Effects of a distal mutation on active site chemistry

Biochemistry

Volumn 45, Issue 5, 2006, Pages 1383-1392

  Wang, Lin ^a   Tharp, Scott ^a   Selzer, Tzvia ^b,c   Benkovic, Stephen J ^b   Kohen, Amnon ^a  

^a E11 SSH   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ESCHERICHIA COLI; HYDROGEN; ISOTOPES; MATHEMATICAL MODELS; MUTAGENESIS;

H-AND D-TRANSFER; KINETIC ISOTOPE EFFECTS (KIE); REACTIVE STATES;

BIOCHEMISTRY;

DIHYDROFOLATE REDUCTASE; GLYCINE; HYDROGEN; VALINE;

ARTICLE; CATALYSIS; CONTROLLED STUDY; ENERGY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME STRUCTURE; ESCHERICHIA COLI; MOLECULAR DYNAMICS; MUTATION; NONHUMAN; PRIORITY JOURNAL; TEMPERATURE DEPENDENCE;

BINDING SITES; CARBON ISOTOPES; CATALYSIS; CHEMISTRY; DEUTERIUM; DEUTERIUM EXCHANGE MEASUREMENT; ENZYME ACTIVATION; ESCHERICHIA COLI; KINETICS; MODELS, CHEMICAL; MUTATION; TEMPERATURE; TETRAHYDROFOLATE DEHYDROGENASE; TRITIUM;

ESCHERICHIA COLI;

EID: 32244432145     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0518242     Document Type: Article

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