Isolation of a new canine cytochrome P450 cDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression

Drug Metabolism and Disposition

Volumn 26, Issue 3, 1998, Pages 278-283

  Blaisdell, Joyce ^b   Goldstein, Joyce A ^b   Bai, Stephen A ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMPICILLIN; COMPLEMENTARY DNA; CYTOCHROME P450; KANAMYCIN; NEW DRUG; PHOSPHORUS 32; TETRACYCLINE; XENOBIOTIC AGENT;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DRUG CLEARANCE; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GENETIC POLYMORPHISM; GENOME; LIVER METABOLISM; LIVER MICROSOME; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; XENOBIOTIC METABOLISM;

AMINO ACID SEQUENCE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BASE SEQUENCE; CLONING, MOLECULAR; CYTOCHROME P-450 ENZYME SYSTEM; DOGS; FEMALE; GENE EXPRESSION REGULATION; GENOTYPE; ISOENZYMES; LIVER; MALE; MOLECULAR SEQUENCE DATA; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES;

EID: 0031892910     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Chenevix-Trench O, Young J, Coggan M and Board P (1995) Glutathione S-transferase M1 and T1 polymorphisms: Susceptibility to colon cancer and age of onset. Carcinogenesis 16:1655-1657.
2. Chomczynski P and Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
3. Ciaccio PJ, Graves PE, Bourque DP, Glinsmann-Gibson B and Halpert JR (1991) cDNA and deduced amino acid sequences of a dog liver cytochrome P-450 of the IIIA gene subfamily. Biochim Biophys Acta 1088:319-322.
4. de Morals SMF, Schweikl H, Blaisdell J and Goldstein JA (1993) Gene structure and upstream regulatory regions of human CYP2C9 and CYP2C18. Biochem Biophys Res Commun 194: 194-201.
5. Duignan DB, Sipes IG, Leonard TB and Halpert JR (1987) Purification and characterization of the dog hepatic cytochrome P-450 isozyme responsible for the metabolism of 2,2′, 4,4′, 5,5′-hexachlorobiphenyl. Arch Biochem Biophys 255:290-303.
6. Fukuta H, Ohi H, Uchida T, Komori M, Kitada M and Kamataki T (1992) Toxicological significance of dog liver cytochrome P-450: Examination with the enzyme expressed in Saccharomyces cerevisiae using recombinant expression plasmid. Mutat Res 269:97-105.
7. Gaedigk AG, Blum M, Gaedigk M and Meyer UA (1991) Deletion of the entire P450 CYP2D gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/ sparteine polymorphism. Am J Hum Genet 48:943-950.
8. Ged C, Umbenhauer DR, Bellew TM, Bork RW, Srivastava PK, Shinri N, Lloyd RS and Guengerich FP (1987) Characterization of cDNAs, mRNAs and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4-hydroxylase. Biochemistry 27:6929-6940.
9. Goldstein JA and de Morais SMF (1994) Biochemistry and molecular biology of the human CYP2C subfamily. Pharmacogenetics 4:285-299.
10. Graves PE, Elhag GA, Ciaccio PJ, Bourque DP and Halpert JR (1990) cDNA and deduced amino acid sequences of a dog hepatic cytochrome P450IIB responsible for the metabolism of 2,2′,4,4′, 5,5′-hexachlorobiphenyl. Arch Biochem Biophys 281:106-115.
11. Guengerich FP (1990) Enzymatic oxidation of xenobiotic chemicals. Crit Rev Biochem Mol Biol 25:97-153.
12. John GH, Hasler JA, He Y and Halpert JR (1994) Escherichia coli expression and characterization of cytochromes P450 2B11, 2B1 and 2B5. Arch Biochem Biophys 314:367-375.
13. Katoh T, Inatomi H, Nagaoka A and Sugita A (1995) Cytochrome P4501A1 gene polymorphism and homozygote deletion of the glutathione S-transferase M1 gene in urothelial cancer patients. Carcinogenesis 16:655-657.
14. Kedzie KM, Philpot RM and Halpert JR (1991) Functional expression of mammalian cytochromes P450IIB in the yeast Sacchraromyces cerevisiae. Arch Biochem Biophys 291:176-186.
15. Kedzie KM, Grimm SW, Chen F and Halpert JR (1993) Hybrid enzymes for structure-function analysis of cytochrome P-450 2B11. Biochim Biophys Acta 1164:124-132.
16. Komori M, Shimada H, Miura T and Kamataki T (1989) Interspecies homology of liver microsomal cytochrome P-450: A form of dog cytochrome P-450 (P-450-D1) crossreactive with antibodies to rat P-450-male. Biochem Pharmacol 38:235-240.
17. Romkes M, Faletto MB, Blaisdell JA, Raucy JL and Goldstein JA (1991) Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily. Biochemistry 30:3247-3255.
18. Sakamoto K, Kirita S, Baba T, Nakamura Y, Yamazoe Y, Kato R, Takanaka A and Matsybara T (1995) A new cytochrome P450 form belonging to the CYP2D in dog liver microsomes: Purification, cDNA cloning and enzyme characterization. Arch Biochem Biophys 319:372-382.
19. Skoda RC, Gonzalez FJ, Demierre A and Meyer UA (1988) Two mutant alleles of the human cytochrome P450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs. Proc Natl Acad Sci USA 85:5240-5243.
20. Soucek P and Gut I (1992) Cytochromes P-450 in rats: Structures, functions, properties and relevant human forms. Xenobiotica 22:83-103.
21. Uchida T, Komori M, Kitada M and Kamataki T (1990) Isolation of cDNAs coding for three different forms of liver microsomal cytochrome P-450 from polychlorinated biphenyl-treated beagle dogs. Mol Pharmacol 38: 644-651.
22. Umbenhauer DR, Martin MV, Lloyd RS and Guengerich FP (1987) Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase. Biochemistry 26:1094-1099.
23. Yoshioka H, Morohashi K, Sogawa K, Miyata T, Kawajiri K, Hirose T, Inayama S, Fujii-Kuriyama Y and Omura T (1987) Structural analysis and specific expression of microsomal cytochrome P-450(M-1) mRNA in male rat livers. J Biol Chem 262:1706-1711.
24. Zaphiropoulos PG, Mode A, Strom A, Moller C, Fernandez C and Gustafsson J-A (1988) cDNA cloning sequence and regulation of a major female-specific and growth hormone-inducible rat liver cytochrome P-450 active in 15β-hydroxylation of steroid sulfates. Proc Natl Acad Sci USA 85:4214-4217.