CYP2D-related metabolism in animals of the Canoidea superfamily - Species differences

Veterinary Research Communications

Volumn 30, Issue 5, 2006, Pages 505-512

  Ishizuka, M ^a   Lee, J J ^a   Masuda, M ^a   Akahori, F ^b   Kazusaka, A ^a   Fujita, S ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b AZABU UNIVERSITY   (Japan)

Author keywords

Canoidea; Metabolism; Propranolol; Regioselectivity; Species differences

Indexed keywords

BUNITROLOL; CYTOCHROME P450 2D; IMIPRAMINE; OXYGENASE; PROPRANOLOL; XENOBIOTIC AGENT;

ANIMAL CELL; ARTICLE; BEAR; CATALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEALKYLATION; DOG; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME ACTIVITY; EXPERIMENTAL STUDY; FOX; LIVER MICROSOME; MALE; MINK; NONHUMAN; SPECIES DIFFERENCE; STEREOCHEMISTRY;

ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC UPTAKE INHIBITORS; ANIMALS; CANIDAE; CYTOCHROME P-450 ENZYME SYSTEM; DOGS; FOXES; HYDROXYLATION; IMIPRAMINE; ISOENZYMES; LIVER; MALE; MICROSOMES, LIVER; MINK; PROPANOLAMINES; PROPRANOLOL; RATS; REACTIVE NITROGEN SPECIES; STEREOISOMERISM; URSIDAE;

ANIMALIA; CANIDAE; CANIS FAMILIARIS; MUSTELA; MUSTELA VISON; URSUS ARCTOS; VULPES VULPES;

EID: 33744934459     PISSN: 01657380     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11259-006-3213-8     Document Type: Article

References (10)

1. Fujita, S., Umeda, S., Funae, Y., Imaoka, S., Abe, H., Ishida, R., Adachi, T., Masuda, M., Kazusaka, A. and Suzuki, T., 1993. Regio- and stereoselective propranolol metabolism by 15 forms of purified cytochrome P450 from rat liver. Journal of Pharmacology and Experimental Therapeutics, 264, 226-233
2. Guttendorf, R.J., Kostenbauder, H.B. and Wedlund, P.J., 1991. Stereoselective differences in propranolol disposition in female Sprague-Dawley and Dark Agouti rats. Drug Metabolism and Disposition, 19, 251-256
3. Lowry, O.H., Rosebrough, N.J., Farr, L. and Randall, R.J., 1951. Protein measurement with the folin phenol reagent. Journal of Biological Chemistry, 193, 265-275
4. Masubuchi, Y., Hosokawa, S., Horie, T., Suzuki, T., Ohmori, S., Kitada, M. and Narimatsu, S., 1994. Cytochrome P450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ring-hydroxylase and CYP1A2 as N -desisopropylase. Drug Metabolism and Disposition, 22, 909-915
5. Nakamura, A., Yamamoto, Y., Tasaki, T., Sugimoto, C., Masuda, M., Kazusaka, A. and Fujita, S., 1995a. Purification and characterization of a dog cytochrome P450 isozyme belonging to the CYP2D subfamily and development of its antipeptide antibody. Drug Metabolism and Disposition, 23, 1268-1273
6. Omura, T. and Sato, R., 1964. The carbon monoxide binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. Journal of Biological Chemistry, 239, 2370-2385
7. Silber, B. and Riegelman, S., 1980. Stereospecific assay for (-)- and (+)-propranolol in human and dog plasma. Journal of Pharmacology and Experimental Therapeutics, 215, 643-648
8. Suzuki, T., Narimatsu, S., Fujita, S., Masubuchi, Y., Umeda, S., Imaoka, S. and Funae, Y, 1992. Purification and characterization of a cytochrome P-450 isozyme catalyzing bunitrolol 4-hydroxylation in liver microsomes of male rats. Drug Metabolism and Disposition, 20, 367-373
9. Tasaki, T., Iwata, H., Kazusaka, A. and Fujita, S., 1998. Regio- and stereoselectivity in propranolol metabolism by dog liver microsomes and the expressed dog CYP2D15. Journal of Biochemistry (Tokyo), 123, 747-751
10. Walle., T. and Walle, U.K., 1979. Stereoselective oral bioavailability of (+/-)-propranolol in the dog. A GC-MS study using a stable isotope technique. Research Communications in Chemical Pathology and Pharmacology, 23, 453-464