Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats

British Journal of Pharmacology

Volumn 137, Issue 6, 2002, Pages 761-770

  Chiarugi, Alberto ^a,b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

AP 1; Autoimmunity; Multiple sclerosis; NF B; PARP

Indexed keywords

6(5H) PHENANTHRIDINONE; ADENOSINE TRIPHOSPHATE; BENZAMIDE; BENZOIC ACID; CYCLOOXYGENASE 2; CYTOKINE; DNA; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NITRIC OXIDE SYNTHASE; PHENANTHRIDINE DERIVATIVE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVITY; GENOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSCRIPTION INITIATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; BENZAMIDES; BENZOIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; INTERFERON TYPE II; INTERLEUKIN-2; LYMPH NODES; LYMPHOCYTES; NAD; PHENANTHRENES; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, INBRED LEW; RNA, MESSENGER; SPINAL CORD; TIME FACTORS; TRANS-ACTIVATION (GENETICS); TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036855413     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704934     Document Type: Article

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