Electron paramagnetic resonance-guided normobaric hyperoxia treatment protects the brain by maintaining penumbral oxygenation in a rat model of transient focal cerebral ischemia

Journal of Cerebral Blood Flow and Metabolism

Volumn 26, Issue 10, 2006, Pages 1274-1284

  Liu, Shimin ^a   Liu, Wenlan ^a   Ding, Wei ^a   Miyake, Minoru ^a,c   Rosenberg, Gary A ^b   Liu, Ke Jian ^a,b  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

^c KAGAWA UNIVERSITY   (Japan)

Author keywords

Caspase; Cerebral ischemia; Interstitial pO2; MMP; Normobaric hyperoxia

Indexed keywords

CASPASE 8; GELATINASE B; OXYGEN; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN PERFUSION; CONTROLLED STUDY; DISEASE MODEL; ELECTRON SPIN RESONANCE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; NORMOBARIC HYPEROXIA TREATMENT; OUTCOME ASSESSMENT; OXIMETRY; OXYGEN TENSION; OXYGEN THERAPY; OXYGEN TISSUE LEVEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT STRAIN; REPERFUSION; TISSUE OXYGENATION; TRANSIENT ISCHEMIC ATTACK;

ANIMALS; BLOOD PRESSURE; CASPASES; CEREBROVASCULAR CIRCULATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYGUANOSINE; DISEASE MODELS, ANIMAL; ELECTROCHEMISTRY; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME ACTIVATION; HYPEROXIA; ISCHEMIC ATTACK, TRANSIENT; MALE; MATRIX METALLOPROTEINASES; OXYGEN; OXYGEN INHALATION THERAPY; PARTIAL PRESSURE; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDES;

EID: 33746972929     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jcbfm.9600277     Document Type: Article

References (30)

1. Anantharam V, Kitazawa M, Wagner J, Kaul S, Kanthasamy AG (2002) Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl. J Neurosci 22:1738-51
2. Asahi M, Asahi K, Wang X, Lo EH (2000) Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats. J Cereb Blood Flow Metab 20:452-7
3. Astrup J, Siesjo BK, Symon L (1981) Thresholds in cerebral ischemia-the ischemic penumbra. Stroke 12:723-5
4. Bonita R, Stewart A, Beaglehole R (1990) International trends in stroke mortality: 1970-1985. Stroke 21:989-992
5. Chan PH, Kawase M, Murakami K, Chen SF, Li Y, Calagui B, Reola L, Carlson E, Epstein CJ (1998) Overexpression of SOD1 in transgenic rats protects vulnerable neurons against ischemic damage after global cerebral ischemia and reperfusion. J Neurosci 18:8292-9
6. Clancy B, Cauller LJ (1998) Reduction of background autofluorescence in brain sections following immersion in sodium borohydride. J Neurosci Methods 83:97-102
7. Fisher M (1997) Characterizing the target of acute stroke therapy. Stroke 28:866-72
8. Gasche Y, Copin JC, Sugawara T, Fujimura M, Chan PH (2001) Matrix metalloproteinase inhibition prevents oxidative stress-associated blood-brain barrier disruption after transient focal cerebral ischemia. J Cereb Blood Flow Metab 21:1393-400
9. Helbock HJ, Beckman KB, Ames BN (1999) 8-Hydroxy-deoxyguanosine and 8-hydroxyguanine as biomarkers of oxidative DNA damage. Methods Enzymol 300:156-166
10. Jamieson D, Chance B, Cadenas E, Boveris A (1986) The relation of free radical production to hyperoxia. Annu Rev Physiol 48:703-19
11. Kim HY, Singhal AB, Lo EH (2005) Normobaric hyperoxia extends the reperfusion window in focal cerebral ischemia. Ann Neurol 57:571-5
12. Koizumi J, Yoshida Y, Nakazawa T, Ooneda G (1986) Experimental studies of ischemic brain edema, I: a new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Jpn J Stroke 8:1-8
13. Lehrmann E, Christensen T, Zimmer J, Diemer NH, Finsen B (1997) Microglial and macrophage reactions mark progressive changes and define the penumbra in the rat neocortex and striatum after transient middle cerebral artery occlusion. J Comp Neurol 386:461-76
14. Li Y, Kawamura S, Shirasawa M, Yasui N, Fukasawa H (1994) Failure of normobaric oxygen therapy to reduce ischemic brain damage in rats. Undersea Hyperb Med 21:245-9
15. Liu S, Connor J, Peterson S, Shuttleworth CW, Liu KJ (2002) Direct visualization of trapped erythrocytes in rat brain after focal ischemia and reperfusion. J Cereb Blood Flow Metab 22:1222-30
16. Liu S, Shi H, Liu W, Furuichi T, Timmins GS, Liu KJ (2004) Interstitial pO2 in ischemic penumbra and core are differentially affected following transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab 24:343-9
17. McCoy CL, McIntyre DJ, Robinson SP, Aboagye EO, Griffiths JR (1996) Magnetic resonance spectroscopy and imaging methods for measuring tumour and tissue oxygenation. Br J Cancer Suppl 27:S226-S231
18. Morita-Fujimura Y, Fujimura M, Yoshimoto T, Chan PH (2001) Superoxide during reperfusion contributes to caspase-8 expression and apoptosis after transient focal stroke. Stroke 32:2356-61
19. Murakami K, Kondo T, Kawase M, Li Y, Sato S, Chen SF, Chan PH (1998) Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency. J Neurosci 18:205-13
20. Narkowicz CK, Vial JH, McCartney PW (1993) Hyperbaric oxygen therapy increases free radical levels in the blood of humans. Free Radical Res Commun 19:71-80
21. Planas AM, Sole S, Justicia C (2001) Expression and activation of matrix metalloproteinase-2 and -9 in rat brain after transient focal cerebral ischemia. Neurobiol Dis 8:834-46
22. Rogers DC, Campbell CA, Stretton JL, Mackay KB (1997) Correlation between motor impairment and infarct volume after permanent and transient middle cerebral artery occlusion in the rat. Stroke 28:2060-5; discussion 2066
23. Roos JA, Jackson-Friedman C, Lyden P (1998) Effects of hyperbaric oxygen on neurologic outcome for cerebral ischemia in rats. Acad Emerg Med 5:18-24
24. Rusyniak DE, Kirk MA, May JD, Kao LW, Brizendine EJ, Welch JL, Cordell WH, Alonso RJ (2003) Hyperbaric oxygen therapy in acute ischemic stroke: results of the Hyperbaric Oxygen in Acute Ischemic Stroke Trial Pilot Study. Stroke 34:571-4
25. Singhal AB, Dijkhuizen RM, Rosen BR, Lo EH (2002a) Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke. Neurology 58:945-52
26. Singhal AB, Wang X, Sumii T, Mori T, Lo EH (2002b) Effects of normobaric hyperoxia in a rat model of focal cerebral ischemia-reperfusion. J Cereb Blood Flow Metab 22:861-8
27. Singhal AB, Benner T, Roccatagliata L, Koroshetz WJ, Schaefer PW, Lo EH, Buonanno FS, Gonzalez RG, Sorensen AG (2005) A pilot study of normobaric oxygen therapy in acute ischemic stroke. Stroke 36:797-802
28. Sugo N, Hurn PD, Morahan MB, Hattori K, Traystman RJ, DeVries AC (2002) Social stress exacerbates focal cerebral ischemia in mice. Stroke 33:1660-4
29. Sugawara T, Yu F, Ma L, Hsia CJ, Chan PH (2001) Delayed treatment with polynitroxyl albumin reduces infarct size after stroke in rats. Neuroreport 12:3609-12
30. Westermaier T, Hungerhuber E, Zausinger S, Baethmann A, Schmid-Elsaesser R (2003) Neuroprotective efficacy of intra-arterial and intravenous magnesium sulfate in a rat model of transient focal cerebral ischemia. Acta Neurochir (Wien) 145:393-9