Expression of apoptosis related proteins in brains of patients with Alzheimer's disease

Neuroscience Letters

Volumn 303, Issue 2, 2001, Pages 79-82

  Engidawork, Ephrem ^a   Gulesserian, Talin ^a   Seidl, Rainer ^a   Cairns, Nigel ^b   Lubec, Gert ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Alzheimer's disease; Apoptosis; Apoptosis related proteins; Cerebellum; Enzyme linked immunsorbent assay technique; Frontal cortex; Western blot

Indexed keywords

CAENORHABDITIS ELEGANS DEATH PROTEASE; CASPASE 2; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE; PROTEINASE; RECEPTOR INTERACTING PROTEIN ASSOCIATED ICH 1; UNCLASSIFIED DRUG; ZIPPER INTERACTING PROTEIN KINASE;

ADULT; AGED; ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CAENORHABDITIS ELEGANS; CELL DENSITY; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; MALE; NERVE CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION;

AGED; ALZHEIMER DISEASE; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CARRIER PROTEINS; CEREBELLUM; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; FEMALE; FRONTAL LOBE; HUMANS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NEURONS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 0035805391     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(01)01618-4     Document Type: Article

References (26)

1. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FASL/tumor necrosis factor receptor interacting protein, RIP
2. Kinase cascades regulating entry into apoptosis
3. Apoptosis inhibitory activity of cytoplasmic p21 (Cip1/WaF1) in monocyte differentiation
4. Separate domains of p21 involved in the inhibition of CDK kinase and PCNA
5. Correlates of p53 and Fas (CD95) mediated apoptosis in Alzheimer's disease
6. RAIDD is a new death adaptor molecule
7. WAF1/CIP1 is induced in p53 mediated G1 arrest and apoptosis
8. Alteration of caspases and apoptosis related proteins in brains of patients with Alzheimer's disease
9. Increased protein levels of serotonin transporter in frontal cortex of patients with Down syndrome
10. BOD (Bcl-2 related ovarian death gene) is an ovarian BH3 domain containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members
11. ZIP kinase, a novel serine/threonine kinase which mediates apoptosis
12. Alteration of proteins regulating apoptosis Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32 in Alzheimer's disease
13. Regulators of cell death
14. The cerebellum in Alzheimer's disease
15. Par-4: An emerging pivotal player in neuronal apoptosis and neurodegenerative disorders
16. Apoptosis related protein expression in the hippocampus in Alzheimer's disease
17. Bim: A novel member of the Bcl-2 family that promotes apoptosis
18. Interaction partners of Dlk/ZIP kinase: Co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis
19. Genetic determinants of p53 induced apoptosis and growth arrest
20. Mutant genes in familial Alzheimer's disease and transgenic models
21. Apoptosis associated protein p53 and APO-1/Fas (CD95) in brains of adult patients with Down syndrome
22. A nonenzymatic p21 protein inhibitor of stress activated protein kinases
23. Induction of p21 (Waf-1/CIP1) during differentiation
24. Requirement for ceramide initiated SAPK/JNK signaling in stress induced apoptosis
25. Fas ligand induced c-Jun kinase activation in lymphoid cells requires extensive receptor aggregation but is independent of DAXX, and Fas mediated cell death does not involve DAXX, RIP or RAIDD
26. Targeted in vivo expression of the cyclin dependent kinase inhibitor p21 halts hepatocytes cell cycle progression, postnatal liver development and regeneration