Role of peroxynitrite and neuronal nitric oxide synthase in the activation of poly(ADP-ribose) synthetase in a murine model of cerebral ischemia-reperfusion

Neuroscience Letters

Volumn 248, Issue 1, 1998, Pages 41-44

  Endres, Matthias ^a   Scott, Gwen ^b   Namura, Shobu ^a   Salzman, Andrew L ^b   Huang, Paul L ^a   Moskowitz, Michael A ^a   Szabó, Csaba ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Cerebral ischemia; Neuronal nitric oxide synthase; Peroxynitrite; Poly(ADP ribose) synthetase; Reperfusion

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BRAIN ISCHEMIA; CELL VIABILITY; ENZYME ACTIVATION; ENZYME ACTIVITY; MOUSE; NERVE CELL LESION; NEUROTOXICITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REPERFUSION INJURY;

ANIMALS; BRAIN ISCHEMIA; ENZYME ACTIVATION; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; NEURONS; NITRATES; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; OXIDANTS; POLY(ADP-RIBOSE) POLYMERASES; REPERFUSION INJURY;

EID: 0032557410     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00224-9     Document Type: Article

References (21)

1. Beckman J.S., Ye Y.Z., Chen J., Conger K.A. The interaction of nitric oxide with oxygen radicals and scavengers in cerebral ischemic injury. Adv. Neurol. 71:1996;339-350.
2. Choi D.W. Glutamate neurotoxocity and diseases of the nervous system. Neuron. 1:1988;623-634.
3. Dalkara T., Moskowitz M.A. Neurotoxic and neuroprotective roles of nitric oxide in cerebral ischemia. Int. Rev. Neurobiol. 40:1997;319-336.
4. Dawson V.L., Kizushi V.M., Huang P.L., Synder S.H., Dawson T.M. Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide deficient mice. J. Neurosci. 16:1996;2479-2487.
5. Eliasson M.J.L., Sampei K., Mandir A.S., Hurn P.D., Traystman R.J., Bao J., Wang Z.-Q., Dawson T.M., Snyder S., Dawson V.L. Poly(ADP-ribose)polymerase gene disruption renders mice resistant to cerebral ischemia. Nat. Med. 3:1997;1089-1095.
6. Endres M., Wang Z.-Q., Namura S., Waeber C., Moskowitz M.A. Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase. J. Cereb. Blood Flow Metab. 17:1997;1143-1151.
7. Hara H., Huang P.L., Panahian N., Fishman M.C., Moskowitz M.A. Reduced brain edema and infarction volume in mice lacking the neuronal isoform of nitric oxide synthase after transient MCA occlusion. J. Cereb. Blood Flow Metab. 16:1996;605-611.
8. Huang Z., Huang P.L., Panahian N., Dalkara T., Fishman M.C., Moskowitz M.A. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science. 265:1994;1883-1885.
9. Ikai K., Ueda K., Hayashi O. Immunohistochemical demonstration of poly(adenosine diphosphate-ribose) in nuclei of various rat tissues. J. Histochem. Cytochem. 28:1980;670-676.
10. Kano T., Shimizu-Sasamata M., Huang P.L., Fishman M.C., Moskowitz M.A., Lo E.H. Nitric oxide as an amplifier of neurotransmitter release in vivo: differential effects on glutamatergic vs gabaergic systems after NO synthase gene knockout. J. Cereb. Blood Flow Metab. 17(Suppl. 1):1997;S387.
11. Kennedy M., Szabó C., Salzman A.L. Activation of polyADP ribosyl synthetase (PARS) mediates cytotoxicity induced by peroxynitrite in human intestinal epithelial cells. Gastroenterology. 114:1998;510-518.
12. Malinski T., Bailey F., Zhang Z.G., Chopp M. Nitric oxide measured by a porphyrinic microsensor in rat brain after transient middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 13:1993;355-358.
13. + content, and p53 accumulation. Arch. Biochem. Biophys. 327:1996;1-10.
14. Szabó C. DNA strand breakage and activation of poly-ADP ribosyltransferase: a cytotoxic pathway triggered by peroxynitrite. Free Radic. Biol. Med. 21:1996;855-869.
15. Szabó C., Cuzzocrea S., Zingarelli B., O'Connor M., Salzman A.L. Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite. J. Clin Invest. 100:1997;723-735.
16. Szabó C., Wong H.R., Bauer P.I., Kirsten E., O'Connor M., Zingarelli B., Mendeleyev J., Hasko G., Vizi E.S., Salzman A.L., Kun E. Regulation of components of the inflammatory response by 5-iodo-6amino-1,2,-benzopyrone, and inhibitor of poly (ADP-ribose) synthetase and pleiotropic modifier of cellular signal pathways. Int. J. Oncol. 10:1997;1093-1101.
17. Szabó C., Zingarelli B., O'Connor M., Salzman A.L. DNA strand breakage activation of poly-ADP ribosyl synthetase, and cellular energy depletion are involved in the cycotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite. Proc. Natl. Acad. Sci. USA. 93:1996;1753-1758.
18. Tamir S., Burney S., Tannenbaum S.R. DNA damage by nitric oxide. Chem. Res. Toxicol. 9:1996;821-827.
19. Zhang J., Dawson V. L, Dawson T.M., Snyder S.H. Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. Science. 263:1994;687-689.
20. Zhang F., Casey R.M., Ross M.E., Iadecola C. Aminoguanidine ameliorates and L-arginine worsens brain damage from intraluminal middle cerebral artery occlusion. Stroke. 27:1996;317-323.
21. Zimmerman M. Ethical principles for the maintenance and use of animals in neuroscience research. Neurosci. Lett. 73:1987;1.