-
1
-
-
0022616654
-
Alzheimer's disease
-
Katzman R. Alzheimer's disease. New Engl J Med 1986; 314: 964-973.
-
(1986)
New Engl J Med
, vol.314
, pp. 964-973
-
-
Katzman, R.1
-
2
-
-
0031921466
-
Mutant genes in familial Alzheimer's disease and transgenic models
-
Price DL, Sisodia SS. Mutant genes in familial Alzheimer's disease and transgenic models. Annu Rev Neurosci 1998; 21: 479-505.
-
(1998)
Annu Rev Neurosci
, vol.21
, pp. 479-505
-
-
Price, D.L.1
Sisodia, S.S.2
-
3
-
-
0024364877
-
Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease
-
Masliah E, Terry RD, DeTeresa RM, Hansen LA. Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease. Neurosci Lett 1989; 103: 234-239.
-
(1989)
Neurosci Lett
, vol.103
, pp. 234-239
-
-
Masliah, E.1
Terry, R.D.2
DeTeresa, R.M.3
Hansen, L.A.4
-
4
-
-
0026032039
-
Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease
-
Masliah E, Terry RD, Alford M, DeTeresa R, Hansen LA. Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease. Am J Pathol 1991; 138: 235-246.
-
(1991)
Am J Pathol
, vol.138
, pp. 235-246
-
-
Masliah, E.1
Terry, R.D.2
Alford, M.3
DeTeresa, R.4
Hansen, L.A.5
-
5
-
-
0025987048
-
Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairement
-
Terry RD, Masliah E, Salmon DP, et al. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairement. Ann Neurol 1991; 30: 572-580.
-
(1991)
Ann Neurol
, vol.30
, pp. 572-580
-
-
Terry, R.D.1
Masliah, E.2
Salmon, D.P.3
-
6
-
-
0032575687
-
Is apoptosi key in Alzheimer's disease?
-
Barinaga M. Is apoptosi key in Alzheimer's disease? Science 1998; 281: 1303-1304.
-
(1998)
Science
, vol.281
, pp. 1303-1304
-
-
Barinaga, M.1
-
7
-
-
0028577208
-
Immunohistochemical evidence for apoptosis in Alzheimer's disease
-
Su JH, Anderson AJ, Cummings BJ, Cotman CW. Immunohistochemical evidence for apoptosis in Alzheimer's disease. NeuroReport 1994; 5: 2529-2533.
-
(1994)
NeuroReport
, vol.5
, pp. 2529-2533
-
-
Su, J.H.1
Anderson, A.J.2
Cummings, B.J.3
Cotman, C.W.4
-
8
-
-
0028833215
-
Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ
-
Lassmann H, Bancher C, Breitschopf H, et al. Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ. Acta Neuropathol 1995; 89: 35-41.
-
(1995)
Acta Neuropathol
, vol.89
, pp. 35-41
-
-
Lassmann, H.1
Bancher, C.2
Breitschopf, H.3
-
9
-
-
0029120647
-
Evidence for apoptotic cell death in Alzheimer's disease
-
Smale G, Nichols NR, Brady DR, Finch CE, Horton Jr WE. Evidence for apoptotic cell death in Alzheimer's disease. Exp Neurol 1995; 133: 225-230.
-
(1995)
Exp Neurol
, vol.133
, pp. 225-230
-
-
Smale, G.1
Nichols, N.R.2
Brady, D.R.3
Finch, C.E.4
Horton W.E., Jr.5
-
10
-
-
0029976253
-
DNA damage and apoptosis in Alzheimer's disease: Colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay
-
Anderson AJ, Su JH, Cotman CW DNA damage and apoptosis in Alzheimer's disease: Colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay. J Neurosci 1996; 16: 1710-1719.
-
(1996)
J Neurosci
, vol.16
, pp. 1710-1719
-
-
Anderson, A.J.1
Su, J.H.2
Cotman, C.W.3
-
11
-
-
0029852587
-
In situ labeling of dying cortical neurons in normal aging and in Alzheimer's disease: Correlations with senile plaques and disease progression
-
Troncoso JC, Sukhov RR, Kawas CH, Koliatsos VE. In situ labeling of dying cortical neurons in normal aging and in Alzheimer's disease: correlations with senile plaques and disease progression. J Neuropathol Exp Med 1996; 55: 1134-1142.
-
(1996)
J Neuropathol Exp Med
, vol.55
, pp. 1134-1142
-
-
Troncoso, J.C.1
Sukhov, R.R.2
Kawas, C.H.3
Koliatsos, V.E.4
-
12
-
-
0029549426
-
A cautionary note on the use of the TUNEL stain to determine apoptosis
-
Charnaut-Marlangue C, Ben-Ari Y. A cautionary note on the use of the TUNEL stain to determine apoptosis. NeuroReport 1995; 7: 61-64.
-
(1995)
NeuroReport
, vol.7
, pp. 61-64
-
-
Charnaut-Marlangue, C.1
Ben-Ari, Y.2
-
13
-
-
0029294613
-
In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A caution note
-
Grasl-Kraupp B, Ruttkay-Nedecky B, Koudelka H, Bukowska K, Bursch W, Schulte-Hermann R. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a caution note. Hepatol 1995; 21: 1465-1468.
-
(1995)
Hepatol
, vol.21
, pp. 1465-1468
-
-
Grasl-Kraupp, B.1
Ruttkay-Nedecky, B.2
Koudelka, H.3
Bukowska, K.4
Bursch, W.5
Schulte-Hermann, R.6
-
14
-
-
0031884393
-
Apoptosis in neurological disease
-
Savits SI, Rosenbaum DM. Apoptosis in neurological disease. Neurosurgery 1998; 42: 555-574.
-
(1998)
Neurosurgery
, vol.42
, pp. 555-574
-
-
Savits, S.I.1
Rosenbaum, D.M.2
-
15
-
-
0031880094
-
A suicide note from Alzheimer disease neurons
-
Perry G, Nunomura A, Smith MA. A suicide note from Alzheimer disease neurons. Nat Med 1998; 4: 897-898.
-
(1998)
Nat Med
, vol.4
, pp. 897-898
-
-
Perry, G.1
Nunomura, A.2
Smith, M.A.3
-
16
-
-
0032514882
-
Apoptosis and Alzheimer's disease
-
Perry G, Nunomura A. Apoptosis and Alzheimer's disease. Science 1998; 282: 1268.
-
(1998)
Science
, vol.282
, pp. 1268
-
-
Perry, G.1
Nunomura, A.2
-
17
-
-
0026448963
-
The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death
-
Yuan J, Horvits HR. The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death. Development 1992; 116: 309-320.
-
(1992)
Development
, vol.116
, pp. 309-320
-
-
Yuan, J.1
Horvits, H.R.2
-
18
-
-
0027525104
-
The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme
-
Yuan J, Shaham S, Ledoux S, Ellis HM, Horvits HR. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell 1993; 75: 641-652.
-
(1993)
Cell
, vol.75
, pp. 641-652
-
-
Yuan, J.1
Shaham, S.2
Ledoux, S.3
Ellis, H.M.4
Horvits, H.R.5
-
19
-
-
0028288277
-
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian protooncogene bcl-2
-
Hengartner MO, Horvits HR. C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian protooncogene bcl-2. Cell 1994; 76: 665-676.
-
(1994)
Cell
, vol.76
, pp. 665-676
-
-
Hengartner, M.O.1
Horvits, H.R.2
-
20
-
-
0026517239
-
Molecular cloning of the interleukin-1-β converting enzyme
-
Cerretti DP, Kozlosky CJ, Mosley B, et al. Molecular cloning of the interleukin-1-β converting enzyme. Science 1992; 256: 97-100.
-
(1992)
Science
, vol.256
, pp. 97-100
-
-
Cerretti, D.P.1
Kozlosky, C.J.2
Mosley, B.3
-
21
-
-
0030745646
-
Apaf-1, a human protein homologous to C. elegans CED-4 participates in cytochrome c-dependent activation of caspase-3
-
Zou H, Henzel WJ, Liu X, Lutschg A, Wang X. Apaf-1, a human protein homologous to C. elegans CED-4 participates in cytochrome c-dependent activation of caspase-3. Cell 1997; 90: 405-413.
-
(1997)
Cell
, vol.90
, pp. 405-413
-
-
Zou, H.1
Henzel, W.J.2
Liu, X.3
Lutschg, A.4
Wang, X.5
-
23
-
-
0030046508
-
Life, death, and the pursuit of apoptosis
-
White E. Life, death, and the pursuit of apoptosis. Genes & Dev 1996; 10: 1-15.
-
(1996)
Genes & Dev
, vol.10
, pp. 1-15
-
-
White, E.1
-
25
-
-
0029318670
-
A sticky business
-
Hacker G, Vaux DL. A sticky business. Curr Biol 1995; 5: 622-624.
-
(1995)
Curr Biol
, vol.5
, pp. 622-624
-
-
Hacker, G.1
Vaux, D.L.2
-
26
-
-
0031037897
-
The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
-
Kluck RM, Bossi-Wetzel E, Green DR, Newmeyer DD. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 1997; 275: 1132-1136.
-
(1997)
Science
, vol.275
, pp. 1132-1136
-
-
Kluck, R.M.1
Bossi-Wetzel, E.2
Green, D.R.3
Newmeyer, D.D.4
-
27
-
-
0031036872
-
Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
-
Yang J, Liu X, Bhalla K, et al. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 1997; 275: 1129-1132.
-
(1997)
Science
, vol.275
, pp. 1129-1132
-
-
Yang, J.1
Liu, X.2
Bhalla, K.3
-
28
-
-
0032509773
-
Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease
-
Kitamura Y, Shimohama S, Kamoshima W, et al. Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease. Brain Res 1998; 780: 260-269.
-
(1998)
Brain Res
, vol.780
, pp. 260-269
-
-
Kitamura, Y.1
Shimohama, S.2
Kamoshima, W.3
-
29
-
-
0030638139
-
Bax protein expression is increased in Alzheimer's brain: Correlations with DNA damage, Bcl-2 expression and brain pathology
-
Su JH, Deng G, Cotman CW Bax protein expression is increased in Alzheimer's brain: correlations with DNA damage, Bcl-2 expression and brain pathology. J Neuropathol Exp Neurol 1997; 56: 86-93.
-
(1997)
J Neuropathol Exp Neurol
, vol.56
, pp. 86-93
-
-
Su, J.H.1
Deng, G.2
Cotman, C.W.3
-
30
-
-
0033358871
-
Caspases land on APP: One small step for apoptosis, one giant leap for amyloidosis
-
Tanzi RE. Caspases land on APP: One small step for apoptosis, one giant leap for amyloidosis. Nat Neurosci 1999; 2: 585-586.
-
(1999)
Nat Neurosci
, vol.2
, pp. 585-586
-
-
Tanzi, R.E.1
-
31
-
-
0030868903
-
Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family proteases
-
Kim TW, Pettingel WH, Jung YK, Kovacs DM, Tanzi RE. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family proteases. Science 1997; 277: 373-376.
-
(1997)
Science
, vol.277
, pp. 373-376
-
-
Kim, T.W.1
Pettingel, W.H.2
Jung, Y.K.3
Kovacs, D.M.4
Tanzi, R.E.5
-
32
-
-
0032146775
-
Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motorneurons
-
Barnes NY, Li L, Yoshikawa K, Schwartz LM, Oppenheim RW, Milligan CE. Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motorneurons. J Neurosci 1998; 18: 5869-5880.
-
(1998)
J Neurosci
, vol.18
, pp. 5869-5880
-
-
Barnes, N.Y.1
Li, L.2
Yoshikawa, K.3
Schwartz, L.M.4
Oppenheim, R.W.5
Milligan, C.E.6
-
33
-
-
0031615875
-
Autoproteolytic activation of pro-caspases by oligomerization
-
Yang X, Chang HY, Baltimore D. Autoproteolytic activation of pro-caspases by oligomerization. Mol Cell 1998; 1: 319-325.
-
(1998)
Mol Cell
, vol.1
, pp. 319-325
-
-
Yang, X.1
Chang, H.Y.2
Baltimore, D.3
-
34
-
-
0031760611
-
Caspase dependent DNA fragmentation might be associated with excitotoxicity in Alzheimer disease
-
Masliah E, Mallory M, Alford M, Tanaka S, Hansen LA. Caspase dependent DNA fragmentation might be associated with excitotoxicity in Alzheimer disease. J Neuropatho Exp Neurol 1998; 57: 1041-1052.
-
(1998)
J Neuropatho Exp Neurol
, vol.57
, pp. 1041-1052
-
-
Masliah, E.1
Mallory, M.2
Alford, M.3
Tanaka, S.4
Hansen, L.A.5
-
35
-
-
0030960657
-
Immunohistochemical analysis of in vivo patterns of expression of CPP32 (caspase 3), a cell death protease
-
Krajewski M, Wang H-G, Krajewski S, et al. Immunohistochemical analysis of in vivo patterns of expression of CPP32 (caspase 3), a cell death protease. Cancer Res 1997; 57: 1605-1613.
-
(1997)
Cancer Res
, vol.57
, pp. 1605-1613
-
-
Krajewski, M.1
Wang, H.-G.2
Krajewski, S.3
-
36
-
-
0033574268
-
Changes in caspase expression in Alzheimer's disease: Comparison with development and aging
-
Shimohama S, Tanino H, Fujimoto S. Changes in caspase expression in Alzheimer's disease: Comparison with development and aging. Biochem Biophys Res Commun 1999; 256: 381-384.
-
(1999)
Biochem Biophys Res Commun
, vol.256
, pp. 381-384
-
-
Shimohama, S.1
Tanino, H.2
Fujimoto, S.3
-
37
-
-
0029910952
-
Programmed cell death in the developing nervous system
-
Burek MJ, Oppenheim RW Programmed cell death in the developing nervous system. Brain Pathol 1996; 6: 427-446.
-
(1996)
Brain Pathol
, vol.6
, pp. 427-446
-
-
Burek, M.J.1
Oppenheim, R.W.2
-
38
-
-
0032501043
-
Differential expression of rat brain Bcl-2 family proteins in development and aging
-
Shimohama S, Fujimoto S, Sumida Y, Tanino H. Differential expression of rat brain Bcl-2 family proteins in development and aging. Biochem Biophys Res Commun 1998; 252: 92-96.
-
(1998)
Biochem Biophys Res Commun
, vol.252
, pp. 92-96
-
-
Shimohama, S.1
Fujimoto, S.2
Sumida, Y.3
Tanino, H.4
-
39
-
-
0029972806
-
p53: Puzzle and paradigm
-
Ko LJ, Prives C. p53: puzzle and paradigm. Genes Dev 1996; 10: 1054-1072.
-
(1996)
Genes Dev
, vol.10
, pp. 1054-1072
-
-
Ko, L.J.1
Prives, C.2
-
40
-
-
17144442666
-
Changes of p53 in the brains of patients with Alzheimer's disease
-
Kitamura Y, Shimohama S, Kamoshima W, Matsuoka Y, Nomura Y, Taniguchi T. Changes of p53 in the brains of patients with Alzheimer's disease. Biochem Biophys Res Commun 1997; 232: 418-421.
-
(1997)
Biochem Biophys Res Commun
, vol.232
, pp. 418-421
-
-
Kitamura, Y.1
Shimohama, S.2
Kamoshima, W.3
Matsuoka, Y.4
Nomura, Y.5
Taniguchi, T.6
-
41
-
-
0030921323
-
Abnormal expression of the cell cycle regulators p16 and CDK4 in Alzheimer's disease
-
McShea A, Harris PLR, Webster KR, Wahl AF, Smith MA. Abnormal expression of the cell cycle regulators p16 and CDK4 in Alzheimer's disease. Am J Pathol 1997; 150: 1933-1939.
-
(1997)
Am J Pathol
, vol.150
, pp. 1933-1939
-
-
McShea, A.1
Harris, P.L.R.2
Webster, K.R.3
Wahl, A.F.4
Smith, M.A.5
-
42
-
-
0031172065
-
NF-κB: A crucial transcription factor for glial and neuronal cell function
-
O'Neill LAJ, Kaltschmidt C. NF-κB: a crucial transcription factor for glial and neuronal cell function. Trends Neurosci 1997; 20: 252-258.
-
(1997)
Trends Neurosci
, vol.20
, pp. 252-258
-
-
O'Neill, L.A.J.1
Kaltschmidt, C.2
-
43
-
-
0031149046
-
The c-Jun transcription factor-bipotential mediator of neuronal death, survival and regeneration
-
Herdegen T, Skene P, Bahr M. The c-Jun transcription factor-bipotential mediator of neuronal death, survival and regeneration. Trends Neurosci 1997; 20: 227-231.
-
(1997)
Trends Neurosci
, vol.20
, pp. 227-231
-
-
Herdegen, T.1
Skene, P.2
Bahr, M.3
-
44
-
-
0030780804
-
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
-
Yang DD, Kuan C-Y, Whitmarsh AJ, et al. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 1997; 389: 865-870.
-
(1997)
Nature
, vol.389
, pp. 865-870
-
-
Yang, D.D.1
Kuan, C.-Y.2
Whitmarsh, A.J.3
-
45
-
-
0030671370
-
Alteration of transcription factors NF-κB and STAT1 in Alzheimer's disease brains
-
Kitamura Y, Shimohama S, Ota T, Matsuoka Y, Nomura Y, Taniguchi T. alteration of transcription factors NF-κB and STAT1 in Alzheimer's disease brains. Neurosci Lett 1997; 237: 17-20.
-
(1997)
Neurosci Lett
, vol.237
, pp. 17-20
-
-
Kitamura, Y.1
Shimohama, S.2
Ota, T.3
Matsuoka, Y.4
Nomura, Y.5
Taniguchi, T.6
-
46
-
-
0029610011
-
The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases
-
McGeer PL, McGeer EG. The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res Rev 1995; 21: 195-218.
-
(1995)
Brain Res Rev
, vol.21
, pp. 195-218
-
-
McGeer, P.L.1
McGeer, E.G.2
-
47
-
-
0346386580
-
Widespread peroxynitrite-mediated damage in Alzheimer's disease
-
Smith MA, Harris PLR, Sayre LM, Beckman JS, Perry G. Widespread peroxynitrite-mediated damage in Alzheimer's disease. J Neurosci 1997; 17: 2653-2657.
-
(1997)
J Neurosci
, vol.17
, pp. 2653-2657
-
-
Smith, M.A.1
Harris, P.L.R.2
Sayre, L.M.3
Beckman, J.S.4
Perry, G.5
-
48
-
-
0032967259
-
Apoptotic cell death in neurons and glial cells: Implications for Alzheimer's disease
-
Kitamura Y, Taniguchi T, Shimohama S. Apoptotic cell death in neurons and glial cells: Implications for Alzheimer's disease. Jpn J Pharmacol 1999; 79: 1-5.
-
(1999)
Jpn J Pharmacol
, vol.79
, pp. 1-5
-
-
Kitamura, Y.1
Taniguchi, T.2
Shimohama, S.3
-
49
-
-
0032551633
-
Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain
-
Pasinetti GM, Aisen PS. Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain. Neuroscience 1998; 87: 319-324.
-
(1998)
Neuroscience
, vol.87
, pp. 319-324
-
-
Pasinetti, G.M.1
Aisen, P.S.2
-
50
-
-
0033608169
-
Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-γ in Alzheimer's disease brains
-
Kitamura Y, Shimohama S, Koike H, et al. Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-γ in Alzheimer's disease brains. Biochem Biophys Res Commun 1999; 254: 582-586.
-
(1999)
Biochem Biophys Res Commun
, vol.254
, pp. 582-586
-
-
Kitamura, Y.1
Shimohama, S.2
Koike, H.3
-
51
-
-
0027268393
-
Clinical trial of indomethacin in Alzheimer's disease
-
Rogers J, Kirby LC, Hempelman SR, et al. Clinical trial of indomethacin in Alzheimer's disease. Neurology 1993; 43: 1609-1611.
-
(1993)
Neurology
, vol.43
, pp. 1609-1611
-
-
Rogers, J.1
Kirby, L.C.2
Hempelman, S.R.3
-
52
-
-
0028170818
-
Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease
-
Selkoe DJ. Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease. Ann Rev Cell Biol 1994; 10: 373-403.
-
(1994)
Ann Rev Cell Biol
, vol.10
, pp. 373-403
-
-
Selkoe, D.J.1
-
53
-
-
0028981717
-
The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice
-
LaFela FM, Tinkle BT, Bieberich CJ, Haudenschild CC, Jay G. The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nat Genet 1995; 9: 21-30.
-
(1995)
Nat Genet
, vol.9
, pp. 21-30
-
-
LaFela, F.M.1
Tinkle, B.T.2
Bieberich, C.J.3
Haudenschild, C.C.4
Jay, G.5
-
54
-
-
0029813177
-
Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F β-amyloid precursor protein and Alzheimer's disease
-
Masliah E, Sisk A, Mallory M, Mucke L, Schenk D, Games D. Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F β-amyloid precursor protein and Alzheimer's disease. J Neurosci 1996; 16: 5795-5811.
-
(1996)
J Neurosci
, vol.16
, pp. 5795-5811
-
-
Masliah, E.1
Sisk, A.2
Mallory, M.3
Mucke, L.4
Schenk, D.5
Games, D.6
-
55
-
-
0031034226
-
Expression of mutant amyloid precursor proteins induces apoptosis in PC12 cells
-
Zhao B, Chrest FJ, Horton Jr. WE, Sisodia SS, Kusiak JW. Expression of mutant amyloid precursor proteins induces apoptosis in PC12 cells. J Neurosci Res 1997; 47: 253-263.
-
(1997)
J Neurosci Res
, vol.47
, pp. 253-263
-
-
Zhao, B.1
Chrest, F.J.2
Horton W.E., Jr.3
Sisodia, S.S.4
Kusiak, J.W.5
-
57
-
-
0027191973
-
Apoptosis mediated neurotoxicity induced by chronic application of β amyloid fragment 25-35
-
Forloni G, Chiesa R, Smiroldo S, et al. Apoptosis mediated neurotoxicity induced by chronic application of β amyloid fragment 25-35. NeuroReport 1993; 4: 523-526.
-
(1993)
NeuroReport
, vol.4
, pp. 523-526
-
-
Forloni, G.1
Chiesa, R.2
Smiroldo, S.3
-
58
-
-
0027257708
-
Apoptosis is induced by beta-amyloid in cultured central nervous system neurons
-
Loo DT, Copani A, Pike CJ, Whittemore ER, Walencewicz AJ, Cotman CW. Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. Proc Natl Acad Sci USA 1993; 90: 7951-7955.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 7951-7955
-
-
Loo, D.T.1
Copani, A.2
Pike, C.J.3
Whittemore, E.R.4
Walencewicz, A.J.5
Cotman, C.W.6
-
59
-
-
0029031348
-
Apoptotic cell death induced by β-amyloid peptide is cell type dependent
-
Gschwind M, Huber G. Apoptotic cell death induced by β-amyloid peptide is cell type dependent. J Neurochem 1995; 65: 292-300.
-
(1995)
J Neurochem
, vol.65
, pp. 292-300
-
-
Gschwind, M.1
Huber, G.2
-
60
-
-
0028207907
-
Amyloid β peptide induces necrosis rather than apoptosis
-
Behl C, Davis J, Klier FG, Schubert D. Amyloid β peptide induces necrosis rather than apoptosis. Brain Res 1994; 645: 253-264.
-
(1994)
Brain Res
, vol.645
, pp. 253-264
-
-
Behl, C.1
Davis, J.2
Klier, F.G.3
Schubert, D.4
-
61
-
-
0029860523
-
Amyloid β peptide of Alzheimer's disease downregulates Bcl-2 and upregulates Bax expression in human neurons
-
Paradis E, Douillard H, Koutroumanis M, Goodyer C, LeBlanc A. Amyloid β peptide of Alzheimer's disease downregulates Bcl-2 and upregulates Bax expression in human neurons. J Neurosci 1996; 16: 7533-7539.
-
(1996)
J Neurosci
, vol.16
, pp. 7533-7539
-
-
Paradis, E.1
Douillard, H.2
Koutroumanis, M.3
Goodyer, C.4
LeBlanc, A.5
-
62
-
-
0026570528
-
β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
-
Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel RE. β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 1992; 12: 376-389.
-
(1992)
J Neurosci
, vol.12
, pp. 376-389
-
-
Mattson, M.P.1
Cheng, B.2
Davis, D.3
Bryant, K.4
Lieberburg, I.5
Rydel, R.E.6
-
64
-
-
0028233494
-
Hydrogen peroxide mediates amyloid β protein toxicity
-
Behl C, Davis J, Lesley R, Schubert D. Hydrogen peroxide mediates amyloid β protein toxicity. Cell 1994; 77: 817-827.
-
(1994)
Cell
, vol.77
, pp. 817-827
-
-
Behl, C.1
Davis, J.2
Lesley, R.3
Schubert, D.4
-
65
-
-
0029056516
-
Cell death induced by β-amyloid 1-40 in MES23.5 hybrid clone: The role of nitric oxide and NMDA-gated channel activation leading to apoptosis
-
Le WD, Colom LV, Wie WJ, Smith RG, Alexianu M, Appel SH. Cell death induced by β-amyloid 1-40 in MES23.5 hybrid clone: the role of nitric oxide and NMDA-gated channel activation leading to apoptosis. Brain Res 1995; 686: 49-60.
-
(1995)
Brain Res
, vol.686
, pp. 49-60
-
-
Le, W.D.1
Colom, L.V.2
Wie, W.J.3
Smith, R.G.4
Alexianu, M.5
Appel, S.H.6
-
66
-
-
0027996904
-
Expression of the low affinity nerve growth factor receptor enhances β-amyloid peptide toxicity
-
Rabizadeh S, Bitler CM, Butcher LL, Bredesen DE. Expression of the low affinity nerve growth factor receptor enhances β-amyloid peptide toxicity. Proc Natl Acad Sci USA 1994; 91: 10703-10706.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 10703-10706
-
-
Rabizadeh, S.1
Bitler, C.M.2
Butcher, L.L.3
Bredesen, D.E.4
-
67
-
-
0031982670
-
Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease
-
Mattson MP, Guo Q, Furukawa K, Pedersen WA. Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease. J Neurochem 1998; 70: 1-14.
-
(1998)
J Neurochem
, vol.70
, pp. 1-14
-
-
Mattson, M.P.1
Guo, Q.2
Furukawa, K.3
Pedersen, W.A.4
-
68
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo
-
Borchelt DR, Thinakaran G, Eckman CB, et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo. Neuron 1996; 17: 1005-1013.
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
-
69
-
-
16044366039
-
Increased amyloid-β42 (43) in brains of mice expressing mutant presenilin 1
-
Duff K, Eckman C, Zehr C, et al. Increased amyloid-β42 (43) in brains of mice expressing mutant presenilin 1. Nature 1996; 383: 710-713.
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
-
70
-
-
16044373524
-
The amyloid β protein deposited in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D, Eckman C, Jensen M, et al. The amyloid β protein deposited in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 1996; 2: 864-870.
-
(1996)
Nat Med
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
-
71
-
-
12644258498
-
The presenilin 2 mutation (N141I) linked to familial Alzheimer's disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue
-
Tomita T, Maruyama K, Saldo TC, et al. The presenilin 2 mutation (N141I) linked to familial Alzheimer's disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue. Proc Natl Acad Sci USA 1997; 94: 2025-2030.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 2025-2030
-
-
Tomita, T.1
Maruyama, K.2
Saldo, T.C.3
-
72
-
-
0029856850
-
Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3
-
Vito P, Wolozin B, Ganjei JK, Iwasaki K, Lacana ED, Adamio L. Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3. J Biol Chem 1996; 271: 31025-31028.
-
(1996)
J Biol Chem
, vol.271
, pp. 31025-31028
-
-
Vito, P.1
Wolozin, B.2
Ganjei, J.K.3
Iwasaki, K.4
Lacana, E.D.5
Adamio, L.6
-
73
-
-
0030580281
-
Cotman CW Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells
-
Deng G, Pike CJ, Cotman CW Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells. FEBS Lett 1996; 397: 50-54.
-
(1996)
FEBS Lett
, vol.397
, pp. 50-54
-
-
Deng, G.1
Pike, C.J.2
-
74
-
-
10544224542
-
Participation of presenilin 2 in apoptosis: Enhanced basal activity conferred by an Alzheimer mutation
-
Wolozin B, Iwasaki K, Vito P, et al. Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science 1996; 274: 1710-1713.
-
(1996)
Science
, vol.274
, pp. 1710-1713
-
-
Wolozin, B.1
Iwasaki, K.2
Vito, P.3
-
75
-
-
0030891662
-
Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide
-
Guo Q, Furukawa K, Sopher BL, et al. Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide. NeuroReport 1996; 8: 379-383.
-
(1996)
NeuroReport
, vol.8
, pp. 379-383
-
-
Guo, Q.1
Furukawa, K.2
Sopher, B.L.3
-
76
-
-
0030917601
-
Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid β-peptide: Involvement of calcium and oxyradicals
-
Guo Q, Sopher BL, Pham DG, et al. Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid β-peptide: involvement of calcium and oxyradicals. J Neurosci 1997; 17: 4212-4222.
-
(1997)
J Neurosci
, vol.17
, pp. 4212-4222
-
-
Guo, Q.1
Sopher, B.L.2
Pham, D.G.3
-
77
-
-
0033016172
-
Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice
-
Guo Q, Fu W, Sopher BL, et al. Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice. Nat Med 1999; 5: 101-106.
-
(1999)
Nat Med
, vol.5
, pp. 101-106
-
-
Guo, Q.1
Fu, W.2
Sopher, B.L.3
-
78
-
-
0032400818
-
Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis
-
Bursztajn S, DeSouza R, McPhie DL, et al. Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis. J Neurosci 1998; 18: 9790-9799.
-
(1998)
J Neurosci
, vol.18
, pp. 9790-9799
-
-
Bursztajn, S.1
DeSouza, R.2
McPhie, D.L.3
-
79
-
-
0033617402
-
Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-β precursor protein and amyloidogenic Aβ peptide formation
-
Gervais FG, Xu D, Robertson GS, et al. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-β precursor protein and amyloidogenic Aβ peptide formation. Cell 1999; 97: 395-406.
-
(1999)
Cell
, vol.97
, pp. 395-406
-
-
Gervais, F.G.1
Xu, D.2
Robertson, G.S.3
-
80
-
-
0029906585
-
Assessment of normal and mutant human presenilin function in Caenorhabditis elegans
-
Levitan D, Doyle TG, Brousseau D, et al. Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proc Natl Acad Sci USA 1996; 93: 14940-14944.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 14940-14944
-
-
Levitan, D.1
Doyle, T.G.2
Brousseau, D.3
-
81
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presemlin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D, Eckman C, Jensen M, et al. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presemlin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 1996; 2: 864-870.
-
(1996)
Nat Med
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
-
82
-
-
0030788767
-
Presenilin 1 interaction in the brain with a novel member of the Armadillo family
-
Zhou J, Liyanage U, Medina M, et al. Presenilin 1 interaction in the brain with a novel member of the Armadillo family. NeuroReport 1997; 8: 2085-2090.
-
(1997)
NeuroReport
, vol.8
, pp. 2085-2090
-
-
Zhou, J.1
Liyanage, U.2
Medina, M.3
-
83
-
-
0031866596
-
Direct association of presenilin-1 with beta-catenin
-
Murayama M, Tanaka S, Palacino J, et al. Direct association of presenilin-1 with beta-catenin. FEBS Lett 1998; 433: 73-77.
-
(1998)
FEBS Lett
, vol.433
, pp. 73-77
-
-
Murayama, M.1
Tanaka, S.2
Palacino, J.3
-
84
-
-
13144265717
-
Presenilin 1 associates with glycogen synthase kanase-3 beta and its substrate tau
-
Takashima A, Murayama M, Murayama O, et al. Presenilin 1 associates with glycogen synthase kanase-3 beta and its substrate tau. Proc Natl Acad Sci USA 1998; 95: 9637-9641.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 9637-9641
-
-
Takashima, A.1
Murayama, M.2
Murayama, O.3
-
85
-
-
0032568821
-
The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin
-
Yu G, Chen F, Levesque G, et al. The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin. J Biol Chem 1998; 273: 16470-16475.
-
(1998)
J Biol Chem
, vol.273
, pp. 16470-16475
-
-
Yu, G.1
Chen, F.2
Levesque, G.3
-
86
-
-
0032531793
-
Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
-
Zhang Z, Hartmann H, Do VM, et al. Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature 1998; 395: 698-702.
-
(1998)
Nature
, vol.395
, pp. 698-702
-
-
Zhang, Z.1
Hartmann, H.2
Do, V.M.3
-
87
-
-
0032905727
-
Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex
-
Nishimura M, Yu G, Levesque G, et al. Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex. Nat Med 1999; 5: 164-169.
-
(1999)
Nat Med
, vol.5
, pp. 164-169
-
-
Nishimura, M.1
Yu, G.2
Levesque, G.3
-
88
-
-
0033168352
-
Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB
-
Weihl CC, Ghadge GD, Kennedy SG, Hay N, Miller RJ, Roos RP. Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB. J Neurosci 1999; 19: 5360-5369.
-
(1999)
J Neurosci
, vol.19
, pp. 5360-5369
-
-
Weihl, C.C.1
Ghadge, G.D.2
Kennedy, S.G.3
Hay, N.4
Miller, R.J.5
Roos, R.P.6
-
89
-
-
0031053586
-
Regulation of neuronal survival by the serine-threonine protein kinase Akt
-
Dudek H, Datta SR, Franke TF, et al. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 1997; 275: 661-665.
-
(1997)
Science
, vol.275
, pp. 661-665
-
-
Dudek, H.1
Datta, S.R.2
Franke, T.F.3
-
90
-
-
0030904561
-
The PI3-kinase/Akt signaling pathway delivers an anti-apoptotic signal
-
Kennedy SG, Wagner AJ, Conzen SD, et al. The PI3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev 1997; 11: 701-713.
-
(1997)
Genes Dev
, vol.11
, pp. 701-713
-
-
Kennedy, S.G.1
Wagner, A.J.2
Conzen, S.D.3
|