-
2
-
-
0027145018
-
Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism
-
Andersson T., Miners J.O., Veronese M.E., Tassaneeyakul W., Meyer U.A., and Birkett D.J. Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism. Br. J. Clin. Pharmacol. 36 (1993) 521-530
-
(1993)
Br. J. Clin. Pharmacol.
, vol.36
, pp. 521-530
-
-
Andersson, T.1
Miners, J.O.2
Veronese, M.E.3
Tassaneeyakul, W.4
Meyer, U.A.5
Birkett, D.J.6
-
3
-
-
0024412071
-
Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver
-
Aoyama T., Yamano S., Waxman D.J., Lapenson D.P., Meyer U.A., Fischer V., Tyndale R., Inaba T., Kalow W., Gelboin H.V., and Gonzalez F.J. Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. J. Biol. Chem. 264 (1989) 10388-10395
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 10388-10395
-
-
Aoyama, T.1
Yamano, S.2
Waxman, D.J.3
Lapenson, D.P.4
Meyer, U.A.5
Fischer, V.6
Tyndale, R.7
Inaba, T.8
Kalow, W.9
Gelboin, H.V.10
Gonzalez, F.J.11
-
4
-
-
0002231220
-
Food-drug interactions: Emphasis on grapefruit juice effects
-
Bailey D.G. Food-drug interactions: Emphasis on grapefruit juice effects. Can. J. Clin. Pharmacol. 2 (1995) 10-14
-
(1995)
Can. J. Clin. Pharmacol.
, vol.2
, pp. 10-14
-
-
Bailey, D.G.1
-
5
-
-
0026099498
-
Interaction of citrus juices with felodipine and nifedipine
-
Bailey D.G., Spence J.D., Munoz C., and Arnold J.M.O. Interaction of citrus juices with felodipine and nifedipine. Lancet 337 (1991) 268-269
-
(1991)
Lancet
, vol.337
, pp. 268-269
-
-
Bailey, D.G.1
Spence, J.D.2
Munoz, C.3
Arnold, J.M.O.4
-
6
-
-
0027773068
-
Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics
-
Bailey D.G., Arnold J.M.O., Strong H.A., Munoz C., and Spence J.D. Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics. Clin. Pharmacol. Ther. 54 (1993) 589-594
-
(1993)
Clin. Pharmacol. Ther.
, vol.54
, pp. 589-594
-
-
Bailey, D.G.1
Arnold, J.M.O.2
Strong, H.A.3
Munoz, C.4
Spence, J.D.5
-
7
-
-
0028153858
-
Grapefruit juice and drugs: how significant is the interaction
-
Bailey D.G., Arnold J.M.O., and Spence J.D. Grapefruit juice and drugs: how significant is the interaction. Clin Pharmacokinet. 26 (1994) 91-98
-
(1994)
Clin Pharmacokinet.
, vol.26
, pp. 91-98
-
-
Bailey, D.G.1
Arnold, J.M.O.2
Spence, J.D.3
-
8
-
-
0027180917
-
Induction of cytochrome P450 and peroxisomal enzymes by clofibric acid in vivo and in vitro
-
Bars R.G., Bell D.R., and Elcombe C.R. Induction of cytochrome P450 and peroxisomal enzymes by clofibric acid in vivo and in vitro. Biochem. Pharmacol. 45 (1993) 2045-2053
-
(1993)
Biochem. Pharmacol.
, vol.45
, pp. 2045-2053
-
-
Bars, R.G.1
Bell, D.R.2
Elcombe, C.R.3
-
9
-
-
0018789335
-
Partial purification of human liver cytochrome P-450
-
Beaune P., Dansette P., Flinois J.P., Columelli S., Mansuy D., and Leroux J.P. Partial purification of human liver cytochrome P-450. Biochem. Biophys. Res. Commun. 88 (1979) 826-832
-
(1979)
Biochem. Biophys. Res. Commun.
, vol.88
, pp. 826-832
-
-
Beaune, P.1
Dansette, P.2
Flinois, J.P.3
Columelli, S.4
Mansuy, D.5
Leroux, J.P.6
-
10
-
-
0027304729
-
Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs
-
Bell D.R., Plant N.J., Rider C.C., Na L., Brown S., Ateitalla I., Acharya S.K., Davies M.H., Elias E., Jenkins N.A., Gilbert D.J., Copeland N.G., and Elcombe C.R. Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs. Biochem. J. 294 (1993) 173-180
-
(1993)
Biochem. J.
, vol.294
, pp. 173-180
-
-
Bell, D.R.1
Plant, N.J.2
Rider, C.C.3
Na, L.4
Brown, S.5
Ateitalla, I.6
Acharya, S.K.7
Davies, M.H.8
Elias, E.9
Jenkins, N.A.10
Gilbert, D.J.11
Copeland, N.G.12
Elcombe, C.R.13
-
11
-
-
0028916159
-
Particular ability of cytochromes P450 3A to form inhibitory P450-iron-metabolite complexes upon metabolic oxidation of amino drugs
-
Bensoussan C., Delaforge M., and Mansuy D. Particular ability of cytochromes P450 3A to form inhibitory P450-iron-metabolite complexes upon metabolic oxidation of amino drugs. Biochem. Pharmacol. 49 (1995) 591-602
-
(1995)
Biochem. Pharmacol.
, vol.49
, pp. 591-602
-
-
Bensoussan, C.1
Delaforge, M.2
Mansuy, D.3
-
12
-
-
0022550688
-
Oxidation of 4-aryl- and 4-alkyl-substituted 2,6-dimethyl-3,5-bis(alkoxycarbonyl)-1,4-dihydropyridines by human liver microsomes and immunochemical evidence for the involvement of a form of cytochrome P-450
-
Böcker R.H., and Guengerich F.P. Oxidation of 4-aryl- and 4-alkyl-substituted 2,6-dimethyl-3,5-bis(alkoxycarbonyl)-1,4-dihydropyridines by human liver microsomes and immunochemical evidence for the involvement of a form of cytochrome P-450. J. Med. Chem. 29 (1986) 1596-1603
-
(1986)
J. Med. Chem.
, vol.29
, pp. 1596-1603
-
-
Böcker, R.H.1
Guengerich, F.P.2
-
13
-
-
0015730994
-
Studies on the metabolism of ethynylestradiol in vitro and in vivo: The significance of 2-hydroxylation and the formation of polar products
-
Bolt H.M., Kappus H., and Remmer H. Studies on the metabolism of ethynylestradiol in vitro and in vivo: The significance of 2-hydroxylation and the formation of polar products. Xenobiotica 3 (1973) 773-785
-
(1973)
Xenobiotica
, vol.3
, pp. 773-785
-
-
Bolt, H.M.1
Kappus, H.2
Remmer, H.3
-
14
-
-
0017601139
-
Interaction of rifampicin treatment with pharmacokinetics and metabolism of ethinyloestradiol in man
-
Bolt H.M., Bolt M., and Kappus H. Interaction of rifampicin treatment with pharmacokinetics and metabolism of ethinyloestradiol in man. Acta Endocrinol. (Copenhagen) 85 (1977) 189-197
-
(1977)
Acta Endocrinol. (Copenhagen)
, vol.85
, pp. 189-197
-
-
Bolt, H.M.1
Bolt, M.2
Kappus, H.3
-
15
-
-
0025989135
-
Effects of disulfiram on hepatic P450IIE1, other microsomal enzymes, and hepatotoxicity in rats
-
Brady J.F., Xiao F., Wang M.H., Li Y., Ning S.M., Gapac J.M., and Yang C.S. Effects of disulfiram on hepatic P450IIE1, other microsomal enzymes, and hepatotoxicity in rats. Toxicol. Appl. Pharmacol. 108 (1991) 366-373
-
(1991)
Toxicol. Appl. Pharmacol.
, vol.108
, pp. 366-373
-
-
Brady, J.F.1
Xiao, F.2
Wang, M.H.3
Li, Y.4
Ning, S.M.5
Gapac, J.M.6
Yang, C.S.7
-
16
-
-
0018134916
-
Influence of corticosteroids on hexobarbital and tolbutamide disposition
-
Breimer D.D., Zilly W., and Richter E. Influence of corticosteroids on hexobarbital and tolbutamide disposition. Clin. Pharmacol. Ther. 24 (1978) 208-212
-
(1978)
Clin. Pharmacol. Ther.
, vol.24
, pp. 208-212
-
-
Breimer, D.D.1
Zilly, W.2
Richter, E.3
-
17
-
-
0025646757
-
Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae
-
Brian W.R., Sari M.-A., Iwasaki M., Shimada T., Kaminsky L.S., and Guengerich F.P. Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae. Biochemistry 29 (1990) 11280-11292
-
(1990)
Biochemistry
, vol.29
, pp. 11280-11292
-
-
Brian, W.R.1
Sari, M.-A.2
Iwasaki, M.3
Shimada, T.4
Kaminsky, L.S.5
Guengerich, F.P.6
-
18
-
-
0027997441
-
Aromatase inhibitors in the treatment of breast cancer
-
Brodie A.M.H. Aromatase inhibitors in the treatment of breast cancer. J. Steroid Biochem. Mol. Biol. 49 (1994) 281-287
-
(1994)
J. Steroid Biochem. Mol. Biol.
, vol.49
, pp. 281-287
-
-
Brodie, A.M.H.1
-
19
-
-
0000759380
-
Enzymatic metabolism of drugs and other foreign compounds
-
Brodie Gillette B.B.J.R., and LaDu B.N. Enzymatic metabolism of drugs and other foreign compounds. Annu. Rev. Biochem. 27 (1958) 427-454
-
(1958)
Annu. Rev. Biochem.
, vol.27
, pp. 427-454
-
-
Brodie Gillette, B.B.J.R.1
LaDu, B.N.2
-
20
-
-
0025950370
-
Debrisoquine/sparteine hydroxylation genotype and phenotype: Analysis of common mutations and alleles of CYP2D6 in a European population
-
Broly F., Gaedigk A., Heim M., Eichelbaum M., Morike K., and Meyer U.A. Debrisoquine/sparteine hydroxylation genotype and phenotype: Analysis of common mutations and alleles of CYP2D6 in a European population. DNA Cell Biol. 10 (1991) 545-558
-
(1991)
DNA Cell Biol.
, vol.10
, pp. 545-558
-
-
Broly, F.1
Gaedigk, A.2
Heim, M.3
Eichelbaum, M.4
Morike, K.5
Meyer, U.A.6
-
21
-
-
0019379906
-
Cytochrome P-450: A pharmacological necessity or a biochemical curiosity
-
Burke M.D. Cytochrome P-450: A pharmacological necessity or a biochemical curiosity. Biochem. Pharmacol. 30 (1981) 181-187
-
(1981)
Biochem. Pharmacol.
, vol.30
, pp. 181-187
-
-
Burke, M.D.1
-
22
-
-
0024343858
-
Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines
-
Butler M.A., Iwasaki M., Guengerich F.P., and Kadlubar F.F. Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines. Proc. Natl. Acad. Sci. U. S. A. 86 (1989) 7696-7700
-
(1989)
Proc. Natl. Acad. Sci. U. S. A.
, vol.86
, pp. 7696-7700
-
-
Butler, M.A.1
Iwasaki, M.2
Guengerich, F.P.3
Kadlubar, F.F.4
-
23
-
-
0026879487
-
Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites
-
Butler M.A., Lang N.P., Young J.F., Caporaso N.E., Vineis P., Hayes R.B., Teitel C.H., Massengill J.P., Lawsen M.F., and Kadlubar F.F. Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites. Pharmacogenetics 2 (1992) 116-127
-
(1992)
Pharmacogenetics
, vol.2
, pp. 116-127
-
-
Butler, M.A.1
Lang, N.P.2
Young, J.F.3
Caporaso, N.E.4
Vineis, P.5
Hayes, R.B.6
Teitel, C.H.7
Massengill, J.P.8
Lawsen, M.F.9
Kadlubar, F.F.10
-
24
-
-
0026582870
-
Comparison of a novel thin-layer chromatographic-fluorescence detection method with a spectrofluorometric method for the determination of 7-hydroxycoumarin in human urine
-
Cholerton S., Idle M.E., Vas A., Gonzalez F.J., and Idle J.R. Comparison of a novel thin-layer chromatographic-fluorescence detection method with a spectrofluorometric method for the determination of 7-hydroxycoumarin in human urine. J. Chromatogr. 575 (1992) 325-330
-
(1992)
J. Chromatogr.
, vol.575
, pp. 325-330
-
-
Cholerton, S.1
Idle, M.E.2
Vas, A.3
Gonzalez, F.J.4
Idle, J.R.5
-
25
-
-
0026032564
-
Inhibition of dapsone-induced methaemoglobinaemia by cimetidine in the rat during chronic dapsone administration
-
Coleman M.D., Tingle M.D., and Park B.K. Inhibition of dapsone-induced methaemoglobinaemia by cimetidine in the rat during chronic dapsone administration. J. Pharm. Pharmacol. 43 (1991) 186-190
-
(1991)
J. Pharm. Pharmacol.
, vol.43
, pp. 186-190
-
-
Coleman, M.D.1
Tingle, M.D.2
Park, B.K.3
-
26
-
-
0024603850
-
Metabolism of cyclosporin A. IV. Purification and identification of the rifampicininducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily
-
Combalbert J., Fabre I., Fabre G., Dalet I., Derancourt J., Cano J.P., and Maurel P. Metabolism of cyclosporin A. IV. Purification and identification of the rifampicininducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily. Drug Metab. Dispos. 17 (1989) 197-207
-
(1989)
Drug Metab. Dispos.
, vol.17
, pp. 197-207
-
-
Combalbert, J.1
Fabre, I.2
Fabre, G.3
Dalet, I.4
Derancourt, J.5
Cano, J.P.6
Maurel, P.7
-
27
-
-
0014125542
-
Pharmacological implications of microsomal enzyme induction
-
Conney A.H. Pharmacological implications of microsomal enzyme induction. Pharmacol. Rev. 19 (1967) 317-366
-
(1967)
Pharmacol. Rev.
, vol.19
, pp. 317-366
-
-
Conney, A.H.1
-
28
-
-
84930288145
-
The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene
-
Conney A.H., Miller E.C., and Miller J.A. The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene. Cancer Res. 16 (1956) 450-459
-
(1956)
Cancer Res.
, vol.16
, pp. 450-459
-
-
Conney, A.H.1
Miller, E.C.2
Miller, J.A.3
-
29
-
-
0029586252
-
Structure of cytochrome P450eryF involved in erythromycin biosynthesis
-
Cupp-Vickery J.R., and Poulos T.L. Structure of cytochrome P450eryF involved in erythromycin biosynthesis. Nature Struct. Biol. 2 (1995) 144-153
-
(1995)
Nature Struct. Biol.
, vol.2
, pp. 144-153
-
-
Cupp-Vickery, J.R.1
Poulos, T.L.2
-
30
-
-
0028260641
-
The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans
-
de Morais S.M.F., Wilkinson G.R., Blaisdell J., Nakamura K., Meyer U.A., and Goldstein J.A. The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans. J. Biol. Chem. 269 (1994) 15419-15422
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 15419-15422
-
-
de Morais, S.M.F.1
Wilkinson, G.R.2
Blaisdell, J.3
Nakamura, K.4
Meyer, U.A.5
Goldstein, J.A.6
-
31
-
-
0029118476
-
Xenobiotic-inducible transcription of cytochrome P450 genes
-
Denison M.S., and Whitlock J.P. Xenobiotic-inducible transcription of cytochrome P450 genes. J. Biol. Chem. 270 (1995) 18175-18178
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 18175-18178
-
-
Denison, M.S.1
Whitlock, J.P.2
-
32
-
-
0025368026
-
Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome-P450
-
Diaz D., Fabre I., Daujat M., Saintaubert B., Bories P., Michel H., and Maurel P. Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome-P450. Gastroenterology 99 (1990) 737-747
-
(1990)
Gastroenterology
, vol.99
, pp. 737-747
-
-
Diaz, D.1
Fabre, I.2
Daujat, M.3
Saintaubert, B.4
Bories, P.5
Michel, H.6
Maurel, P.7
-
33
-
-
0001786847
-
Enzymology of human liver cytochromes P-450
-
Guengerich F.P. (Ed), CRC Press, Boca Raton, FL
-
Distlerath L.M., and Guengerich F.P. Enzymology of human liver cytochromes P-450. In: Guengerich F.P. (Ed). "Mammalian Cytochromes P-450" 1 (1987), CRC Press, Boca Raton, FL 133-198
-
(1987)
"Mammalian Cytochromes P-450"
, vol.1
, pp. 133-198
-
-
Distlerath, L.M.1
Guengerich, F.P.2
-
34
-
-
0023900613
-
P-450 enzyme induction by 5-ethyl-5-phenylhydantoin and 5,5-diethylhydantoin, analogues of barbiturate tumor promoters phenobarbital and barbital, and promotion of liver and thyroid carcinogenesis initiated by N-nitrosodiethylamine in rats
-
Diwan B.A., Rice J.M., Nims R.W., Lubet R.A., Hu H., and Ward J.M. P-450 enzyme induction by 5-ethyl-5-phenylhydantoin and 5,5-diethylhydantoin, analogues of barbiturate tumor promoters phenobarbital and barbital, and promotion of liver and thyroid carcinogenesis initiated by N-nitrosodiethylamine in rats. Cancer Res. 48 (1988) 2492-2497
-
(1988)
Cancer Res.
, vol.48
, pp. 2492-2497
-
-
Diwan, B.A.1
Rice, J.M.2
Nims, R.W.3
Lubet, R.A.4
Hu, H.5
Ward, J.M.6
-
36
-
-
0028832796
-
Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6
-
Ellis S.W., Hayhurst G.P., Smith G., Lightfoot T., Wong M.M.S., Simula A.P., Ackland M.J., Sternberg M.J.E., Lennard M.S., Tucker G.T., and Wolf C.R. Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6. J. Biol. Chem. 270 (1995) 29055-29058
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 29055-29058
-
-
Ellis, S.W.1
Hayhurst, G.P.2
Smith, G.3
Lightfoot, T.4
Wong, M.M.S.5
Simula, A.P.6
Ackland, M.J.7
Sternberg, M.J.E.8
Lennard, M.S.9
Tucker, G.T.10
Wolf, C.R.11
-
37
-
-
0024379208
-
Dextromethorphan and caffeine as probes for simultaneous determination of debrisoquin-oxidation and N-acetylation phenotypes in children
-
Evans W.E., Relling M.V., Petros W.P., Meyer W.H., Mirro Jr. J., and Crom W.R. Dextromethorphan and caffeine as probes for simultaneous determination of debrisoquin-oxidation and N-acetylation phenotypes in children. Clin. Pharmacol. Ther. 45 (1989) 568-573
-
(1989)
Clin. Pharmacol. Ther.
, vol.45
, pp. 568-573
-
-
Evans, W.E.1
Relling, M.V.2
Petros, W.P.3
Meyer, W.H.4
Mirro Jr., J.5
Crom, W.R.6
-
38
-
-
0021990937
-
Additional routes in the metabolism of phenacetin
-
Fischbach T., and Lenk W. Additional routes in the metabolism of phenacetin. Xenobiotica 15 (1985) 149-164
-
(1985)
Xenobiotica
, vol.15
, pp. 149-164
-
-
Fischbach, T.1
Lenk, W.2
-
39
-
-
0023754383
-
Xenobiotic and endobiotic inhibitors of cytochrome P-450dbl function, the target of the debrisoquine/sparteine type polymorphism
-
Fonne-Pfister R., and Meyer U.A. Xenobiotic and endobiotic inhibitors of cytochrome P-450dbl function, the target of the debrisoquine/sparteine type polymorphism. Biochem. Pharmacol. 37 (1988) 3829-3835
-
(1988)
Biochem. Pharmacol.
, vol.37
, pp. 3829-3835
-
-
Fonne-Pfister, R.1
Meyer, U.A.2
-
40
-
-
0021228687
-
1-Ethynylpyrene, a suicide inhibitor of cytochrome P-450 dependent benzo[a]pyrene hydroxylase activity in liver microsomes
-
Gan L.S.L., Acebo A.L., and Alworth W.L. 1-Ethynylpyrene, a suicide inhibitor of cytochrome P-450 dependent benzo[a]pyrene hydroxylase activity in liver microsomes. Biochemistry 23 (1984) 3827-3836
-
(1984)
Biochemistry
, vol.23
, pp. 3827-3836
-
-
Gan, L.S.L.1
Acebo, A.L.2
Alworth, W.L.3
-
41
-
-
0024427759
-
The increase in urinary excretion of 6β-hydroxycortisol as a marker of human hepatic cytochrome P450IIIA induction
-
Ged C., Rouillon J.M., Pichard L., Combalbert J., Bressot N., Bories P., Michel H., Beaune P., and Maurel P. The increase in urinary excretion of 6β-hydroxycortisol as a marker of human hepatic cytochrome P450IIIA induction. Br. J. Clin. Pharmacol. 28 (1989) 373-387
-
(1989)
Br. J. Clin. Pharmacol.
, vol.28
, pp. 373-387
-
-
Ged, C.1
Rouillon, J.M.2
Pichard, L.3
Combalbert, J.4
Bressot, N.5
Bories, P.6
Michel, H.7
Beaune, P.8
Maurel, P.9
-
43
-
-
0027264011
-
Peroxisome proliferators: Paradigms and prospects
-
Gibson G.G. Peroxisome proliferators: Paradigms and prospects. Toxicol. Lett. 68 (1993) 193-201
-
(1993)
Toxicol. Lett.
, vol.68
, pp. 193-201
-
-
Gibson, G.G.1
-
44
-
-
0028912205
-
Expression of cytochrome P450 3A5 in Escherichia coli: Effects of 5′ modifications, purification, spectral characterization, reconstitution conditions, and catalytic activities
-
Gillam E.M., Guo Z.J., Ueng Y.-F., Yamazaki H., Cock I., Reilly P.E.B., Hooper W.D., and Guengerich F.P. Expression of cytochrome P450 3A5 in Escherichia coli: Effects of 5′ modifications, purification, spectral characterization, reconstitution conditions, and catalytic activities. Arch. Biochem. Biophys. 317 (1995) 374-384
-
(1995)
Arch. Biochem. Biophys.
, vol.317
, pp. 374-384
-
-
Gillam, E.M.1
Guo, Z.J.2
Ueng, Y.-F.3
Yamazaki, H.4
Cock, I.5
Reilly, P.E.B.6
Hooper, W.D.7
Guengerich, F.P.8
-
46
-
-
0024236331
-
The molecular biology of cytochrome P450s
-
Gonzalez F.J. The molecular biology of cytochrome P450s. Pharmacol. Rev. 40 (1989) 243-288
-
(1989)
Pharmacol. Rev.
, vol.40
, pp. 243-288
-
-
Gonzalez, F.J.1
-
47
-
-
0025940815
-
Molecular genetics of the debrisoquin-sparteine polymorphism
-
Gonzalez F.J., and Meyer U.A. Molecular genetics of the debrisoquin-sparteine polymorphism. Clin. Pharmacol. Ther. 50 (1991) 233-238
-
(1991)
Clin. Pharmacol. Ther.
, vol.50
, pp. 233-238
-
-
Gonzalez, F.J.1
Meyer, U.A.2
-
48
-
-
0023854270
-
Characterization of the common genetic defect in humans deficient in debrisoquine metabolism
-
Gonzalez F.J., Skoda R.C., Kimura S., Umeno M., Zanger Nebert U.M., Gelboin D.W.H.V., Hardwick J.P., and Meyer U.A. Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature (London) 331 (1988) 442-446
-
(1988)
Nature (London)
, vol.331
, pp. 442-446
-
-
Gonzalez, F.J.1
Skoda, R.C.2
Kimura, S.3
Umeno, M.4
Zanger Nebert, U.M.5
Gelboin, D.W.H.V.6
Hardwick, J.P.7
Meyer, U.A.8
-
49
-
-
0026324032
-
Expression of mammalian cytochrome P450 using vaccinia virus
-
Waterman M.R., and Johnson E.F. (Eds), Academic Press, San Diego, CA
-
Gonzalez F.J., Aoyama T., and Gelboin H.V. Expression of mammalian cytochrome P450 using vaccinia virus. In: Waterman M.R., and Johnson E.F. (Eds). "Methods in Enzymology" 206 (1991), Academic Press, San Diego, CA 85-92
-
(1991)
"Methods in Enzymology"
, vol.206
, pp. 85-92
-
-
Gonzalez, F.J.1
Aoyama, T.2
Gelboin, H.V.3
-
50
-
-
0026319743
-
Expression of mammalian cytochrome P450 using baculovirus
-
Waterman M.R., and Johnson E.F. (Eds), Academic Press, San Diego, CA
-
Gonzalez F.J., Kimura S., Tamura S., and Gelboin H.V. Expression of mammalian cytochrome P450 using baculovirus. In: Waterman M.R., and Johnson E.F. (Eds). "Methods in Enzymology" 206 (1991), Academic Press, San Diego, CA 93-99
-
(1991)
"Methods in Enzymology"
, vol.206
, pp. 93-99
-
-
Gonzalez, F.J.1
Kimura, S.2
Tamura, S.3
Gelboin, H.V.4
-
51
-
-
0028316987
-
Atypical metabolism of deprenyl and its enantiomer, (S)-(+)-N,α-dimethyl-N-propynylphenethylamine, by cytochrome P450 2D6
-
Grace J.M., Kinter M.T., and Macdonald T.L. Atypical metabolism of deprenyl and its enantiomer, (S)-(+)-N,α-dimethyl-N-propynylphenethylamine, by cytochrome P450 2D6. Chem. Res. Toxicol. 7 (1994) 286-290
-
(1994)
Chem. Res. Toxicol.
, vol.7
, pp. 286-290
-
-
Grace, J.M.1
Kinter, M.T.2
Macdonald, T.L.3
-
52
-
-
0001786847
-
Enzymology of rat liver cytochromes P-450
-
Guengerich F.P. (Ed), CRC Press, Boca Raton, FL
-
Guengerich F.P. Enzymology of rat liver cytochromes P-450. In: Guengerich F.P. (Ed). "Mammalian Cytochromes P-450" 1 (1987), CRC Press, Boca Raton, FL 1-54
-
(1987)
"Mammalian Cytochromes P-450"
, vol.1
, pp. 1-54
-
-
Guengerich, F.P.1
-
53
-
-
0023883363
-
Oxidation of 17α-ethynylestradiol by human liver cytochrome P-450
-
Guengerich F.P. Oxidation of 17α-ethynylestradiol by human liver cytochrome P-450. Mol. Pharmacol. 33 (1988) 500-508
-
(1988)
Mol. Pharmacol.
, vol.33
, pp. 500-508
-
-
Guengerich, F.P.1
-
54
-
-
0024593072
-
Characterization of human microsomal cytochrome P-450 enzymes
-
Guengerich F.P. Characterization of human microsomal cytochrome P-450 enzymes. Annu. Rev. Pharmacol. Toxicol. 29 (1989) 241-264
-
(1989)
Annu. Rev. Pharmacol. Toxicol.
, vol.29
, pp. 241-264
-
-
Guengerich, F.P.1
-
55
-
-
0025184340
-
Mechanism-based inactivation of human liver cytochrome P-450 IIIA4 by gestodene
-
Guengerich F.P. Mechanism-based inactivation of human liver cytochrome P-450 IIIA4 by gestodene. Chem. Res. Toxicol. 3 (1990) 363-371
-
(1990)
Chem. Res. Toxicol.
, vol.3
, pp. 363-371
-
-
Guengerich, F.P.1
-
56
-
-
0025688510
-
Metabolism of 17α-ethynylestradiol in humans
-
Guengerich F.P. Metabolism of 17α-ethynylestradiol in humans. Life Sci. 47 (1990) 1981-1988
-
(1990)
Life Sci.
, vol.47
, pp. 1981-1988
-
-
Guengerich, F.P.1
-
57
-
-
0001680211
-
Cytochrome P450 enzymes
-
Guengerich F.P. Cytochrome P450 enzymes. Am. Sci. 81 (1993) 440-447
-
(1993)
Am. Sci.
, vol.81
, pp. 440-447
-
-
Guengerich, F.P.1
-
58
-
-
0002888510
-
Human cytochrome P450 enzymes
-
Ortiz de Montellano P.R. (Ed), Plenum, New York
-
Guengerich F.P. Human cytochrome P450 enzymes. In: Ortiz de Montellano P.R. (Ed). "Cytochrome P450". 2nd ed. (1995), Plenum, New York 473-535
-
(1995)
"Cytochrome P450". 2nd ed.
, pp. 473-535
-
-
Guengerich, F.P.1
-
60
-
-
0025992864
-
Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes
-
Guengerich F.P., and Shimada T. Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes. Chem. Res. Toxicol. 4 (1991) 391-407
-
(1991)
Chem. Res. Toxicol.
, vol.4
, pp. 391-407
-
-
Guengerich, F.P.1
Shimada, T.2
-
61
-
-
0022998708
-
Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism
-
Guengerich F.P., Martin M.V., Beaune P.H., Kremers P., Wolff T., and Waxman D.J. Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism. J. Biol. Chem. 261 (1986) 5051-5060
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 5051-5060
-
-
Guengerich, F.P.1
Martin, M.V.2
Beaune, P.H.3
Kremers, P.4
Wolff, T.5
Waxman, D.J.6
-
63
-
-
0026035519
-
Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects
-
Guengerich F.P., Kim D.-H., and Iwasaki M. Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem. Res. Toxicol. 4 (1991) 168-179
-
(1991)
Chem. Res. Toxicol.
, vol.4
, pp. 168-179
-
-
Guengerich, F.P.1
Kim, D.-H.2
Iwasaki, M.3
-
64
-
-
0001398078
-
The importance of cytochrome P450 3A enzymes in drug metabolism
-
Waterman M.R., and Hildebrand M. (Eds), Springer-Verlag, Berlin
-
Guengerich F.P., Gillam E.M.J., Martin M.V., Baba T., Kim B.-R., Shimada T., Raney K.D., and Yun C.-H. The importance of cytochrome P450 3A enzymes in drug metabolism. In: Waterman M.R., and Hildebrand M. (Eds). "Schering Foundation Workshop 13, Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research" (1994), Springer-Verlag, Berlin 161-186
-
(1994)
"Schering Foundation Workshop 13, Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research"
, pp. 161-186
-
-
Guengerich, F.P.1
Gillam, E.M.J.2
Martin, M.V.3
Baba, T.4
Kim, B.-R.5
Shimada, T.6
Raney, K.D.7
Yun, C.-H.8
-
65
-
-
77956780430
-
-
Lechner M.C. (Ed), John Libbey Eurotext, Paris Proceedings of the Eighth International Conference on Cytochrome P450: Biochemistry, Biophysics, and Molecular Biology"
-
Guengerich F.P., Kim B.-R., Gillam E.M.J., and Shimada T. In: Lechner M.C. (Ed). Mechanisms of enhancement and inhibition of cytochrome P450 catalytic activity (1994), John Libbey Eurotext, Paris 97-101 Proceedings of the Eighth International Conference on Cytochrome P450: Biochemistry, Biophysics, and Molecular Biology"
-
(1994)
Mechanisms of enhancement and inhibition of cytochrome P450 catalytic activity
, pp. 97-101
-
-
Guengerich, F.P.1
Kim, B.-R.2
Gillam, E.M.J.3
Shimada, T.4
-
66
-
-
0029852566
-
New applications of bacterial systems to problems in toxicology
-
Guengerich F.P., Gillam E.M.J., and Shimada T. New applications of bacterial systems to problems in toxicology. Crit. Rev. Toxicol. 26 (1996) 551-583
-
(1996)
Crit. Rev. Toxicol.
, vol.26
, pp. 551-583
-
-
Guengerich, F.P.1
Gillam, E.M.J.2
Shimada, T.3
-
67
-
-
0027489375
-
Use of human hepatocyte cultures for drug metabolism studies
-
Guillouzo A., Morel F., Fardel O., and Meunier B. Use of human hepatocyte cultures for drug metabolism studies. Toxicology 82 (1993) 209-219
-
(1993)
Toxicology
, vol.82
, pp. 209-219
-
-
Guillouzo, A.1
Morel, F.2
Fardel, O.3
Meunier, B.4
-
68
-
-
0028071497
-
Expression of modified human cytochrome P450 1A1 in Escherichia coli: Effects of 5′ substitution, stabilization, purification, spectral characterization, and catalytic properties
-
Guo Z., Gillam E.M.J., Ohmori S., Tukey R.H., and Guengerich F.P. Expression of modified human cytochrome P450 1A1 in Escherichia coli: Effects of 5′ substitution, stabilization, purification, spectral characterization, and catalytic properties. Arch. Biochem. Biophys. 312 (1994) 436-446
-
(1994)
Arch. Biochem. Biophys.
, vol.312
, pp. 436-446
-
-
Guo, Z.1
Gillam, E.M.J.2
Ohmori, S.3
Tukey, R.H.4
Guengerich, F.P.5
-
69
-
-
0002563715
-
Enzyme inhibition and stimulation
-
Guengerich F.P. (Ed), Pergamon, New York
-
Halpert J.A., and Guengerich F.P. Enzyme inhibition and stimulation. In: Guengerich F.P. (Ed). "Biotransformation" 3 (1997), Pergamon, New York 21-35
-
(1997)
"Biotransformation"
, vol.3
, pp. 21-35
-
-
Halpert, J.A.1
Guengerich, F.P.2
-
70
-
-
0022253108
-
On the mechanism of the inactivation of the major phenobarbital-inducible isozyme of rat liver cytochrome P-450 by chloramphenicol
-
Halpert J.A., Miller N.E., and Gorsky L.D. On the mechanism of the inactivation of the major phenobarbital-inducible isozyme of rat liver cytochrome P-450 by chloramphenicol. J. Biol. Chem. 260 (1985) 8397-8403
-
(1985)
J. Biol. Chem.
, vol.260
, pp. 8397-8403
-
-
Halpert, J.A.1
Miller, N.E.2
Gorsky, L.D.3
-
71
-
-
0027326075
-
Research on the aryl hydrocarbon (dioxin) receptor is primed to take off
-
Hankinson O. Research on the aryl hydrocarbon (dioxin) receptor is primed to take off. Arch. Biochem. Biophys. 300 (1993) 1-5
-
(1993)
Arch. Biochem. Biophys.
, vol.300
, pp. 1-5
-
-
Hankinson, O.1
-
72
-
-
0019784520
-
Specificity in the activation and inhibition by flavonoids of benzol[a]pyrene hydroxylation by cytochrome P-450 isozymes from rabbit liver microsomes
-
Huang M.T., Johnson E.F., Müller-Eberhard U., Koop D.R., Coon M.J., and Conney A.H. Specificity in the activation and inhibition by flavonoids of benzol[a]pyrene hydroxylation by cytochrome P-450 isozymes from rabbit liver microsomes. J. Biol. Chem. 256 (1981) 10897-10901
-
(1981)
J. Biol. Chem.
, vol.256
, pp. 10897-10901
-
-
Huang, M.T.1
Johnson, E.F.2
Müller-Eberhard, U.3
Koop, D.R.4
Coon, M.J.5
Conney, A.H.6
-
73
-
-
0023522162
-
The cytochromes P-488-a unique family of enzymes involved in chemical toxicity and carcinogenesis
-
Ioannides C., and Parke D.V. The cytochromes P-488-a unique family of enzymes involved in chemical toxicity and carcinogenesis. Biochem. Pharmacol. 36 (1987) 4197-4207
-
(1987)
Biochem. Pharmacol.
, vol.36
, pp. 4197-4207
-
-
Ioannides, C.1
Parke, D.V.2
-
74
-
-
0025313982
-
The cytochrome P450 I gene family of microsomal hemoproteins and their role in the metabolic activation of chemicals
-
Ioannides C., and Parke D.V. The cytochrome P450 I gene family of microsomal hemoproteins and their role in the metabolic activation of chemicals. Drug Metab. Rev. 22 (1990) 1-85
-
(1990)
Drug Metab. Rev.
, vol.22
, pp. 1-85
-
-
Ioannides, C.1
Parke, D.V.2
-
75
-
-
0027751340
-
Induction of cytochrome P4501 as an indicator of potential chemical carcinogenesis
-
Ioannides C., and Parke D.V. Induction of cytochrome P4501 as an indicator of potential chemical carcinogenesis. Drug Metab. Rev. 25 (1993) 485-501
-
(1993)
Drug Metab. Rev.
, vol.25
, pp. 485-501
-
-
Ioannides, C.1
Parke, D.V.2
-
76
-
-
0026046988
-
A three-dimensional molecular template for substrates of human cytochrome P450 involved in debrisoquine 4-hydroxylation
-
Islam S.A., Wolf C.R., Lennard M.S., and Sternberg M.J.E. A three-dimensional molecular template for substrates of human cytochrome P450 involved in debrisoquine 4-hydroxylation. Carcinogenesis (London) 12 (1991) 2211-2219
-
(1991)
Carcinogenesis (London)
, vol.12
, pp. 2211-2219
-
-
Islam, S.A.1
Wolf, C.R.2
Lennard, M.S.3
Sternberg, M.J.E.4
-
77
-
-
0016075464
-
Anti-epileptic drugs and failure of oral contraceptives
-
Janz D., and Schmidt D. Anti-epileptic drugs and failure of oral contraceptives. Lancet 1 (1974) 1113
-
(1974)
Lancet
, vol.1
, pp. 1113
-
-
Janz, D.1
Schmidt, D.2
-
78
-
-
0027136288
-
Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine
-
Johansson I., Lundqvist E., Bertilsson L., Dahl M.L., Sjöqvist F., and Ingelman-Sundberg M. Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. Proc. Natl. Acad. Sci. U. S. A. 90 (1993) 11825-11829
-
(1993)
Proc. Natl. Acad. Sci. U. S. A.
, vol.90
, pp. 11825-11829
-
-
Johansson, I.1
Lundqvist, E.2
Bertilsson, L.3
Dahl, M.L.4
Sjöqvist, F.5
Ingelman-Sundberg, M.6
-
79
-
-
0027070491
-
Cytochrome P-455 nm complex formation in the metabolism of phenylalkylamines. XII. Enantioselectivity and temperature dependence in microsomes and reconstituted cytochrome P-450 systems from rat liver
-
Jönsson K.H., and Lindeke B. Cytochrome P-455 nm complex formation in the metabolism of phenylalkylamines. XII. Enantioselectivity and temperature dependence in microsomes and reconstituted cytochrome P-450 systems from rat liver. Chirality 4 (1992) 469-477
-
(1992)
Chirality
, vol.4
, pp. 469-477
-
-
Jönsson, K.H.1
Lindeke, B.2
-
80
-
-
0024422521
-
Interaction with the pharmacokinetics of ethinylestradiol of progestogens contained in oral contraceptives
-
Jung-Hoffmann C., and Kuhl H. Interaction with the pharmacokinetics of ethinylestradiol of progestogens contained in oral contraceptives. Contraception 40 (1990) 299-312
-
(1990)
Contraception
, vol.40
, pp. 299-312
-
-
Jung-Hoffmann, C.1
Kuhl, H.2
-
81
-
-
0027197152
-
The use of caffeine for enzyme assays: A critical appraisal
-
Kalow W., and Tang B.K. The use of caffeine for enzyme assays: A critical appraisal. Clin. Pharmacol. Ther. 53 (1993) 503-514
-
(1993)
Clin. Pharmacol. Ther.
, vol.53
, pp. 503-514
-
-
Kalow, W.1
Tang, B.K.2
-
82
-
-
0027299613
-
Marked endogenous activation of the CYP1A1 and CYP1A2 genes in the congenitally jaundiced Gunn rat
-
Kapitulnik J., and Gonzalez F.J. Marked endogenous activation of the CYP1A1 and CYP1A2 genes in the congenitally jaundiced Gunn rat. Mol. Pharmacol. 43 (1993) 722-725
-
(1993)
Mol. Pharmacol.
, vol.43
, pp. 722-725
-
-
Kapitulnik, J.1
Gonzalez, F.J.2
-
83
-
-
0011221256
-
Stimulation of bilirubin catabolism in jaundiced Gunn rats by an inducer of microsomal mixed-function monooxygenases
-
Kapitulnik J., and Ostrow J.D. Stimulation of bilirubin catabolism in jaundiced Gunn rats by an inducer of microsomal mixed-function monooxygenases. Proc. Natl. Acad. Sci. U. S. A. 75 (1978) 682-685
-
(1978)
Proc. Natl. Acad. Sci. U. S. A.
, vol.75
, pp. 682-685
-
-
Kapitulnik, J.1
Ostrow, J.D.2
-
84
-
-
0028300816
-
Human liver carbamazepine metabolism: Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation
-
Kerr B.M., Thummel K.E., Wurden C.J., Klein S.M., Kroetz D.L., Gonzalez F.J., and Levy R.H. Human liver carbamazepine metabolism: Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation. Biochem. Pharmacol. 47 (1994) 1969-1979
-
(1994)
Biochem. Pharmacol.
, vol.47
, pp. 1969-1979
-
-
Kerr, B.M.1
Thummel, K.E.2
Wurden, C.J.3
Klein, S.M.4
Kroetz, D.L.5
Gonzalez, F.J.6
Levy, R.H.7
-
85
-
-
0028355767
-
Relationship in healthy subjects between CYP2E1 genetic polymorphism and the 6-hydroxylation of chlorzoxazone: A putative measure of CYP2E1 activity
-
Kim R.B., O'Shea D., and Wilkinson G.R. Relationship in healthy subjects between CYP2E1 genetic polymorphism and the 6-hydroxylation of chlorzoxazone: A putative measure of CYP2E1 activity. Pharmacogenetics 4 (1994) 162-165
-
(1994)
Pharmacogenetics
, vol.4
, pp. 162-165
-
-
Kim, R.B.1
O'Shea, D.2
Wilkinson, G.R.3
-
86
-
-
0029035739
-
Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms
-
Kim R.B., O'Shea D., and Wilkinson G.R. Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms. Clin. Pharmacol. Ther. 57 (1995) 645-655
-
(1995)
Clin. Pharmacol. Ther.
, vol.57
, pp. 645-655
-
-
Kim, R.B.1
O'Shea, D.2
Wilkinson, G.R.3
-
87
-
-
0027770062
-
Absence of correlations among 3 putative in vivo probes of human cytochrome P4503A activity in young healthy men
-
Kinirons M.T., O'Shea D., Downing T.E., Fitzwilliam A.T., Joellenbeck L., Groopman J.D., Wilkinson G.R., and Wood A.J.J. Absence of correlations among 3 putative in vivo probes of human cytochrome P4503A activity in young healthy men. Clin. Pharmacol. Ther. 54 (1993) 621-629
-
(1993)
Clin. Pharmacol. Ther.
, vol.54
, pp. 621-629
-
-
Kinirons, M.T.1
O'Shea, D.2
Downing, T.E.3
Fitzwilliam, A.T.4
Joellenbeck, L.5
Groopman, J.D.6
Wilkinson, G.R.7
Wood, A.J.J.8
-
88
-
-
0018385578
-
Partial purification and properties of cytochrome P450 from homogenates of human fetal livers
-
Kitada M., and Kamataki T. Partial purification and properties of cytochrome P450 from homogenates of human fetal livers. Biochem. Pharmacol. 28 (1979) 793-797
-
(1979)
Biochem. Pharmacol.
, vol.28
, pp. 793-797
-
-
Kitada, M.1
Kamataki, T.2
-
89
-
-
0028298286
-
Inhibition of terfenadine metabolism: Pharmacokinetic and pharmacodynamic consequences
-
Kivistö K.T., Neuvonen P.J., and Klotz U. Inhibition of terfenadine metabolism: Pharmacokinetic and pharmacodynamic consequences. Clin. Pharmacokinet. 27 (1994) 1-5
-
(1994)
Clin. Pharmacokinet.
, vol.27
, pp. 1-5
-
-
Kivistö, K.T.1
Neuvonen, P.J.2
Klotz, U.3
-
90
-
-
0023180558
-
Formation of 4-ethoxy-4′-nitrosodiphenylamine in the reaction of the phenacetin metabolite 4-nitrosophenetol with glutathione
-
Klehr H., Eyer P., and Schäfer W. Formation of 4-ethoxy-4′-nitrosodiphenylamine in the reaction of the phenacetin metabolite 4-nitrosophenetol with glutathione. Biol. Chem. Hoppe-Seyler 368 (1987) 895-902
-
(1987)
Biol. Chem. Hoppe-Seyler
, vol.368
, pp. 895-902
-
-
Klehr, H.1
Eyer, P.2
Schäfer, W.3
-
91
-
-
0023355128
-
Hepatic metabolism of tolbutamide: Characterization of the form of cytochrome P-450 involved in methyl hydroxylation and relationship to in vivo disposition
-
Knodell R.G., Hall S.D., Wilkinson G.R., and Guengerich F.P. Hepatic metabolism of tolbutamide: Characterization of the form of cytochrome P-450 involved in methyl hydroxylation and relationship to in vivo disposition. J. Pharmacol. Exp. Ther. 241 (1987) 1112-1119
-
(1987)
J. Pharmacol. Exp. Ther.
, vol.241
, pp. 1112-1119
-
-
Knodell, R.G.1
Hall, S.D.2
Wilkinson, G.R.3
Guengerich, F.P.4
-
92
-
-
0025985781
-
Differential inhibition of human liver cytochromes P-450 by cimetidine
-
Knodell R.G., Browne D., Gwodz G.P., Brian W.R., and Guengerich F.P. Differential inhibition of human liver cytochromes P-450 by cimetidine. Gastroenterology 101 (1991) 1680-1691
-
(1991)
Gastroenterology
, vol.101
, pp. 1680-1691
-
-
Knodell, R.G.1
Browne, D.2
Gwodz, G.P.3
Brian, W.R.4
Guengerich, F.P.5
-
94
-
-
0026553661
-
A predictive model for substrates of cytochrome P450-debrisoquine (2D6)
-
Koymans L., Vermeulen N.P.E., te van Acker S.A., Koppele B.E.J.M., Heykants J.J.P., Lavrijsen K., Meuldermans W., and Donne-Op den Kelder G.M. A predictive model for substrates of cytochrome P450-debrisoquine (2D6). Chem. Res. Toxicol. 5 (1992) 211-219
-
(1992)
Chem. Res. Toxicol.
, vol.5
, pp. 211-219
-
-
Koymans, L.1
Vermeulen, N.P.E.2
te van Acker, S.A.3
Koppele, B.E.J.M.4
Heykants, J.J.P.5
Lavrijsen, K.6
Meuldermans, W.7
Donne-Op den Kelder, G.M.8
-
95
-
-
0023921505
-
Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs
-
Kronbach T., Fischer V., and Meyer U.A. Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs. Clin. Pharmacol. Ther. 43 (1988) 630-635
-
(1988)
Clin. Pharmacol. Ther.
, vol.43
, pp. 630-635
-
-
Kronbach, T.1
Fischer, V.2
Meyer, U.A.3
-
96
-
-
0004197262
-
-
CRC Press, Boca Raton, FL 253-281
-
Kuby S.A. "A Study of Enzymes," 1 (1991), CRC Press, Boca Raton, FL 253-281
-
(1991)
"A Study of Enzymes,"
, vol.1
-
-
Kuby, S.A.1
-
97
-
-
0027380074
-
Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline
-
Kunze K.L., and Trager W.F. Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline. Chem. Res. Toxicol. 6 (1993) 649-656
-
(1993)
Chem. Res. Toxicol.
, vol.6
, pp. 649-656
-
-
Kunze, K.L.1
Trager, W.F.2
-
98
-
-
0027999623
-
Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps
-
Lang N.P., Butler M.A., Massengill J., Lawson M., Stotts R.C., Maurer-Jensen M., and Kadlubar F.F. Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps. Cancer Epidemiol. Biomarkers Prev. 3 (1994) 675-682
-
(1994)
Cancer Epidemiol. Biomarkers Prev.
, vol.3
, pp. 675-682
-
-
Lang, N.P.1
Butler, M.A.2
Massengill, J.3
Lawson, M.4
Stotts, R.C.5
Maurer-Jensen, M.6
Kadlubar, F.F.7
-
99
-
-
0019955123
-
In vivo activation of zoxazolamine metabolism by flavone
-
Lasker J.M., Huang M.-T., and Conney A.H. In vivo activation of zoxazolamine metabolism by flavone. Science 216 (1982) 1419-1421
-
(1982)
Science
, vol.216
, pp. 1419-1421
-
-
Lasker, J.M.1
Huang, M.-T.2
Conney, A.H.3
-
100
-
-
0025951558
-
Activation of acetaminophen-reactive metabolite formation by methylxanthines and known cytochrome P-450 activators
-
Lee C.A., Thummel K.E., Kalhorn T.F., Nelson S.D., and Slattery J.T. Activation of acetaminophen-reactive metabolite formation by methylxanthines and known cytochrome P-450 activators. Drug Metab. Dispos. 19 (1991) 966-971
-
(1991)
Drug Metab. Dispos.
, vol.19
, pp. 966-971
-
-
Lee, C.A.1
Thummel, K.E.2
Kalhorn, T.F.3
Nelson, S.D.4
Slattery, J.T.5
-
101
-
-
0027222793
-
Structure of the retinoid X receptor a DNA binding domain: A helix required for homodimeric DNA binding
-
Lee M.S., Kliewer S.A., Provencal J., Wright P.E., and Evans R.M. Structure of the retinoid X receptor a DNA binding domain: A helix required for homodimeric DNA binding. Science 260 (1993) 1117-1121
-
(1993)
Science
, vol.260
, pp. 1117-1121
-
-
Lee, M.S.1
Kliewer, S.A.2
Provencal, J.3
Wright, P.E.4
Evans, R.M.5
-
102
-
-
0028906113
-
Evidence for the ligand-independent activation of the AH receptor
-
Lesca P., Peryt B., Larrieu G., Alvinerie M., Galtier P., Daujat M., Maurel P., and Hoogenboom L. Evidence for the ligand-independent activation of the AH receptor. Biochem. Biophys. Res. Commun. 209 (1995) 474-482
-
(1995)
Biochem. Biophys. Res. Commun.
, vol.209
, pp. 474-482
-
-
Lesca, P.1
Peryt, B.2
Larrieu, G.3
Alvinerie, M.4
Galtier, P.5
Daujat, M.6
Maurel, P.7
Hoogenboom, L.8
-
103
-
-
0015560113
-
Breakdown of cytochrome P-450 heme by secobarbital and other allyl-containing barbiturates
-
Levin W., Jacobson M., Sernatinger E., and Kuntzman R. Breakdown of cytochrome P-450 heme by secobarbital and other allyl-containing barbiturates. Drug Metab. Dispos. 1 (1973) 275-285
-
(1973)
Drug Metab. Dispos.
, vol.1
, pp. 275-285
-
-
Levin, W.1
Jacobson, M.2
Sernatinger, E.3
Kuntzman, R.4
-
104
-
-
0029121648
-
Transcriptional regulation of the genes encoding cytochromes P450BM-1 and P450BM-3 in Bacillus megaterium by the binding of Bm 3R1 repressor to Barbie box elements and operator sites
-
Liang Q., and Fulco A.J. Transcriptional regulation of the genes encoding cytochromes P450BM-1 and P450BM-3 in Bacillus megaterium by the binding of Bm 3R1 repressor to Barbie box elements and operator sites. J. Biol. Chem. 270 (1995) 18606
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 18606
-
-
Liang, Q.1
Fulco, A.J.2
-
105
-
-
0029059604
-
4-hydroxylation of estradiol by human uterine myometrium and myoma microsomes: Implications for the mechanism of uterine tumorigenesis
-
Liehr J.G., Ricci M.J., Jefcoate C.R., Hannigan E.V., Hokanson J.A., and Zhu B.T. 4-hydroxylation of estradiol by human uterine myometrium and myoma microsomes: Implications for the mechanism of uterine tumorigenesis. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 9220-9224
-
(1995)
Proc. Natl. Acad. Sci. U. S. A.
, vol.92
, pp. 9220-9224
-
-
Liehr, J.G.1
Ricci, M.J.2
Jefcoate, C.R.3
Hannigan, E.V.4
Hokanson, J.A.5
Zhu, B.T.6
-
106
-
-
0024551516
-
Optimization of cryopreservation procedures for rat and human hepatocytes
-
Loretz L.J., Li A.P., Flye M.W., and Wilson A.G.E. Optimization of cryopreservation procedures for rat and human hepatocytes. Xenobiotica 19 (1989) 489-498
-
(1989)
Xenobiotica
, vol.19
, pp. 489-498
-
-
Loretz, L.J.1
Li, A.P.2
Flye, M.W.3
Wilson, A.G.E.4
-
107
-
-
0026545245
-
The erythromycin breath test selectively measures P450IIIA in patients with severe liver disease
-
Lown K., Kolars J., Turgeon K., Merion R., Wrighton S.A., and Watkins P.B. The erythromycin breath test selectively measures P450IIIA in patients with severe liver disease. Clin. Pharmacol. Ther. 51 (1992) 229-238
-
(1992)
Clin. Pharmacol. Ther.
, vol.51
, pp. 229-238
-
-
Lown, K.1
Kolars, J.2
Turgeon, K.3
Merion, R.4
Wrighton, S.A.5
Watkins, P.B.6
-
108
-
-
0024524508
-
Induction of cytochrome P-450b and its relationship to liver tumor promotion
-
Lubet R.A., Nims R.W., Ward J.M., Rice J.M., and Diwan B.A. Induction of cytochrome P-450b and its relationship to liver tumor promotion. J. Am. Coll. Toxicol. 8 (1989) 259-268
-
(1989)
J. Am. Coll. Toxicol.
, vol.8
, pp. 259-268
-
-
Lubet, R.A.1
Nims, R.W.2
Ward, J.M.3
Rice, J.M.4
Diwan, B.A.5
-
109
-
-
0025058297
-
Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450 IIIA
-
Lucey M.R., Kolars J.C., Merion R.M., Campbell D.A., Aldrich M., and Watkins P.B. Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450 IIIA. Lancet 335 (1990) 11-15
-
(1990)
Lancet
, vol.335
, pp. 11-15
-
-
Lucey, M.R.1
Kolars, J.C.2
Merion, R.M.3
Campbell, D.A.4
Aldrich, M.5
Watkins, P.B.6
-
110
-
-
0017695082
-
Polymorphic hydroxylation of debrisoquine in man
-
Mahgoub A., Idle J.R., Dring L.G., Lancaster R., and Smith R.L. Polymorphic hydroxylation of debrisoquine in man. Lancet 2 (1977) 584-586
-
(1977)
Lancet
, vol.2
, pp. 584-586
-
-
Mahgoub, A.1
Idle, J.R.2
Dring, L.G.3
Lancaster, R.4
Smith, R.L.5
-
111
-
-
0021098245
-
Nitrosoalkane complexes of iron-porphyrins: Analogy between the bonding properties of nitrosoalkanes and dioxygen
-
Mansuy D., Battioni P., Chottard J.C., Riche C., and Chiaroni A. Nitrosoalkane complexes of iron-porphyrins: Analogy between the bonding properties of nitrosoalkanes and dioxygen. J. Am. Chem. Soc. 105 (1983) 455-463
-
(1983)
J. Am. Chem. Soc.
, vol.105
, pp. 455-463
-
-
Mansuy, D.1
Battioni, P.2
Chottard, J.C.3
Riche, C.4
Chiaroni, A.5
-
112
-
-
0025367754
-
Expression of cytochrome P-450 enzymes in cultured human hepatocytes
-
Morel F., Beaune P.H., Ratanasavanh D., Flinois J.-P., Yang C.-S., Guengerich F.P., and Guillouzo A. Expression of cytochrome P-450 enzymes in cultured human hepatocytes. Eur. J. Biochem. 191 (1990) 437-444
-
(1990)
Eur. J. Biochem.
, vol.191
, pp. 437-444
-
-
Morel, F.1
Beaune, P.H.2
Ratanasavanh, D.3
Flinois, J.-P.4
Yang, C.-S.5
Guengerich, F.P.6
Guillouzo, A.7
-
113
-
-
0026763065
-
Characterization of a rabbit gene encoding a clofibrate-inducible fatty acid ω-hydroxylase: CYP4A6
-
Muerhoff A.S., Griffin K.J., and Johnson E.F. Characterization of a rabbit gene encoding a clofibrate-inducible fatty acid ω-hydroxylase: CYP4A6. Arch. Biochem. Biophys. 296 (1992) 66-72
-
(1992)
Arch. Biochem. Biophys.
, vol.296
, pp. 66-72
-
-
Muerhoff, A.S.1
Griffin, K.J.2
Johnson, E.F.3
-
114
-
-
0024829409
-
The Ah locus: Genetic differences in toxicity, cancer, mutation, and birth defects
-
Nebert D.W. The Ah locus: Genetic differences in toxicity, cancer, mutation, and birth defects. Crit. Rev. Toxicol. 20 (1989) 153-174
-
(1989)
Crit. Rev. Toxicol.
, vol.20
, pp. 153-174
-
-
Nebert, D.W.1
-
115
-
-
0027446505
-
The P450 superfamily: Update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature
-
Nelson D.R., Kamataki T., Waxman D.J., Guengerich F.P., Estabrook R.W., Feyereisen R., Gonzalez F.J., Coon M.J., Gunsalus I.C., Gotoh O., Okuda K., and Nebert D.W. The P450 superfamily: Update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol. 12 (1993) 1-51
-
(1993)
DNA Cell Biol.
, vol.12
, pp. 1-51
-
-
Nelson, D.R.1
Kamataki, T.2
Waxman, D.J.3
Guengerich, F.P.4
Estabrook, R.W.5
Feyereisen, R.6
Gonzalez, F.J.7
Coon, M.J.8
Gunsalus, I.C.9
Gotoh, O.10
Okuda, K.11
Nebert, D.W.12
-
116
-
-
0015787943
-
Wirkung van Rifampicin auf den Menstrationszylkus und die Östrogenausscheidung bei Einnahme oraler Kontrazeptive
-
Nocke-Finck L., Brewer H., and Reimers D. Wirkung van Rifampicin auf den Menstrationszylkus und die Östrogenausscheidung bei Einnahme oraler Kontrazeptive. Dtsch. Med. Wochenschr. 98 (1973) 1521-1523
-
(1973)
Dtsch. Med. Wochenschr.
, vol.98
, pp. 1521-1523
-
-
Nocke-Finck, L.1
Brewer, H.2
Reimers, D.3
-
118
-
-
0020533983
-
Suicidal destruction of cytochrome P-450 during oxidative drug metabolism
-
Ortiz de Montellano P.R., and Correia M.A. Suicidal destruction of cytochrome P-450 during oxidative drug metabolism. Annu. Rev. Pharmacol. Toxicol. 23 (1983) 481-503
-
(1983)
Annu. Rev. Pharmacol. Toxicol.
, vol.23
, pp. 481-503
-
-
Ortiz de Montellano, P.R.1
Correia, M.A.2
-
119
-
-
0001883559
-
Inhibition of cytochrome P-450 enzymes
-
Ortiz de Montellano P.R. (Ed), Plenum, New York
-
Ortiz de Montellano P.R., and Reich N.O. Inhibition of cytochrome P-450 enzymes. In: Ortiz de Montellano P.R. (Ed). "Cytochrome P-450" (1986), Plenum, New York 273-314
-
(1986)
"Cytochrome P-450"
, pp. 273-314
-
-
Ortiz de Montellano, P.R.1
Reich, N.O.2
-
120
-
-
0018437950
-
Self-catalyzed destruction of cytochrome P-450: Covalent binding of ethynyl sterols to prosthetic heme
-
Ortiz de Montellano P.R., Kunze K.L., Yost G.S., and Mico B.A. Self-catalyzed destruction of cytochrome P-450: Covalent binding of ethynyl sterols to prosthetic heme. Proc. Natl. Acad. Sci. U. S. A. 76 (1979) 746-749
-
(1979)
Proc. Natl. Acad. Sci. U. S. A.
, vol.76
, pp. 746-749
-
-
Ortiz de Montellano, P.R.1
Kunze, K.L.2
Yost, G.S.3
Mico, B.A.4
-
121
-
-
0021345446
-
Competitive inhibition of sparteine oxidation in human liver by β-adrenoceptor antagonists and other cardiovascular drugs
-
Otton S.V., Inaba T., and Kalow W. Competitive inhibition of sparteine oxidation in human liver by β-adrenoceptor antagonists and other cardiovascular drugs. Life Sci. 34 (1984) 73-80
-
(1984)
Life Sci.
, vol.34
, pp. 73-80
-
-
Otton, S.V.1
Inaba, T.2
Kalow, W.3
-
122
-
-
0024832058
-
Modulation of cytochrome P450 isozymes in human liver, by ethanol and drug intake
-
Perrot N., Nalpas B., Yang C.S., and Beaune P.H. Modulation of cytochrome P450 isozymes in human liver, by ethanol and drug intake. Eur. J. Clin. Invest. 19 (1989) 549-555
-
(1989)
Eur. J. Clin. Invest.
, vol.19
, pp. 549-555
-
-
Perrot, N.1
Nalpas, B.2
Yang, C.S.3
Beaune, P.H.4
-
123
-
-
0027533906
-
Nuclear uptake of the Ah (dioxin) receptor in response to omeprazole: Transcriptional activation of the human CYP1A1 gene
-
Quattrochi L.C., and Tukey R.H. Nuclear uptake of the Ah (dioxin) receptor in response to omeprazole: Transcriptional activation of the human CYP1A1 gene. Mol. Pharmacol. 43 (1993) 504-508
-
(1993)
Mol. Pharmacol.
, vol.43
, pp. 504-508
-
-
Quattrochi, L.C.1
Tukey, R.H.2
-
124
-
-
0025761693
-
Crystal structures of cytochrome P-450CAM complexed with camphane, thiocamphor and adamatane: Factors controlling P-450 substrate hydroxylation
-
Raag R., and Poulos T.L. Crystal structures of cytochrome P-450CAM complexed with camphane, thiocamphor and adamatane: Factors controlling P-450 substrate hydroxylation. Biochemistry 30 (1991) 2674-2684
-
(1991)
Biochemistry
, vol.30
, pp. 2674-2684
-
-
Raag, R.1
Poulos, T.L.2
-
125
-
-
0027501367
-
Phenobarbital induction and tissue-specific expression of the rat CYP2B2 gene in transgenic mice
-
Ramsden R., Sommer K.M., and Omiecinski C.J. Phenobarbital induction and tissue-specific expression of the rat CYP2B2 gene in transgenic mice. J. Biol. Chem. 268 (1993) 21722-21726
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 21722-21726
-
-
Ramsden, R.1
Sommer, K.M.2
Omiecinski, C.J.3
-
126
-
-
0021254807
-
Mechanism-based enzyme inactivators
-
Rando R.R. Mechanism-based enzyme inactivators. Pharmacol. Rev. 36 (1984) 111-142
-
(1984)
Pharmacol. Rev.
, vol.36
, pp. 111-142
-
-
Rando, R.R.1
-
127
-
-
0026587191
-
Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: Significance of aflatoxin Q1 as a detoxication product of aflatoxin B1
-
Raney K.D., Shimada T., Kim D.-H., Groopman J.D., Harris T.M., and Guengerich F.P. Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: Significance of aflatoxin Q1 as a detoxication product of aflatoxin B1. Chem. Res. Toxicol. 5 (1992) 202-210
-
(1992)
Chem. Res. Toxicol.
, vol.5
, pp. 202-210
-
-
Raney, K.D.1
Shimada, T.2
Kim, D.-H.3
Groopman, J.D.4
Harris, T.M.5
Guengerich, F.P.6
-
128
-
-
0345246445
-
Regulation of cytochrome P-450b/e gene expression by a heme- and phenobarbitone-modulated transcription factor
-
Rangarajan P.N., and Padmanaban G. Regulation of cytochrome P-450b/e gene expression by a heme- and phenobarbitone-modulated transcription factor. Proc. Natl. Acad. Sci. U. S. A. 86 (1989) 3963-3967
-
(1989)
Proc. Natl. Acad. Sci. U. S. A.
, vol.86
, pp. 3963-3967
-
-
Rangarajan, P.N.1
Padmanaban, G.2
-
129
-
-
0026004460
-
An overview of peroxisome proliferator-induced hepatocarcinogenesis
-
Rao M.S., and Reddy J.K. An overview of peroxisome proliferator-induced hepatocarcinogenesis. Environ. Health Perspect. 93 (1991) 205-209
-
(1991)
Environ. Health Perspect.
, vol.93
, pp. 205-209
-
-
Rao, M.S.1
Reddy, J.K.2
-
130
-
-
0015062805
-
Rifampicin und andere Antituberkulotika bei gleichzeitiger oraler Kontrzeption
-
Reimers D., and Jezek A. Rifampicin und andere Antituberkulotika bei gleichzeitiger oraler Kontrzeption. Przx. Pneumol. 25 (1971) 255-262
-
(1971)
Przx. Pneumol.
, vol.25
, pp. 255-262
-
-
Reimers, D.1
Jezek, A.2
-
131
-
-
34250951164
-
The acceleration of evipan oxidation and the demethylation of methylaminopyrine by barbiturates
-
Remmer H. The acceleration of evipan oxidation and the demethylation of methylaminopyrine by barbiturates. Arch. Exp. Pathol. Pharmakol. 237 (1959) 296-307
-
(1959)
Arch. Exp. Pathol. Pharmakol.
, vol.237
, pp. 296-307
-
-
Remmer, H.1
-
132
-
-
0026519541
-
Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: A role for P-4502C9 in the etiology of (S)-warfarin-drug interactions
-
Rettie A.E., Korzekwa K.R., Kunze K.L., Lawrence R.F., Eddy A.C., Aoyama T., Gelboin H.V., Gonzalez F.J., and Trager W.F. Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: A role for P-4502C9 in the etiology of (S)-warfarin-drug interactions. Chem. Res. Toxicol. 5 (1992) 54-59
-
(1992)
Chem. Res. Toxicol.
, vol.5
, pp. 54-59
-
-
Rettie, A.E.1
Korzekwa, K.R.2
Kunze, K.L.3
Lawrence, R.F.4
Eddy, A.C.5
Aoyama, T.6
Gelboin, H.V.7
Gonzalez, F.J.8
Trager, W.F.9
-
133
-
-
0028210729
-
Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9
-
Rettie A.E., Wienkers L.C., Gonzalez F.J., Trager W.F., and Korzekwa K.R. Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9. Pharmacogenetics 4 (1994) 39-42
-
(1994)
Pharmacogenetics
, vol.4
, pp. 39-42
-
-
Rettie, A.E.1
Wienkers, L.C.2
Gonzalez, F.J.3
Trager, W.F.4
Korzekwa, K.R.5
-
134
-
-
0001400418
-
Liver tumor inhibition and adrenal histologic responses in rats to which 3′-methyl-4-dimethylaminoazobenzene and 20-methylcholanthrene were simultaneously administered
-
Richardson H.L., Stier A.R., and Borsos-Nachrnebel E. Liver tumor inhibition and adrenal histologic responses in rats to which 3′-methyl-4-dimethylaminoazobenzene and 20-methylcholanthrene were simultaneously administered. Cancer Res. 12 (1952) 356-361
-
(1952)
Cancer Res.
, vol.12
, pp. 356-361
-
-
Richardson, H.L.1
Stier, A.R.2
Borsos-Nachrnebel, E.3
-
135
-
-
0028316164
-
Indentification of active-site peptides from 3H-labeled 2-ethynylnaphthaleneinactivated P450 2B1 and 2B4 using amino acid sequencing and mass spectrometry
-
Roberts E.S., Hopkins N.E., Zaluzec E.J., Gage D.A., Alworth W.L., and Hollenberg P.F. Indentification of active-site peptides from 3H-labeled 2-ethynylnaphthaleneinactivated P450 2B1 and 2B4 using amino acid sequencing and mass spectrometry. Biochemistry 33 (1994) 3766-3771
-
(1994)
Biochemistry
, vol.33
, pp. 3766-3771
-
-
Roberts, E.S.1
Hopkins, N.E.2
Zaluzec, E.J.3
Gage, D.A.4
Alworth, W.L.5
Hollenberg, P.F.6
-
136
-
-
0029124814
-
In vitro metabolism of terfenadine by a purified recombinant fusion protein containing cytochrome P450 3A4 and NADPH-P450 reductase
-
Rodrigues A.D., Mulford D.J., Lee R.D., Surber B.W., Kukulka M.J., Ferrero J.L., Thomas S.B., Shet M.S., and Estabrook R.W. In vitro metabolism of terfenadine by a purified recombinant fusion protein containing cytochrome P450 3A4 and NADPH-P450 reductase. Drug Metab. Dispos. 23 (1995) 765-775
-
(1995)
Drug Metab. Dispos.
, vol.23
, pp. 765-775
-
-
Rodrigues, A.D.1
Mulford, D.J.2
Lee, R.D.3
Surber, B.W.4
Kukulka, M.J.5
Ferrero, J.L.6
Thomas, S.B.7
Shet, M.S.8
Estabrook, R.W.9
-
137
-
-
0026699994
-
Increase of cytochrome P450IA2 activity by omeprazole: Evidence by the 13C-[N-3-methyl]-caffeine breath test in poor and extensive metabolizers of S-mephenytoin
-
Rost K.L., Brösicke H., Brockmöller J., Scheffler M., Helg H., and Roots I. Increase of cytochrome P450IA2 activity by omeprazole: Evidence by the 13C-[N-3-methyl]-caffeine breath test in poor and extensive metabolizers of S-mephenytoin. Clin. Pharmacol. Ther. 52 (1992) 170-180
-
(1992)
Clin. Pharmacol. Ther.
, vol.52
, pp. 170-180
-
-
Rost, K.L.1
Brösicke, H.2
Brockmöller, J.3
Scheffler, M.4
Helg, H.5
Roots, I.6
-
138
-
-
0028051743
-
Specific and dose-dependent enzyme induction by omeprazole in human beings
-
Rost K.L., Brösicke H., Heinemeyer G., and Roots I. Specific and dose-dependent enzyme induction by omeprazole in human beings. Hepatology 20 (1994) 1204-1212
-
(1994)
Hepatology
, vol.20
, pp. 1204-1212
-
-
Rost, K.L.1
Brösicke, H.2
Heinemeyer, G.3
Roots, I.4
-
139
-
-
0026662551
-
Cytochrome P450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat
-
Sattler M., Guengerich F.P., Yun C.-H., Christians U., and Sewing K.-F. Cytochrome P450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat. Drug Metab. Dispos. 20 (1992) 753-761
-
(1992)
Drug Metab. Dispos.
, vol.20
, pp. 753-761
-
-
Sattler, M.1
Guengerich, F.P.2
Yun, C.-H.3
Christians, U.4
Sewing, K.-F.5
-
140
-
-
0028958395
-
Phenotypic variability in induction of P-glycoprotein mRNA by aromatic hydrocarbons in primary human hepatocytes
-
Schuetz E.G., Schuetz J.D., Thompson M.T., Fisher R.A., Madariage J.R., and Strom S.C. Phenotypic variability in induction of P-glycoprotein mRNA by aromatic hydrocarbons in primary human hepatocytes. Mol. Carcinog. 12 (1995) 61-65
-
(1995)
Mol. Carcinog.
, vol.12
, pp. 61-65
-
-
Schuetz, E.G.1
Schuetz, J.D.2
Thompson, M.T.3
Fisher, R.A.4
Madariage, J.R.5
Strom, S.C.6
-
141
-
-
0023949862
-
Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by α-naphthoflavone
-
Schwab G.E., Raucy J.L., and Johnson E.F. Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by α-naphthoflavone. Mol. Pharmacol. 33 (1988) 493-499
-
(1988)
Mol. Pharmacol.
, vol.33
, pp. 493-499
-
-
Schwab, G.E.1
Raucy, J.L.2
Johnson, E.F.3
-
142
-
-
0025294782
-
Furafylline is a potent and selective inhibitor of cytochrome P450 1A2 in man
-
Sesardic D., Boobis A., Murray B., Murray S., Segura J., De La Torre R., and Davies D. Furafylline is a potent and selective inhibitor of cytochrome P450 1A2 in man. Br. J. Clin. Pharmacol. 29 (1990) 651-663
-
(1990)
Br. J. Clin. Pharmacol.
, vol.29
, pp. 651-663
-
-
Sesardic, D.1
Boobis, A.2
Murray, B.3
Murray, S.4
Segura, J.5
De La Torre, R.6
Davies, D.7
-
143
-
-
0020075333
-
Impaired oxidation of debrisoquine in patients with perhexiline neuropathy
-
Shah R.R., Oates N.S., Idle J.R., Smith R.L., and Lockhart J.D.F. Impaired oxidation of debrisoquine in patients with perhexiline neuropathy. Br. Med. J. 284 (1982) 295-299
-
(1982)
Br. Med. J.
, vol.284
, pp. 295-299
-
-
Shah, R.R.1
Oates, N.S.2
Idle, J.R.3
Smith, R.L.4
Lockhart, J.D.F.5
-
145
-
-
0028930481
-
Mechanism-based enzyme inactivators
-
Academic Press, San Diego, CA 240-283
-
Silverman R.B. Mechanism-based enzyme inactivators. "Methods in Enzymology," Vol. 249 (1995), Academic Press, San Diego, CA 240-283
-
(1995)
"Methods in Enzymology," Vol. 249
-
-
Silverman, R.B.1
-
146
-
-
0027314831
-
Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: Molecular modeling and inhibition studies
-
Strobl G.R., von Kruedener S., Stöckigt J., Guengerich F.P., and Wolff T. Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: Molecular modeling and inhibition studies. J. Med. Chem. 36 (1993) 1136-1145
-
(1993)
J. Med. Chem.
, vol.36
, pp. 1136-1145
-
-
Strobl, G.R.1
von Kruedener, S.2
Stöckigt, J.3
Guengerich, F.P.4
Wolff, T.5
-
147
-
-
0028236905
-
Screening of unsubstituted cyclic compounds as inhibitors of monoamine oxidases
-
Thull U., and Testa B. Screening of unsubstituted cyclic compounds as inhibitors of monoamine oxidases. Biochem. Pharmacol. 47 (1994) 2307-2310
-
(1994)
Biochem. Pharmacol.
, vol.47
, pp. 2307-2310
-
-
Thull, U.1
Testa, B.2
-
148
-
-
77956754418
-
-
K.E. Thummel D.D. Shen R.L. Carithers Jr. P. Hartwell T.D. Podoll W.F. Trager K.L. Kunze 1993. Prediction of in vivo midazolam clearance from hepatic CYP3A content and midazolam 1′-hydroxylation activity in liver transplant patients. Abstr., North Am. International Society for the Study of Xenobiotics Meet., 5th, Tucson, AZ, 1993, 4, p. 235
-
K.E. Thummel D.D. Shen R.L. Carithers Jr. P. Hartwell T.D. Podoll W.F. Trager K.L. Kunze 1993). Prediction of in vivo midazolam clearance from hepatic CYP3A content and midazolam 1′-hydroxylation activity in liver transplant patients. Abstr., North Am. International Society for the Study of Xenobiotics Meet., 5th, Tucson, AZ, 1993, Vol. 4, p. 235
-
-
-
-
149
-
-
0028807269
-
Mechanism of time-dependent inhibition of 5 α-reductases by DL(1)-4-azasteroids: Toward perfection of rates of time-dependent inhibition by using ligand-binding energies
-
Tian G.C., Mook R.A., Moss M.L., and Frye S.V. Mechanism of time-dependent inhibition of 5 α-reductases by DL(1)-4-azasteroids: Toward perfection of rates of time-dependent inhibition by using ligand-binding energies. Biochemistry 34 (1995) 13453-13459
-
(1995)
Biochemistry
, vol.34
, pp. 13453-13459
-
-
Tian, G.C.1
Mook, R.A.2
Moss, M.L.3
Frye, S.V.4
-
150
-
-
0028986147
-
Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes
-
Ueng Y.-F., Shimada T., Yamazaki H., and Guengerich F.P. Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes. Chem. Res. Toxicol. 8 (1995) 218-225
-
(1995)
Chem. Res. Toxicol.
, vol.8
, pp. 218-225
-
-
Ueng, Y.-F.1
Shimada, T.2
Yamazaki, H.3
Guengerich, F.P.4
-
151
-
-
0026453659
-
A study of the interaction of omeprazole and warfarin in anticoagulated patients
-
Unge P., Svedberg L.E., Nordgren A., Blom H., Andersson T., and Lagerström P.O. A study of the interaction of omeprazole and warfarin in anticoagulated patients. Br. J. Clin. Pharmacol. 34 (1992) 509-512
-
(1992)
Br. J. Clin. Pharmacol.
, vol.34
, pp. 509-512
-
-
Unge, P.1
Svedberg, L.E.2
Nordgren, A.3
Blom, H.4
Andersson, T.5
Lagerström, P.O.6
-
152
-
-
0026681640
-
In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: Identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism
-
Vincent S.H., Karanam B.V., Painter S.K., and Chiu S.H.L. In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: Identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism. Arch. Biochem. Biophys. 294 (1992) 454-460
-
(1992)
Arch. Biochem. Biophys.
, vol.294
, pp. 454-460
-
-
Vincent, S.H.1
Karanam, B.V.2
Painter, S.K.3
Chiu, S.H.L.4
-
153
-
-
0018877218
-
Purification of human liver cytochrome P-450 and comparison to the enzyme isolated from rat liver
-
Wang P., Mason P.S., and Guengerich F.P. Purification of human liver cytochrome P-450 and comparison to the enzyme isolated from rat liver. Arch. Biochem. Biophys. 199 (1980) 206-219
-
(1980)
Arch. Biochem. Biophys.
, vol.199
, pp. 206-219
-
-
Wang, P.1
Mason, P.S.2
Guengerich, F.P.3
-
154
-
-
0025944905
-
Biotransformation of lovastatin. IV. Identification of cytochrome P-450 3A proteins as the major enzymes responsible for the oxidative metabolism of lovastatin in rat and human liver microsomes
-
Wang R.W., Kari P.H., Lu A.Y.H., Thomas P.E., Guengerich F.P., and Vyas K.P. Biotransformation of lovastatin. IV. Identification of cytochrome P-450 3A proteins as the major enzymes responsible for the oxidative metabolism of lovastatin in rat and human liver microsomes. Arch. Biochem. Biophys. 290 (1991) 355-361
-
(1991)
Arch. Biochem. Biophys.
, vol.290
, pp. 355-361
-
-
Wang, R.W.1
Kari, P.H.2
Lu, A.Y.H.3
Thomas, P.E.4
Guengerich, F.P.5
Vyas, K.P.6
-
155
-
-
0041301863
-
Identification of an inducible form of cytochrome P-450 in human liver
-
Watkins P.B., Wrighton S.A., Maurel P., Schuetz E.G., Mendez-Picon G., Parker G.A., and Guzelian P.S. Identification of an inducible form of cytochrome P-450 in human liver. Proc. Natl. Acad. Sci. U. S. A. 82 (1985) 6310-6314
-
(1985)
Proc. Natl. Acad. Sci. U. S. A.
, vol.82
, pp. 6310-6314
-
-
Watkins, P.B.1
Wrighton, S.A.2
Maurel, P.3
Schuetz, E.G.4
Mendez-Picon, G.5
Parker, G.A.6
Guzelian, P.S.7
-
156
-
-
0025063782
-
The erythromycin breath test as a predictor of cyclosporine blood levels
-
Watkins P.B., Hamilton T.A., Annesley T.M., Ellis C.N., Kolars J.C., and Voorhees J.J. The erythromycin breath test as a predictor of cyclosporine blood levels. Clin. Pharmacol. Ther. 48 (1990) 120-129
-
(1990)
Clin. Pharmacol. Ther.
, vol.48
, pp. 120-129
-
-
Watkins, P.B.1
Hamilton, T.A.2
Annesley, T.M.3
Ellis, C.N.4
Kolars, J.C.5
Voorhees, J.J.6
-
158
-
-
16044362289
-
Co-inheritance of deficient oxidative metabolism of encainide and debrisoquine
-
Woosley R.L., Roden D.M., Duff H.J., Carey E.L., Wood A.J.J., and Wilkinson G.R. Co-inheritance of deficient oxidative metabolism of encainide and debrisoquine. Am. Soc. Clin. Invest. 29 (1981) 501
-
(1981)
Am. Soc. Clin. Invest.
, vol.29
, pp. 501
-
-
Woosley, R.L.1
Roden, D.M.2
Duff, H.J.3
Carey, E.L.4
Wood, A.J.J.5
Wilkinson, G.R.6
-
159
-
-
0027474601
-
Mechanism of the cardiotoxic actions of terfenadine
-
Woosley R.L., Chen Y., Freiman J.P., and Gillis R.A. Mechanism of the cardiotoxic actions of terfenadine. JAMA, J. Am. Med. Assoc. 269 (1993) 1532-1536
-
(1993)
JAMA, J. Am. Med. Assoc.
, vol.269
, pp. 1532-1536
-
-
Woosley, R.L.1
Chen, Y.2
Freiman, J.P.3
Gillis, R.A.4
-
160
-
-
0026750647
-
The human hepatic cytochromes P450 involved in drug metabolism
-
Wrighton S.A., and Stevens J.C. The human hepatic cytochromes P450 involved in drug metabolism. Crit. Rev. Toxicol. 22 (1992) 1-21
-
(1992)
Crit. Rev. Toxicol.
, vol.22
, pp. 1-21
-
-
Wrighton, S.A.1
Stevens, J.C.2
-
161
-
-
0026468125
-
Modification of cytochrome P450 1A2 enzymes by the mechanism-based inactivator 2-ethynylnaphthalene and the photoaffinity label 4-azidobiphenyl
-
Yun C.-H., Hammons G.J., Jones G., Martin M.V., Hopkins N.E., Alworth W.L., and Guengerich F.P. Modification of cytochrome P450 1A2 enzymes by the mechanism-based inactivator 2-ethynylnaphthalene and the photoaffinity label 4-azidobiphenyl. Biochemistry 31 (1992) 10556-10563
-
(1992)
Biochemistry
, vol.31
, pp. 10556-10563
-
-
Yun, C.-H.1
Hammons, G.J.2
Jones, G.3
Martin, M.V.4
Hopkins, N.E.5
Alworth, W.L.6
Guengerich, F.P.7
-
162
-
-
0027168405
-
Oxidation of the antihistaminic drug terfenadine in human liver microsomes: Role of cytochrome P450 3A(4) in N-dealkylation and C-hydroxylation
-
Yun C.-H., Okerholm R.A., and Guengerich F.P. Oxidation of the antihistaminic drug terfenadine in human liver microsomes: Role of cytochrome P450 3A(4) in N-dealkylation and C-hydroxylation. Drug Metab. Dispos. 21 (1993) 403-409
-
(1993)
Drug Metab. Dispos.
, vol.21
, pp. 403-409
-
-
Yun, C.-H.1
Okerholm, R.A.2
Guengerich, F.P.3
-
163
-
-
0016758480
-
Induction of drug metabolism in man after rifampicin treatment measured by increased hexobarbital and tolbutamide clearance
-
Zilly W., Breimer D.D., and Richter E. Induction of drug metabolism in man after rifampicin treatment measured by increased hexobarbital and tolbutamide clearance. Eur. J. Clin. Pharmacol. 9 (1975) 219-227
-
(1975)
Eur. J. Clin. Pharmacol.
, vol.9
, pp. 219-227
-
-
Zilly, W.1
Breimer, D.D.2
Richter, E.3
|