: Inhibition of oxidative drug metabolism by orphenadrine: In vitro and in vivo evidence for isoenzyme specific complexation of cytochrome P-450 and inhibition kinetics. Mol. Pharmacol. 1998, 35, 763-743.
16. Rodriques, A. D.: Measurement of human liver microsomal cytochrome P450 2D6 activity using (O-methyl-14C) dextromethorphan as substrate. Meth. Enzymol. 1996, 272, 186-195.
17. Roussel, F., D. B. Duignan, M. P. Lawson, R. Scott Obach, C. A. Strick & D. J. Tweedie: Expression and characterisation of canine cytochrome P450 2D15. Arch. Biochem. Biophys. 1998, 357, 27-36.
18. Sai, Y., R. Dai, T. J. Yang, K. W. Krausz, F. J. Gonzales, H. V. Gelboin & M. Shou: Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochrome P450. Xenobiotica 2000, 30, 327-343.
19. Skaanild, M. T. & C. Friis: cytochrome P450 sex differences in mini-pigs and conventional pigs. Pharmacology & Toxicology 1999, 85, 174-180.
20. Sohn, D. R, S. G. Shin, C. W. Park, M. Kusaka, K. Chiba & T. Ishizaki: Metoprolol oxidation polymorphism in a Korean population comparison with native Japanese and Chinese populations. Brit. J. Clin. Pharmacol 1991, 32, 504-507.
21. Spina, E., G. M. Campo, A. Avenoso, A. P. Caputi, P. Pacifici, G. Strada, A. Bartoli & E. Perucca: Cyp2D6-related oxidation polymorphism in Italy. Pharmacol. Res. 1994, 29, 281-289.
22. Von Moltke, L. L., D. J. Greenblatt, J. M. Grassi, B. W. Granda, K. Venkatakrishnan, J. Schmider, J. S. Harmatz & R. I. Shader: Multiple human cytochromes contribute to biotransformation of destromethorphan in vitro: Role of CYP2C9, CYP2C19, CYP2D6, and CYP3A. J. Pharm. Pharmacol. 1998, 50, 997-1004.