MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype

Clinical Pharmacology and Therapeutics

Volumn 79, Issue 4, 2006, Pages 325-338

  Lamba, Jatinder ^a,b,c,d   Strom, Stephen ^a,b,c,d   Venkataramanan, Raman ^a,b,c,d   Thummel, Kenneth E ^a,b,c,d   Lin, Yvonne S ^a,b,c,d   Liu, Wei ^a,b,c,d   Cheng, Cheng ^a,b,c,d   Lamba, Vishal ^a,b,c,d   Watkins, Paul B ^a,b,c,d   Schuetz, Erin ^a,b,c,d  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A4; DNA; GLYCOPROTEIN P; MIDAZOLAM HYDROXYLASE; MULTIDRUG RESISTANCE PROTEIN 1; OXYGENASE; PREGNANE X RECEPTOR; RIFAMPICIN; UNCLASSIFIED DRUG;

ALLELE; ANALYSIS OF VARIANCE; ARTICLE; BASE PAIRING; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; GENE DELETION; GENOTYPE; HETEROZYGOTE; HOMOZYGOSITY; HUMAN; HUMAN CELL; HUMAN TISSUE; INTESTINE; INTESTINE BIOPSY; LIVER CELL; LIVER FUNCTION; MALE; PHARMACOGENETICS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ADOLESCENT; ADULT; AGED; COHORT STUDIES; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENES, MDR; GENOTYPE; HUMANS; INTESTINE, SMALL; LIVER; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RIFAMPIN; RNA, MESSENGER;

EID: 33645876468     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clpt.2005.11.013     Document Type: Article

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