Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency

Journal of Neuroscience

Volumn 18, Issue 1, 1998, Pages 205-213

  Murakami, Kensuke ^a   Kondo, Takeo ^a   Kawase, Makoto ^a,b   Li, Yibing ^a   Sato, Shuzo ^a   Chen, Sylvia F ^a   Chan, Pak H ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

Cerebral ischemia; DNA fragmentation; Manganese superoxide dismutase; Mitochondrial injury; Oxidative stress; Superoxide anion

Indexed keywords

FREE RADICAL; MANGANESE SUPEROXIDE DISMUTASE; OXYGEN RADICAL; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN MITOCHONDRION; CONTROLLED STUDY; DNA DEGRADATION; ENZYME DEFICIENCY; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

EID: 0031974368     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-01-00205.1998     Document Type: Article

References (12)

1. Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA, Nicotera P (1995) Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15:961-973.
2. Barone FC, Knudsen DJ, Nelson AH, Feuerstein GZ, Willette RN (1993) Mouse strain differences in susceptibility to cerebral ischemia are related to cerebral vascular anatomy. J Cereb Blood Flow Metab 13:683-692.
3. Bindokas VP, Jordan J, Lee CC, Miller RJ (1996) Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine. J Neurosci 16:1324-1336.
4. Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton SA (1995) Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/ Superoxide in cortical cell cultures. Proc Natl Acad Sci USA 92:7162-7166.
5. Chan PH, Kamii H, Yang G, Gafni J, Epstein CJ, Carlson E, Reola L (1993) Brain infarction is not reduced in SOD-1 transgenic mice after a permanent focal cerebral ischemia. NeuroReport 5:293-296.
6. Dugan LL, Sensi SL, Canzoniero LM, Handran SD, Rothman SM, Lin TS, Goldberg MP, Choi DW (1995) Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate. J Neurosci 15:6377-6388.
7. Greenlund LJ, Deckwerth TL, Johnson Jr EM (1995) Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death. Neuron 14:303-315.
8. Hillered L, Chan PH (1989) Brain mitochondrial swelling induced by arachidonic acid and other long chain free fatty acids. J Neurosci Res 24:247-250.
9. Johnson LV, Walsh ML, Bockus BJ, Lan BC (1981) Monitoring of relative mitochondrial membrane potential in living cell by fluorescence microscopy. J Cell Biol 88:526-535.
10. Kane DJ, Sarafian TA, Anton R, Hahn H, Gralla EB, Valentine JS, Ord T, Bredesen DE (1993) Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 262:1274-1277.
11. Kinouchi H, Epstein CJ, Mizui T, Carlson E, Chen SF, Chan PH (1991) Attenuation of focal cerebral ischemic injury in transgenic mice over-expressing CuZn Superoxide dismutase. Proc Natl Acad Sci USA 88:11158-11162.
12. Kondo T, Li Y, Sato S, Murakami K, Copin J-C, Huang T-T, Epstein CJ, Chan PH (1997a) Subcellular localization of Superoxide anions following focal cerebral ischemia and reperfusion. J Cereb Blood Flow Metab [Suppl] 17:5102.