메뉴 건너뛰기




Volumn 54, Issue 12, 2002, Pages 1603-1613

Aβ immunization and anti-Aβ antibodies: Potential therapies for the prevention and treatment of Alzheimer's disease

Author keywords

Alzheimer's disease; Amyloid; Immunization; Transgenic mice

Indexed keywords

ANTIBODIES; BIOCHEMISTRY; BRAIN; DRUG THERAPY; NEUROLOGY;

EID: 0037038814     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(02)00158-8     Document Type: Article
Times cited : (57)

References (50)
  • 1
    • 0031038918 scopus 로고    scopus 로고
    • Alzheimer's disease: Genotypes, phenotype, and treatments
    • Selkoe D.J. Alzheimer's disease: genotypes, phenotype, and treatments. Science. 275:1997;630-631.
    • (1997) Science , vol.275 , pp. 630-631
    • Selkoe, D.J.1
  • 2
    • 0034718027 scopus 로고    scopus 로고
    • Biochemical detection of Aβ isoforms: Implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease
    • Golde T.E., Eckman C.B., Younkin S.G. Biochemical detection of Aβ isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease. Biochim. Biophys. Acta. 1502:2000;172-187.
    • (2000) Biochim. Biophys. Acta , vol.1502 , pp. 172-187
    • Golde, T.E.1    Eckman, C.B.2    Younkin, S.G.3
  • 3
    • 0032491494 scopus 로고    scopus 로고
    • Genetic neurodegenerative diseases: The human illness and transgenic models
    • Price D.L., Sisodia S.S., Borchelt D.R. Genetic neurodegenerative diseases: the human illness and transgenic models. Science. 282:1998;1079-1083.
    • (1998) Science , vol.282 , pp. 1079-1083
    • Price, D.L.1    Sisodia, S.S.2    Borchelt, D.R.3
  • 12
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
    • DeMattos R.B., Bales K.R., Cummins D.J., Dodart J.-C., Paul S.M., Holtzman D.M. Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 98:2001;8850-8855.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 8850-8855
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Dodart, J.-C.4    Paul, S.M.5    Holtzman, D.M.6
  • 14
    • 0034107615 scopus 로고    scopus 로고
    • Neuroanatomical abnormalities in behaviorally characterized APP(V717F) transgenic mice
    • Dodart J.C., Mathis C., Saura J., Bales K.R., Paul S.M., Ungerer A. Neuroanatomical abnormalities in behaviorally characterized APP(V717F) transgenic mice. Neurobiol. Dis. 7:2000;71-85.
    • (2000) Neurobiol. Dis. , vol.7 , pp. 71-85
    • Dodart, J.C.1    Mathis, C.2    Saura, J.3    Bales, K.R.4    Paul, S.M.5    Ungerer, A.6
  • 16
    • 0030612033 scopus 로고    scopus 로고
    • APPsw transgenic mice develop age-related Aβ deposits and neuropil abnormalities, but no neuronal loss in CA1
    • Irizarry M.C., McNamara M., Fedorchak K., Hsiao K., Hyman B.T. APPsw transgenic mice develop age-related Aβ deposits and neuropil abnormalities, but no neuronal loss in CA1. J. Neuropath. Exp. Neurol. 56:1997;965-973.
    • (1997) J. Neuropath. Exp. Neurol. , vol.56 , pp. 965-973
    • Irizarry, M.C.1    McNamara, M.2    Fedorchak, K.3    Hsiao, K.4    Hyman, B.T.5
  • 17
    • 0030611097 scopus 로고    scopus 로고
    • Aβ deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse
    • Irizarry M.C., Soriano F., McNamara M., Page K.J., Schenk D., Games D., Hyman B.T. Aβ deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse. J. Neurosci. 17:1997;7053-7059.
    • (1997) J. Neurosci. , vol.17 , pp. 7053-7059
    • Irizarry, M.C.1    Soriano, F.2    McNamara, M.3    Page, K.J.4    Schenk, D.5    Games, D.6    Hyman, B.T.7
  • 18
    • 0029813177 scopus 로고    scopus 로고
    • Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F β-amyloid precursor protein and Alzheimer's disease
    • Masliah E., Sisk A., Mallory M., Mucke L., Schenk D., Games D. Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F β-amyloid precursor protein and Alzheimer's disease. J. Neurosci. 16:1996;5795-5811.
    • (1996) J. Neurosci. , vol.16 , pp. 5795-5811
    • Masliah, E.1    Sisk, A.2    Mallory, M.3    Mucke, L.4    Schenk, D.5    Games, D.6
  • 21
    • 0011469238 scopus 로고    scopus 로고
    • Age-dependent deficits in spatial memory and hippocampal LTP in vivo in APP transgenic mice
    • Jones M.W., Bliss T.V.P., Hsiao K.K., Chapman P.F. Age-dependent deficits in spatial memory and hippocampal LTP in vivo in APP transgenic mice. Soc. Neurosci. Abstr. 24:1998;729.
    • (1998) Soc. Neurosci. Abstr. , vol.24 , pp. 729
    • Jones, M.W.1    Bliss, T.V.P.2    Hsiao, K.K.3    Chapman, P.F.4
  • 22
    • 2242470701 scopus 로고    scopus 로고
    • Overexpression of mutant β-amyloid precursor protein severely attenuates hippocampal synaptic transmission in an Alzheimer's disease mouse model
    • Hsia A.Y., Mucke L., Malenka R.C., Nicoll R.A. Overexpression of mutant β-amyloid precursor protein severely attenuates hippocampal synaptic transmission in an Alzheimer's disease mouse model. Soc. Neurosci. Abstr. 24:1998;729.
    • (1998) Soc. Neurosci. Abstr. , vol.24 , pp. 729
    • Hsia, A.Y.1    Mucke, L.2    Malenka, R.C.3    Nicoll, R.A.4
  • 24
    • 0035863055 scopus 로고    scopus 로고
    • Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease
    • Kawarabayashi T., Younkin L.H., Saido T.C., Shoji M., Ashe K.H., Younkin S.G. Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J. Neurosci. 21:2001;372-381.
    • (2001) J. Neurosci. , vol.21 , pp. 372-381
    • Kawarabayashi, T.1    Younkin, L.H.2    Saido, T.C.3    Shoji, M.4    Ashe, K.H.5    Younkin, S.G.6
  • 29
    • 0344431341 scopus 로고    scopus 로고
    • Structural neurology: Are seeds at the root of neuronal degeneration
    • Lansbury P.T.J. Structural neurology: are seeds at the root of neuronal degeneration. Neuron. 19:1997;1151-1154.
    • (1997) Neuron , vol.19 , pp. 1151-1154
    • Lansbury, P.T.J.1
  • 30
    • 0033616587 scopus 로고    scopus 로고
    • In situ AFM study of Alzheimer's β-amyloid peptide on different substrates: New insights into mechanism of β sheet formation
    • Kowalewski T., Holtzman D.M. In situ AFM study of Alzheimer's β-amyloid peptide on different substrates: new insights into mechanism of β sheet formation. Proc. Natl. Acad. Sci USA. 96:1999;3688-3693.
    • (1999) Proc. Natl. Acad. Sci USA , vol.96 , pp. 3688-3693
    • Kowalewski, T.1    Holtzman, D.M.2
  • 35
    • 0034884382 scopus 로고    scopus 로고
    • Immunization with a nontoxic/nonfibrillar amyloid-β homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice
    • Sigurdsson E.M., Scholtzova H., Mehta P., Frangione B., Wisniewski T. Immunization with a nontoxic/nonfibrillar amyloid-β homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice. Am. J. Pathol. 159:2001;439-447.
    • (2001) Am. J. Pathol. , vol.159 , pp. 439-447
    • Sigurdsson, E.M.1    Scholtzova, H.2    Mehta, P.3    Frangione, B.4    Wisniewski, T.5
  • 38
    • 0035106780 scopus 로고    scopus 로고
    • Imaging of amyloid-β deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy
    • Backsai B.J., Kajdasz S.T., Christie R.H., Carter C., Games D., Seubert P., Schenk D., Hyman B.T. Imaging of amyloid-β deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nature Med. 7:2001;369-372.
    • (2001) Nature Med. , vol.7 , pp. 369-372
    • Backsai, B.J.1    Kajdasz, S.T.2    Christie, R.H.3    Carter, C.4    Games, D.5    Seubert, P.6    Schenk, D.7    Hyman, B.T.8
  • 41
    • 0032995727 scopus 로고    scopus 로고
    • Receptor-mediated transport of human amyloidβ protein 1-40 and 1-42 at the blood-brain barrier
    • Poduslo J.F., Curran G.L., Sanyal B., Selkoe D.J. Receptor-mediated transport of human amyloidβ protein 1-40 and 1-42 at the blood-brain barrier. Neurobiol. Dis. 6:1999;190-199.
    • (1999) Neurobiol. Dis. , vol.6 , pp. 190-199
    • Poduslo, J.F.1    Curran, G.L.2    Sanyal, B.3    Selkoe, D.J.4
  • 42
    • 0035968932 scopus 로고    scopus 로고
    • Amyloid β peptide as a vaccine for Alzheimer's disease involves receptor-mediated transport at the blood-brain barrier
    • Poduslo J.F., Curran G.L. Amyloid β peptide as a vaccine for Alzheimer's disease involves receptor-mediated transport at the blood-brain barrier. NeuroReport. 12:2001;3197-3200.
    • (2001) NeuroReport , vol.12 , pp. 3197-3200
    • Poduslo, J.F.1    Curran, G.L.2
  • 43
    • 0030035294 scopus 로고    scopus 로고
    • Fate of cerebrospinal fluid-borne amyloid β-peptide: Rapid clearance into blood and appreciable accumulation by cerebral arteries
    • Ghersi-Egea J.F., Gorevic P.D., Ghiso J., Frangione B., Patlak C.S., Fensternacher J.D. Fate of cerebrospinal fluid-borne amyloid β-peptide: rapid clearance into blood and appreciable accumulation by cerebral arteries. J. Neurochem. 67:1996;880-883.
    • (1996) J. Neurochem. , vol.67 , pp. 880-883
    • Ghersi-Egea, J.F.1    Gorevic, P.D.2    Ghiso, J.3    Frangione, B.4    Patlak, C.S.5    Fensternacher, J.D.6
  • 45
    • 0035082722 scopus 로고    scopus 로고
    • Amyloid β40/42 clearance across the blood-brain barrier following intraventricular injections in wild-type, apoE knockout and human apoE3 or E4 expressing transgenic mice
    • Ji Y., Permanne B., Sigurdsson E.M., Holtzman D.M., Wisniewski T. Amyloid β40/42 clearance across the blood-brain barrier following intraventricular injections in wild-type, apoE knockout and human apoE3 or E4 expressing transgenic mice. J. Alzheimer's Dis. 3:2001;23-30.
    • (2001) J. Alzheimer's Dis. , vol.3 , pp. 23-30
    • Ji, Y.1    Permanne, B.2    Sigurdsson, E.M.3    Holtzman, D.M.4    Wisniewski, T.5
  • 47
    • 0035979145 scopus 로고    scopus 로고
    • Aβ immunization: Moving Aβ peptide from brain to blood
    • Lee V.M.-Y. Aβ immunization: moving Aβ peptide from brain to blood. Proc. Natl. Acad. Sci. USA. 98:2001;8931-8932.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 8931-8932
    • Lee, V.M.-Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.