p53-dependent Aph-1 and Pen-2 anti-apoptotic phenotype requires the integrity of the γ-secretase complex but is independent of its activity

Journal of Biological Chemistry

Volumn 282, Issue 14, 2007, Pages 10516-10525

  Dunys, Julie ^a   Kawarai, Toshitaka ^b   Sevalle, Jean ^a   Dolcini, Virginia ^a   St George Hyslop, Peter ^b   Da Costa, Cristine Alves ^a   Checler, Frédéric ^a  

^a INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC PHENOTYPES; DNA FRAGMENTATION; GENE INACTIVATION; SECRETASE COMPLEXES;

CELL DEATH; DNA; ESTERS; FIBROBLASTS; GENE EXPRESSION; MOLECULAR WEIGHT;

ENZYME ACTIVITY;

AMYLOID PRECURSOR PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1A PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1B PROTEIN; CASPASE 3; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; DNA FRAGMENT; ETOPOSIDE; GAMMA SECRETASE; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PRESENILIN ENHANCER 2; PROTEIN P53; STAUROSPORINE; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; APH 1 PROTEIN, HUMAN; APH-1 PROTEIN, HUMAN; ENZYME INHIBITOR; MEMBRANE PROTEIN; MULTIPROTEIN COMPLEX; NICASTRIN PROTEIN; PRESENILIN; PSENEN PROTEIN, HUMAN; SECRETASE;

APOPTOSIS; ARTICLE; CELL DEATH; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; EMBRYO; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME MECHANISM; HUMAN; HUMAN CELL; MAMMAL CELL; MOLECULAR BIOLOGY; NICK END LABELING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; RNA TRANSCRIPTION; BIOSYNTHESIS; CELL LINE; METABOLISM;

MAMMALIA;

AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; APOPTOSIS; CASPASE 3; CELL LINE; ENZYME INHIBITORS; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MULTIPROTEIN COMPLEXES; PHENOTYPE; POLY(ADP-RIBOSE) POLYMERASES; PRESENILINS; STAUROSPORINE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 34249854658     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M611572200     Document Type: Article

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