Trimethadione metabolism and microsomal monooxygenases in untreated and phenobarbital-treated rhesus monkeys

Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology

Volumn 120, Issue 2, 1998, Pages 317-320

  Tanaka, Einosuke ^a   Taniguchi, Tomoyoshi ^b   Sawa, Yoshio ^b   Ohmori, Shigeru ^c   Kitada, Mitsukazu ^c   Horie, Tohoru ^b  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b CHIBA UNIVERSITY HOSPITAL   (Japan)

^c EISAI CO LTD   (Japan)

Author keywords

Cytochrome P450 subfamily; Dimethadione; Immunoblotting; Induction; Liver; Phenobarbital; Rhesus monkey; Trimethadione

Indexed keywords

4 NITROANISOLE DEMETHYLASE; CYTOCHROME P450 ISOENZYME; DIMETHADIONE; PHENOBARBITAL; TRIMETHADIONE; UNSPECIFIC MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DRUG METABOLISM; ENZYME INDUCTION; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER MICROSOME METABOLISM; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RHESUS MONKEY;

ANILINE HYDROXYLASE; ANIMALS; ANTICONVULSANTS; CYTOCHROME P-450 ENZYME SYSTEM; DIMETHADIONE; ENZYME INDUCTION; ISOENZYMES; MACACA MULATTA; MALE; MICROSOMES, LIVER; OXIDOREDUCTASES, N-DEMETHYLATING; OXIDOREDUCTASES, O-DEMETHYLATING; PHENOBARBITAL; TRIMETHADIONE;

EID: 0031679822     PISSN: 07428413     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0742-8413(98)10065-8     Document Type: Article

References (16)

1. Daling Z, Tanaka E, Nakamura T, Horie T. Effect of E-5110, a novel non-steroidal anti-flammatory drug, on trimethadione metabolism as an indicator of hepatic drug-oxidizing capacity in beagle dog. Xenobiotica 1994;24(3):215-20.
2. Guengerich FP, Wang P, Davidson NK. Estimation of isozymes of microsomal cytochrome P-450 in rat, rabbits, and humans using immunochemical staining coupled with sodium dodecyl sulfate polyacrylamide gel electrophoresis. Biochemistry 1982;21(7):1698-706.
3. Imai Y, Ito A, Sato R. Evidence for biochemically different type of vesicles in the hepatic microsomal function. J Biochem 1966;60:417-28.
4. Kamataki T, Kitada M, Shigematsu H, Kitagawa H. The involvement of cytochrome P-448 and P-450 in NADH-dependent O-demethylation of p-nitroanisole in rat liver microsomes. Jpn J Pharmacol 1979;29(2):191-201.
5. Kitada M, Kato T, Ohmori S, et al. Immunochemical characterization and toxicological significance of P-450HFLb purified from human fetal livers. Biochim Biophys Acta 1992;1117(3):301-5.
6. Laemmli UK. Cleavage of structural protein during the assembly of the head of bacteriophage T4. Nature 1970;227(259):680-5.
7. Lowry OH, Rosebrough. NJ, Farr AL, Randall RJ. Protein measurement with folin phenol reagent. J Biol Chem 1951;193:265-75.
8. Nakamura M, Tanaka E, Misawa S, Shimada T, Imaoka S, Funae Y. Trimethadione metabolism, a useful indicator for assessing hepatic drug-oxidizing capacity. Biochem Pharmacol 1994;47(2):247-51.
9. Nash T. The colorimetric estimation of formaldehyde by means of the Hantzsh reaction. Biochem J 1953;55:416-21.
10. Ohmori S, Horie T, Guengerich FP, Kouchi M, Kitada M. Purification and characterization of two forms of hepatic microsomal cytochrome P450 from untreated cynomolgus monkeys. Arch Biochem Biophys 1993;305(2):405-13.
11. Ohmori S, Shirakawa. C, Motohashi K, et al. Purification from liver microsomes from untreated cynomolgus monkeys of cytochrome P450 closely related to human cytochrome P450 2B6. Mol Pharmacol 1993;43(2):183-90.
12. Ohmori S, Chiba. K, Nakase. H, Horie. T, Kitada M. Characterization of monkey cytochrome P450, P450 CMLd, responsible for S-mephenytoin 4′-hydroxylation in hepatic microsomes of cynomolgus monkeys. Arch Biochem Biophys 1994;311(2):395-401.
13. Omura T, Sato R. The carbon monoxide binding pigment of liver microsomes.I. Evidence for its hemoprotein nature. J Biol Chem 1964;239:2370-8.
14. Tanaka E, Kinoshita H, Yamamoto T, Kuroiwa. Y, Tkakabatake E. Pharmacokinetics studies of trimethadione and its metabolite in rats with chemical-induced liver injury. J Pharmacobio-Dyn 1981;4(4):576-83.
15. Tanaka E, Ishikawa A, Abei M, Kobayashi S. Trimethadione metabolism as a probe drug to estimate hepatic oxidizing capacity in humans. Comp Biochem Physiol 1996;115C(3):211-6.
16. Tanaka E, Misawa S. Improved method for the determination of trimethadione and its demethylated metabolite, dimethadione, in human serum by gas chromatography. J Chromatogr Biomed Appl 1992;584(2):267-9.