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Volumn 36, Issue 2, 2005, Pages 179-190

Effect of breed and gender on bovine liver cytochrome P450 3A (CYP3A) expression and inter-species comparison with other domestic ruminants

Author keywords

Breed; CYP3A; Gender; Liver drug metabolism; Ruminants

Indexed keywords

CYTOCHROME P450 3A; DRUG METABOLIZING ENZYME;

EID: 14844360679     PISSN: 09284249     EISSN: None     Source Type: Journal    
DOI: 10.1051/vetres:2004066     Document Type: Article
Times cited : (41)

References (61)
  • 2
    • 0038729506 scopus 로고    scopus 로고
    • CYP3A5*3 and *6 single nucleotide polymorphisms in three distinct Asian populations
    • Balram C., Zhou Q., Cheung Y.B., Lee E.J., CYP3A5*3 and *6 single nucleotide polymorphisms in three distinct Asian populations, Eur. J. Clin. Pharmacol. 59 (2003) 123-126.
    • (2003) Eur. J. Clin. Pharmacol. , vol.59 , pp. 123-126
    • Balram, C.1    Zhou, Q.2    Cheung, Y.B.3    Lee, E.J.4
  • 3
    • 0742321729 scopus 로고    scopus 로고
    • Cytochrome P4503A and their regulation
    • Burk O., Wojnowski L., Cytochrome P4503A and their regulation, Arch. Pharmacol. 369 (2004) 105-124.
    • (2004) Arch. Pharmacol. , vol.369 , pp. 105-124
    • Burk, O.1    Wojnowski, L.2
  • 4
    • 0034041915 scopus 로고    scopus 로고
    • Pharmacokinetic behaviour of albendazole sulphoxide enantiomers in male and female sheep
    • Capece B.P.S., Castells G., Pérez F., Arboix M., Cristòfol C., Pharmacokinetic behaviour of albendazole sulphoxide enantiomers in male and female sheep, Vet. Res. Commun. 24 (2000) 339-348.
    • (2000) Vet. Res. Commun. , vol.24 , pp. 339-348
    • Capece, B.P.S.1    Castells, G.2    Pérez, F.3    Arboix, M.4    Cristòfol, C.5
  • 7
    • 0023353208 scopus 로고
    • Hepatic cytochrome P-450 dependent drug metabolizing enzyme activities in cattle, goats, and sheep
    • Dalvi R.R., Nunn V.A., Juskevich J., Hepatic cytochrome P-450 dependent drug metabolizing enzyme activities in cattle, goats, and sheep, J. Anim. Sci. 10 (1987) 164-168.
    • (1987) J. Anim. Sci. , vol.10 , pp. 164-168
    • Dalvi, R.R.1    Nunn, V.A.2    Juskevich, J.3
  • 8
    • 0003172279 scopus 로고
    • Effects of age, sex and breed on antipyrine disposition in calves
    • Depelchin B.O., Bloden S., Michaux C., Ansay M., Effects of age, sex and breed on antipyrine disposition in calves, Vet. Res. 44 (1988) 135-139.
    • (1988) Vet. Res. , vol.44 , pp. 135-139
    • Depelchin, B.O.1    Bloden, S.2    Michaux, C.3    Ansay, M.4
  • 9
    • 0032807651 scopus 로고    scopus 로고
    • Lack of sex-influence on the in vitro metabolism of ivermectin by hepatic microsomal preparations in cattle
    • Dupuy J., Eeckhoutte C., Sutra J.F., Mage C., Alvinerie M., Lack of sex-influence on the in vitro metabolism of ivermectin by hepatic microsomal preparations in cattle, Vet. Res. Commun. 23 (1999) 223-227.
    • (1999) Vet. Res. Commun. , vol.23 , pp. 223-227
    • Dupuy, J.1    Eeckhoutte, C.2    Sutra, J.F.3    Mage, C.4    Alvinerie, M.5
  • 11
    • 0037465616 scopus 로고    scopus 로고
    • Enhancement of moxidectin bioavailability in lamb by a natural flavonoid: Quercetin
    • Dupuy J., Larrieu G., Sutra J.F., Lespine A., Alvinerie M., Enhancement of moxidectin bioavailability in lamb by a natural flavonoid: quercetin, Vet. Parasitol. 25 (2003) 337-347.
    • (2003) Vet. Parasitol. , vol.25 , pp. 337-347
    • Dupuy, J.1    Larrieu, G.2    Sutra, J.F.3    Lespine, A.4    Alvinerie, M.5
  • 12
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapeutics
    • Evans W.E., Relling M.V., Pharmacogenomics: translating functional genomics into rational therapeutics, Science 286 (1999) 487-491.
    • (1999) Science , vol.286 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 13
    • 0033573017 scopus 로고    scopus 로고
    • Sex difference in the daily rhythm of hepatic P450 monooxygenase activities in rats is regulated by growth hormone release
    • Furukawa T., Manabe S., Watanabe T., Sharyo S., Mori Y., Sex difference in the daily rhythm of hepatic P450 monooxygenase activities in rats is regulated by growth hormone release, Toxicol. Appl. Pharmacol. 161 (1999) 219-224.
    • (1999) Toxicol. Appl. Pharmacol. , vol.161 , pp. 219-224
    • Furukawa, T.1    Manabe, S.2    Watanabe, T.3    Sharyo, S.4    Mori, Y.5
  • 15
    • 0029128720 scopus 로고
    • Gender effects in pharmacokinetics and pharmacodynamics
    • Harris R.Z., Benet L.Z., Schwartz J.B., Gender effects in pharmacokinetics and pharmacodynamics, Drugs 50 (1995) 222-239.
    • (1995) Drugs , vol.50 , pp. 222-239
    • Harris, R.Z.1    Benet, L.Z.2    Schwartz, J.B.3
  • 16
    • 0034655747 scopus 로고    scopus 로고
    • Regulation of cytochrome P450 (CYP) genes by nuclear receptors
    • Honkakoski P., Negishi M., Regulation of cytochrome P450 (CYP) genes by nuclear receptors, Biochem. J. 347 (2000) 321-337.
    • (2000) Biochem. J. , vol.347 , pp. 321-337
    • Honkakoski, P.1    Negishi, M.2
  • 17
    • 0032875044 scopus 로고    scopus 로고
    • The effect of sex on antipyrine metabolism in cattle at different ages
    • Janus K., Antoszek J., The effect of sex on antipyrine metabolism in cattle at different ages, J. Vet. Pharmacol. Ther. 22 (1999) 163-169.
    • (1999) J. Vet. Pharmacol. Ther. , vol.22 , pp. 163-169
    • Janus, K.1    Antoszek, J.2
  • 18
    • 0033870363 scopus 로고    scopus 로고
    • The effect of sex and age on caffeine pharmacokinetics in cattle
    • Janus K., Antoszek J., The effect of sex and age on caffeine pharmacokinetics in cattle, Res. Vet. Sci. 69 (2000) 33-37.
    • (2000) Res. Vet. Sci. , vol.69 , pp. 33-37
    • Janus, K.1    Antoszek, J.2
  • 19
    • 0034571275 scopus 로고    scopus 로고
    • A comparison of the ontogeny of enterocytic and hepatic cytochromes P450 3A in the rat
    • Johnson T.N., Tanner M.S., Tucker G.T., A comparison of the ontogeny of enterocytic and hepatic cytochromes P450 3A in the rat, Biochem. Pharmacol. 60 (2000) 1601-1610.
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 1601-1610
    • Johnson, T.N.1    Tanner, M.S.2    Tucker, G.T.3
  • 20
    • 0026716863 scopus 로고
    • Sex-specific cytochrome P450 as a cause of sex- and species-related differences in drug toxicity
    • Kato R., Yamazoe Y., Sex-specific cytochrome P450 as a cause of sex- and species-related differences in drug toxicity, Toxicol. Lett. 65 (1992) 661-667.
    • (1992) Toxicol. Lett. , vol.65 , pp. 661-667
    • Kato, R.1    Yamazoe, Y.2
  • 21
    • 0025204431 scopus 로고
    • Maturational development of drug-metabolizing enzymes in sheep
    • Kawalek J.C., El Said K.R., Maturational development of drug-metabolizing enzymes in sheep, Am. J. Vet. Res. 51 (1990) 1736-1741.
    • (1990) Am. J. Vet. Res. , vol.51 , pp. 1736-1741
    • Kawalek, J.C.1    El Said, K.R.2
  • 22
    • 0002120851 scopus 로고
    • Serum growth hormone concentration in Hereford and Angus calves: Effects of breed, sire, sex, age, age of dam, and diet
    • Keller D.G., Smith V.G., Coulter G.H., King G.J., Serum growth hormone concentration in Hereford and Angus calves: effects of breed, sire, sex, age, age of dam, and diet, Can. J. Anim. Sci. 59 (1979) 367-373.
    • (1979) Can. J. Anim. Sci. , vol.59 , pp. 367-373
    • Keller, D.G.1    Smith, V.G.2    Coulter, G.H.3    King, G.J.4
  • 23
    • 0036799870 scopus 로고    scopus 로고
    • The nuclear pregnane X receptor: A key regulator of xenobiotic metabolism
    • Kliewer S.A., Goodwin B., Willson T.M. The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism, Endocr. Rev. 23 (2002) 687-702.
    • (2002) Endocr. Rev. , vol.23 , pp. 687-702
    • Kliewer, S.A.1    Goodwin, B.2    Willson, T.M.3
  • 24
    • 1642301013 scopus 로고    scopus 로고
    • Sex difference in induction of hepatic CYP2B and CYP3A subfamily enzymes by nicardipine and nifedipine in rats
    • Konno Y., Sekimoto M., Nemoto K., Degawa M., Sex difference in induction of hepatic CYP2B and CYP3A subfamily enzymes by nicardipine and nifedipine in rats, Toxicol. Appl. Pharmacol. 196 (2004) 20-28.
    • (2004) Toxicol. Appl. Pharmacol. , vol.196 , pp. 20-28
    • Konno, Y.1    Sekimoto, M.2    Nemoto, K.3    Degawa, M.4
  • 25
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli U.K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature 227 (1970) 680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 26
    • 0037131879 scopus 로고    scopus 로고
    • Genetic contribution to variable human CYP3A-mediated metabolism
    • Lamba J.K., Lyn Y.S., Schuetz E.G., Thummel K.E., Genetic contribution to variable human CYP3A-mediated metabolism, Adv. Drug Deliv. Rev. 54 (2002) 1271-1294.
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. 1271-1294
    • Lamba, J.K.1    Lyn, Y.S.2    Schuetz, E.G.3    Thummel, K.E.4
  • 27
    • 0024469748 scopus 로고
    • Rat liver microsomal progesterone metabolism: Evidence for differential troleandomycin and pregnenolone 16α-carbonitrile inductive effects in the cytochrome P-450 III family
    • Larroque C., Lange R., Maurel P., Langlois R., van Lier J.E., Rat liver microsomal progesterone metabolism: evidence for differential troleandomycin and pregnenolone 16α-carbonitrile inductive effects in the cytochrome P-450 III family, J. Steroid Biochem. 33 (1989) 277-286.
    • (1989) J. Steroid Biochem. , vol.33 , pp. 277-286
    • Larroque, C.1    Lange, R.2    Maurel, P.3    Langlois, R.4    van Lier, J.E.5
  • 28
    • 0028020553 scopus 로고
    • Age and gender effect on the inducibility of steroid metabolizing cytochrome P450 in rat liver
    • Lee P.-C., Struve M.F., Werlin S.L., Age and gender effect on the inducibility of steroid metabolizing cytochrome P450 in rat liver, Biochem. Mol. Biol. Int. 34 (1994) 861-870.
    • (1994) Biochem. Mol. Biol. Int. , vol.34 , pp. 861-870
    • Lee, P.-C.1    Struve, M.F.2    Werlin, S.L.3
  • 29
    • 0029849464 scopus 로고    scopus 로고
    • Expression and inducibility of cytochrome P450 proteins in the liver of chick embryo
    • Machala M., Nezveda K., Irizar A., Bu-Abbas A., Ioannides C., Expression and inducibility of cytochrome P450 proteins in the liver of chick embryo, Arch. Toxicol. 71 (1996) 57-63.
    • (1996) Arch. Toxicol. , vol.71 , pp. 57-63
    • Machala, M.1    Nezveda, K.2    Irizar, A.3    Bu-Abbas, A.4    Ioannides, C.5
  • 31
    • 0001949071 scopus 로고    scopus 로고
    • The CYP3 family
    • Ioannides C. (Ed.), CRC Press, Boca Raton, Florida
    • Maurel P., The CYP3 family, in: Ioannides C. (Ed.), Cytochrome P450: Metabolic and Toxicological Aspects, CRC Press, Boca Raton, Florida, 1996, pp. 241-270.
    • (1996) Cytochrome P450: Metabolic and Toxicological Aspects , pp. 241-270
    • Maurel, P.1
  • 32
    • 0032499416 scopus 로고    scopus 로고
    • Strain differences in CYP3A-mediated C-8 hydroxylation (1,3,7-trimethyluric acid formation) of caffeine in Wistar and Dark Agouti rats
    • Morita K., Maeda Y., Masuda M., Kazusaka A., Imaoka S., Funae Y., Fujita S., Strain differences in CYP3A-mediated C-8 hydroxylation (1,3,7-trimethyluric acid formation) of caffeine in Wistar and Dark Agouti rats, Biochem. Pharmacol. 55 (1998) 1405-1411.
    • (1998) Biochem. Pharmacol. , vol.55 , pp. 1405-1411
    • Morita, K.1    Maeda, Y.2    Masuda, M.3    Kazusaka, A.4    Imaoka, S.5    Funae, Y.6    Fujita, S.7
  • 33
    • 0031948975 scopus 로고    scopus 로고
    • Sex-dependent metabolism of xenobiotics
    • Mugford C.A., Kedderis G.L., Sex-dependent metabolism of xenobiotics, Drug Metab. Rev. 30 (1998) 441-498.
    • (1998) Drug Metab. Rev. , vol.30 , pp. 441-498
    • Mugford, C.A.1    Kedderis, G.L.2
  • 35
    • 0034965391 scopus 로고    scopus 로고
    • Biotranformation enzymes as determinants of xenobiotic toxicity in domestic animals
    • Nebbia C., Biotranformation enzymes as determinants of xenobiotic toxicity in domestic animals, Vet. J. 161 (2001) 238-252.
    • (2001) Vet. J. , vol.161 , pp. 238-252
    • Nebbia, C.1
  • 37
    • 0037981410 scopus 로고    scopus 로고
    • Comparative expression of liver cytochrome P450dependent monooxygenases in the horse and in other agricultural and laboratory species
    • Nebbia C., Dacasto M., Rossetto Giaccherino A., Giuliano Albo A., Carletti M., Comparative expression of liver cytochrome P450-dependent monooxygenases in the horse and in other agricultural and laboratory species, Vet. J. 165 (2003) 53-64.
    • (2003) Vet. J. , vol.165 , pp. 53-64
    • Nebbia, C.1    Dacasto, M.2    Rossetto Giaccherino, A.3    Giuliano Albo, A.4    Carletti, M.5
  • 38
    • 50449100139 scopus 로고
    • The carbon monoxide binding pigment of liver microsomes. II. Solubilisation, purification, properties
    • Omura T., Sato R., The carbon monoxide binding pigment of liver microsomes. II. Solubilisation, purification, properties, J. Biol. Chem. 239 (1964) 2379-2385.
    • (1964) J. Biol. Chem. , vol.239 , pp. 2379-2385
    • Omura, T.1    Sato, R.2
  • 39
    • 0002669498 scopus 로고    scopus 로고
    • The cytochrome P450 oxidative system
    • Woolf T.F. (Ed.), Marcel Dekker, New York
    • Ortiz de Montellano P.R., The cytochrome P450 oxidative system, in: Woolf T.F. (Ed.), Handbook of drug metabolism, Marcel Dekker, New York, 1999, pp. 109-130.
    • (1999) Handbook of Drug Metabolism , pp. 109-130
    • Ortiz de Montellano, P.R.1
  • 40
    • 0027240718 scopus 로고
    • Sexual dimorphism in avian hepatic monooxygenases
    • Pampori N.A., Shapiro B.H., Sexual dimorphism in avian hepatic monooxygenases, Biochem. Pharmacol. 46 (1993) 885-890.
    • (1993) Biochem. Pharmacol. , vol.46 , pp. 885-890
    • Pampori, N.A.1    Shapiro, B.H.2
  • 41
    • 0025060158 scopus 로고
    • Purification of a sheep liver cytochrome P-450 from the P450IIIA gene subfamily. Its contribution to the N-dealkylation of veterinary drugs
    • Pineau T., Galtier P., Bonfils C., Derancourt J., Maurel P., Purification of a sheep liver cytochrome P-450 from the P450IIIA gene subfamily. Its contribution to the N-dealkylation of veterinary drugs, Biochem. Pharmacol. 39 (1990) 901-909.
    • (1990) Biochem. Pharmacol. , vol.39 , pp. 901-909
    • Pineau, T.1    Galtier, P.2    Bonfils, C.3    Derancourt, J.4    Maurel, P.5
  • 42
    • 0033020104 scopus 로고    scopus 로고
    • Induction and suppression of murine CYP-mediated biotransformation by dithianon: Organ- and sex-related differences
    • Pozzetti L., Paolini M., Barillari J., Cantelli-Forti G., Induction and suppression of murine CYP-mediated biotransformation by dithianon: organ- and sex-related differences, Cancer Lett. 141 (1999) 47-56.
    • (1999) Cancer Lett. , vol.141 , pp. 47-56
    • Pozzetti, L.1    Paolini, M.2    Barillari, J.3    Cantelli-Forti, G.4
  • 43
    • 0035042684 scopus 로고    scopus 로고
    • CYP3A regulation: From pharmacology to nuclear receptors
    • Quattrochi L.C., Guzelian P.S., CYP3A regulation: from pharmacology to nuclear receptors, Drug Metab. Dispos. 29 (2001) 615-622.
    • (2001) Drug Metab. Dispos. , vol.29 , pp. 615-622
    • Quattrochi, L.C.1    Guzelian, P.S.2
  • 45
    • 0032488562 scopus 로고    scopus 로고
    • Sexually dimorphic expression of rat CYP3A9 and CYP3A18 genes is regulated by growth hormone
    • Robertson G.R., Farrell G.C., Liddle C., Sexually dimorphic expression of rat CYP3A9 and CYP3A18 genes is regulated by growth hormone, Biochem. Biophys. Res. Commun. 242 (1998) 57-60.
    • (1998) Biochem. Biophys. Res. Commun. , vol.242 , pp. 57-60
    • Robertson, G.R.1    Farrell, G.C.2    Liddle, C.3
  • 46
    • 0028009291 scopus 로고
    • Consideration of sheep as a minor species: Comparison of drug metabolism and disposition with other domestic ruminants
    • Short C.R., Consideration of sheep as a minor species: comparison of drug metabolism and disposition with other domestic ruminants, Vet. Hum. Toxicol. 36 (1994) 24-40.
    • (1994) Vet. Hum. Toxicol. , vol.36 , pp. 24-40
    • Short, C.R.1
  • 47
    • 0024260819 scopus 로고
    • Comparative drug metabolism and disposition in minor species
    • Short C.R., Barker S.A., Flory W., Comparative drug metabolism and disposition in minor species, Vet. Hum. Toxicol. 30 (1988) 2-8.
    • (1988) Vet. Hum. Toxicol. , vol.30 , pp. 2-8
    • Short, C.R.1    Barker, S.A.2    Flory, W.3
  • 49
    • 0035452218 scopus 로고    scopus 로고
    • A study of the expression of the xenobiotic-metabolising cytochrome P450 proteins and of testosterone metabolism in bovine liver
    • Sivapathasundaram S., Magnisali P., Coldham N.G., Howells L.C., Sauer MJ., Ioannides C., A study of the expression of the xenobiotic-metabolising cytochrome P450 proteins and of testosterone metabolism in bovine liver, Biochem. Pharmacol. 62 (2001) 635-645.
    • (2001) Biochem. Pharmacol. , vol.62 , pp. 635-645
    • Sivapathasundaram, S.1    Magnisali, P.2    Coldham, N.G.3    Howells, L.C.4    Sauer, M.J.5    Ioannides, C.6
  • 52
    • 0032825471 scopus 로고    scopus 로고
    • Cytochrome P450 sex differences in minipigs and conventional pigs
    • Skaanild M.T., Friis C., Cytochrome P450 sex differences in minipigs and conventional pigs, Pharmacol. Toxicol. 85 (1999) 174-180.
    • (1999) Pharmacol. Toxicol. , vol.85 , pp. 174-180
    • Skaanild, M.T.1    Friis, C.2
  • 56
    • 0032731634 scopus 로고    scopus 로고
    • Gender-related differences in pharmacokinetics and their clinical significance
    • Tanaka E., Gender-related differences in pharmacokinetics and their clinical significance, J. Clin. Pharm. Ther. 24 (1999) 339-346.
    • (1999) J. Clin. Pharm. Ther. , vol.24 , pp. 339-346
    • Tanaka, E.1
  • 57
    • 0009482260 scopus 로고
    • Electrophoretic transfert of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
    • Towbin H., Staehelin T., Gordon J., Electrophoretic transfert of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications, Proc. Natl. Acad. Sci. USA 76 (1979) 4350-4354.
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehelin, T.2    Gordon, J.3
  • 58
    • 0027432032 scopus 로고
    • Cytochrome P450 induction and metabolism of alkoxyresorufins, ethylmorphine and testosterone in cultured hepatocytes from goats, sheep and cattle
    • Van't Klooster G.A.E., Blaauboer B.J., Noordhoek A., van Miert A.S.J.P.A.M., Cytochrome P450 induction and metabolism of alkoxyresorufins, ethylmorphine and testosterone in cultured hepatocytes from goats, sheep and cattle, Biochem. Pharmacol. 46 (1993) 1781-1790.
    • (1993) Biochem. Pharmacol. , vol.46 , pp. 1781-1790
    • Van't Klooster, G.A.E.1    Blaauboer, B.J.2    Noordhoek, A.3    van Miert, A.S.J.P.A.M.4
  • 59
    • 0017794681 scopus 로고
    • Assay of formaldehyde during microsomal oxidations reactions
    • Werringloer J., Assay of formaldehyde during microsomal oxidations reactions, Methods Enzymol. C 52 (1978) 297-302.
    • (1978) Methods Enzymol. C , vol.52 , pp. 297-302
    • Werringloer, J.1
  • 60
    • 0027261395 scopus 로고
    • Selective changes in oxidative xenobiotic metabolism in vivo and in vitro after parenteral administration of recombinant bovine somatotrophin to rats
    • Witkamp R.F., Kolker H.J., Nijmeijer S.M., Noordhoek J., van Miert A.S., Selective changes in oxidative xenobiotic metabolism in vivo and in vitro after parenteral administration of recombinant bovine somatotrophin to rats, Res. Vet. Sci. 55 (1993) 31-37.
    • (1993) Res. Vet. Sci. , vol.55 , pp. 31-37
    • Witkamp, R.F.1    Kolker, H.J.2    Nijmeijer, S.M.3    Noordhoek, J.4    van Miert, A.S.5
  • 61
    • 0031885157 scopus 로고    scopus 로고
    • Identification of cytochrome P4503A4 as the major enzyme responsible for the metabolism of ivermectin by human liver microsomes
    • Zeng Z., Andrew N.W., Arison B.H., Luffer-Atlas D., Wang R.W., Identification of cytochrome P4503A4 as the major enzyme responsible for the metabolism of ivermectin by human liver microsomes, Xenobiotica 28 (1998) 313-321.
    • (1998) Xenobiotica , vol.28 , pp. 313-321
    • Zeng, Z.1    Andrew, N.W.2    Arison, B.H.3    Luffer-Atlas, D.4    Wang, R.W.5


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