Allosteric behavior in cytochrome P450-dependent in vitro drug-drug interactions: A prospective based on conformational dynamics

Chemical Research in Toxicology

Volumn 14, Issue 4, 2001, Pages 338-347

  Atkins, William M ^a   Wang, Regina W ^b   Lu, Anthony Y H ^c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE CARBAMOYLTRANSFERASE; CYTOCHROME P450; NIFEDIPINE; TESTOSTERONE;

ALLOSTERISM; CONFORMATIONAL TRANSITION; DRUG METABOLISM; ENZYME CONFORMATION; ENZYME STRUCTURE; IN VITRO STUDY; MOLECULAR MODEL; NONHUMAN; REVIEW; STRUCTURE ANALYSIS;

ALLOSTERIC REGULATION; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; KINETICS; PHARMACEUTICAL PREPARATIONS; PROTEIN CONFORMATION;

EID: 0035059352     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0002132     Document Type: Review

References (9)

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