The role of enzyme dynamics and tunnelling in catalysing hydride transfer: Studies of distal mutants of dihydrofolate reductase

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 361, Issue 1472, 2006, Pages 1307-1315

  Wang, Lin ^a   Goodey, Nina M ^b   Benkovic, Stephen J ^b   Kohen, Amnon ^a  

^a University of Iowa   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Dihydrofolate reductase; Distal mutation; Enzyme dynamics; Hydrogen tunnelling; Kinetic isotope effect; Structure dynamics function relationship

Indexed keywords

CATALYSIS; ENZYME ACTIVITY; FECAL COLIFORM; THEORETICAL STUDY;

ESCHERICHIA COLI;

EID: 33748354485     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.2006.1871     Document Type: Conference Paper

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