Long-term oral n-acetylcysteine reduces exhaled hydrogen peroxide in stable COPD

Pulmonary Pharmacology and Therapeutics

Volumn 18, Issue 1, 2005, Pages 41-47

  De Benedetto, Fernando ^a   Aceto, Antonio ^b   Dragani, Beatrice ^b   Spacone, Antonella ^a   Formisano, Stefano ^c   Pela, Riccardo ^d   Donner, Claudio F ^e   Sanguinetti, Claudio M ^f  

^a SAN CAMILLO DE LELLIS HOSPITAL   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c San Francesco d'Assisi Institute   (Italy)

^d Mazzoni Hospital   (Italy)

^e SAN FILIPPO NERI HOSPITAL   (Italy)

^f IRCCS   (Italy)

Author keywords

Antioxidants; COPD; Exhaled air condensate; Hydrogen peroxide; Oral N acetylcysteine; Oxidants; Stable state

Indexed keywords

ACETYLCYSTEINE; HYDROGEN PEROXIDE; PLACEBO;

ADULT; AGED; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EXHALATION; FEMALE; FOLLOW UP; HUMAN; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL;

ACETYLCYSTEINE; ADMINISTRATION, ORAL; AGED; BREATH TESTS; DRUG ADMINISTRATION SCHEDULE; EXHALATION; FEMALE; HUMANS; HYDROGEN PEROXIDE; MALE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SPIROMETRY; TIME FACTORS;

EID: 10644250916     PISSN: 10945539     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pupt.2004.09.030     Document Type: Article

References (30)

1. J.E. Repine, A. Bast, and I. Lankhorst The oxidative stress study group. Oxidative stress in chronic obstructive pulmonary disease Am J Respir Crit Care Med 156 1997 341 357
2. C.F. Donner Antioxidants R. Stockley S. Rennard K. Rabe B. Celli COPD 2004 Blackwell Publishing Oxford (in press)
3. B. Halliwell Antioxidants in human health and disease Ann Rev Nutr 16 1996 33 50
4. E.J. Morcillo, J. Estera, and J. Cortijo Oxidative stress and pulmonary inflammation: pharmacological intervention with antioxidants Pharmacol Res 40 1999 393 404
5. I.N. Acworth, D.R. McCabe, and T.J. Mahler The analysis of free radicals, their reaction products, and antioxidants S.I. Baskin H. Salem Oxidants, antioxidants and free radicals 1997 Taylor and Francis Washington 23 77
6. A. Bast, G.R.M.M. Haenem, and C.J.A. Doelmann Oxidants and antioxidants: state of the art Am J Med 91 Suppl. 3c 1991 1S 13S
7. P.N.R. Dekhuijzen, K.K.H. Aben, and I. Dekker Increased exhalation of hydrogen peroxide in patients with stable and unstable chronic obstructive pulmonary disease Am J Respir Crit Care Med 154 1996 813 816
8. F. De Benedetto, A. Aceto, A. Spacone, S. Formisano, C.F. Donner, C.M.. Sanguinetti, R. Pela, and B. Dragani Validation of new technique to asses exhaled hydrogen peroxide: results from normal and COPD patients Mon Arch Chest Dis 3 2000 185 188
9. S. El-Chemaly, M. Salathe, and S. Baier Hydrogen peroxidase-scavenging properties of normal human airway secretions Am J Respir Crit Care 167 2003 425 430
10. J.E. Repine, and J.E. Heffner Lung antioxidants R.G. Crystal J.B. West P.J. Weibel P.J. Barnes The lung: scientific foundations 1997 Lippincott-Raven Publishers Philadelphia, PA 2259 2269
11. L. Allegra, M. del Sasso, and C. Bovio Human neutrophil oxidative bursts and their in vitro modulation by different N-acetylcysteine concentrations Arzneimittelforschung 52 2002 669 676
12. P. Moldèus, I.A. Cotgreave, and M. Berggren Lung protection by thiol containing antioxidant: N-actylcysteine Respiration 50 Suppl. 1 1986 31 42
13. W.B. Davis, and E.R. Patch Extracellular antioxidant defences R.G. Crystal J.B. West P.J. Weibel P.J. Barnes The lung: scientific foundations 1997 Lippincott-Raven Publishers Philadelphia, PA 2271 2278
14. E.M. Grandjean, P. Berthet, and R. Ruffmann Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: a meta-analysis of published double-blind placebo-controlled clinical trials Excerpta Med 22 2 2000 208 221
15. C. Stey, J. Steurer, S. Bachmann, T.C. Medici, and M.R. Tramèr The effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systemic review Eur Respir J 16 2000 253 262
16. American Thoracic Society Lung function testing: selection of reference values and interpretative strategies (statement) Am Rev Respir Dis 144 1991 1201 1218
17. W. Mac Nee, and I. Rahman Oxidants and antioxidants as therapeutic targets in chronic obstructive pulmonary disease Am J Respir Crit Care Med 160 1999 S58 S65
18. W.J.C. Van Beurden, G.A. Harff, and P.N.R. Dekuijzen Effects of inhaled corticosteroids with different lung deposition on exhaled hydrogen peroxide in stable COPD patients Respiration 70 2003 242 248
19. I.M. Ferreira, M.S. Hazari, and C. Gutierrez Exhaled nitric oxide and hydrogen peroxide in patients with chronic obstructive pulmonary disease Am J Respir Crit Care Med 164 2001 1012 1015
20. D. Novak, M. Kasielski, and A. Antczak Increased content of thiobarbituric and acid-reactive substances and hydrogen peroxide in the expired breath condensate of patients with stable chronic obstructive pulmonary disease: no significant effect of cigarette smoking Respir Med 93 1999 389 396
21. A.L. Sheffner The reduction in vitro in viscosity of mucoprotein solutions by a new mucolytic agent. N acetyl-L-cysteine Ann NY Acad Sci 106 1963 298 310
22. B. Grassier, A. Cabanis, and S. Lebegue Decrease of hypochlorous acid and hydroxyl radical generated by stimulated human neutrophils: comparison in vitro of some thiol-containing drugs Methods Find Exp Clin Pharmacol 16 1 1994 9 13
23. O. Aruoma, B. Halliwell, and M. Hoey The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide and hypochlorous acid Free Radic Biol Med 6 6 1989 593 597
24. R. Pela, A.M. Calcagni, and S.N-. Subiaco N-acetylcysteine reduces the exacerbation rate in patients with moderate to severe COPD Respiration 66 1999 495 500
25. C.M.J.M. Gerrits, R.M.C. Herings, and H.G.M. Leufkens N-acetylcysteine reduces the risk of re-hospitalisation among patients with chronic obstructive pulmonary disease Eur Respir J 21 2003 795 798
26. W.J. Van Beurden, G.A. Harff, and P.N.R. Dekhuijzen An efficient and reproducible method for measuring hydrogen peroxide in exhaled breath condensate Respir Med 96 3 2002 197 203
27. M.B. Schleiss, and O. Holz The concentration of hydrogen peroxide in exhaled air depends on expiratory flow rate Eur Resp J. 16 2000 115 118
28. H. Ekroos, J. Touminen, and A.R. Sovijarvi Exhaled nitric oxide and its long-term variation in healthy non-smoking subjects Clin Physiol 20 6 2000 434 439
29. W.J.C. Van Beurden, P.N.R. Dekhuijzen, and G.A. Harff Variability of exhaled hydrogen peroxide in stable COPD patients and matched healthy controls Respiration 69 2002 211 216
30. M. Kasielski, and D. Novak Long-term administration of N-acetylcysteine decreases hydrogen peroxide exhalation in subjects with chronic obstructive pulmonary disease Respir Med 95 2001 448 456