Nonperfect synchronization of reaction center rehybridization in the transition state of the hydride transfer catalyzed by dihydrofolate reductase

Journal of the American Chemical Society

Volumn 127, Issue 42, 2005, Pages 14879-14886

  Pu, Jingzhi ^a   Ma, Shuhua ^a   Garcia Viloca, Mireia ^a,c   Gao, Jiali ^a   Truhlar, Donald G ^a   Kohen, Amnon ^b  

^a University of Minnesota   (United States)

^b E11 SSH   (United States)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME-CATALYZED REACTIONS; EQUILIBRIUM EFFECTS; KINETIC ISOTOPE EFFECTS; REHYBRIDIZATION;

CARBON; CATALYSIS; ESCHERICHIA COLI; HYDRIDES; ISOTOPES; MOLECULAR STRUCTURE;

ENZYMES;

CARBON; DIHYDROFOLATE REDUCTASE; DIHYDROFOLIC ACID; ISOTOPE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TETRAHYDROFOLIC ACID;

ARTICLE; CATALYST; CHEMICAL BOND; CHEMICAL REACTION KINETICS; COMPUTER SIMULATION; ESCHERICHIA COLI; HYBRIDIZATION; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; NONHUMAN; RELIABILITY;

CARBON; CATALYSIS; COMPUTER SIMULATION; ESCHERICHIA COLI; MODELS, CHEMICAL; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 27144461162     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja054170t     Document Type: Article

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