Effect of mutation on enzyme motion in dihydrofolate reductase

Journal of the American Chemical Society

Volumn 125, Issue 13, 2003, Pages 3745-3750

  Watney, James B ^a   Agarwal, Pratul K ^a   Hammes Schiffer, Sharon ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTATIONS; REDUCTASES;

COMPUTER SIMULATION; ENZYMES; ESCHERICHIA COLI; FREE ENERGY; HYDRIDES; MOLECULAR DYNAMICS;

MUTAGENESIS;

DIHYDROFOLATE REDUCTASE;

ARTICLE; ENERGY; ENZYME KINETICS; ENZYME MECHANISM; ESCHERICHIA COLI; GENE MUTATION; MATHEMATICAL ANALYSIS; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; QUANTUM CHEMISTRY; SIMULATION;

AMINO ACID SUBSTITUTION; COMPUTER SIMULATION; ESCHERICHIA COLI; GLYCINE; HUMANS; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; QUANTUM THEORY; TETRAHYDROFOLATE DEHYDROGENASE; THERMODYNAMICS; VALINE;

EID: 0037414270     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja028487u     Document Type: Article

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