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Volumn 110, Issue 7, 2007, Pages 2610-2619

p6INK4A tumor suppressor gene expression and CD3 ε deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD3 EPSILON ANTIGEN; PROTEIN P16INK4A; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CCND3 PROTEIN, HUMAN; CCND3 PROTEIN, MOUSE; CD3E PROTEIN, HUMAN; CYCLIN D3; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLINE; LMO1 PROTEIN, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR; MESSENGER RNA; NOTCH1 RECEPTOR; NUCLEAR PROTEIN; ONCOPROTEIN; TAL1 PROTEIN, HUMAN; TAL1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

EID: 34948889311     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2007-01-066209     Document Type: Article
Times cited : (13)

References (62)
  • 1
    • 0025984266 scopus 로고
    • Translocations, master genes, and differences between the origins of acute and chronic leukemias
    • Rabbitts TH. Translocations, master genes, and differences between the origins of acute and chronic leukemias. Cell. 1991;67:641-644.
    • (1991) Cell , vol.67 , pp. 641-644
    • Rabbitts, T.H.1
  • 2
    • 27244440324 scopus 로고    scopus 로고
    • Molecular genetics of acute lymphoblastic leukemia
    • Armstrong SA, Look AT. Molecular genetics of acute lymphoblastic leukemia. J Clin Oncol. 2005;23:6306-6315.
    • (2005) J Clin Oncol , vol.23 , pp. 6306-6315
    • Armstrong, S.A.1    Look, A.T.2
  • 3
    • 33646366173 scopus 로고    scopus 로고
    • Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia
    • Grabher C, von Boehmer H, Look A. Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia. Nat Rev Cancer. 2006;6:347-359.
    • (2006) Nat Rev Cancer , vol.6 , pp. 347-359
    • Grabher, C.1    von Boehmer, H.2    Look, A.3
  • 4
    • 33747608619 scopus 로고    scopus 로고
    • Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: From thymocyte to lymphoblast
    • Graux C, Cools J, Michaux L, Vandenberghe P, Hagemeijer A. Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: from thymocyte to lymphoblast. Leukemia. 2006;20:1496-1510.
    • (2006) Leukemia , vol.20 , pp. 1496-1510
    • Graux, C.1    Cools, J.2    Michaux, L.3    Vandenberghe, P.4    Hagemeijer, A.5
  • 5
    • 21844440323 scopus 로고    scopus 로고
    • Unique features of the pre-T-cell receptor alpha-chain: Not just a surrogate
    • von Boehmer H. Unique features of the pre-T-cell receptor alpha-chain: not just a surrogate. Nat Rev Immunol. 2005;5:571-577.
    • (2005) Nat Rev Immunol , vol.5 , pp. 571-577
    • von Boehmer, H.1
  • 6
    • 0004328021 scopus 로고
    • Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript
    • Begley C, Aplan P, Davey M, et al. Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript. Proc Natl Acad Sci U S A. 1989;86:2031-2035.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 2031-2035
    • Begley, C.1    Aplan, P.2    Davey, M.3
  • 7
    • 34948870781 scopus 로고    scopus 로고
    • Role of the TAL 1/SCL transcription factor in normal and leukemic hematopoiesis
    • Ravid K, Licht JD, eds, New York, NY: Wiley-Liss;
    • Brandt SJ. Role of the TAL 1/SCL transcription factor in normal and leukemic hematopoiesis. In: Ravid K, Licht JD, eds. Transcription Factors. New York, NY: Wiley-Liss; 2001.
    • (2001) Transcription Factors
    • Brandt, S.J.1
  • 8
    • 0030999645 scopus 로고    scopus 로고
    • The LIM-only protein LMO2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA1 and Ldb1/NLI proteins
    • Wadman IA, Osada H, Grutz GG, et al. The LIM-only protein LMO2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA1 and Ldb1/NLI proteins. EMBO J. 1997;16:3141-3157.
    • (1997) EMBO J , vol.16 , pp. 3141-3157
    • Wadman, I.A.1    Osada, H.2    Grutz, G.G.3
  • 9
    • 0025014636 scopus 로고
    • The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein
    • Chen Q, Cheng J, Tasi L, et al. The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. EMBO J. 1990;9:415-424.
    • (1990) EMBO J , vol.9 , pp. 415-424
    • Chen, Q.1    Cheng, J.2    Tasi, L.3
  • 10
    • 0025357145 scopus 로고
    • Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemias
    • Bernard O, Guglielmi P, Jonveaux P, et al. Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemias. Genes Chromosomes Cancer. 1990;1:194-208.
    • (1990) Genes Chromosomes Cancer , vol.1 , pp. 194-208
    • Bernard, O.1    Guglielmi, P.2    Jonveaux, P.3
  • 11
    • 0025642707 scopus 로고
    • Disruption of the Human SCL locus by "illegitimate" V-(D)-J recombinase activity
    • Aplan P, Lombardi D, Ginsberg A, Cossman J, Bertness L, Kirsch I. Disruption of the Human SCL locus by "illegitimate" V-(D)-J recombinase activity. Science. 1990;250:1426-1429.
    • (1990) Science , vol.250 , pp. 1426-1429
    • Aplan, P.1    Lombardi, D.2    Ginsberg, A.3    Cossman, J.4    Bertness, L.5    Kirsch, I.6
  • 12
    • 17144474314 scopus 로고    scopus 로고
    • Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia
    • Ferrando AA, Neuberg DS, Staunton J, et al. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell. 2002;1:75-87.
    • (2002) Cancer Cell , vol.1 , pp. 75-87
    • Ferrando, A.A.1    Neuberg, D.S.2    Staunton, J.3
  • 13
    • 1442307956 scopus 로고    scopus 로고
    • Biallelic transcriptional activation of oncogenic transcription factors in T-cell acute lymphoblastic leukemia
    • Ferrando A, Herblot S, Palmero T, et al. Biallelic transcriptional activation of oncogenic transcription factors in T-cell acute lymphoblastic leukemia. Blood. 2004;103:1909-1911.
    • (2004) Blood , vol.103 , pp. 1909-1911
    • Ferrando, A.1    Herblot, S.2    Palmero, T.3
  • 14
    • 22044457152 scopus 로고    scopus 로고
    • HOXA genes are included in genetic and biologic networks defining acute T-cell leukemia (T-ALL)
    • Soulier J, Clappier E, Cayuela M, et al. HOXA genes are included in genetic and biologic networks defining acute T-cell leukemia (T-ALL). Blood. 2005;106:274-286.
    • (2005) Blood , vol.106 , pp. 274-286
    • Soulier, J.1    Clappier, E.2    Cayuela, M.3
  • 15
    • 0029815976 scopus 로고    scopus 로고
    • Tal-1 induces T cell acute leukemia accelerated by casein kinase IIα
    • Kelliher MA, Seldin DC, Leder P. Tal-1 induces T cell acute leukemia accelerated by casein kinase IIα. EMBO J. 1996;15:5160-5166.
    • (1996) EMBO J , vol.15 , pp. 5160-5166
    • Kelliher, M.A.1    Seldin, D.C.2    Leder, P.3
  • 16
    • 0029981648 scopus 로고    scopus 로고
    • Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice
    • Larson RC, Lavenir I, Larson TA, et al. Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice. EMBO J. 1996;15:1021-1027.
    • (1996) EMBO J , vol.15 , pp. 1021-1027
    • Larson, R.C.1    Lavenir, I.2    Larson, T.A.3
  • 17
    • 0030921503 scopus 로고    scopus 로고
    • An SCL gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice
    • Aplan PD, Jones CA, Chervinsky DS, Chuanzen W, McGuire EA, Gross KW. An SCL gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice. EMBO J. 1997;16:2408-2419.
    • (1997) EMBO J , vol.16 , pp. 2408-2419
    • Aplan, P.D.1    Jones, C.A.2    Chervinsky, D.S.3    Chuanzen, W.4    McGuire, E.A.5    Gross, K.W.6
  • 18
    • 0027970946 scopus 로고
    • T cell tumours of disparate phenotype in mice transgenic for Rbtn-2
    • Larson RC, Fisch P, Larson TA, et al. T cell tumours of disparate phenotype in mice transgenic for Rbtn-2. Oncogene. 1994;9:3675-3681.
    • (1994) Oncogene , vol.9 , pp. 3675-3681
    • Larson, R.C.1    Fisch, P.2    Larson, T.A.3
  • 19
    • 0029113214 scopus 로고
    • The oncogenic LIM protein Rbtn2 causes thymic developmental aberrations that precede malignancy in transgenic mice
    • Larson RC, Osada H, Larson TA, Lavenir I, Rabbitts TH. The oncogenic LIM protein Rbtn2 causes thymic developmental aberrations that precede malignancy in transgenic mice. Oncogene. 1995;11:853-862.
    • (1995) Oncogene , vol.11 , pp. 853-862
    • Larson, R.C.1    Osada, H.2    Larson, T.A.3    Lavenir, I.4    Rabbitts, T.H.5
  • 20
    • 0033043388 scopus 로고    scopus 로고
    • Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: Parallels with E2A-deficient mice
    • Chervinsky DS, Zhao X-F, Lam DH, Ellsworth M, Gross KW, Aplan PD. Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice. Mol Cell Biol. 1999;19:5025-5035.
    • (1999) Mol Cell Biol , vol.19 , pp. 5025-5035
    • Chervinsky, D.S.1    Zhao, X.-F.2    Lam, D.H.3    Ellsworth, M.4    Gross, K.W.5    Aplan, P.D.6
  • 21
    • 0035140870 scopus 로고    scopus 로고
    • Development and characterization of T cell leukemia cell lines established from SCL/LMO1 double transgenic mice
    • Chervinsky D, Lam D, Zhao X, Melman M, Aplan P. Development and characterization of T cell leukemia cell lines established from SCL/LMO1 double transgenic mice. Leukemia. 2001;15:141-147.
    • (2001) Leukemia , vol.15 , pp. 141-147
    • Chervinsky, D.1    Lam, D.2    Zhao, X.3    Melman, M.4    Aplan, P.5
  • 22
    • 33646877029 scopus 로고    scopus 로고
    • p16Ink4a or p19Arf loss contributes to Tal1-induced leukemogenesis in mice
    • Shank-Calvo J, Draheim K, Bhasin M, Kelliher M. p16Ink4a or p19Arf loss contributes to Tal1-induced leukemogenesis in mice. Oncogene. 2006;25:3023-3031.
    • (2006) Oncogene , vol.25 , pp. 3023-3031
    • Shank-Calvo, J.1    Draheim, K.2    Bhasin, M.3    Kelliher, M.4
  • 23
    • 0027938776 scopus 로고
    • Candidate tumor-suppressor genes MTS1 (p16(INK4A)) and MTS2 (p15(INK4B)) display frequent homozygous deletions in primary cells from T- but not B-cell lineage acute lymphoblastic leukemias
    • Herbert J, Cayuela JM, Berkeley J, Sigaux F. Candidate tumor-suppressor genes MTS1 (p16(INK4A)) and MTS2 (p15(INK4B)) display frequent homozygous deletions in primary cells from T- but not B-cell lineage acute lymphoblastic leukemias. Blood. 1994;84:4038-4044.
    • (1994) Blood , vol.84 , pp. 4038-4044
    • Herbert, J.1    Cayuela, J.M.2    Berkeley, J.3    Sigaux, F.4
  • 24
    • 0028899626 scopus 로고
    • Homozygous MTS1 (p16INK4A) deletion in primary tumor cells of 163 leukemic patients
    • Cayuela J, Herbert J, Sigaux F. Homozygous MTS1 (p16INK4A) deletion in primary tumor cells of 163 leukemic patients. Blood. 1995;85:854.
    • (1995) Blood , vol.85 , pp. 854
    • Cayuela, J.1    Herbert, J.2    Sigaux, F.3
  • 25
    • 0030780646 scopus 로고    scopus 로고
    • Disruption of the multiple tumor suppressor gene MTS1/p16(INK4a)/ CDKN2 by illegitimate V(D)J recombinase activity in T-cell acute lymphoblastic leukemias
    • Cayuela J, Gardie B, Sigaux F. Disruption of the multiple tumor suppressor gene MTS1/p16(INK4a)/ CDKN2 by illegitimate V(D)J recombinase activity in T-cell acute lymphoblastic leukemias. Blood. 1997;90:3720-3726.
    • (1997) Blood , vol.90 , pp. 3720-3726
    • Cayuela, J.1    Gardie, B.2    Sigaux, F.3
  • 26
    • 0031987331 scopus 로고    scopus 로고
    • Genomic alterations of the p19ARF encoding exons in T-cell acute lymphoblastic leukemia
    • Gardie B, Cayuela JM, Martini S, Sigaux F. Genomic alterations of the p19ARF encoding exons in T-cell acute lymphoblastic leukemia. Blood. 1998;91:1016-1020.
    • (1998) Blood , vol.91 , pp. 1016-1020
    • Gardie, B.1    Cayuela, J.M.2    Martini, S.3    Sigaux, F.4
  • 27
    • 0031035406 scopus 로고    scopus 로고
    • Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia
    • Batova A, Diccianni M, Yu J, et al. Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia. Cancer Res. 1997;57:832-836.
    • (1997) Cancer Res , vol.57 , pp. 832-836
    • Batova, A.1    Diccianni, M.2    Yu, J.3
  • 28
    • 0031860559 scopus 로고    scopus 로고
    • Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells
    • Drexler H. Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells. Leukemia. 1998;12:845-859.
    • (1998) Leukemia , vol.12 , pp. 845-859
    • Drexler, H.1
  • 29
    • 0037075887 scopus 로고    scopus 로고
    • Ortega S, Malumbres M, Barbacid M. Cyclin Ddependent kinases, INK4 inhibitors and cancer. Biochim Biophys Acta. 2002;1602:73-87.
    • Ortega S, Malumbres M, Barbacid M. Cyclin Ddependent kinases, INK4 inhibitors and cancer. Biochim Biophys Acta. 2002;1602:73-87.
  • 30
    • 14644410453 scopus 로고    scopus 로고
    • The signals and pathways activating cellular senescence
    • Ben-Porath I, Weinberg R. The signals and pathways activating cellular senescence. Int J Biochem Cell Biol. 2005;37:961-976.
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 961-976
    • Ben-Porath, I.1    Weinberg, R.2
  • 31
    • 13944270339 scopus 로고    scopus 로고
    • Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
    • Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell. 2005;120:513-522.
    • (2005) Cell , vol.120 , pp. 513-522
    • Campisi, J.1
  • 32
    • 0029915461 scopus 로고    scopus 로고
    • Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia
    • Cayuela JM, Madani A, Sanhes L, Stern MH, Sigaux F. Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia. Blood. 1996;87:2180-2186.
    • (1996) Blood , vol.87 , pp. 2180-2186
    • Cayuela, J.M.1    Madani, A.2    Sanhes, L.3    Stern, M.H.4    Sigaux, F.5
  • 33
    • 24644519817 scopus 로고    scopus 로고
    • Two types of chromosome 1p losses with opposite significance in gliomas
    • Idbaih A, Marie Y, Pierron G, et al. Two types of chromosome 1p losses with opposite significance in gliomas. Ann Neurol. 2005;58:483-487.
    • (2005) Ann Neurol , vol.58 , pp. 483-487
    • Idbaih, A.1    Marie, Y.2    Pierron, G.3
  • 34
    • 0036499117 scopus 로고    scopus 로고
    • Transgenic expression of the p16ink4a cyclin-dependent kinase inhibitor leads to enhanced apoptosis and differentiation of CD4-CD8- immature thymocytes
    • Lagresle C, Gardie B, Eyquem S, et al. Transgenic expression of the p16ink4a cyclin-dependent kinase inhibitor leads to enhanced apoptosis and differentiation of CD4-CD8- immature thymocytes. J Immunol. 2002;168:2325-2331.
    • (2002) J Immunol , vol.168 , pp. 2325-2331
    • Lagresle, C.1    Gardie, B.2    Eyquem, S.3
  • 36
    • 0029094319 scopus 로고
    • Altered T cell development in mice with a targeted mutation of the C3-ε gene
    • Malissen M, Gillet A, Ardouin L, et al. Altered T cell development in mice with a targeted mutation of the C3-ε gene. EMBO J. 1995;14:4641-4653.
    • (1995) EMBO J , vol.14 , pp. 4641-4653
    • Malissen, M.1    Gillet, A.2    Ardouin, L.3
  • 37
    • 0026728357 scopus 로고
    • Thymic overexpression of Ttg-1 in transgenic mice results in T-cell acute lymphoblastic leukemia/ lymphoma
    • McGuire EA, Rintoul CE, Sclar GM, Korsmeyer SJ. Thymic overexpression of Ttg-1 in transgenic mice results in T-cell acute lymphoblastic leukemia/ lymphoma. Mol Cell Biol. 1992;12:4186-4196.
    • (1992) Mol Cell Biol , vol.12 , pp. 4186-4196
    • McGuire, E.A.1    Rintoul, C.E.2    Sclar, G.M.3    Korsmeyer, S.J.4
  • 38
    • 0034252945 scopus 로고    scopus 로고
    • SCL and LMO1 alter thymocyte differentiation: Inhibition of E2A-HEB function and pre-Tα chain expression
    • Herblot S, Steff A-M, Hugo P, Aplan P, Hoang T. SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-Tα chain expression. Nat Immunol. 2000;1:138-144.
    • (2000) Nat Immunol , vol.1 , pp. 138-144
    • Herblot, S.1    Steff, A.-M.2    Hugo, P.3    Aplan, P.4    Hoang, T.5
  • 39
    • 0029065488 scopus 로고
    • Crucial role of the pre-T-cell receptor α gene in development of ab but not γδ T cells
    • Fehling H, Krotkova A, Saint-Ruf C, von Boehmer H. Crucial role of the pre-T-cell receptor α gene in development of ab but not γδ T cells. Nature. 1995;375:795-798.
    • (1995) Nature , vol.375 , pp. 795-798
    • Fehling, H.1    Krotkova, A.2    Saint-Ruf, C.3    von Boehmer, H.4
  • 40
    • 9144229104 scopus 로고    scopus 로고
    • Requirement for cyclin D3 in lymphocyte development and T cell leukemias
    • Sicinska E, Aifantis I, Le Cam L, et al. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell. 2003;4:451-461.
    • (2003) Cancer Cell , vol.4 , pp. 451-461
    • Sicinska, E.1    Aifantis, I.2    Le Cam, L.3
  • 41
    • 33644982096 scopus 로고    scopus 로고
    • Cyclin D2 dysregulation by chromosomal translocations to TCR loci in T-cell acute lymphoblastic leukemias
    • Clappier E, Cuccuini W, Cayuela J, et al. Cyclin D2 dysregulation by chromosomal translocations to TCR loci in T-cell acute lymphoblastic leukemias. Leukemia. 2005;20:82-86.
    • (2005) Leukemia , vol.20 , pp. 82-86
    • Clappier, E.1    Cuccuini, W.2    Cayuela, J.3
  • 42
    • 5044225888 scopus 로고    scopus 로고
    • Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
    • Weng A, Ferrando A, Lee W, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science. 2004;306:269-271.
    • (2004) Science , vol.306 , pp. 269-271
    • Weng, A.1    Ferrando, A.2    Lee, W.3
  • 43
    • 30444436343 scopus 로고    scopus 로고
    • Activating Notch1 mutations in mouse models of T-ALL
    • O'Neil J, Calvo J, McKenna K, et al. Activating Notch1 mutations in mouse models of T-ALL. Blood. 2006;107:781-785.
    • (2006) Blood , vol.107 , pp. 781-785
    • O'Neil, J.1    Calvo, J.2    McKenna, K.3
  • 44
    • 33644756556 scopus 로고    scopus 로고
    • Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma
    • Lin Y, Nichols R, Letterio J, Aplan P. Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma. Blood. 2005;107:2540-2543.
    • (2005) Blood , vol.107 , pp. 2540-2543
    • Lin, Y.1    Nichols, R.2    Letterio, J.3    Aplan, P.4
  • 45
    • 33646374372 scopus 로고    scopus 로고
    • Notch1 promotes survival of E2A-deficient T cell lymphomas through Pre-T cell receptor dependent and independent mechanisms
    • Reschly E, Spaulding C, Vilimas T, et al. Notch1 promotes survival of E2A-deficient T cell lymphomas through Pre-T cell receptor dependent and independent mechanisms. Blood. 2006;107:4115-4121.
    • (2006) Blood , vol.107 , pp. 4115-4121
    • Reschly, E.1    Spaulding, C.2    Vilimas, T.3
  • 46
    • 0032576841 scopus 로고    scopus 로고
    • A full-length Notch1 allele is dispensable for transformation associated with a provirally activated truncated Notch1 allele in Moloney MuLV-infected MMTV(D)/myc transgenic mice
    • Girard L, Jolicoeur P. A full-length Notch1 allele is dispensable for transformation associated with a provirally activated truncated Notch1 allele in Moloney MuLV-infected MMTV(D)/myc transgenic mice. Oncogene. 1998;16:517-522.
    • (1998) Oncogene , vol.16 , pp. 517-522
    • Girard, L.1    Jolicoeur, P.2
  • 47
    • 0034284471 scopus 로고    scopus 로고
    • A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice
    • Feldman B, Hampton T, Cleary M. A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice. Blood. 2000;96:1906-1913.
    • (2000) Blood , vol.96 , pp. 1906-1913
    • Feldman, B.1    Hampton, T.2    Cleary, M.3
  • 48
    • 0034024722 scopus 로고    scopus 로고
    • Two distinct Notch1 mutant alleles are involved in the induction of T-cell leukemia in cmyc transgenic mice
    • Hoemann C, Beaulieu N, Girard L, Rebai N, Jolicoeur P. Two distinct Notch1 mutant alleles are involved in the induction of T-cell leukemia in cmyc transgenic mice. Mol Cell Biol. 2000;20:3831-3842.
    • (2000) Mol Cell Biol , vol.20 , pp. 3831-3842
    • Hoemann, C.1    Beaulieu, N.2    Girard, L.3    Rebai, N.4    Jolicoeur, P.5
  • 49
    • 0033819792 scopus 로고    scopus 로고
    • Identification of Notch1 as a frequent target for provirus insertional mutagenesis in T-cell lymphomas induced by leukemogenic mutants of mouse mammary tumor virus
    • Yanagawa S, Lee J, Kakimi K, Matsuda Y, Honjo T, Ishimoto A. Identification of Notch1 as a frequent target for provirus insertional mutagenesis in T-cell lymphomas induced by leukemogenic mutants of mouse mammary tumor virus. J Virol. 2000;47:9786-9791.
    • (2000) J Virol , vol.47 , pp. 9786-9791
    • Yanagawa, S.1    Lee, J.2    Kakimi, K.3    Matsuda, Y.4    Honjo, T.5    Ishimoto, A.6
  • 50
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4A
    • Serrano M, Lin A, McCurrach M, Beach D, Lowe S. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4A. Cell. 1997;88:593-602.
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.2    McCurrach, M.3    Beach, D.4    Lowe, S.5
  • 51
    • 0032190629 scopus 로고    scopus 로고
    • Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
    • Lin A, Barradas M, Stone J, van Aelst L, Serrano M, Lowe S. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev. 1998;12:3008-3019.
    • (1998) Genes Dev , vol.12 , pp. 3008-3019
    • Lin, A.1    Barradas, M.2    Stone, J.3    van Aelst, L.4    Serrano, M.5    Lowe, S.6
  • 52
    • 23244447037 scopus 로고    scopus 로고
    • BRAFE600-associated senescence-like cell cycle arrest of human naevi
    • Michaloglou C, Vredeveld L, Soengas M, et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature. 2005;436:720-724.
    • (2005) Nature , vol.436 , pp. 720-724
    • Michaloglou, C.1    Vredeveld, L.2    Soengas, M.3
  • 54
    • 0035963295 scopus 로고    scopus 로고
    • The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice
    • O'Neil J, Billa M, Oikemus S, Kelliher M. The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice. Oncogene. 2001;20:3897-3905.
    • (2001) Oncogene , vol.20 , pp. 3897-3905
    • O'Neil, J.1    Billa, M.2    Oikemus, S.3    Kelliher, M.4
  • 55
    • 2942579675 scopus 로고    scopus 로고
    • TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB
    • O'Neil J, Shank J, Cusson N, Murre C, Kelliher M. TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB. Cancer Cell. 2004;5:587-596.
    • (2004) Cancer Cell , vol.5 , pp. 587-596
    • O'Neil, J.1    Shank, J.2    Cusson, N.3    Murre, C.4    Kelliher, M.5
  • 56
    • 0035418581 scopus 로고    scopus 로고
    • scid thymocytes with TCRβ gene rearrangements are targets for the oncogenic effect of SCL and LMO1 transgenes
    • Chervinsky DS, Lam DH, Melman MP, Gross KW, Aplan PD. scid thymocytes with TCRβ gene rearrangements are targets for the oncogenic effect of SCL and LMO1 transgenes. Cancer Res. 2001;61:6382-6387.
    • (2001) Cancer Res , vol.61 , pp. 6382-6387
    • Chervinsky, D.S.1    Lam, D.H.2    Melman, M.P.3    Gross, K.W.4    Aplan, P.D.5
  • 57
    • 33645281796 scopus 로고    scopus 로고
    • Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling
    • Campese AF, Garbe AI, Zhang F, Grassi F, Screpanti I, von Boehmer H. Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling. Blood. 2006;108:305-310.
    • (2006) Blood , vol.108 , pp. 305-310
    • Campese, A.F.1    Garbe, A.I.2    Zhang, F.3    Grassi, F.4    Screpanti, I.5    von Boehmer, H.6
  • 58
    • 0027489782 scopus 로고
    • Restoration of early thymocyte differentiation in T-cell receptor β-chain-deficient mutant mice by transmembrane signaling through CD3
    • Levelt CN, Mombaerts P, Iglesias A, Tonegawa S, Eichmann K. Restoration of early thymocyte differentiation in T-cell receptor β-chain-deficient mutant mice by transmembrane signaling through CD3. Proc Natl Acad Sci U S A. 1993;90:11401-11405.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 11401-11405
    • Levelt, C.N.1    Mombaerts, P.2    Iglesias, A.3    Tonegawa, S.4    Eichmann, K.5
  • 59
    • 0028203979 scopus 로고
    • CD3 components at the surface of pro-T cells can mediate pre-T cell development in vivo
    • Jacobs H, Vandeputte D, Tolkamp L, de Vries E, Borst J, Berns A. CD3 components at the surface of pro-T cells can mediate pre-T cell development in vivo. Eur J Immunol. 1994;24:934-939.
    • (1994) Eur J Immunol , vol.24 , pp. 934-939
    • Jacobs, H.1    Vandeputte, D.2    Tolkamp, L.3    de Vries, E.4    Borst, J.5    Berns, A.6
  • 60
    • 0028174201 scopus 로고
    • CD3 epsilon-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2-/- mice in the absence of TCR beta chain expression
    • Shinkai Y, Alt F. CD3 epsilon-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2-/- mice in the absence of TCR beta chain expression. Int Immunol. 1994;6:996-1001.
    • (1994) Int Immunol , vol.6 , pp. 996-1001
    • Shinkai, Y.1    Alt, F.2
  • 61
    • 0030847208 scopus 로고    scopus 로고
    • Restoration of thymopoiesis in pTα-/- mice by anti-CD3ε antibody treatment or with transgenes encoding activated Lck or tailless pTα
    • Fehling H, Iritani B, Krotkova A, et al. Restoration of thymopoiesis in pTα-/- mice by anti-CD3ε antibody treatment or with transgenes encoding activated Lck or tailless pTα. Immunity. 1997;6:703-714.
    • (1997) Immunity , vol.6 , pp. 703-714
    • Fehling, H.1    Iritani, B.2    Krotkova, A.3
  • 62
    • 0028467163 scopus 로고
    • An activated lck transgene promotes thymocyte development in RAG-1 mutant mice
    • Mombaerts P, Anderson S, Perlmutter R, Mak T, Tonegawa S. An activated lck transgene promotes thymocyte development in RAG-1 mutant mice. Immunity. 1994;1:261-267.
    • (1994) Immunity , vol.1 , pp. 261-267
    • Mombaerts, P.1    Anderson, S.2    Perlmutter, R.3    Mak, T.4    Tonegawa, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.