Scid thymocytes with TCRβ gene rearrangements are targets for the oncogenic effect of SCL and LMO1 transgenes

Cancer Research

Volumn 61, Issue 17, 2001, Pages 6382-6387

  Chervinsky, David S ^a   Lam, Du H ^a,b   Melman, Michael P ^b   Gross, Kenneth W ^a   Aplan, Peter D ^b  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; DNA BINDING PROTEIN; DNA DEPENDENT PROTEIN KINASE; LMO1 PROTEIN, MOUSE; METALLOPROTEIN; NUCLEAR PROTEIN; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE; TAL1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR; CD4 ANTIGEN; CD8 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANIMAL; ARTICLE; C3H MOUSE; C57BL MOUSE; CELL CLONE; COMPARATIVE STUDY; CROSS BREEDING; CYTOLOGY; FEMALE; GENE REARRANGEMENT; GENETICS; IMMUNOLOGY; MALE; MOUSE; MOUSE MUTANT; PHYSIOLOGY; PROTO ONCOGENE; T CELL LEUKEMIA; T LYMPHOCYTE; THYMUS; TRANSGENE; TRANSGENIC MOUSE; ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CHROMOSOME TRANSLOCATION; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; GENE OVEREXPRESSION; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; THYMOCYTE;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CLONE CELLS; CROSSES, GENETIC; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; FEMALE; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; LEUKEMIA, T-CELL, ACUTE; MALE; METALLOPROTEINS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, SCID; MICE, TRANSGENIC; NUCLEAR PROTEINS; ONCOGENE PROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENES; T-LYMPHOCYTES; THYMUS GLAND; TRANSCRIPTION FACTORS; TRANSGENES;

EID: 0035418581     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? A pediatric oncology group study
2. Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia
3. T-cell-directed TAL-1 expression induces T-cell malignancies in transgenic mice
4. Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIα
5. Protein dimerization between Lmo2 (Rbtn2) and Tall alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice
6. Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: Parallels with E2A-deficient mice
7. An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice
8. Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia
9. Defects of the mismatch repair gene MSH2 are implicated in the development of murine and human lymphoblastic lymphomas and are associated with the aberrant expression of rhombotin-2 (Lmo-2) and Tal-1 (SCL)
10. The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells
11. SCL and LMO1 alter thymocyte differentiation: Inhibition of E2A-HEB function and pre-T α chain expression
12. A severe combined immunodeficiency mutation in the mouse
13. DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect
14. Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency
15. Thymic overexpression of Ttg-1 in transgenic mice results in T-cell acute lymphoblastic leukemia/lymphoma
16. Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice
17. Rescue of T cell-specific V(D)J recombination in SCID mice by DNA-damaging agents
18. Coding joint formation of endogenous T cell receptor genes in lymphoid cells from scid mice: Unusual P-nucleotide additions in VJ-coding joints
19. The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism
20. The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination
21. p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes
22. V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors
23. Mutations in the p53 and SCID genes cooperate in tumorigenesis
24. No requirement for V(D)J recombination in p53-deficient thymic lymphoma
25. V(D)J recombination is not required for the development of lymphoma in p53-deficient mice
26. Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor α/β lineage: T cell receptor δ gene deletion mechanism affects multiple genes
27. Disruption of the SCL locus in T-lymphoid malignancies correlates with commitment to the T-cell receptor α β lineage