IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness

Journal of Biological Chemistry

Volumn 279, Issue 25, 2004, Pages 26748-26753

  Qin, Jinzhong ^a,c   Jiang, Zhengfan ^a   Qian, Youcun ^a   Casanova, Jean Laurent ^b   Li, Xiaoxia ^a,b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c CLEVELAND STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; MUTAGENESIS; PROTEINS;

GENE EXPRESSION; KINASE ACTIVITY;

BIOCHEMISTRY;

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 8; IRAK KINASE; IRAK4 KINASE; PHOSPHOTRANSFERASE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHOSPHORYLATION; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MUTANT; PRIORITY JOURNAL; PROTEIN FAMILY; REPORTER GENE; SIGNAL TRANSDUCTION; UBIQUITINATION; WILD TYPE;

BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; E-SELECTIN; ENZYME ACTIVATION; FIBROBLASTS; GENES, REPORTER; GENETIC COMPLEMENTATION TEST; HUMANS; INTERLEUKIN-1; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTERLEUKIN-8; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LUCIFERASES; MAP KINASE KINASE 4; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MODELS, BIOLOGICAL; MUTATION; NF-KAPPA B; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PLASMIDS; PRECIPITIN TESTS; RECEPTORS, INTERLEUKIN-1; TIME FACTORS; TRANSFECTION; UBIQUITIN;

EID: 2942748292     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M400785200     Document Type: Article

References (28)

1. Mitcham, J. L., Parnet, P., Bonnert, T. P., Garka, K. E., Gerhart, M. J., Slack, J. L., Gayle, M. A., Dower, S. K., and Sims, J. E. (1996) J. Biol. Chem. 271, 5777-5783
2. Medzhitov, R., Preston-Hurlburt, P., and Janeway, C. A., Jr. (1997) Nature 388, 394-397
3. Dinarello, C. A. (1996) Blood 87, 2095-2147
4. Rock, F. L., Hardiman, G., Timans, J. C., Kastelein, R. A., and Bazan, J. F. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 588-593
5. Takeuchi, O., Kawai, T., Sanjo, H., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Takeda, K., and Akira, S. (1999) Gene (Amst.) 231, 59-65
6. Chuang, T. H., and Ulevitch, R. J. (2000) Eur. Cytokine Netw. 11, 372-378
7. Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., and Akira, S. (2000) Nature 408, 740-745
8. Barnes, P. J., and Karin, M. (1997) N. Engl. J. Med. 336, 1066-1071
9. O'Neill, L. A. (1995) Biochim. Biophys. Acta 1266, 31-44
10. O'Neill, L. A. (1997) Biochem. Soc. Trans. 25, 295-302
11. Jiang, Z., Johnson, H. J., Nie, H., Qin, J., Bird, T. A., and Li, X. (2002) J. Biol. Chem.
12. Jiang, Z., Ninomiya-Tsuji, J., Qian, Y., Matsumoto, K., and Li, X. (2002) Mol. Cell. Biol. 22, 7158-7167
13. Janssens, S., and Beyaert, R. (2003) Mol. Cell 11, 293-302
14. Wesche, H., Henzel, W. J., Shillinglaw, W., Li, S., and Cao, Z. (1997) Immunity 7, 837-847
15. Burns, K., Clatworthy, J., Martin, L., Martinon, F., Plumpton, C., Maschera, B., Lewis, A., Ray, K., Tschopp, J., and Volpe, F. (2000) Nat. Cell Biol. 2, 346-351
16. Li, S., Strelow, A., Fontana, E. J., and Wesche, H. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 5567-5572
17. Suzuki, N., Suzuki, S., Duncan, G. S., Millar, D. G., Wada, T., Mirtsos, C., Takada, H., Wakeham, A., Itie, A., Li, S., Penninger, J. M., Wesche, H., Ohashi, P. S., Mak, T. W., and Yeh, W. C. (2002) Nature 416, 750-756
18. Cao, Z., Henzel, W. J., and Gao, X. (1996) Science 271, 1128-1131
19. Li, X., Commane, M., Burns, C., Vithalani, K., Cao, Z., and Stark, G. R. (1999) Mol. Cell. Biol. 19, 4643-4652
20. Cao, Z., Xiong, J., Takeuchi, M., Kurama, T., and Goeddel, D. V. (1996) Nature 383, 443-446
21. Mercurio, F., Zhu, H., Murray, B. W., Shevchenko, A., Bennett, B. L., Li, J., Young, D. B., Barbosa, M., Mann, M., Manning, A., and Rao, A. (1997) Science 278, 860-866
22. Regnier, C. H., Song, H. Y., Gao, X., Goeddel, D. V., Cao, Z., and Rothe, M. (1997) Cell 90, 373-383
23. Woronicz, J. D., Gao, X., Cao, Z., Rothe, M., and Goeddel, D. V. (1997) Science 278, 866-869
24. Zandi, E., Rothwarf, D. M., Delhase, M., Hayakawa, M., and Karin, M. (1997) Cell 91, 243-252
25. Ninomiya-Tsuji, J., Kishimoto, K., Hiyama, A., Inoue, J., Cao, Z., and Matsumoto, K. (1999) Nature 398, 252-256
26. Picard, C., Puel, A., Bonnet, M., Ku, C. L., Bustamante, J., Yang, K., Soudais, C., Dupuis, S., Feinberg, J., Fieschi, C., Elbim, C., Hitchcock, R., Lammas, D., Davies, G., Al Ghonaium, A., Al Rayes, H., Al Jumaah, S., Al Hajjar, S., Al Mohsen, I. Z., Frayha, H. H., Rucker, R., Hawn, T. R., Aderem, A., Tufenkeji, H., Haraguchi, S., Day, N. K., Good, R. A., Gougerot-Pocidalo, M. A., Ozinsky, A., and Casanova, J. L. (2003) Science 299, 2076-2079
27. Medvedev, A. E., Lentschat, A., Kulms, D. B., Blanco, J. C., Salkowski, C., Zhang, S., Arditi, M., Gallin, J. I., and Vogel, S. N. (2003) J. Exp. Med. 198, 521-531
28. Yamamoto, M., Sato, S., Hemmi, H., Sanjo, H., Uematsu, S., Kaisho, T., Hoshino, K., Takeuchi, O., Kobayashi, M., Fujita, T., Takeda, K., and Akira, S. (2002) Nature 420, 324-329