IκB-independent control of NF-κB activity by modulatory phosphorylations

Trends in Biochemical Sciences

Volumn 26, Issue 3, 2001, Pages 186-190

  Schmitz, M Lienhard ^a   Bacher, Susanne ^a   Kracht, Michael ^b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

IKAPPAB ALPHA; IKAPPAB BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN B REL; PROTEIN DERIVATIVE; PROTEIN INHIBITOR; PROTEIN P100; PROTEIN P105; PROTEIN P50; PROTEIN P52; PROTEIN SUBUNIT; SYNAPTOTAGMIN; TRANSCRIPTION FACTOR REL; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CYTOPLASM; ENZYME ACTIVATION; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; TRANSACTIVATION;

BINDING SITES; DNA; I-KAPPA B PROTEINS; NF-KAPPA B; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS);

EID: 0035282213     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(00)01753-9     Document Type: Review

References (36)

1. Phosphorylation meets ubiquitination: The control of NF-κB activity
2. Regulation of inducible gene expression by the transcription factor NF-κB
3. The IKK complex: An integrator of all signals that activate NF-κB?
4. NF-κB and the innate immune response
5. Cotranslational dimerization of the rel homology domain of NF-κB1 generates p50-p105 heterodimers and is required for effective p50 production
6. The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor
7. Identification of complex formation between two intracellular tyrosine kinase substrates: Human c-Rel and the p105 precursor of p50 NF-κB
8. NF-κB/Rel family members are physically associated phosphoproteins
9. Activation of NF-κB in vivo is regulated by multiple phosphorylations
10. NF-κB p105 is a target of IκB kinases and controls signal induction of Bcl-3-p50 complexes
11. Transactivation domain 2 (TA2) of p65 NF-κB. Similarity to TA1 and phorbol ester-stimulated activity and phosphorylation in intact cells
12. Activation of nuclear transcription factor NF-κB by interleukin-1 is accompanied by casein kinase II-mediated phosphorylation of the p65 subunit
13. TNFα-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II
14. Regulation of NF-κB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Cζ in primary endothelial cells
15. IκB kinases phosphorylate NF-κB p65 subunit on serine 536 in the transactivation domain
16. Activation of nuclear factor-κB-dependent transcription by tumor necrosis factor-α is mediated through phosphorylation of RelA/p65 on serine 529
17. Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells
18. TNFα activation of NF-κB requires the phosphorylation of Ser 471 in the transactivation domain of c-Rel
19. cRel-TD kinase: A serine/threonine kinase binding in vivo and in vitro c-Rel and phosphorylating its transactivation domain
20. IκB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex
21. The transcriptional activity of NF-κB is regulated by the IκB-associated PKAc subunit through a cyclic AMP-independent mechanism
22. Phosphorylation of NF-κB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300
23. Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation
24. Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating κB enhancer activation
25. Activation of transcription factor NF-κB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways
26. The p38 mitogen-activated protein kinase is required for NF-κB-dependent gene expression. The role of TATA-binding protein (TBP)
27. Stress-activated protein kinase/Jun N-terminal kinase is required for interleukin (IL)-1-induced IL-6 and IL-8 gene expression in the human epidermal carcinoma cell line KB
28. p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-κB p65 transactivation mediated by tumor necrosis factor
29. Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine- or stress-activated signal transduction pathways
30. Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-κB activation
31. Phosphatidylinositol 3-kinase as a mediator of TNF-induced NF-κB activation
32. Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-κB p65/RelA subunit
33. Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-κB
34. NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase
35. Kinase regulation in inflammatory response
36. Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation