Cerebral tissue oxygenation and oxidative brain injury during ischemia and reperfusion

Frontiers in Bioscience

Volumn 12, Issue 4, 2007, Pages 1318-1328

  Shi, Honglian ^a   Liu, Ke Jian ^a  

^a UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

Antioxidant; Cerebral Ischemia; EPR; HIF; Oximetry; Oxygen; ReviewWA; Stroke

Indexed keywords

EID: 34248995460     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/2150     Document Type: Article

References (123)

1. P Wolf, J Cobb and R D'Agostino: Epidemiology of stroke. In: Stroke Pathophysiology, Diagnosis and Management. Eds: H Bamett, J Mohr, B Stein F Yatsu. Churchill Liveingston, Inc, New York (1992)
2. C ladecola: Mechanisms of cerebral ischemie damage. In: Cerebral Ischemia. Ed: W Walz. Humana Press (1999)
3. J. Baron: Pathophysiology of acute cerebral ischemia: PET studies in humans. J Cereb Blood Flow 1, 22-31 (1991)
4. M. Furlan, G. Marchai, F. Viader, J. M. Derlon and J. C. Baron: Spontaneous neurological recovery after stroke and the fate of the ischemie penumbra. Ann Neural 40(2), 216-226 (1996)
5. A. R. Young, G. Sette, O. Touzani, P. Rioux, J. M. Derlon, E. T. MacKenzie and J. C. Baron: Relationships between high oxygen extraction fraction in the acute stage and final infarction in reversible middle cerebral artery occlusion: an investigation in anesthetized baboons with positron emission tomography. J Cereb Blood Flow Metab 16 (6), 1176-1188 (1996)
6. G. Del Zoppo: Reperfusion Damage: the Role of PMN Leukocytes. Primer Cerebrovas Dis 217-220 (1997)
7. C. ladecola: Bright and dark sides of nitric oxide in ischemie brain injury. Trends Neurosci 20(3), 132-139 (1997)
8. F. T. Charbel, W. E. Hoffman, M. Misra, K. Hannigan and J. I. Ausman: Cerebral interstitial tissue oxygen tension, pH, HCO3, CO2. Surgic Neural 48 (4), 414-417 (1997)
9. R. D. Braun, J. L. Lanzen, S. A. Snyder and M. W. Dewhirst: Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents. Am J Physiol Heart Circ Physiol 280(6), H2533-2544 (2001)
10. A. D. Shaw, Z. Li, Z. Thomas and C. W. Stevens: Assessment of tissue oxygen tension: comparison of dynamic fluorescence quenching and polarographic electrode technique. Crit Care 6(1), 76-80 (2002)
11. 2 measurements by phosphorescence quenching: characteristics and applications of an automated system. Microvasc Res 65(1), 32-38 (2003)
12. J. C. Kolb, P. N. Ainslie, K. Ide and M. J. Poulin: Effects of 5 consecutive nocturnal hypoxic exposures on respiratory control and hematogenesis in humans. Adv Exp Med Biol 551, 305-310 (2004)
13. 2 mapping. J Biomed Opt 8(1), 53-62 (2003)
14. S. Liu, G. S. Timmins, H. Shi, C. M. Gasparovic and K. J. Liu: Application of in vivo EPR in brain research: monitoring tissue oxygenation, blood flow, and oxidative stress. NMR Biomed 17(5), 327-334 (2004)
15. 2 in ischemie penumbra and core are differentially affected following transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab 24(3), 343-349 (2004)
16. J. F. Dunn and H. M. Swartz: In vivo electron paramagnetic resonance oximetry with particulate materials. Methods 30(2), 159-166 (2003)
17. S. Subramanian, K. Yamada, A. Irie, R. Murugesan, J. A. Cook, N. Devasahayam, G. M. Van Dam, J. B. Mitchell and M. C. Krishna: Noninvasive in vivo oximetric imaging by radiofrequency FT EPR. Magn Reson Med 47(5), 1001-1008 (2002)
18. G. Ilangovan, H. Li, J. L. Zweier, M. C. Krishna, J. B. Mitchell and P. Kuppusamy: In vivo measurement of regional oxygenation and imaging of redox status in RIF-1 murine tumor: effect of carbogen-breathing. Magn Reson Med 48(4), 723-730 (2002)
19. S. S. Velan, R. G. Spencer, J. L. Zweier and P. Kuppusamy: Electron paramagnetic resonance oxygen mapping (EPROM): direct visualization of oxygen concentration in tissue. Magn Reson Med 43(6), 804-809 (2000)
20. E. L. Rolett, A. Azzawi, K. J. Liu, M. N. Yongbi, H. M. Swartz and J. F. Dunn: Critical oxygen tension in rat brain: a combined (31)P-NMR and EPR oximetry study. Am J Physiol Reg Integr Comp Physiol 279( 1 ), R9-R16 (2000)
21. F. G. Hempel: Oxygen tensions measured in cat cerebral cortex under hyperbaric conditions. JAppl Physiol 46(1), 53-60 (1979)
22. P. Kuppusamy, R. A. Shankar and J. L. Zweier: In vivo measurement of arterial and venous oxygenation in the rat using 3D spectral-spatial electron paramagnetic resonance imaging. Phys Med Biol 43(7), 1837-1844 (1998)
23. 2 in the liver in vivo in mice. Magn Reson Med 34(6), 888-892 (1995)
24. M. Bias, B. B. Williams, A. Parasca, C. Mailer, C. A. Pelizzari, M. A. Lewis, J. N. River, G. S. Karczmar, E. D. Earth and H. J. Halpem: Quantitative tumor oxymetric images from 4D electron paramagnetic resonance imaging (EPRI): methodology and comparison with blood oxygen level-dependent (BOLD) MRI. Magn Reson Med 49(4), 682-91 (2003)
25. S. Love: Oxidative stress in brain ischemia. Brain Pathol9(1), 119-131 (1999)
26. R. G. Knowles and S. Moncada: Nitric oxide synthases in mammals. Biochem .7298 ( Pt 2), 249-58 (1994)
27. M. A. Moro, A. Cardenas, O. Hurtado, J. C. Leza and I. Lizasoain: Role of nitric oxide after brain ischaemia. Cell Calcium 36(3-4), 265-275 (2004)
28. U. Dirnagl, C. ladecola and M. A. Moskowitz: Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 22(9), 391-397 (1999)
29. A. Lewen, P. Matz and P. H. Chan: Free radical pathways in CNS injury. J Neurotrauma 17(10), 871-890 (2000)
30. S. P. Mahadik, T. K. Makar, J. N. Murthy, A. Ortiz, C. G. Wakade and S. E. Karpiak: Temporal changes in Superoxide dismutase, glutathione peroxidase, and catalase levels in primary and peri-ischemic tissue. Monosialoganglioside (GM1) treatment effects. Mol Chem Neuropathol 18(1-2), 1-14 (1993)
31. H. Karibe, S. F. Chen, G. J. Zarow, J. Garni, S. H. Graham, P. H. Chan and P. R. Weinstein: Mild intraischemic hypothermia suppresses consumption of endogenous antioxidants after temporary focal ischemia in rats. Brain Res 649(1-2), 12-18 (1994)
32. M. F. Anderson and N. R. Sims: The effects of focal ischemia and reperfusion on the glutathione content of mitochondria from rat brain subrogions. J Neurochem 81(3), 541-549 (2002)
33. H. Landolt, T. W. Lutz, H. Langemann, D. Stauble, A. Mendelowitsch, O. Gratzl and C. G. Honegger: Extracellular antioxidants and amino acids in the cortex of the rat: monitoring by microdialysis of early ischemie changes. J Cereb Blood Flow Metab 12(1), 96-102 (1992)
34. S. H. Back, J. Y. Kirn, J. H. Choi, E. M. Park, M. Y. Han, C. H. Kim, Y. S. Ahn and Y. M. Park: Reduced glutathione oxidation ratio and 8 ohdG accumulation by mild ischemie pretreatment. Brain Res 856(1-2), 28-36 (2000)
35. P. Lyrer, H. Landolt, A. Kabiersch, H. Langemann and H. Kaeser: Levels of low molecular weight scavengers in the rat brain during focal ischemia. Brain Res 567(2), 317-320 (1991)
36. K. Kramer, H. P. Voss, J. A. Grimbergen, C. Smink, H. Timmerman and A. Bast: Glutathione mobilization during cerebral ischemia and reperfusion in the rat. Gen Pharmacol 23(1), 105-108 (1992)
37. E. Zaidan and N. R. Sims: Alterations in the glutathione content of mitochondria following short-term forebrain ischemia in rats. Neurosci Lett 218(2), 75-78 (1996)
38. N. R. Sims, V. K. Williams, E. Zaidan and J. A. Powell: The antioxidant defences of brain mitochondria during short-term forebrain ischemia and recirculation in the rat. Brain Res Mol Brain Res 60(2), 141-914 (1998)
39. R. Levy, S. Glozman, D. Milman, C. Seruty, Z. Hagay, E. Yavin and Y. Groner: Ischemie reperfusion brain injury in fetal transgenic mice with elevated levels of copper-zinc Superoxide dismutase. J Perinat Med 30(2), 158-165 (2002)
40. D. M. Hermann, T. Kuroiwa, R. Hata, F. Gillardon, U. Ito and G. Mies: Expression of redox factor-1, p53-activated gene 608 and caspase-3 messenger RNAs following repeated unilateral common carotid artery occlusion in gerbils-relationship to delayed cell injury and secondary failure of energy state. Neuroscience 102(4), 779-787 (2001)
41. Y. Takagi, F. Horikawa, K. Nozaki, T. Sugino, N. Hashimoto and J. Yodoi: Expression and distribution of redox regulatory protein, thioredoxin during transient focal brain ischemia in the rat. Neurosci Lett 251(1), 25-28 (1998)
42. S. Liu, M. Liu, S. Peterson, M. Miyake, V. Vallyathan and K. J. Liu: Hydroxyl radical formation is greater in striatal core than in penumbra in a rat model of ischemie stroke. J Neurosci Res 71(6), 882-888 (2003)
43. E. Candelario-Jalil, N. H. Mhadu, S. M. Al-Dalain, G. Martinez and O. S. Leon: Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils. Neurosci Res 41(3), 233-241 (2001)
44. R. B. Mason, R. M. Pluta, S. Walbridge, D. A. Wink, E. H. Oldfield and R. J. Boock: Production of reactive oxygen species after reperfusion in vitro and in vivo: protective effect of nitric oxide. J Neurosurg 93(1), 99-107 (2000)
45. T. Kondo, A. G. Reaume, T. T. Huang, E. Carlson, K. Murakami, S. F. Chen, E. K. Hoffman, R. W. Scott, C. J. Epstein and P. H. Chan: Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia. J Neurosci 17(11), 4180-4189 (1997)
46. Y. Gasche, J. C. Copin, T. Sugawara, M. Fujimura and P. H. Chan: Matrix metalloproteinase inhibition prevents oxidative stress-associated blood-brain barrier disruption after transient focal cerebral ischemia. J Cereb Blood Flow Metab21(12), 1393-1400(2001)
47. M. Asahi, K. Asahi, X. Wang and E. H. Lo: Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolie focal cerebral ischemia in rats. J Cereb Blood Flow Metab 20(3), 452-457 (2000)
48. T. Sugawara, F. Yu, L. Ma, C. J. Hsia and P. H. Chan: Delayed treatment with polynitroxyl albumin reduces infarct size after stroke in rats. Neuroreport 12(16), 3609-3612 (2001)
49. Y. Gursoy-Ozdemir, H. Bolay, O. Saribas and T. Dalkara: Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia. Stroke 31 (8), 1974-1980 (2000)
50. Z. Gu, M. Kaul, B. Yan, S. J. Kridel, J. Cui, A. Strongin, J. W. Smith, R. C. Liddington and S. A. Lipton: S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death. Science 297(5584), 11 Soil 90 (2002)
51. M. Christophe and S. Nicolas: Mitochondria: a target for neuroprotective interventions in cerebral ischemiareperfusion. Curr Pharm Des 12(6), 739-757 (2006)
52. K. L. Allen, A. L. Busza, E. Proctor, M. D. King, S. R. Williams, H. A. Crockard and D. G. Gadian: Controllable graded cerebral ischaemia in the gerbil: studies of cerebral blood flow and energy metabolism by hydrogen clearance and 3IP NMR spectroscopy. NMR Biomed 6(3), 181-186 (1993)
53. K. L. Alien, A. Almeida, T. E. Bates and J. B. Clark: Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. JNeurochem 64(5), 2222-2229 (1995)
54. R. A. Kirkland and J. L. Franklin: Evidence for redox regulation of cytochrome C release during programmed neuronal death: antioxidant effects of protein synthesis and caspase inhibition. J Neurosci 21(6), 1949-1963 (2001)
55. K. Murakami, T. Kondo, M. Kawase, Y. Li, S. Sato, S. F. Chen and P. H. Chan: Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese Superoxide dismutase deficiency. J Neurosci 18(1), 205-213 (1998)
56. M. Fujimura, Y. Morita-Fujimura, K. Murakami, M. Kawase and P. H. Chan: Cytosolic redistribution of cytochrome c after transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab 18(11), 1239-1247(1998)
57. J. Chen, T. Nagayama, K. Jin, R. A. Steuer, R. L. Zhu, S. H. Graham and R. P. Simon: Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. J Neurosci 18(13), 4914-4928 (1998)
58. J. Chen, Y. Li, L. Wang, M. Lu and M. Chopp: Caspase inhibition by Z-V AD increases the survival of grafted bone marrow cells and improves functional outcome after MCAo in rats. J Neural Sci 199(1-2), 17-24 (2002)
59. B. Ni, X. Wu, Y. Su, D. Stephenson, E. B. Smalstig, J. Clemens and S. M. Paul: Transient global forebrain ischemia induces a prolonged expression of the caspase-3 mRNA in rat hippocampal CA1 pyramidal neurons. J Cereb Blood Flow Metab 18(3), 248-256 (1998)
60. M. Endres, G. Scott, S. Namura, A. L. Salzman, P. L. Huang, M. A. Moskowitz and C. Szabo: Role of peroxynitrite and neuronal nitric oxide synthase in the activation of poly(ADP-ribose) synthetase in a murine model of cerebral ischemia-reperfusion. Neurosci Lett 248(1), 41-44 (1998)
61. J. B. Schulz, M. Weller, R. T. Matthews, M. T. Heneka, P. Groscurth, J. C. Martinou, J. Lommatzsch, R. von Coelln, U. Wullner, P. A. Loschmann, M. F. Beai, J. Dichgans and T. Klockgether: Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia. Cell Death different 5(10), 847-857 (1998)
62. K. Fink, J. Zhu, S. Namura, M. Shimizu-Sasamata, M. Endres, J. Ma, T. Dalkara, J. Yuan and M. A. Moskowitz: Prolonged therapeutic window for ischemie brain damage
63. caused by delayed caspase activation. J Cereb Blood Flow Metab 18(10), 1071-1076 (1998)
64. H. Hara, R. M Friedlander, V. Gagliardini, C. Ayata, K. Fink, Z. Huang, M. Shimizu-Sasamata, J. Yuan and M. A. Moskowitz: Inhibition of interleukin Ibeta converting enzyme family proteases reduces ischemie and excitotoxic neuronal damage. Proc Natl Acad Sci USA 94(5), 2007-2012 (1997)
65. K. Kuida, T. F. Haydar, C. Y. Kuan, Y. Gu, C. Taya, H. Karasuyama, M. S. Su, P. Rakic and R. A. Flavell: Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94(3), 325-337 (1998)
66. K. Kajiwara, K. Ikeda, R. Kuroi, R. Hashimoto, S. Tokumaru and S. Kojo: Hydrogen peroxide and hydroxyl radical involvement in the activation of caspase-3 in chemically induced apoptosis of HL-60 cells. Cell Mol Life Sci 58(3), 485-491 (2001)
67. R. M. Kluck, S. J. Martin, B. M. Hoffman, J. S. Zhou, D. R. Green and D. D. Newmeyer: Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system. EMBO J 16(15), 4639-4649 (1997)
68. V. Anantharam, M. Kitazawa, J. Wagner, S. Kaul and A. G. Kanthasamy: Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl. J Neurosci 22(5), 1738-1751 (2002)
69. A. Chiarugi: Poly(ADP-ribosyl)ation and stroke. Pharmacol Res 52(1), 15-24 (2005)
70. S. W. Yu., H. Wang, M. F. Poitras, C. Coombs, W. J. Bowers, H. J. Federoff, G. G. Poirier, T. M. Dawson and V. L. Dawson: Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science 297(5579), 259-263 (2002)
71. L. Giovannelli, A. Cozzi, I. Guarnieri, P. Dolara and F. Moroni: Comet assay as a novel approach for studying DNA damage in focal cerebral ischemia: differential effects of NMDA receptor antagonists and poly(ADP-ribose) polymerase inhibitors. J Cereb Blood Flow Metab 22(6), 697-704 (2002)
72. M. Endres, Z. Q. Wang, S. Namura, C. Waeber and M. A. Moskowitz: Ischemie brain injury is mediated by the activation of poly(ADP-ribose)polymerase. J Cereb Blood Flow Metab 17(11), 1143-1151 (1997)
73. T. Tokime, K. Nozaki, T. Sugino, H. Kikuchi, N. Hashimoto and K. Ueda: Enhanced poly(ADP-ribosyl)ation after focal ischemia in rat brain. J Cereb Blood Flow Metab 18(9), 991-997 (1998)
74. F. J. Oliver, J. Menissier-de Murcia, C. Nacci, P. Decker, R. Andriantsitohaina, S. Muller, G. de la Rubia, J. C. Stoclet and G. de Murcia: Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice. Embo J 18(16), 4446-4454 (1999)
75. P. O. Hassa and M. O. Hottiger: The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders. Cell Mol Life Sci 59(9), 1534-1553 (2002)
76. A. Chiarugi: Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats. Br J Pharmacol 137(6), 761-770 (2002)
77. H. C. Ha, L. D. Hester and S. H. Snyder: Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia. Proc Natl Acad Sci USA 99(5), 3270-3275 (2002)
78. J. Wesierska-Gadek, G. Schmid and C. Cerni: ADP-ribosylation of wild-type p53 in vitro: binding of p53 protein to specific p53 consensus sequence prevents its modification. Biochem Biophys Res Commun 224(1), 96-102 (1996)
79. J. Wesierska-Gadek and G. Schmid: Overexpressed poly(ADP-ribose) polymerase delays the release of rat cells from p53-mediated G(l) checkpoint. J Cell Biochem 80(1), 85-103 (2000)
80. R. P. Strosznajder, H. Jesko and A. Zambrzycka: Poly(ADP-ribose) polymerase: the nuclear target in signal transduction and its role in brain ischemia-reperfusion injury. Mol Neurobiol 31(1-3), 149-167 (2005)
81. G. L. Wang, B. H. Jiang, E. A. Rue and G. L. Semenza: Hypoxia-inducible factor l is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92(12), 5510-5514 (1995)
82. B. H. Jiang, E. Rue, G. L. Wang, R. Roe and G. L. Semenza: Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J Biol Chem 271(30), 17771-17778 (1996)
83. L. E. Huang, Z. Arany, D. M. Livingston and H. F. Bunn: Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem 271(50), 32253-32259 (1996)
84. E. C. Hoffman, H. Reyes, F. F. Chu, F. Sander, L. H. Conley, B. A. Brooks and O. Hankinson: Cloning of a factor required for activity of the Ah (dioxin) receptor. Science 252(5008), 954-958 (1991)
85. J. A. Forsythe, B. H. Jiang, N. V. Iyer, F. Agani, S. W. Leung, R. D. Koos and G. L. Semenza: Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16(9), 4604-4613 (1996)
86. Y. Liu, S. R. Cox, T. Monta and S. Kourembanas: Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5' enhancer. Circ Res 77(3), 638-643 (1995)
87. G. L. Semenza: Angiogenesis in ischemie and neoplastic disorders. Annu Rev Med 54, 17-28 (2003)
88. G. L. Semenza: Targeting HIF-1 for cancer therapy. Nature Rev Cancer 3(10), 721-732 (2003)
89. G. L. Semenza: HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol Med 8(4 Suppl), S62-67 (2002)
90. M. Bergeron, A. Y. Yu, K. E. Solway, G. L. Semenza and F. R. Sharp: Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain. Eu J Neurosci 11(12), 4159-4170 (1999)
91. O. Pascual, M. Denavit-Saubie, S. Dumas, T. Kietzmann, G. Ghilini, J. Mallet and J. M. Pequignot: Selective cardiorespiratory and catecholaminergic areas express the hypoxia-inducible factor-1 alpha (HIF-1 alpha) under in vivo hypoxia in rat brainstem. Eu J Neurosci 14(12), 1981-1991 (2001)
92. S. M. Stroka, T. Burkhardt, I. Desbaillets, R. H. Wenger, D. A. Neil, C. Bauer, M. Gassmann and D. Candinas: HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia. FASEB J 15(13), 2445-2453 (2001)
93. N. M. Jones and M. Bergeron: Hypoxie preconditioning induces changes in HIF-1 target genes in neonatal rat brain. J Cereb Blood Flow Metab 21 (9), 1105-1114 (2001 )
94. K. Ruscher, N. Isaev, G. Trendelenburg, M. Weih, L. lurato, A. Meisel and U. Dirnagl: Induction of hypoxia inducible factor I by oxygen glucose deprivation is attenuated by hypoxic preconditioning in rat cultured neurons. Neurosci Lett 254(2), 117-120 ( 1998)
95. L. A. Palmer, G. L. Semenza, M. H. Stoler and R. A. Johns: Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1. Am J Physiol 274(2 Pt 1), L212-219 (1998)
96. D. E. Millhorn, R. Raymond, L. Conforti, W. Zhu, D. Beitner-Johnson, T. Filisko, M. B. Center, S. Kobayashi and M. Peng: Regulation of gene expression for tyrosine hydroxylase in oxygen sensitive cells by hypoxia. Kidney Inter 51(2), 527-535(1997)
97. G. L. Semenza, B. H. Jiang, S. W. Leung, R. Passantino, J. P. Concordet, P. Maire and A. Giallongo: Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem 271(51), 32529-32537 (1996)
98. P. Carmeliet, Y. Dor, J. M. Herbert, D. Fukumura, K. Brusselmans, M. Dewerchin, M. Neeman, F. Bono, R. Abramovitch, P. Maxwell, C. J. Koch, P. Ratcliffe, L. Moons, R. K. Jain, D. Collen, E. Keshert and E. Keshet: Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394(6692), 485-490 (1998)
99. M. Volm and R. Koomagi: Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer. Anticancer Res 20(3A), 1527-1533 (2000)
100. M. W. Halterman and H. J. Federoff: HIF-lalpha and p53 promote hypoxia-induced delayed neuronal death in models of CNS ischemia. Exp Neural 159(1), 65-72 (1999)
101. N. Nighoghossian and P. Trouillas: Hyperbaric oxygen in the treatment of acute ischemie stroke: an unsettled issue. J Neural Sci 150( 1 ), 27-31 (1997)
102. K. Sunami, Y. Takeda, M. Hashimoto and M. Hirakawa: Hyperbaric oxygen reduces infarct volume in rats by increasing oxygen supply to the ischemie periphery. Crit Care Med 28(8), 2831-2836 (2000)
103. R. Veltkamp, D. S. Warner, F. Domoki, A. D. Brinkhous, J. F. Toole and D. W. Busija: Hyperbaric oxygen decreases infarct size and behavioral deficit after transient focal cerebral ischemia in rats. Brain Res 853(1), 68-73 (2000)
104. N. Nighoghossian, P. Trouillas, P. Adeleine and F. Salord: Hyperbaric oxygen in the treatment of acute ischemie stroke. A double-blind pilot study. Stroke 26(8), 1369-1372 (1995)
105. D. C. Anderson, A. G. Bottini, W. M. Jagiella, B. Westphal, S. Ford, G. L. Rockswold and R. B. Loewenson: A pilot study of hyperbaric oxygen in the treatment of human stroke. Stroke 22(9), 1137-1142 (1991)
106. J. A. Roos, C. Jackson-Friedman and P. Lyden: Effects of hyperbaric oxygen on neurologic outcome for cerebral ischemia in rats. Acad Emerg Med 5(1), 18-24 (1998)
107. D. E. Rusyniak, M. A. Kirk, J. D. May, L. W. Kao, E. J. Brizendine, J. L. Welch, W. H. Cordell, and R. J. Alonso: Hyperbaric oxygen in acute ischemie stroke trial pilot: hyperbaric oxygen therapy in acute ischemie stroke: results of the hyperbaric oxygen in acute ischemie stroke trial pilot study. Stroke 34(2), 571-574 (2003)
108. G. G. Rogatsky, E. G. Shifrin and A. Mayevsky: Optimal dosing as a necessary condition for the efficacy of hyperbaric oxygen therapy in acute ischemie stroke: a critical review. Neural Res 25(1), 95-98 (2003)
109. A. B. Singhai, R. M. Dijkhuizen, B. R. Rosen and E. H. Lo: Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke. Neurology 58(6), 945-952 (2002)
110. O. Miyamoto and R. N. Auer: Hypoxia, hyperoxia, ischemia, and brain necrosis. Neurology 54(2), 362-371 (2000)
111. Y. Li, S. Kawamura, M. Shirasawa, N. Yasui and H. Fukasawa: Failure of normobaric oxygen therapy to reduce ischemie brain damage in rats. Undersea Hyperbar Med 21(3), 245-249 (1994)
112. S. G. Jenkinson: Oxygen toxicity. New Horiz 1(4), 504-511(1993)
113. S. Liu, W. Liu, W. Ding, M. Miyake, G. A. Rosenberg and K. J. Liu: Electron paramagnetic resonance-guided normobaric hyperoxia treatment protects the brain by maintaining penumbral oxygenation in a rat model of transient focal cerebral ischemia. J Cereb Blood Flow Metab, 2006 Jan 18; [Epub ahead of print]
114. R. Schmid-Elsaesser, S. Zausinger, E. Hungerhaber, A. Baethmann and H. J. Reulen: Neuroprotective properties of a novel antioxidant (U-101033E) with improved blood-brain barrier permeability in focal cerebral ischemia. Acta Neurochirurg Supp 70, 176-178 (1997)
115. R. Schmid-Elsaesser, S. Zausinger, E. Hungerhuber, A. Baethmann and H. J. Reulen: Neuroprotective effects of combination therapy with tirilazad and magnesium in rats subjected to reversible focal cerebral ischemia. Neurosurgery 44(1), 163-71 (1999)
116. Z. Shutenko, Y. Henry, E. Pinard, J. Seylaz, P. Potier, F. Berthet, P. Girard and R. Sercombe: Influence of the antioxidant quercetin in vivo on the level of nitric oxide determined by electron paramagnetic resonance in rat brain during global ischemia and reperfusion. Biochem Pharmacol 57(2), 199-208(1999)
117. A. Germano, C. Imperatore, D. d'Avella, G. Costa and F. Tomasello: Antivasospastic and brain-protective effects of a hydroxyl radical scavenger (AVS) after experimental subarachnoid hemorrhage. J Neurosurg 88(6), 1075-1081 (1998)
118. R. J. Hamm, M. D. Temple, B. R. Pike and E. F. Ellis: The effect of postinjury administration of polyethylene glycolconjugated Superoxide dismutase (pegorgotein, Dismutec) or lidocaine on behavioral function following fluid-percussion brain injury in rats. J Neurotrauma 13(6), 325-332 (1996)
119. S. Kuroda and B. K. Siesjo: Reperfusion damage following focal ischemia: pathophysiology and therapeutic windows. Clin Neurosci 4(4), 199-212 (1997)
120. M. Nakashima, M. Niwa, T. Iwai and T. Uematsu: Involvement of free radicals in cerebral vascular reperfusion injury evaluated in a transient focal cerebral ischemia model of rat. Free Radie Biol Med 26(5-6), 722-729(1999)
121. S. L. Leib, Y. S. Kim, L. L. Chow, R. A. Sheldon and M. G. Tauber: Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci. J Clin Invest 98(11), 2632-2639 (1996)
122. P. H. Chan: Role of oxidants in ischemie brain damage. Stroke 27(6), 1124-1129 (1996)
123. Y. Wang, C. F. Chang, J. Chou, H. L. Chen, X. Deng, B. K. Harvey, J. L. Cadet and P. C. Bickford: Dietary supplementation with blueberries, spinach, or spirulina reduces ischemie brain damage. Exp Neural 193(1), 75-84 (2005)