Of flies and men; p53, a tumour suppressor

FEBS Letters

Volumn 567, Issue 1, 2004, Pages 86-91

  Sutcliffe, Josephine E ^a   Brehm, Alexander ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Apoptosis; Cell cycle; DNA repair; Drosophila melanogaster; p53

Indexed keywords

ATM PROTEIN; CALPAIN; CALPASTATIN; CHECKPOINT KINASE 2; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR; HISTONE ACETYLTRANSFERASE PCAF; HISTONE DEACETYLASE; PROTEIN BAX; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; SILENT INFORMATION REGULATOR PROTEIN 2; SUMO PROTEIN;

ACETYLATION; AMINO TERMINAL SEQUENCE; APOPTOSIS; CANCER INHIBITION; CARBOXY TERMINAL SEQUENCE; CELL GROWTH; CELL NUCLEUS; CONFERENCE PAPER; DNA BINDING; DNA REPLICATION; DROSOPHILA; HUMAN; MICROTUBULE; MITOSIS INHIBITION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE; UPREGULATION;

DROSOPHILA; DROSOPHILA MELANOGASTER; GENETTA; MELANOGASTER;

EID: 2542431130     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2004.03.122     Document Type: Conference Paper

References (56)

1. Adams M.D., Celniker S.E., Holt R.A. The genome sequence of Drosophila melanogastor. Science. 287:2000;2185-2195
2. Bernards A., Hariharan I.K. Of flies and men-studying human disease in Drosophila. Curr. Opin. Genet. Dev. 11:2001;274-278
3. Fortini M.E., et al. A survey of human disease gene counterparts in the Drosophila genome. J. Cell Biol. 150:2000;F23-F30
4. Hollstein M., et al. p53 mutations in human cancers. Science. 253:1991;49-53
5. Vousden K.H. p53: death star. Cell. 101:2000;691-694
6. Vousden K.H. Activation of p53 tumour suppressor protein. Biochemia et Biophysica Acta. 1602(47-59):2002
7. Kubbutat M.H., Jones S.N., Vousden K.H. Regulation of p53 stability by MDM2. Nature. 387:1997;299-303
8. Jones S.N., et al. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature. 378:1995;206-208
9. Montes de Oca Luna R., Wagner D.S., Lazono G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature. 378:1995;203-206
10. Benetti R., et al. The death substrate Gas2 binds m-calpain and increases susceptibility to p53-dependent apoptosis. EMBO J. 20:2001;2702-2714
11. Kubbutat M.H., Vousden K.H. Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability. Mol. Cell. Biol. 17:1997;460-468
12. Masdehors P., et al. Deregulation of the ubiquitin system and p53 proteolysis modify the apoptotic response in B-CLL lymphocytes. Blood. 96:2000;269-274
13. Canman C.E., et al. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science. 281:1998;1677-1679
14. Hekmat-Nejad M., et al. Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint. Curr. Biol. 10:2000;1565-1573
15. Yang J., et al. ATM and ATR: sensing DNA damage. World J. Gastroentrol. 10:2004;155-160
16. Bartek J., Lukas J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell. 3:2004;421-429
17. Maya R., et al. ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev. 15:2001;1067-1077
18. Mayo L.D., Turchi J.J., Berberich S.J. Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53. Cancer Res. 57:1997;5013-5016
19. Sionov R.V., et al. c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitination. Mol. Cell. Biol. 21:2001;5869-5878
20. Giannakakou P., et al. p53 is associated with cellular microtubules and is transported to the nucleus by dynein. Nat. Cell. Biol. 2:2000;709-717
21. Stommel J.M., et al. A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J. 18:1999;1660-1672
22. Zhang Y., Xiong Y. A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation. Science. 292:2001;1910-1915
23. Freedman D., Wu L., Levine A.J. Functions of the MDM2 oncoprotein. Cell Mol. Life Sci. 55:1999;96-107
24. Shikama N., et al. A novel coactivator for p300 that regulates the p53 response. Molecular Cell. 4:1999;365-376
25. Samuels-Lev Y., et al. ASPP proteins-specifically stimulate the apoptotic function of p53. Molecular Cell. 8:2001;781-794
26. Appella E., Anderson C.W. Post-translational modifications and activation of p53 by genotoxic stresses. Eur. J. Biochem. 268:2001;2764-2772
27. Keller D.M., et al. A DNA damage - induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. Molecular Cell. 7:2001;283-292
28. Hupp T.R., et al. Regulation of the specific DNA binding function of p53. Cell. 71:1992;875-886
29. Gostissa M., et al. Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1. EMBO J. 18:1999;6462-6471
30. Muller S., et al. c-Jun and p53 activity is modulated by SUMO-1 modification. J. Biol. Chem. 275:2000;13321-13329
31. Rodrigeuz M.S., et al. SUMO-1 modification activates the transcriptional response of p53. EMBO J. 18:1999;6455-6461
32. Gu W., Roeder R.G. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell. 90:1997;595-606
33. Ito A., et al. p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2. EMBO J. 20:2001;1331-1340
34. Liu L., et al. p53 sites acetylated in vitro by PCAF and p300 are acetylated in response to DNA damage. Mol. Cell. Biol. 19:1999;1202-1209
35. Sakaguchi K., et al. DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev. 12:1998;2831-2841
36. Avantaggiati M.L., et al. Recruitment of p300/CBP in p53-dependent signal pathways. Cell. 89:1997;1175-1184
37. Gu W., Shi X.-L., Roeder R.G. Synergistic activation of transcription by CBP and p53. Nature. 387:1997;819-823
38. Lill N.L., et al. Binding and modulation of p53 by p300/CBP coactivators. Nature. 387:1997;823-827
39. Luo J., et al. Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. PNAS. 101:2004;2259-2264
40. Barlev N.A., et al. Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases. Molecular Cell. 8:2001;1243-1254
41. Espinosa J.M., Emerson B.M. Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment. Molecular Cell. 8:2001;57-69
42. Mujtaba S., et al. Structural mechanism of bromodomain of the coactivator CBP in p53 transcriptional activation. Molecular Cell. 13:2004;251-263
43. Luo J., et al. Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature. 408:2000;377-381
44. Ito A., et al. MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. EMBO J. 21:2002;6236-6245
45. Langley E., et al. Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J. 21:2002;2383-2396
46. Brodsky M.H., et al. Drosophila p53 binds to damage response element at the reaper locus. Cell. 101:2000;103-113
47. Jin S., et al. Identification and characterization of a p53 homologue in Drosophila melanogaster. PNAS. 97(13):2000;7301-7306
48. Ollman M., et al. Drosophila p53 is a structural and functional homolog of the tumour suppressor p53. Cell. 101:2000;91-101
49. Lee J.H., et al. In vivo p53 function is indispensable for DNA damage-induced apoptotic signaling in Drosophila. FEBS. 550:2003;5-10
50. Sogame N., Kim M., Abrams J.M. Drosophila p53 preserves genomic stability by regulating cell death. PNAS. 100(8):2003;4696-4701
51. Jassim O.W., Fink J.L., Cagan R.L. Dmp53 protects the Drosophila retina during a developmentally regulated DNA damage response. EMBO J. 22(20):2003;5622-5623
52. Folberg-Blum A., et al. Overexpression of mouse Mdm2 induces developmental phenotypes in Drosophila. Oncogene. 21:2002;2413-2417
53. Xu J., Xin S., Du W. Drosophila Chk2 is required for DNA damage-mediated cell cycle arrest and apoptosis. FEBS Lett. 508:2001;394-398
54. Peters M., et al. Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila. PNAS. 99(17):2002;11305-11310
55. Brodsky M.H., et al. Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage. Mol. Cell. Biol. 24(3):2004;1219-1231
56. Derry W.B., Putzke A.P., Rothman J.H. Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance. Science. 294:2001;591-595