Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant

Biochemistry

Volumn 36, Issue 50, 1997, Pages 15792-15800

  Cameron, Craig E ^a   Benkovic, Stephen J ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; BACTERIAL ENZYME; DIHYDROFOLATE REDUCTASE; DIHYDROFOLIC ACID; GLYCINE; LEUCINE; MUTANT PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PROLINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SERINE; TETRAHYDROFOLIC ACID; VALINE;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DYNAMICS; ENZYME BINDING; ENZYME KINETICS; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

BINDING SITES; CATALYSIS; ESCHERICHIA COLI; FLUORESCENCE; GLYCINE; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NADP; PROTEIN BINDING; PROTEIN CONFORMATION; TETRAHYDROFOLATE DEHYDROGENASE; THERMODYNAMICS; VALINE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 0031443372     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9716231     Document Type: Article

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