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Volumn 28, Issue 3, 1996, Pages 255-258

New insights into the genetics of Alzheimer's disease

Author keywords

Alzheimer's disease; Amyloid; Apolipoprotein E; APP; Genetics; Presenilin 1; Presenilin 2

Indexed keywords

AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E;

EID: 0029945015     PISSN: 07853890     EISSN: None     Source Type: Journal    
DOI: 10.3109/07853899609033127     Document Type: Short Survey
Times cited : (64)

References (38)
  • 1
    • 0027442581 scopus 로고
    • Heterogeneity in Alzeimer's Disease
    • Hardy J, Duff K. Heterogeneity in Alzeimer's Disease. Ann Med 1993; 25: 437-40.
    • (1993) Ann Med , vol.25 , pp. 437-440
    • Hardy, J.1    Duff, K.2
  • 2
    • 0028322017 scopus 로고
    • An increased percentage of long amyloid beta-protein secreted by familial amyloid beta-protein precursor (APP717) mutants
    • Suzuki N, Cheung TT, Xai XD, et al. An increased percentage of long amyloid beta-protein secreted by familial amyloid beta-protein precursor (APP717) mutants. Science 1994; 264: 1336-40.
    • (1994) Science , vol.264 , pp. 1336-1340
    • Suzuki, N.1    Cheung, T.T.2    Xai, X.D.3
  • 3
    • 0028246308 scopus 로고
    • Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid β-protein precursor
    • Haass C, Hung AY, Selkoe DJ, Teplow DB. Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid β-protein precursor. J Biol Chem. 1994; 269: 17741-8.
    • (1994) J Biol Chem. , vol.269 , pp. 17741-17748
    • Haass, C.1    Hung, A.Y.2    Selkoe, D.J.3    Teplow, D.B.4
  • 4
    • 0027194791 scopus 로고
    • Gene dose of Apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    • Corder EH, Saunders AM, Strittmatter WJ, et al. Gene dose of Apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993; 261: 921-3.
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3
  • 5
    • 0029004341 scopus 로고
    • Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
    • Sherrington R, Roagaev EI, Liang Y, et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 1995; 375: 754-60.
    • (1995) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1    Roagaev, E.I.2    Liang, Y.3
  • 6
    • 0029087026 scopus 로고
    • Candidate locus for the chromosome 1 familial Alzheimer's disease locus
    • Levy-Lahad E, Wasco W, Wijsman E, et al. Candidate locus for the chromosome 1 familial Alzheimer's disease locus. Science 1995; 268: 973-7.
    • (1995) Science , vol.268 , pp. 973-977
    • Levy-Lahad, E.1    Wasco, W.2    Wijsman, E.3
  • 7
    • 0025826774 scopus 로고
    • Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesions
    • Poirier J, Hess M, May P, Finch CE. Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesions. Mol Brain Res 1991; 11: 97-106.
    • (1991) Mol Brain Res , vol.11 , pp. 97-106
    • Poirier, J.1    Hess, M.2    May, P.3    Finch, C.E.4
  • 8
    • 0025971426 scopus 로고
    • Apolipoprotein E immunoreactivity in cerebral deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creuzfeldt-Jakob disease
    • Namba Y, Tomonaga M, Kawasaki H, Otono E, Ikeda K. Apolipoprotein E immunoreactivity in cerebral deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creuzfeldt-Jakob disease. Brain Res 1991; 541: 163-6.
    • (1991) Brain Res , vol.541 , pp. 163-166
    • Namba, Y.1    Tomonaga, M.2    Kawasaki, H.3    Otono, E.4    Ikeda, K.5
  • 9
    • 0026542786 scopus 로고
    • Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid
    • Wisniewski T, Frangione B. Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid. Neurosci Lett 1993; 135: 235-9.
    • (1993) Neurosci Lett , vol.135 , pp. 235-239
    • Wisniewski, T.1    Frangione, B.2
  • 10
    • 0023090682 scopus 로고
    • Association of an apolipoprotein CII allele with familial dementia of the Alzheimer type
    • Schellenberg GD, Deeb SS, Boehnke M, et al. Association of an apolipoprotein CII allele with familial dementia of the Alzheimer type. J Neurogenet 1987; 4: 97-108.
    • (1987) J Neurogenet , vol.4 , pp. 97-108
    • Schellenberg, G.D.1    Deeb, S.S.2    Boehnke, M.3
  • 11
    • 0027407565 scopus 로고
    • Apolipoprotein E: High avidity binding to beta-amyloid and increased frequency of type 4 allele in late onset familial Alzheimer's disease
    • Strittmatter WJ, Saunders AM, Schmechel D, et al. Apolipoprotein E: high avidity binding to beta-amyloid and increased frequency of type 4 allele in late onset familial Alzheimer's disease. Proc Natl Acad Sci USA 1993; 90: 1977-81.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 1977-1981
    • Strittmatter, W.J.1    Saunders, A.M.2    Schmechel, D.3
  • 12
    • 0028167740 scopus 로고
    • Association of apolipoprotein E phenotypes with last onset Alzheimer's disease: Population based study
    • Kuusisto J, Koivisto K, Kervinen K, et al. Association of apolipoprotein E phenotypes with last onset Alzheimer's disease: population based study. BMJ 1994; 309: 636-8.
    • (1994) BMJ , vol.309 , pp. 636-638
    • Kuusisto, J.1    Koivisto, K.2    Kervinen, K.3
  • 13
    • 0028340614 scopus 로고
    • Confirmation that familial clustering and age of onset in late onset Alzheimer's disease are determined at the ApoE locus
    • Houlden H, Crook R, Hardy J, Roques P, Collinge J, Rossor M. Confirmation that familial clustering and age of onset in late onset Alzheimer's disease are determined at the ApoE locus. Neurosci Lett 1994; 174: 222-4.
    • (1994) Neurosci Lett , vol.174 , pp. 222-224
    • Houlden, H.1    Crook, R.2    Hardy, J.3    Roques, P.4    Collinge, J.5    Rossor, M.6
  • 14
    • 0027203749 scopus 로고
    • ApoE genotype and Alzheimer's disease
    • Houlden H, Collinge J, Kennedy A, et al. ApoE genotype and Alzheimer's disease. Lancet 1993; 342: 737-8.
    • (1993) Lancet , vol.342 , pp. 737-738
    • Houlden, H.1    Collinge, J.2    Kennedy, A.3
  • 15
    • 0028350675 scopus 로고
    • ApoE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's disease
    • Van Broeckhoven C, Backhovens H, Cruts M, et al. ApoE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's disease. Neurosci Lett 1994; 169: 179-80.
    • (1994) Neurosci Lett , vol.169 , pp. 179-180
    • Van Broeckhoven, C.1    Backhovens, H.2    Cruts, M.3
  • 16
    • 0028670363 scopus 로고
    • Apolipoprotein Eε2 allele promotes longevity and protects patients with Down's syndrome from the development of dementia
    • Royston MC, Mann D, Pickering-Brown S, et al. Apolipoprotein Eε2 allele promotes longevity and protects patients with Down's syndrome from the development of dementia. Neuroreport 1994; 5: 2583-95.
    • (1994) Neuroreport , vol.5 , pp. 2583-2595
    • Royston, M.C.1    Mann, D.2    Pickering-Brown, S.3
  • 17
    • 0028178047 scopus 로고
    • Apolipoprotein E, ε4 allele as a major risk factor for sporadic early and late onset forms of Alzheimer's disease: Analysis of the 19q13.2 chromosomal region
    • Chartier MC, Harlin MC, Parfitt M, et al. Apolipoprotein E, ε4 allele as a major risk factor for sporadic early and late onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region. Hum Mol Genet 1994; 3: 569-74.
    • (1994) Hum Mol Genet , vol.3 , pp. 569-574
    • Chartier, M.C.1    Harlin, M.C.2    Parfitt, M.3
  • 19
    • 0028816355 scopus 로고
    • Apolipoprotein E and Alzheimer's disease: Ethnic variation in genetic risk
    • Maestre G, Ottamen R, Stern Y, et al. Apolipoprotein E and Alzheimer's disease: ethnic variation in genetic risk. Ann Neurol 1995; 37: 254-9.
    • (1995) Ann Neurol , vol.37 , pp. 254-259
    • Maestre, G.1    Ottamen, R.2    Stern, Y.3
  • 20
    • 0028026997 scopus 로고
    • Apolipoprotein E4 allele in a population-based study of early onset Alzheimer's disease
    • van Duijn CM, Deknijff P, Cruts P, et al. Apolipoprotein E4 allele in a population-based study of early onset Alzheimer's disease. Nat Genet 1994; 7: 74-8.
    • (1994) Nat Genet , vol.7 , pp. 74-78
    • Van Duijn, C.M.1    Deknijff, P.2    Cruts, P.3
  • 21
    • 0028305380 scopus 로고
    • Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer's disease
    • Corder EH, Saunders AM, Risch NJ, et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer's disease. Nat Genet 1994; 7: 180-4.
    • (1994) Nat Genet , vol.7 , pp. 180-184
    • Corder, E.H.1    Saunders, A.M.2    Risch, N.J.3
  • 22
    • 12044254746 scopus 로고
    • Binding of human apolipoprotein E to beta/A4 peptide: Isoform-specific effects and implications for late onset Alzheimer's disease
    • Strittmatter WJ, Weisgraber KH, Huang D, et al. Binding of human apolipoprotein E to beta/A4 peptide: isoform-specific effects and implications for late onset Alzheimer's disease. Proc Natl Acad Sci USA 1993; 90: 8098-102.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8098-8102
    • Strittmatter, W.J.1    Weisgraber, K.H.2    Huang, D.3
  • 23
    • 0027936838 scopus 로고
    • Apolipoprotein E affects the rate of Alzheimer's disease expression: Beta-amyloid burden is a secondary consequence dependent on ApoE genotype and duration of disease
    • Roses AD. Apolipoprotein E affects the rate of Alzheimer's disease expression: beta-amyloid burden is a secondary consequence dependent on ApoE genotype and duration of disease. J Neuropathol Exp Neurol 1994; 5: 429-37.
    • (1994) J Neuropathol Exp Neurol , vol.5 , pp. 429-437
    • Roses, A.D.1
  • 24
    • 0028172930 scopus 로고
    • Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease
    • Poirier J. Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease. Trends Neurosci 1994; 17: 529-30.
    • (1994) Trends Neurosci , vol.17 , pp. 529-530
    • Poirier, J.1
  • 25
    • 0028891759 scopus 로고
    • Nucleotide sequence of the chromosome 14-encoded S182 cDNA and revised secondary structure prediction
    • Slunt H, Thinakaran G, Lee M, Sisodia SS. Nucleotide sequence of the chromosome 14-encoded S182 cDNA and revised secondary structure prediction. Amyloid 1995; 2: 188-90.
    • (1995) Amyloid , vol.2 , pp. 188-190
    • Slunt, H.1    Thinakaran, G.2    Lee, M.3    Sisodia, S.S.4
  • 26
    • 0029115555 scopus 로고
    • The structure of the Presenilin 1 (S182) gene and identification of six novel mutations in early onset Alzheimer's disease families
    • Clark RF, Hutton M, Fuldner, et al. The structure of the Presenilin 1 (S182) gene and identification of six novel mutations in early onset Alzheimer's disease families. Nat Gene 1995; 11: 219-22.
    • (1995) Nat Gene , vol.11 , pp. 219-222
    • Clark, R.F.1    Hutton, M.2    Fuldner3
  • 27
    • 0000821436 scopus 로고
    • Identification of a mutation in Alzheimer's disease which destroys a splice acceptor site in the presenilin-1 gene
    • Perez-Tur J, Froelich S, Prihar G, et al. Identification of a mutation in Alzheimer's disease which destroys a splice acceptor site in the presenilin-1 gene. Neuroreport 1995; 7: 204-7.
    • (1995) Neuroreport , vol.7 , pp. 204-207
    • Perez-Tur, J.1    Froelich, S.2    Prihar, G.3
  • 28
    • 0029052710 scopus 로고
    • Familial Alzheimer's disease chromosome 14 mutations
    • Wasco W, Pettingell WP, Jondro PD, et al. Familial Alzheimer's disease chromosome 14 mutations. Nat Med 1995; 11: 848.
    • (1995) Nat Med , vol.11 , pp. 848
    • Wasco, W.1    Pettingell, W.P.2    Jondro, P.D.3
  • 29
    • 0029101491 scopus 로고
    • Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
    • Rogaev EI, Sherrington R, Rogaeva E, et al. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 1995; 376: 775-8.
    • (1995) Nature , vol.376 , pp. 775-778
    • Rogaev, E.I.1    Sherrington, R.2    Rogaeva, E.3
  • 30
    • 0028812820 scopus 로고
    • Mutations of the presenilin 1 gene in families with early onset Alzheimer's disease
    • Campion D, et al. Mutations of the presenilin 1 gene in families with early onset Alzheimer's disease. Hum Mol Genet 1995; 11: 2373-7.
    • (1995) Hum Mol Genet , vol.11 , pp. 2373-2377
    • Campion, D.1
  • 31
    • 0028861041 scopus 로고
    • Molecular genetic analysis of familial early onset Alzheimer's disease linked to chromosome 14q24.3
    • Cruts M, Backhovens M, Wang SY, et al. Molecular genetic analysis of familial early onset Alzheimer's disease linked to chromosome 14q24.3. Hum Mol Genet 1995; 4: 2363-71.
    • (1995) Hum Mol Genet , vol.4 , pp. 2363-2371
    • Cruts, M.1    Backhovens, M.2    Wang, S.Y.3
  • 32
    • 8044259828 scopus 로고    scopus 로고
    • Complete analysis of the presenilin 1 gene in families with early onset Alzheimer's disease
    • in press
    • Hutton M, Busfield F, Wragg M, et al. Complete analysis of the presenilin 1 gene in families with early onset Alzheimer's disease. Neuroreport (in press).
    • Neuroreport
    • Hutton, M.1    Busfield, F.2    Wragg, M.3
  • 33
    • 0029411573 scopus 로고
    • The presenilins in Alzheimer's disease
    • Van Broeckhoven CM. The presenilins in Alzheimer's disease. Nat Genet 1995; 11: 230-2.
    • (1995) Nat Genet , vol.11 , pp. 230-232
    • Van Broeckhoven, C.M.1
  • 34
    • 0029150716 scopus 로고
    • A familial Alzheimer's disease locus on chromosome 1
    • Levy-Lahad E, Wijsman E, Nemens E, et al. A familial Alzheimer's disease locus on chromosome 1. Science 1995; 268: 970-2.
    • (1995) Science , vol.268 , pp. 970-972
    • Levy-Lahad, E.1    Wijsman, E.2    Nemens, E.3
  • 35
    • 0029116848 scopus 로고
    • Facilitation of lin-12 mediated signaling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
    • Levitan D, Greenwald I. Facilitation of lin-12 mediated signaling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 1995; 377: 351-4.
    • (1995) Nature , vol.377 , pp. 351-354
    • Levitan, D.1    Greenwald, I.2
  • 36
    • 0026688633 scopus 로고
    • Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions
    • Hernault SW, Arduengo PM. Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions. J Cell Biol 1992; 119: 55-68.
    • (1992) J Cell Biol , vol.119 , pp. 55-68
    • Hernault, S.W.1    Arduengo, P.M.2
  • 37
    • 9044240040 scopus 로고
    • Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias
    • Wang Q, Curran ME, Spawski I, et al. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet 1995; 12: 17-23.
    • (1995) Nat Genet , vol.12 , pp. 17-23
    • Wang, Q.1    Curran, M.E.2    Spawski, I.3
  • 38
    • 0028978471 scopus 로고
    • β APP mRNA is increased in cultured fibroblasts from the familial Alzheimer's disease-1 family
    • Querfurth PH, Wijsman EM, St. George Hyslop P, et al. β APP mRNA is increased in cultured fibroblasts from the familial Alzheimer's disease-1 family. Mol Brain Res 1995: 28; 319-37.
    • (1995) Mol Brain Res , vol.28 , pp. 319-337
    • Querfurth, P.H.1    Wijsman, E.M.2    St. George Hyslop, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.