p53-dependent apoptosis suppresses radiation-induced teratogenesis

Nature Medicine

Volumn 2, Issue 5, 1996, Pages 577-580

  Norimura, Toshiyuki ^a   Nomoto, Satoshi ^a   Katsuki, Motoya ^b   Gondo, Yoichi ^b   Kondo, Sohei ^c  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c KINKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CONGENITAL MALFORMATION; EMBRYO; FETUS; FETUS DEATH; MOUSE; NONHUMAN; PRIORITY JOURNAL; TERATOGENESIS;

ANIMALS; APOPTOSIS; EMBRYO; FETAL DEATH; LIMB DEFORMITIES, CONGENITAL; MICE; MICE, TRANSGENIC; NEURAL TUBE DEFECTS; TUMOR SUPPRESSOR PROTEIN P53; X-RAYS;

EID: 0029874308     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0596-577     Document Type: Article

References (23)

1. Gilbert, S.F. Development Biology, 3rd edn. 193-197 (Sinauer Assoc., Sunderland, Massachusetts, 1991).
2. Boué, A., Boué, J. & Gropp, A. Cytogenetics of pregnancy wastage. Adv. Hum. Genet. 14, 1-57 (1985).
3. McKeown, T. Human malformations: Introduction. Br. Med. Bull. 32, 1-3 (1976).
4. Ziegler, A. et al. Sunburn and p53 in the onset of skin cancer. Nature 372, 773-776 (1994).
5. Russell, L.B. & Russell, W.L. An analysis of the changing radiation response of the developing mouse embryo. J. Cell. Comp. Physiol. 43 (suppl. 1), 103-149 (195-4).
6. Mole, R.H. Expectation of malformations after irradiation of the developing human in utero: The experimental basis for predictions. Adv. Radiat. Biol. 15, 217-301 (1992).
7. Nomura, T. High sensitivity of fertilized eggs to radiation and chemicals in mice: Comparison with that of germ cells and embryos at organogenesis. Congenital Anom. 24, 329-337 (1984).
8. Kondo, S. Health Effects of Low-level Radiation, 73-92 (Kinki University Press, Osaka, Japan & Medical Physics Publishing, Madison, Wisconsin, 1993).
9. Lowe, S.W., Schmitt, E.M., Smith, S.W., Osborne, B.A. & Jacks, T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362, 847-849 (1993).
10. Clarke, A.R. et al Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362, 849-852 (1993).
11. Merritt, A.J. et al. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res. 54, 614-617 (1994).
12. Gondo, Y. et al. Gene replacement of the p53 gene with the lacZ gene in mouse embryonic stem cells and mice by using two steps of homologous recombination. Biochem. Biophys. Res. Commun. 202, 830-837 (1994).
13. Armstrong, J.F., Kaufman, M.H., Harrison, D.J. & Clarke, A.R. High-frequency developmental abnormalities in p53-deficient mice. Current Biol. 5, 931-936 (1995).
14. Sah, V.P. et al. A subset of p53-deficient embryos exhibit exencephaly. Nature Genet. 10, 175-180 (1995).
15. Nicol, C.J., Harrison, M.L., Laposa, R.R., Gimelshtein, I.L. & Wells, P.G. A teratologic suppressor role for p53 in benzo[a]pyrene-treated transgenic p53-deficient mice. Nature Genet. 10, 181-187 (1995).
16. Kondo, S. Altruistic cell suicide in relation to radiation hormesis. Int. J. Radiat. Biol. 53, 95-102 (1988).
17. Kondo, S. et al. The threshold effect in mutagenesis by radiation and chemicals in relation to DNA repair and cell replacement repair. in Problems of Threshold in Chemical Mutagenesis (eds. Tazima, Y. et al.) 121-131 (Environmental Mutagen Society of Japan, Mishima, 1984).
18. Fukunaga, A. & Kondo, S. Evidence for cell-replacement repair of X-ray-induced teratogenic damage in male genital imaginal discs of Drosophila melanogaster. Mutat. Res. 151, 243-250 (1985).
19. Miyashita, T. & Reed, J.C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80, 293-299 (1995).
20. Lane, D.P. p53, guardian of the genome. Nature 358, 15-16 (1992).
21. Nomura, T., Hata, S. & Kusafuka, T. Suppression of developmental anomalies by maternal macrophages in mice. J. Exp. Med. 172, 1325-1330 (1990).
22. Nomura, T. Transmission of tumors and malformations to the next generation of mice subsequent to urethan treatment. Cancer Res. 35, 264-266 (1975).
23. Gavrieli, Y., Sherman, Y. & Ben-Sasson, S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119, 493-501 (1992).