Lymphoid precursors

Current Opinion in Immunology

Volumn 12, Issue 2, 2000, Pages 144-150

  Akashi, Koichi ^a   Reya, Tannishtha ^a   Dalma Weiszhausz, Dennise ^a   Weissman, Irving L ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR;

B LYMPHOCYTE; GENE EXPRESSION REGULATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOPOIESIS; NATURAL KILLER CELL; PROLYMPHOCYTE; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMALS; ANTIGENS, DIFFERENTIATION; B-CELL-SPECIFIC ACTIVATOR PROTEIN; CELL DIFFERENTIATION; CELL LINEAGE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS; INTERLEUKIN-7; LIVER; LYMPHOCYTE SUBSETS; MICE; NUCLEAR PROTEINS; RECEPTORS, INTERLEUKIN-7; SEVERE COMBINED IMMUNODEFICIENCY; TRANSCRIPTION FACTORS;

EID: 0034010517     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(99)00064-3     Document Type: Review

References (48)

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44. -/- cells are shown to be multipotent and, depending on the culture conditions and additional cytokines present, can differentiate into functional macrophages, granulocytes, dendritic cells, osteoclasts and NK cells but not erythrocytes or megakaryocytes. Additionally, in vivo studies showed that these cells could differentiate to mature T lymphocytes. RT-PCR studies showed that Pax5 represses lineage-alternative transcription programs of non-B lineage genes.
45. -/- mice in order to ascertain whether these cells could differentiate into lineages other than B cells. Donor cells gave rise to mature T lymphocytes expressing αβ T cell receptors but not myeloid cells. The expression of Pax5 is critical in B lineage differentiation which is not conferred by IgH DJ rearrangement or by the expression of E2A, EBF, λ5, VpreB, Igα or Igβ genes.
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47. +), suggesting that Notch1 blocked B cell proliferation or differentiation at or before the generation of pre-pro-B cells; and the emergence of a thymus-independent immature T cell subpopulation in the bone marrow. These results suggested that Notch1 activity regulates the B versus T cell outcome of a common lymphoid progenitor. Constitutive Notch1 gene expression had no effect on myeloid maturation.
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