Recent studies on the effects of tiamulin and monensin on hepatic cytochrome P450 activities in chickens and turkeys

Journal of Veterinary Pharmacology and Therapeutics

Volumn 20, Issue 5, 1997, Pages 415-418

  Ratz V ^a   Laczay, P ^a   Mora Zs ^a   Csiko Gy ^a   Monostori, K ^b   Vereczkey, L ^b   Lehel, J ^a   Semjen G ^a  

^a UNIVERSITY OF VETERINARY MEDICINE   (Hungary)

^b CTRL RES INSTITUTE FOR CHEMISTRY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; ELANCOBAN; MONENSIN; TIAMULIN; TIAMULIN FUMARATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHICKEN; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SPECIES DIFFERENCE; TURKEY (BIRD);

ANIMALIA; AVES; GALLUS GALLUS; MELEAGRIS GALLOPAVO;

EID: 0030820008     PISSN: 01407783     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2885.1997.00092.x     Document Type: Article

References (25)

1. Aitio, A. (1978) A simple and sensitive assay of 7-ethoxycoumarin deethylation. Analytical Biochemistry, 85, 488-191.
2. Anadón, A., Martínez-Larrañaga, M.R., Díaz, M.J. & Bringas, P. (1989) Effect of tiamulin on antipyrine kinetics in chickens. Journal of Veterinary Pharmacology and Therapeutics, 12, 94-98.
3. Burke, M.D., Thompson, S., Elcombe, C.R., Halpert, J., Haaparanta, T. & Mayer, R.T. (1985) Ethoxy-, pentoxy-, and benzyloxyphenazone and homologues: a series of substrates to distinguish between different induced cytochromes P-450. Biochemical Pharmacology, 34, 3337-3345.
4. Hanrahan, L.A., Corner, D.E. & Naqi, S.A. (1981) Monensin toxicosis in broiler chickens. Veterinary Pathology, 18, 665-671.
5. Hilbrich, P. & Trautwein, G. (1980) Tiamulin-monensin toxic interaction in the chicken. Der Praktische Tierarzt, 61, 262-265.
6. Imai, Y., Ito, A.G. & Sato, R. (1966) Evidence for biochemically different types of vesicles in hepatic microsomal fraction. Journal of Biochemistry, 60, 417-428.
7. Kamataki, T. (1993) Metabolism of xenobiotics. In Cytochrome P-450. 2nd ed. Eds Omura, T., Ishimura, Y. & Fujii-Kuriyama, Y. pp. 141-158. VCH Publisher In., New York.
8. Laczay, P., Simon, F., Móra, Zs. & Lehel, J. (1989) Compatibility of some new ionophoric anticoccidials with other chemotherapies in broilers. Deutsche Tierärztliche Wohenschrift, 96, 449-451.
9. Laczay, P., Simon, F. & Lehel, J. (1990) Investigations on the influence of monensin, tiamulin and of the simultaneous application of both substances on the activities of the microsomal mixed function oxygenases and of the formation of peroxides in broilers. Deutsche Tierärztliche Wochenschrift, 97, 354-357.
10. Lorr, N.A., Bloom, S.E., Park, S.S., Gelboin, H.V., Miller, H. & Friedman, F.K. (1989) Evidence for a PCN-P450 enzyme in chickens and comparison of its development with that of other phenobarbiral-inducible forms. Molecular Pharmacology, 35, 610-616.
11. Lowry, O.H., Rosebrough, N.J., Farr, A.L. & Randall, R.J. (1951) Protein measurement with Polin phenol reagent. Journal of Biological Chemistry, 193, 267-275.
12. Meingasser, J.G., Schmook, F.P., Czok, R. & Mieth, H. (1979) Enhancement of the anticoccidial activity of polyether antibiotics in chickens by tiamulin. Poultry Science, 58, 308-313.
13. Mollenhauer, H.H., Morre, J.D. & Rowe, L.D. (1990) Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity. Biochimica et Biophysics Acta, 1031, 225-246.
14. Nash, I. (1953) The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. Biochemical Journal, 55, 416-421.
15. Pott, J.M. & Skov, B. (1981) Monensin-tiamulin interactions in pigs. Veterinary Record, 109, 545.
16. Reinke, L.A. & Moyer, J.M. (1985) β-nitrofenol hydroxylation. A microsomal oxidation which is highly inducible by ethanol. Drug Metabolism and Disposition, 13, 548-552.
17. Sinclair, J.F. & Sinclair, P.R. (1993) Avian cytochrome P450. In Cytochrome P450. Eds Schenkman, J.B. & Greim, H. pp. 259-277. Springer Verlag, Berlin, Heidelberg, New York.
18. Umemura, T., Nakamura, H., Goryo, M. & Itakura, C. (1984) Histopathology of monensin-tiamulin myopathy in broiler chicks. Avian Pathology, 13, 459-468.
19. van Vleet, J.F., Amstutz, H.E., Weirich, W.E., Rebar, A.H. & Ferrans, V.I. (1983) Clinical, clinico-pathoiogic, and pathologic alterations of monensin toxicosis in swine. American Journal of Veterinary Research, 44, 1469-1475.
20. Weisman, Y., Schlosberg, A. & Egyed, M.N. (1980) Acute poisoning in turkeys caused by incompatibiliy of monensin and tiamulin. Veterinary Research Communications, 4, 231-235.
21. Witkamp, R.F., Nijmeijer, S.M., Csikó, G. & Van Miert, A.S.I.P.A.M. (1994a) Tiamulin selectively inhibits oxidative hepatic steroid and drug metabolism in vitro in the pig. Journal of Veterinary Pharmacology and Therapeutics, 17, 317-322.
22. Witkamp, R.F., Nijmeijer, S.M. & Van Miert, A.S.I.P.A.M. (1994b) Tiamulin selectively induces and inhibits oxidative drug metabolism in pigs and rats via the formation of stable-inactive-cytochrome P-450 metabolite complex. In Proceedings, 6th EAVPT International Congress, Edinburgh, Ed. P. Lees. pp. 27. Blackwell Scientific Publications, Oxford.
23. Witkamp, R.F., Nijmeijer, S.M., Monshouwer, M. & Van Miert, A.S.I.P.A.M. (1995) The antibiotic tiamulin is a potent inducer and inhibitor of cytochrome P4503A via the formation of a stable metabolic intermediate complex. Drug Metabolism and Disposition, 23, 542-547.
24. Witkamp, R.F., Nijmeijer, S.M. & Van Miert, A.S.I.P.A.M. (1996) Cytochrome P-450 complex formation in rat liver by the antibiotic tiamulin. Antimicrobial Agents and Chemotherapy, 40, 50-54.
25. Wrighton, S.A., Maurel, P., Schuetz, E.G., Watkins, P.B., Young, B. & Guzelian, P.S. (1985) Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid response cytochrome P-450p. Biochemistry, 24, 2171-2178.