A specific role of phosphatidylinositol 3-kinase γ: A regulation of autonomic Ca2+ oscillations in cardiac cells

Journal of Cell Biology

Volumn 152, Issue 4, 2001, Pages 717-727

  Bony, Claire ^a   Roche, Serge ^a   Shuichi, Ueno ^b   Sasaki, Takehiko ^c   Crackower, Michael A ^c   Penninger, Josef ^c   Mano, Hiroyuki ^b   Pucéat, Michel ^a  

^a Centre National de la Recherche Scientifique   (France)

^b JICHI MEDICAL UNIVERSITY   (Japan)

^c AMGEN INSTITUTE   (Canada)

Author keywords

Automaticity; Calcium; Heart; Phosphoinositide kinase; Tyrosine kinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ADENOSINE TRIPHOSPHATE; CALCIUM ION; ISOENZYME; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; WORTMANNIN;

ANIMAL CELL; ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; ENZYME ACTIVITY; HEART AUTOMATICITY; HEART MUSCLE CELL; NEWBORN; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOSINE TRIPHOSPHATE; ANIMALS; ANIMALS, NEWBORN; BIOLOGICAL TRANSPORT; CALCIUM SIGNALING; ENZYME ACTIVATION; HEART; ISOENZYMES; MODELS, BIOLOGICAL; MYOCARDIUM; PERIODICITY; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PROTEIN-TYROSINE KINASES; RATS; RECEPTORS, PURINERGIC P2;

ANIMALIA;

EID: 0035911144     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.152.4.717     Document Type: Article

References (52)

1. Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase
2. A specific function for phosphatidylinositol 3-kinase α (p85-p110α) in cell survival and for phosphatidylinositol 3-kinase β (p85-p110β) in de novo DNA synthesis of human colon carcinoma cells
3. Inositol trisphosphate and calcium signaling
4. Calcium signaling
5. Characterization of a soluble adrenal phosphatidylinositol 4-kinase reveals wortmannin sensitivity of type III phosphatidylinositol kinases
6. Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength
7. Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting
8. Phosphoinositide kinases
9. Specific requirement for the p85-p110α phosphatidylinositol 3-kinase during epidermal growth factor-stimulated actin nucleation in breast cancer cells
10. Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation
11. 2+ spiking
12. Functional characteristics of ES cell-derived cardiac precursor cells identified by tissuespecific expression of the green fluorescent protein. 1998
13. Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110β is synergistically activated by the βγ subunits of G proteins and phosphotyrosyl peptide
14. Gβγ stimulates phosphoinositide 3-kinase-γ by direct interaction with two domains of the catalytic p110 subunit
15. Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases
16. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase γ
17. Phosphoinositide 3-kinase gamma is a mediator of Gbetagamma-dependent Jun kinase activation
18. Src tyrosine kinase is a novel direct effector of G proteins
19. Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase
20. Roles of non-catalytic subunits in Gβγ-induced activation of class i phosphoinositide 3-kinase isoforms β and γ
21. Tec protein-tyrosine kinase is involved in interleukin-3 signaling pathway
22. A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration
23. A fluorescent reporter gene as a marker for ventricular specification in ES-derived cardiac cells
24. Gβγ-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy
25. Activation of phosphatidylinositol 3-kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes
26. 3 generation
27. Differential regulation of protein kinase C isoforms in isolated neonatal and adult rat cardiomyocytes
28. Identification of band 3-like proteins and Cl-/HCO3-exchange in isolated cardiomyocytes
29. Specific activation of adenylyl cyclase V by a purinergic agonist
30. Src family tyrosine kinase regulates intracellular pH in cardiomyocytes
31. Angiotensin II induces activation of phosphatidylinositol 3-kinase in cardiomyocytes
32. The role of phosphoinositide 3-kinase lipid products in cell function
33. Phosphoinositide 3-kinase regulates phospholipase Cγ-mediated calcium signaling
34. Activation of BTK by a phosphorylation mechanism initiated by Src family kinases
35. Regulation of phosphoinositide-specific phospholipase C isozymes
36. The phosphatidylinositol 3-kinase α is required for DNA synthesis induced by some, but not all, growth factors
37. A function for phosphatidylinositol 3-kinase γ (p85α-p110β) in fibroblasts during mitogenesis: Requirement for insulin- and lysophosphatidic acid-mediated signal transduction
38. Farnesylation of Ras is important for the interaction with phosphoinositide 3-kinase gamma
39. Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration
40. Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
41. PtdIns-3,4,5,-P3: A regulatory nexus between tyrosine kinases and sustained calcium signals
42. The conserved phosphoinositide 3-kinase pathway determines heart size in mice
43. Microinjection of antibodies and expression vectors into living myocardial cells. Development of a novel approach to identify candidate genes that regulate cardiac growth and hypertrophy
44. A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits
45. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
46. Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase gamma: Structure-activity analysis and interactions with wortmannin
47. Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages
48. Phosphatidylinositol 3-kinase-dependent membrane association of the Bruton's tyrosine kinase pleckstrin homology domain visualized in single living cells
49. 2+ oscillations drive spontaneous contractions in cardiomyocytes during early development
50. Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor
51. Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription
52. The role of Tec protein-tyrosine kinase in T cell signaling