Synthetic serine elastase inhibitor reduces cigarette smoke-induced emphysema in guinea pigs

American Journal of Respiratory and Critical Care Medicine

Volumn 166, Issue 7, 2002, Pages 954-960

  Wright, Joanne L ^a,b   Farmer, Stephen G ^a,b   Churg, Andrew ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

1 antiprotease; Neutrophil elastase; Proteases; Proteolysis

Indexed keywords

ALPHA 1 ANTITRYPSIN; CHEMOKINE; CIGARETTE SMOKE; DESMOSINE; ELASTASE INHIBITOR; HYDROXYPROLINE; LEUKOCYTE ELASTASE INHIBITOR; MACROPHAGE CHEMOATTRACTANT PROTEIN 1; MACROPHAGE INFLAMMATORY PROTEIN 2; PROTEINASE; SERINE ELASTASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZD 0892;

ACUTE DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CIGARETTE SMOKING; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; GUINEA PIG; LONG TERM CARE; LONG TERM EXPOSURE; LUNG EMPHYSEMA; LUNG LAVAGE; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; DESMOSINE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GUINEA PIGS; HYDROXYPROLINE; MALE; MICE; MICE, INBRED C57BL; MONOCYTE CHEMOATTRACTANT PROTEINS; MONOKINES; NEUTROPHILS; PULMONARY EMPHYSEMA; SERPINS; TIME FACTORS; TOBACCO SMOKE POLLUTION; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036800045     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200202-098OC     Document Type: Article

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