Differential effect of pentoxifylline on lipopolysaccharide-induced downregulation of cytochrome P450

Biochemical Pharmacology

Volumn 52, Issue 8, 1996, Pages 1195-1200

  Monshouwer, Mario ^a   McLellan, Roman A ^b   Delaporte, Enock ^b   Witkamp, Renger F ^a   Van Miert, Adelbert S J P A M ^a   Renton, Kenneth W ^b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b DALHOUSIE UNIVERSITY   (Canada)

Author keywords

cytochrome P450; downregulation; lipopolysaccharide; pentoxifylline; polyIC; t umor necrosis factor

Indexed keywords

CYTOCHROME P450 ISOENZYME; CYTOKINE; DRUG METABOLIZING ENZYME; ERYTHROMYCIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; MESSENGER RNA; PENTOXIFYLLINE; POLYINOSINIC POLYCYTIDYLIC ACID; RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME REGULATION; GENE EXPRESSION; INFLAMMATION; INTERFERON INDUCTION; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030601835     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00468-6     Document Type: Article

References (38)

1. 1. Morgan ET, Suppression of constitutive cytochrome P-450 gene expression in livers of rats undergoing an acute phase response to endotoxin. Mol Pharmacol 36: 699-707, 1989.
2. 2. Renton KW and Knickle LC, Regulation of hepatic cytochrome P450 during infectious disease. Can J Physiol Pharmacol 68: 777-781, 1990.
3. 3. Cribb AE, Delaporte E, Kim SG, Novak RF and Renton KW, Regulation of cytochrome P4501A and cytochrome P4502E induction in the rat during the production of interferon α/β. J Exp Pharmacol Ther 268: 487-494, 1994.
4. 4. Williams SJ and Farrell GC, Inhibition of antipyrine metabolism by interferon. Br J Clin Pharmacol 22: 610-612, 1986.
5. 5. Shedlofsky SI, Israel BC, McClain CJ, Hill DB and Blouin RA, Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism. J Clin Invest 94: 2209-2214, 1994.
6. 6. Renton KW, Effects of interferon inducers and viral infections on the metabolism of drugs. In: Advances in Immuno-pharmacology (Eds. Hadden J, Chedid L, Mullen P and Spreafico F), pp. 17-24. Pergamon Press, Oxford, 1981.
7. 7. Ghezzi PB, Saccardo B, Rossi V, Bianchi M and Dinarello CA, Role of IL-1 in the depression of liver drug metabolism by endotoxin. Infect Immun 54: 837-840, 1986.
8. 8. Ghezzi PB, Saccardo B and Bianchi M, Recombinant TNF depresses cytochrome P450-dependent microsomal drug metabolism in mice. Biochem Biophys Res Commun 136: 316-321, 1986.
9. 9. Chen YL, Florentin I, Batt AM, Ferrari L, Giroud JP and Chauvelot-Moachon L, Effects of interleukin-6 on cytochrome P450 dependent mixed-function oxidases in the rat. Biochem Pharmacol 44: 137-148, 1992.
10. 10. Semmler J, Gebert U, Eisenhut T, Moeller J, Schonharting MM, Allera A and Endres S, Xanthine derivatives; comparison between suppression of tumour necrosis factor-α production and inhibition of cAMP phosphodiesterase. Immunology 78: 520-525, 1993.
11. 11. Neuner P, Klosner G, Schauer E, Pourmojib M, Macheiner W, Grunwald C, Knobler R, Schwarz A, Luger TA and Schwarz T, Pentoxifylline in vivo down-regulates the release of IL-1 beta, I1-6, IL-8 and tumour necrosis factor-alpha by human peripheral blood mononuclear cells. Immunology 83: 262-267, 1994.
12. 12. Mandell GL, ARDS, neutrophils, and pentoxifylline. Am Rev Respir Dis 138: 1103-1105, 1988.
13. 13. Noel P, Nelson S, Bokulic R, Bagby G, Lippton H, Lipscomb G and Summer W, Pentoxifylline inhibits lipopolysaccharide-induced serum tumor necrosis factor and mortality. Life Sci 47: 1023-1029, 1990.
14. 14. El Defrawry EL Masry S, Cohen GM and Mannering GJ, Temporal changes in the microsomal drug metabolizing system of the liver during sexual maturation. Drug Metab Disp 2: 267-278, 1974.
15. 15. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ, Protein measurement with Folin phenol reagent. J Biol Chem 193: 265-275, 1951.
16. 16. Omura T and Sato R, The carbon monoxide-binding pigment of liver microsomes: evidence for its hemoprotein nature. J Biol Chem 239: 2370-2378, 1964.
17. 17. Burke MD, Thompson S, Elcombe CR, Halpert J, Haaparanta T and Mayer RT, Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues; a series of substrates to distinguish between different induced cytochromes P450. Biochem Pharmacol 34: 3337-3345, 1985.
18. 18. Koop DR, Hydroxylation of p-nitrophenol by rabbit ethanol-inducible cytochrome P450 isozyme 3A. Mol Pharmacol 29: 399-404, 1986.
19. 19. Arlotto MA, Sonderfan AJ, Klaassen CD and Parkinson A, Studies on the pregnenolone-16α-carbonitrile-inducible form of rat liver microsomal cytochrome P450 and UDD-glucuronosyl transferase. Biochem Pharmacol 36: 3859-3866, 1987.
20. 20. Smith BJ, SDS polyacrylamide gel electrophoresis of proteins. In: Methods in Molecular Biology, Vol. 1: Proteins, (Ed. Walker JM), pp. 41-55. Humana Press, Clifton, NJ, 1984.
21. 21. Walker JM and Gaastra W, Detection of protein blots using enzymelinked second antibodies or protein A. In: Methods in Molecular Biology, Vol. 3: New Proteins Techniques (Ed. Walker JM), pp. 427-440. Humana Press, Clifton, NJ, 1988.
22. 22. Chomczynski P and Sacchi N, Single-step method of RNA isolation by guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
23. 23. Sambrook J, Fritsch EF and Maniatis T, Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 1989.
24. 24. Christou M, Stewart P, Pottenger LH, Fahl WE and Jefcoate CR, Differences in the modulation of P450IA1 and epoxide hydratase expression by benz[a]anthracene and 2,3,7,8-tetrachlorodibenzo-p-dioxin in mouse embryo versus mouse hepatoma-derived cell lines. Carcinogenesis 11: 1691-1698, 1990.
25. 25. Denhardt DT, A membrane filter technique for the detection of complementary DNA. Biochem Biophys Res Commun 23: 641-646, 1966.
26. 26. Harley CB, Hybridization of oligo(dT) to RNA on nitrocellulose. Gene Anal Technol 4: 17-22, 1987.
27. 27. Stanley LA, Adams DJ, Lindsay R, Meehan RR, Liao W and Wolf CR, Potentiation and suppression of mouse liver cytochrome P450 isozymes during the acute phase response induced by bacterial endotoxin. Eur J Biochem 174: 31-36, 1988.
28. 28. Wright K and Morgan ET, Regulation of cytochrome P450IIC12 expression by interleukin-1α, interleukin-6, and dexamethasone. Mol Pharmacol 39: 468-474, 1991.
29. 29. Armstrong SG and Renton KW, Mechanism of hepatic cytochrome P450 modulation during Listeria monocytogenes infection in mice. Mol Pharmacol 43: 542-547, 1993.
30. 30. Stanley LA, Adams DJ, Balkwill FR, Griffin D and Wolf CR, Differential effects of recombinant interferon α on constitutive and inducible cytochrome P450 isozymes in mouse liver. Biochem Pharmacol 42: 311-320, 1991.
31. 31. Ferrari L, Herber R, Batt AM and Siest G, Differential effects of human recombinant interleukin-1β and dexamethasone on hepatic drug-metabolizing enzymes in male and female rats. Biochem Pharmacol 45: 2269-2277, 1993.
32. 32. Clark MA, Bing BA, Gottschall PE and Williams JF, Differential effect of cytokines on the phenobarbital or 3-methyl-cholanthrene induction of P450 mediated monooxygenase activity in cultured rat hepatocytes. Biochem Pharmacol 49: 97-104, 1995.
33. 33. Abdel-Razzak Z, Loyer P, Fautrel A, Gautier JC, Corcos L, Turlin B, Beaune P and Guillouzo A, Cytokines down-regulate expression of major cytochrome P450 enzymes in adult human hepatocytes in primary culture. Mol Pharmacol 44: 707-715, 1994.
34. 34 Muntané-Relat J, Ourlin JC, Domergue J and Maurel P, Differential effects of cytokines on the inducible expression of CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture. Hepatology 22: 1143-1153, 1995.
35. 35. Abdel-Razzak Z, Corcos L, Fautrel A, Campion JP and Guillouzo A, Transforming growth factor-β1 down-regulates basal and polycyclic aromatic hydrocarbon-induced cytochromes P4501A1 and 1A2 in adult human hepatocytes in primary culture. Mol Pharmacol 46: 1100-1110, 1994.
36. 36. Sharma RJ, Macallan DC, Sedgwick P, Remick DG and Griffin GE, Kinetics of endotoxin-induced acute-phase protein gene expression and its modulation by TNF-α monoclonal antibody. Am J Physiol 262: R786-R793, 1992.
37. 37. Chen YL, Le Vraux V, Giroud JP and Chauvelot-Moachon L, Anti-tumor necrosis factor properties of non-peptide drugs in acute-phase responses. Eur J Pharmacol 271: 319-327, 1994.
38. 38. Berthou F, Goasduff T, Dréano and Ménez JF, Caffeine increases its own metabolism through cytochrome P4501A induction in rats. Life Sci 57: 541-549, 1995.