Imidazolylpyrimidine based CXCR2 chemokine receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 10, 2006, Pages 2724-2728

  Ho, Koc Kan ^a   Auld, Douglas S ^a   Bohnstedt, Adolph C ^a   Conti, Paolo ^b   Dokter, Wim ^b   Erickson, Shawn ^a   Feng, Daming ^a   Inglese, Jim ^a   Kingsbury, Celia ^a   Kultgen, Steven G ^a   Liu, Rong Qiang ^a   Masterson, Christopher M ^a   Ohlmeyer, Michael ^a   Rong, Yajing ^a   Rooseboom, Martijn ^b   Roughton, Andrew ^a   Samama, Philippe ^a   Smit, Martin Jan ^b   Son, Ellen ^a   van der Louw, Jaap ^b   Vogel, Gerard ^b   Webb, Maria ^a   Wijkmans, Jac ^b   You, Ming ^a   more..

^a PHARMACOPEIA INC   (United States)

^b NV ORGANON   (Netherlands)

Author keywords

Chemokine; CXCR2; Microsomal stability; Oral bioavailability; Pyrimidine

Indexed keywords

CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CXCR2; PYRIMIDINE DERIVATIVE;

ANIMAL CELL; AREA UNDER THE CURVE; ARTICLE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG POTENCY; DRUG SCREENING; DRUG STABILITY; DRUG STRUCTURE; FEMALE; LIPOPHILICITY; NONHUMAN; RAT;

ADMINISTRATION, ORAL; ANIMALS; CHO CELLS; CRICETINAE; HUMANS; MICROBIAL SENSITIVITY TESTS; PYRIMIDINES; RECEPTORS, INTERLEUKIN-8B; RECOMBINANT PROTEINS;

ANIMALIA;

EID: 33645885315     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.02.028     Document Type: Article

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