Involvement of free radicals in cerebral vascular reperfusion injury evaluated in a transient focal cerebral ischemia model of rat

Free Radical Biology and Medicine

Volumn 26, Issue 5-6, 1999, Pages 722-729

  Nakashima, Masaya ^a   Niwa, Masayuki ^a   Iwai, Tomohiko ^b   Uematsu, Toshihiko ^a  

^a GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b ASAHI UNIVERSITY   (Japan)

Author keywords

Fisher 344; Free radicals; Ischemia; MCA occlusion; Nitric oxide; Reperfusion brain injury; Wistar

Indexed keywords

FREE RADICAL; HYDROXYL RADICAL; N TERT BUTYL ALPHA PHENYLNITRONE; NORPHENAZONE; OXIPURINOL; SCAVENGER; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTERY OCCLUSION; ARTICLE; BRAIN INFARCTION; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MIDDLE CEREBRAL ARTERY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SPIN TRAPPING; STRAIN DIFFERENCE;

ANIMALS; ANTIPYRINE; BRAIN; CAUDATE NUCLEUS; CEREBRAL INFARCTION; DISEASE MODELS, ANIMAL; FREE RADICAL SCAVENGERS; FREE RADICALS; HIPPOCAMPUS; ISCHEMIC ATTACK, TRANSIENT; MALE; NITROARGININE; NITROGEN OXIDES; PUTAMEN; RATS; RATS, INBRED F344; RATS, WISTAR; REPERFUSION INJURY; SPIN LABELS; SUPERIOR COLLICULUS;

ANIMALIA; MARTES PENNANTI;

EID: 0032972451     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(98)00257-3     Document Type: Article

References (45)

1. Siesjo B.K. Pathophysiology and treatment of focal cerebral ischemia Part II Mechanisms of damage and treatment . J. Neurosurg. 77:1992;337-354.
2. Floyd R.A. Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J. 4:1990;2587-2597.
3. Clough-Helfman C., Phillis J.W. The free radical trapping agent N-tert.-butyl-α-phenylnitrone (PBN) attenuates cerebral ischemic injury in gerbils. Free Radic. Res. Commun. 15:1991;177-186.
4. Pahlmark K., Siesjo B.K. Effects of the spin trap-α-phenyl-N-tert-butyl nitrone (PBN) in transient forebrain ischaemia in the rat. Acta Physiol. Scand. 157:1996;41-51.
5. Cao X., Phillis J.W. alpha-Phenyl-tert-butyl-nitrone reduces cortical infarct and edema in rats subjected to focal ischemia. Brain Res. 644:1994;267-272.
6. Zhao Q., Pahlmark K., Smith M.L., Siesjo B.K. Delayed treatment with the spin trap α-phenyl-N-tert-butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats. Acta Physiol. Scand. 152:1994;349-350.
7. Molinari G.F., Laurent J.P. A classification of experimental models of brain ischemia. Stroke. 7:1976;14-17.
8. Garcia J.H. Experimental ischemic stroke a review . Stroke. 15:1984;5-14.
9. Brint S., Jacewicz M., Kiessling M., Tanabe J., Pulsinelli W. Focal brain ischemia in the rat Methods for reproducible neocortical infarction using tandem occlusion of the distal middle cerebral and ipsilateral common carotid arteries . J. Cereb. Blood Flow Metab. 8:1988;474-485.
10. Duverger D., MacKenzie E.T. The quantification of cerebral infarction following focal ischemia in the rat influence of strain, arterial pressure, blood glucose concentration, and age . J. Cereb. Blood Flow Metab. 8:1988;449-461.
11. Watanabe T., Morita I., Nishi H., Murota S. Preventive effect of MCI-186 on 15-HPETE induced vascular endothelial cell injury in vitro. Prostaglandins Leukot. Essent. Fatty Acids. 33:1988;81-87.
12. Murota S., Morita I., Suda N. The control of vascular endothelial cell injury. Ann. N. Y. Acad. Sci. 598:1990;182-187.
13. Kawai H., Nakai H., Suga M., Yuki S., Watanabe T., Saito K.I. Effects of a novel free radical scavenger, MCl-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model. J. Pharmacol. Exp. Ther. 281:1997;921-927.
14. Koizumi J., Yoshida Y., Nakazawa T., Ooneda G. Experimental studies of ischemic brain edema. 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Jpn. J. Stroke. 8:1986;1-8.
15. Isayama K., Pitts L.H., Nishimura M.C. Evaluation of 2,3,5-triphenyltetrazolium chrolide staining to delineate rat brain infarcts. Stroke. 22:1991;1394-1398.
16. Coyle P., Odenheimer D.J., Sing C.F. Cerebral infarction after middle cerebral artery occlusion in progenies of spontaneously stroke-prone and normal rats. Stroke. 15:1984;711-716.
17. Brown J.O. The morphology of circulus arteriosus cerebri in rats. Anat. Rec. 156:1966;99-106.
18. Oliver C.N., Starke-Reed P.E., Stadtman E.R., Liu G.J., Carney J.M., Floyd R.A. Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/ reperfusion-induced injury to gerbil brain. Proc. Natl. Acad. Sci. 87:1990;5144-5147.
19. Cao W., Carney J.M., Duchon A., Floyd R.A., Chevion M. Oxygen free radical involvement in ischemia and reperfusion injury to brain. Neurosci. Lett. 88:1988;233-238.
20. Morimoto T., Globus M.Y., Busto R., Martinez E., Ginsberg M.D. Simultaneous measurement of salicylate hydroxylation and glutamate release in the penumbral cortex following transient middle cerebral artery occlusion in rats. J. Cereb. Blood Flow Metab. 16:1996;92-99.
21. Watanabe T., Yuki S., Egawa M., Nishi H. Protective effects of MCI-186 on cerebral ischemia Possible involvement of free radical scavenging and antioxidant actions . J. Pharmacol. Exp. Ther. 268:1994;1597-1604.
22. Nishi H., Watanabe T., Sakurai H., Yuki S., Ishibashi A. Effect of MCI-186 on brain edema in rats. Stroke. 20:1989;1236-1240.
23. Abe K., Yuki S., Kogure K. Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger. Stroke. 19:1988;480-485.
24. McCord J.M. Oxygen-derived free radicals in postischemic tissue injury. N. Engl. J. Med. 312:1985;159-163.
25. Lin Y., Phillis J.W. Oxypurinol reduces focal ischemic brain injury in the rat. Neurosci. Lett. 126:1991;187-190.
26. Lin Y., Phillis J.W. Deoxycoformycin and oxypurinol Protection against focal ischemic brain injury in the rat . Brain Res. 571:1992;272-280.
27. Betz A.L., Randall J., Martz D. Xanthine oxidase is not a major source of free radicals in focal cerebral. Am. J. Physiol. 260:1991;H563-H568.
28. Moorhouse P.C., Grootveld M., Halliwell B., Quinlan J.G., Gutteridge J.M. Allopurinol and oxypurinol are hydroxyl radical scavengers. FEBS Letters. 213:1987;23-28.
29. Downey J.M., Miura T., Eddy L.J., Chambers D.E., Mellert T., Hearse D.J., Yellon D.M. Xanthine oxidase is not a source of free radicals in the ischemic rabbit heart. J. Mol. Cell. Cardiol. 19:1987;1053-1060.
30. Godin D.V., Bhimji S. Effects of allopurinol on myocardial ischemic injury induced by coronary artery ligation and reperfusion. Biochem. Pharmacol. 36:1987;2101-2107.
31. Moncada S., Palmer R.M., Higgs E.A. Nitric oxide physiology, pathophysiology, and pharmacology . Pharmacol. Rev. 43:1991;109-142.
32. Kohno K., Niwa M., Nozaki M., Uematsu T., Fujimura H. Role of nitric oxide in the convulsive seizures induced by fluoroquinolones coadministered with 4-biphenyl acetic acid. Gen. Pharmacol. 29:1997;767-770.
33. Akter U., Niwa M., Nose T., Kaida T., Matsuno H., Kozawa O., Uematsu T. Effects of several agents on UVB- and UVA plus systemic fluoroquinolone-induced erythema of guinea pig skin evaluated by reflectance colorimetry. Free Radic. Biol. Med. 24:1998;1113-1119.
34. Garthwaite J., Charles S.L., Chess-Williams R. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature. 336:1988;385-388.
35. Garthwaite J. Neural nitric oxide signalling. Trends Neurosci. 18:1995;51-52.
36. Choi D.W., Koh J.Y., Peters S. Pharmacology of glutamate neurotoxicity in cortical cell culture attenuation by NMDA antagonists . J. Neurosci. 8:1988;185-196.
37. Meldrum B.S., Evans M.C., Swan J.H., Simon R.P. Protection against hypoxic/ischaemic brain damage with excitatory amino acid antagonists. Med. Biol. 65:1987;153-157.
38. Beckman J.S., Beckman T.W., Chen J., Marshall P.A., Freeman B.A. Apparent hydroxyl radical production by peroxynitrite Implications for endothelial injury from nitric oxide and superoxide . Proc. Natl. Acad. Sci. 87:1990;1620-1624.
39. Oh S.M., Betz A.L. Interaction between free radicals and excitatory amino acids in the formation of ischemic brain edema in rats. Stroke. 22:1991;915-921.
40. Nowicki J.P., Duval D., Poignet H., Scatton B. Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse. Eur. J. Pharmacol. 204:1991;339-340.
41. Buisson A., Plotkine M., Boulu R.G. The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischaemia. Br. J. Pharmacol. 106:1992;766-767.
42. Weissman B.A., Kadar T., Brandeis R., Shapira S. NG-nitro-L-arginine enhances neuronal death following transient forebrain ischemia in gerbils. Neurosci. Lett. 146:1992;139-142.
43. Yamamoto S., Golanov E.V., Berger S.B., Reis D.J. Inhibition of nitric oxide synthesis increases focal ischemic infarction in rat. J. Cereb. Blood Flow Metab. 12:1992;717-726.
44. Dawson D.A., Kusumoto K., Graham D.I., McCulloch J., Macrae I.M. Inhibition of nitric oxide synthesis does not reduce infarct volume in a rat model of focal cerebral ischaemia. Neurosci. Lett. 142:1992;151-154.
45. Samdani A.F., Dawson T.M., Dawson V.L. Nitric oxidesynthase in models of focal ischemia. Stroke. 28:1997;1283-1288.