Impact of distal mutations on the network of coupled motions correlated to hydride transfer in dihydrofolate reductase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 19, 2005, Pages 6807-6812

  Wong, Kim F ^a   Selzer, Tzvia ^a   Benkovic, Stephen J ^a   Hammes Schiffer, Sharon ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Enzyme catalysis; Molecular dynamics

Indexed keywords

DIHYDROFOLATE REDUCTASE;

ARTICLE; CATALYSIS; CORRELATION ANALYSIS; ENZYME ACTIVE SITE; ENZYME CONFORMATION; HYBRID; MOLECULAR DYNAMICS; MUTANT; PRIORITY JOURNAL; QUANTUM MECHANICS; SIMULATION; SITE DIRECTED MUTAGENESIS;

BINDING SITES; CARBON; CATALYSIS; COMPUTER SIMULATION; ELECTROSTATICS; ESCHERICHIA COLI; HEAT; HYDROGEN; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; MODELS, STATISTICAL; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN CONFORMATION; TETRAHYDROFOLATE DEHYDROGENASE; THERMODYNAMICS;

EID: 18744380681     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0408343102     Document Type: Article

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