-
1
-
-
0033596124
-
Aberrant rel/nfkb genes and activity in human cancer
-
Rayet B., and Gelinas C. Aberrant rel/nfkb genes and activity in human cancer. Oncogene 18 (1999) 6938-6947
-
(1999)
Oncogene
, vol.18
, pp. 6938-6947
-
-
Rayet, B.1
Gelinas, C.2
-
2
-
-
33646488626
-
NF-kappaB inhibition: a double-edged sword in cancer?
-
Pikarsky E., and Ben-Neriah Y. NF-kappaB inhibition: a double-edged sword in cancer?. Eur J Cancer 42 (2006) 779-784
-
(2006)
Eur J Cancer
, vol.42
, pp. 779-784
-
-
Pikarsky, E.1
Ben-Neriah, Y.2
-
3
-
-
33645999706
-
NF-kappaB and IKK as therapeutic targets in cancer
-
Kim H.J., Hawke N., and Baldwin A.S. NF-kappaB and IKK as therapeutic targets in cancer. Cell Death Differ 13 (2006) 738-747
-
(2006)
Cell Death Differ
, vol.13
, pp. 738-747
-
-
Kim, H.J.1
Hawke, N.2
Baldwin, A.S.3
-
4
-
-
0036546501
-
NF-kappaB in cancer: from innocent bystander to major culprit
-
Karin M., Cao Y., Greten F.R., and Li Z.W. NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2 (2002) 301-310
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 301-310
-
-
Karin, M.1
Cao, Y.2
Greten, F.R.3
Li, Z.W.4
-
5
-
-
4644313276
-
Nuclear factor-kappaB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma
-
Loercher A., Lee T.L., Ricker J.L., Howard A., Geoghegen J., Chen Z., et al. Nuclear factor-kappaB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma. Cancer Res 64 (2004) 6511-6523
-
(2004)
Cancer Res
, vol.64
, pp. 6511-6523
-
-
Loercher, A.1
Lee, T.L.2
Ricker, J.L.3
Howard, A.4
Geoghegen, J.5
Chen, Z.6
-
6
-
-
4143071413
-
In vitro and in vivo activity of the nuclear factor-kappaB inhibitor sulfasalazine in human glioblastomas
-
Robe P.A., Bentires-Alj M., Bonif M., Rogister B., Deprez M., Haddada H., et al. In vitro and in vivo activity of the nuclear factor-kappaB inhibitor sulfasalazine in human glioblastomas. Clin Cancer Res 10 (2004) 5595-5603
-
(2004)
Clin Cancer Res
, vol.10
, pp. 5595-5603
-
-
Robe, P.A.1
Bentires-Alj, M.2
Bonif, M.3
Rogister, B.4
Deprez, M.5
Haddada, H.6
-
7
-
-
0031440245
-
Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer
-
Sovak M.A., Bellas R.E., Kim D.W., Zanieski G.J., Rogers A.E., Traish A.M., et al. Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer. J Clin Invest 100 (1997) 2952-2960
-
(1997)
J Clin Invest
, vol.100
, pp. 2952-2960
-
-
Sovak, M.A.1
Bellas, R.E.2
Kim, D.W.3
Zanieski, G.J.4
Rogers, A.E.5
Traish, A.M.6
-
8
-
-
4043088499
-
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
-
Greten F.R., Eckmann L., Greten T.F., Park J.M., Li Z.W., Egan L.J., et al. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118 (2004) 285-296
-
(2004)
Cell
, vol.118
, pp. 285-296
-
-
Greten, F.R.1
Eckmann, L.2
Greten, T.F.3
Park, J.M.4
Li, Z.W.5
Egan, L.J.6
-
9
-
-
4644324186
-
NF-kappaB functions as a tumour promoter in inflammation-associated cancer
-
Pikarsky E., Porat R.M., Stein I., Abramovitch R., Amit S., Kasem S., et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 431 (2004) 461-466
-
(2004)
Nature
, vol.431
, pp. 461-466
-
-
Pikarsky, E.1
Porat, R.M.2
Stein, I.3
Abramovitch, R.4
Amit, S.5
Kasem, S.6
-
10
-
-
19944427042
-
Targeting NF-kappaB activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells
-
Frelin C., Imbert V., Griessinger E., Peyron A.C., Rochet N., Philip P., et al. Targeting NF-kappaB activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells. Blood 105 (2005) 804-811
-
(2005)
Blood
, vol.105
, pp. 804-811
-
-
Frelin, C.1
Imbert, V.2
Griessinger, E.3
Peyron, A.C.4
Rochet, N.5
Philip, P.6
-
11
-
-
0032905030
-
Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB
-
Wang C.Y., Cusack Jr. J.C., Liu R., and Baldwin Jr. A.S. Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB. Nat Med 5 (1999) 412-417
-
(1999)
Nat Med
, vol.5
, pp. 412-417
-
-
Wang, C.Y.1
Cusack Jr., J.C.2
Liu, R.3
Baldwin Jr., A.S.4
-
12
-
-
0029858387
-
TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB
-
Wang C.Y., Mayo M.W., and Baldwin Jr. A.S. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Science 274 (1996) 784-787
-
(1996)
Science
, vol.274
, pp. 784-787
-
-
Wang, C.Y.1
Mayo, M.W.2
Baldwin Jr., A.S.3
-
13
-
-
0037427122
-
NF-kappaB transcription factor induces drug resistance through MDR1 expression in cancer cells
-
Bentires-Alj M., Barbu V., Fillet M., Chariot A., Relic B., Jacobs N., et al. NF-kappaB transcription factor induces drug resistance through MDR1 expression in cancer cells. Oncogene 22 (2003) 90-97
-
(2003)
Oncogene
, vol.22
, pp. 90-97
-
-
Bentires-Alj, M.1
Barbu, V.2
Fillet, M.3
Chariot, A.4
Relic, B.5
Jacobs, N.6
-
14
-
-
1642579534
-
Evidence that activation of nuclear factor-kappaB is essential for the cytotoxic effects of doxorubicin and its analogues
-
Ashikawa K., Shishodia S., Fokt I., Priebe W., and Aggarwal B.B. Evidence that activation of nuclear factor-kappaB is essential for the cytotoxic effects of doxorubicin and its analogues. Biochem Pharmacol 67 (2004) 353-364
-
(2004)
Biochem Pharmacol
, vol.67
, pp. 353-364
-
-
Ashikawa, K.1
Shishodia, S.2
Fokt, I.3
Priebe, W.4
Aggarwal, B.B.5
-
15
-
-
1842526076
-
Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B
-
Campbell K.J., Rocha S., and Perkins N.D. Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B. Mol Cell 13 (2004) 853-865
-
(2004)
Mol Cell
, vol.13
, pp. 853-865
-
-
Campbell, K.J.1
Rocha, S.2
Perkins, N.D.3
-
16
-
-
0037421484
-
NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia
-
Dajee M., Lazarov M., Zhang J.Y., Cai T., Green C.L., Russell A.J., et al. NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia. Nature 421 (2003) 639-643
-
(2003)
Nature
, vol.421
, pp. 639-643
-
-
Dajee, M.1
Lazarov, M.2
Zhang, J.Y.3
Cai, T.4
Green, C.L.5
Russell, A.J.6
-
17
-
-
20144365514
-
Nuclear factor-kappaB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-kappaB-dependent transcription in cancer cells
-
Ho W.C., Dickson K.M., and Barker P.A. Nuclear factor-kappaB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-kappaB-dependent transcription in cancer cells. Cancer Res 65 (2005) 4273-4281
-
(2005)
Cancer Res
, vol.65
, pp. 4273-4281
-
-
Ho, W.C.1
Dickson, K.M.2
Barker, P.A.3
-
18
-
-
0034689773
-
Role of NF-kappaB in p53-mediated programmed cell death
-
Ryan K.M., Ernst M.K., Rice N.R., and Vousden K.H. Role of NF-kappaB in p53-mediated programmed cell death. Nature 404 (2000) 892-897
-
(2000)
Nature
, vol.404
, pp. 892-897
-
-
Ryan, K.M.1
Ernst, M.K.2
Rice, N.R.3
Vousden, K.H.4
-
19
-
-
0346497823
-
NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK
-
Zhang J.Y., Green C.L., Tao S., and Khavari P.A. NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK. Genes Dev 18 (2004) 17-22
-
(2004)
Genes Dev
, vol.18
, pp. 17-22
-
-
Zhang, J.Y.1
Green, C.L.2
Tao, S.3
Khavari, P.A.4
-
20
-
-
0035348486
-
Aspirin-induced activation of the NF-kappaB signaling pathway: a novel mechanism for aspirin-mediated apoptosis in colon cancer cells
-
Stark L.A., Din F.V., Zwacka R.M., and Dunlop M.G. Aspirin-induced activation of the NF-kappaB signaling pathway: a novel mechanism for aspirin-mediated apoptosis in colon cancer cells. Faseb J 15 (2001) 1273-1275
-
(2001)
Faseb J
, vol.15
, pp. 1273-1275
-
-
Stark, L.A.1
Din, F.V.2
Zwacka, R.M.3
Dunlop, M.G.4
-
21
-
-
0742283971
-
A prospective study of aspirin use and the risk for colorectal adenoma
-
Chan A.T., Giovannucci E.L., Schernhammer E.S., Colditz G.A., Hunter D.J., Willett W.C., et al. A prospective study of aspirin use and the risk for colorectal adenoma. Ann Intern Med 140 (2004) 157-166
-
(2004)
Ann Intern Med
, vol.140
, pp. 157-166
-
-
Chan, A.T.1
Giovannucci, E.L.2
Schernhammer, E.S.3
Colditz, G.A.4
Hunter, D.J.5
Willett, W.C.6
-
22
-
-
0032850948
-
Colorectal cancer prevention by non-steroidal anti-inflammatory drugs: effects of dosage and timing
-
Collet J.P., Sharpe C., Belzile E., Boivin J.F., Hanley J., and Abenhaim L. Colorectal cancer prevention by non-steroidal anti-inflammatory drugs: effects of dosage and timing. Br J Cancer 81 (1999) 62-68
-
(1999)
Br J Cancer
, vol.81
, pp. 62-68
-
-
Collet, J.P.1
Sharpe, C.2
Belzile, E.3
Boivin, J.F.4
Hanley, J.5
Abenhaim, L.6
-
23
-
-
0037421984
-
A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer
-
Sandler R.S., Halabi S., Baron J.A., Budinger S., Paskett E., Keresztes R., et al. A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. N Engl J Med 348 (2003) 883-890
-
(2003)
N Engl J Med
, vol.348
, pp. 883-890
-
-
Sandler, R.S.1
Halabi, S.2
Baron, J.A.3
Budinger, S.4
Paskett, E.5
Keresztes, R.6
-
24
-
-
0028167846
-
Inhibition of NF-kappa B by sodium salicylate and aspirin
-
Kopp E., and Ghosh S. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science 265 (1994) 956-959
-
(1994)
Science
, vol.265
, pp. 956-959
-
-
Kopp, E.1
Ghosh, S.2
-
25
-
-
0032487857
-
The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta
-
Yin M.J., Yamamoto Y., and Gaynor R.B. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature 396 (1998) 77-80
-
(1998)
Nature
, vol.396
, pp. 77-80
-
-
Yin, M.J.1
Yamamoto, Y.2
Gaynor, R.B.3
-
26
-
-
0033578879
-
Sulindac inhibits activation of the NF-kappaB pathway
-
Yamamoto Y., Yin M.J., Lin K.M., and Gaynor R.B. Sulindac inhibits activation of the NF-kappaB pathway. J Biol Chem 274 (1999) 27307-27314
-
(1999)
J Biol Chem
, vol.274
, pp. 27307-27314
-
-
Yamamoto, Y.1
Yin, M.J.2
Lin, K.M.3
Gaynor, R.B.4
-
27
-
-
11244334168
-
Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation
-
Takada Y., Bhardwaj A., Potdar P., and Aggarwal B.B. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23 (2004) 9247-9258
-
(2004)
Oncogene
, vol.23
, pp. 9247-9258
-
-
Takada, Y.1
Bhardwaj, A.2
Potdar, P.3
Aggarwal, B.B.4
-
28
-
-
0033517999
-
Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen
-
Palayoor S.T., Youmell M.Y., Calderwood S.K., Coleman C.N., and Price B.D. Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen. Oncogene 18 (1999) 7389-7394
-
(1999)
Oncogene
, vol.18
, pp. 7389-7394
-
-
Palayoor, S.T.1
Youmell, M.Y.2
Calderwood, S.K.3
Coleman, C.N.4
Price, B.D.5
-
29
-
-
21744444276
-
Nucleolar sequestration of RelA (p65) regulates NF-kappaB-driven transcription and apoptosis
-
Stark L.A., and Dunlop M.G. Nucleolar sequestration of RelA (p65) regulates NF-kappaB-driven transcription and apoptosis. Mol Cell Biol 25 (2005) 5985-6004
-
(2005)
Mol Cell Biol
, vol.25
, pp. 5985-6004
-
-
Stark, L.A.1
Dunlop, M.G.2
-
30
-
-
23744505379
-
Diclofenac attenuates Wnt/beta-catenin signaling in colon cancer cells by activation of NF-kappaB
-
Cho M., Gwak J., Park S., Won J., Kim D.E., Yea S.S., et al. Diclofenac attenuates Wnt/beta-catenin signaling in colon cancer cells by activation of NF-kappaB. FEBS Lett 579 (2005) 4213-4218
-
(2005)
FEBS Lett
, vol.579
, pp. 4213-4218
-
-
Cho, M.1
Gwak, J.2
Park, S.3
Won, J.4
Kim, D.E.5
Yea, S.S.6
-
31
-
-
1342312264
-
Aspirin and the risk of Hodgkin's lymphoma in a population-based case-control study
-
Chang E.T., Zheng T., Weir E.G., Borowitz M., Mann R.B., Spiegelman D., et al. Aspirin and the risk of Hodgkin's lymphoma in a population-based case-control study. J Natl Cancer Inst 96 (2004) 305-315
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 305-315
-
-
Chang, E.T.1
Zheng, T.2
Weir, E.G.3
Borowitz, M.4
Mann, R.B.5
Spiegelman, D.6
-
32
-
-
33645852851
-
Association between nonsteroidal anti-inflammatory drugs and prostate cancer occurrence
-
Dasgupta K., Di Cesar D., Ghosn J., Rajan R., Mahmud S., and Rahme E. Association between nonsteroidal anti-inflammatory drugs and prostate cancer occurrence. Cancer J 12 (2006) 130-135
-
(2006)
Cancer J
, vol.12
, pp. 130-135
-
-
Dasgupta, K.1
Di Cesar, D.2
Ghosn, J.3
Rajan, R.4
Mahmud, S.5
Rahme, E.6
-
33
-
-
33644874116
-
Aspirin induces apoptosis in oesophageal cancer cells by inhibiting the pathway of NF-kappaB downstream regulation of cyclooxygenase-2
-
Liu J.F., Jamieson G.G., Drew P.A., Zhu G.J., Zhang S.W., Zhu T.N., et al. Aspirin induces apoptosis in oesophageal cancer cells by inhibiting the pathway of NF-kappaB downstream regulation of cyclooxygenase-2. ANZ J Surg 75 (2005) 1011-1016
-
(2005)
ANZ J Surg
, vol.75
, pp. 1011-1016
-
-
Liu, J.F.1
Jamieson, G.G.2
Drew, P.A.3
Zhu, G.J.4
Zhang, S.W.5
Zhu, T.N.6
-
34
-
-
33746614125
-
Non-steroidal anti-inflammatory drug use and prostate cancer in a high-risk population
-
Mahmud S.M., Tanguay S., Begin L.R., Franco E.L., and Aprikian A.G. Non-steroidal anti-inflammatory drug use and prostate cancer in a high-risk population. Eur J Cancer Prev 15 (2006) 158-164
-
(2006)
Eur J Cancer Prev
, vol.15
, pp. 158-164
-
-
Mahmud, S.M.1
Tanguay, S.2
Begin, L.R.3
Franco, E.L.4
Aprikian, A.G.5
-
35
-
-
3042841175
-
Regular aspirin use and lung cancer risk
-
Moysich K.B., Menezes R.J., Ronsani A., Swede H., Reid M.E., Cummings K.M., et al. Regular aspirin use and lung cancer risk. BMC Cancer 2 (2002) 31
-
(2002)
BMC Cancer
, vol.2
, pp. 31
-
-
Moysich, K.B.1
Menezes, R.J.2
Ronsani, A.3
Swede, H.4
Reid, M.E.5
Cummings, K.M.6
-
36
-
-
3242771185
-
Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis
-
Shishodia S., Koul D., and Aggarwal B.B. Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis. J Immunol 173 (2004) 2011-2022
-
(2004)
J Immunol
, vol.173
, pp. 2011-2022
-
-
Shishodia, S.1
Koul, D.2
Aggarwal, B.B.3
-
37
-
-
28044459843
-
Non-steroidal anti-inflammatory drugs and risk of neoplastic progression in Barrett's oesophagus: a prospective study
-
Vaughan T.L., Dong L.M., Blount P.L., Ayub K., Odze R.D., Sanchez C.A., et al. Non-steroidal anti-inflammatory drugs and risk of neoplastic progression in Barrett's oesophagus: a prospective study. Lancet Oncol 6 (2005) 945-952
-
(2005)
Lancet Oncol
, vol.6
, pp. 945-952
-
-
Vaughan, T.L.1
Dong, L.M.2
Blount, P.L.3
Ayub, K.4
Odze, R.D.5
Sanchez, C.A.6
-
38
-
-
10844279275
-
N-Acetyltransferase 2 genotype-related sulfapyridine acetylation and its adverse events
-
Tanigawara Y., Kita T., Aoyama N., Gobara M., Komada F., Sakai T., et al. N-Acetyltransferase 2 genotype-related sulfapyridine acetylation and its adverse events. Biol Pharm Bull 25 (2002) 1058-1062
-
(2002)
Biol Pharm Bull
, vol.25
, pp. 1058-1062
-
-
Tanigawara, Y.1
Kita, T.2
Aoyama, N.3
Gobara, M.4
Komada, F.5
Sakai, T.6
-
39
-
-
0035171804
-
N-Acetyltransferase 2 genotype correlates with sulfasalazine pharmacokinetics after multiple dosing in healthy Japanese subjects
-
Kita T., Sakaeda T., Adachi S., Sakai T., Aoyama N., Hatanaka H., et al. N-Acetyltransferase 2 genotype correlates with sulfasalazine pharmacokinetics after multiple dosing in healthy Japanese subjects. Biol Pharm Bull 24 (2001) 1176-1180
-
(2001)
Biol Pharm Bull
, vol.24
, pp. 1176-1180
-
-
Kita, T.1
Sakaeda, T.2
Adachi, S.3
Sakai, T.4
Aoyama, N.5
Hatanaka, H.6
-
40
-
-
0032032469
-
Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B
-
Wahl C., Liptay S., Adler G., and Schmid R.M. Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B. J Clin Invest 101 (1998) 1163-1174
-
(1998)
J Clin Invest
, vol.101
, pp. 1163-1174
-
-
Wahl, C.1
Liptay, S.2
Adler, G.3
Schmid, R.M.4
-
41
-
-
0034322370
-
Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta
-
Weber C.K., Liptay S., Wirth T., Adler G., and Schmid R.M. Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta. Gastroenterology 119 (2000) 1209-1218
-
(2000)
Gastroenterology
, vol.119
, pp. 1209-1218
-
-
Weber, C.K.1
Liptay, S.2
Wirth, T.3
Adler, G.4
Schmid, R.M.5
-
42
-
-
0033543545
-
Inhibition of interleukin-1-stimulated NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity
-
Egan L.J., Mays D.C., Huntoon C.J., Bell M.P., Pike M.G., Sandborn W.J., et al. Inhibition of interleukin-1-stimulated NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity. J Biol Chem 274 (1999) 26448-26453
-
(1999)
J Biol Chem
, vol.274
, pp. 26448-26453
-
-
Egan, L.J.1
Mays, D.C.2
Huntoon, C.J.3
Bell, M.P.4
Pike, M.G.5
Sandborn, W.J.6
-
43
-
-
23444449591
-
Inhibition of cystine uptake disrupts the growth of primary brain tumors
-
Chung W.J., Lyons S.A., Nelson G.M., Hamza H., Gladson C.L., Gillespie G.Y., et al. Inhibition of cystine uptake disrupts the growth of primary brain tumors. J Neurosci 25 (2005) 7101-7110
-
(2005)
J Neurosci
, vol.25
, pp. 7101-7110
-
-
Chung, W.J.1
Lyons, S.A.2
Nelson, G.M.3
Hamza, H.4
Gladson, C.L.5
Gillespie, G.Y.6
-
44
-
-
0034772516
-
Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)-cystine transporter: a new action for an old drug
-
Gout P.W., Buckley A.R., Simms C.R., and Bruchovsky N. Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)-cystine transporter: a new action for an old drug. Leukemia 15 (2001) 1633-1640
-
(2001)
Leukemia
, vol.15
, pp. 1633-1640
-
-
Gout, P.W.1
Buckley, A.R.2
Simms, C.R.3
Bruchovsky, N.4
-
45
-
-
0842311704
-
Suppression of cystine uptake by sulfasalazine inhibits proliferation of human mammary carcinoma cells
-
Narang V.S., Pauletti G.M., Gout P.W., Buckley D.J., and Buckley A.R. Suppression of cystine uptake by sulfasalazine inhibits proliferation of human mammary carcinoma cells. Anticancer Res 23 (2003) 4571-4579
-
(2003)
Anticancer Res
, vol.23
, pp. 4571-4579
-
-
Narang, V.S.1
Pauletti, G.M.2
Gout, P.W.3
Buckley, D.J.4
Buckley, A.R.5
-
46
-
-
0027990979
-
Modulation of cisplatin cytotoxicity by sulphasalazine
-
Awasthi S., Sharma R., Singhal S.S., Herzog N.K., Chaubey M., and Awasthi Y.C. Modulation of cisplatin cytotoxicity by sulphasalazine. Br J Cancer 70 (1994) 190-194
-
(1994)
Br J Cancer
, vol.70
, pp. 190-194
-
-
Awasthi, S.1
Sharma, R.2
Singhal, S.S.3
Herzog, N.K.4
Chaubey, M.5
Awasthi, Y.C.6
-
47
-
-
0037381517
-
The novel neuroprotective action of sulfasalazine through blockade of NMDA receptors
-
Ryu B.R., Lee Y.A., Won S.J., Noh J.H., Chang S.Y., Chung J.M., et al. The novel neuroprotective action of sulfasalazine through blockade of NMDA receptors. J Pharmacol Exp Ther 305 (2003) 48-56
-
(2003)
J Pharmacol Exp Ther
, vol.305
, pp. 48-56
-
-
Ryu, B.R.1
Lee, Y.A.2
Won, S.J.3
Noh, J.H.4
Chang, S.Y.5
Chung, J.M.6
-
48
-
-
0032992467
-
Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB
-
Cronstein B.N., Montesinos M.C., and Weissmann G. Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB. Proc Natl Acad Sci USA 96 (1999) 6377-6381
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 6377-6381
-
-
Cronstein, B.N.1
Montesinos, M.C.2
Weissmann, G.3
-
49
-
-
9144261577
-
Development of sulfasalazine resistance in human T cells induces expression of the multidrug resistance transporter ABCG2 (BCRP) and augmented production of TNFalpha
-
van der Heijden J., de Jong M.C., Dijkmans B.A., Lems W.F., Oerlemans R., Kathmann I., et al. Development of sulfasalazine resistance in human T cells induces expression of the multidrug resistance transporter ABCG2 (BCRP) and augmented production of TNFalpha. Ann Rheum Dis 63 (2004) 138-143
-
(2004)
Ann Rheum Dis
, vol.63
, pp. 138-143
-
-
van der Heijden, J.1
de Jong, M.C.2
Dijkmans, B.A.3
Lems, W.F.4
Oerlemans, R.5
Kathmann, I.6
-
50
-
-
0043074871
-
Aminosalicylates and colorectal cancer in IBD: a not-so bitter pill to swallow
-
Ryan B.M., Russel M.G., Langholz E., and Stockbrugger R.W. Aminosalicylates and colorectal cancer in IBD: a not-so bitter pill to swallow. Am J Gastroenterol 98 (2003) 1682-1687
-
(2003)
Am J Gastroenterol
, vol.98
, pp. 1682-1687
-
-
Ryan, B.M.1
Russel, M.G.2
Langholz, E.3
Stockbrugger, R.W.4
-
51
-
-
84925559665
-
NTP toxicology and carcinogenesis studies of salicylazosulfapyridine (CAS No. 599-79-1) in F344/N rats and B6C3F1 mice (gavage studies)
-
Program N.T. NTP toxicology and carcinogenesis studies of salicylazosulfapyridine (CAS No. 599-79-1) in F344/N rats and B6C3F1 mice (gavage studies). Natl Toxicol Program Tech Rep Ser 457 (1997) 1-327
-
(1997)
Natl Toxicol Program Tech Rep Ser
, vol.457
, pp. 1-327
-
-
Program, N.T.1
-
52
-
-
0031400893
-
Urinary bladder cancer in a girl with a slow-acetylator genotype and treated with sulphasalazine
-
Espin Jaime M.T., Moran Penco J.M., Garcia Agundez J.A., Caballero Loscos M.J., Sanjuan Rodriguez S., Botello Martinez F., et al. Urinary bladder cancer in a girl with a slow-acetylator genotype and treated with sulphasalazine. Br J Urol 80 (1997) 151-152
-
(1997)
Br J Urol
, vol.80
, pp. 151-152
-
-
Espin Jaime, M.T.1
Moran Penco, J.M.2
Garcia Agundez, J.A.3
Caballero Loscos, M.J.4
Sanjuan Rodriguez, S.5
Botello Martinez, F.6
-
53
-
-
0037264854
-
In vitro studies on the lymphoma growth-inhibitory activity of sulfasalazine
-
Gout P.W., Simms C.R., and Robertson M.C. In vitro studies on the lymphoma growth-inhibitory activity of sulfasalazine. Anticancer Drugs 14 (2003) 21-29
-
(2003)
Anticancer Drugs
, vol.14
, pp. 21-29
-
-
Gout, P.W.1
Simms, C.R.2
Robertson, M.C.3
-
54
-
-
21244493649
-
Novel sulfasalazine analogues with enhanced NF-kB inhibitory and apoptosis promoting activity
-
Habens F., Srinivasan N., Oakley F., Mann D.A., Ganesan A., and Packham G. Novel sulfasalazine analogues with enhanced NF-kB inhibitory and apoptosis promoting activity. Apoptosis 10 (2005) 481-491
-
(2005)
Apoptosis
, vol.10
, pp. 481-491
-
-
Habens, F.1
Srinivasan, N.2
Oakley, F.3
Mann, D.A.4
Ganesan, A.5
Packham, G.6
-
55
-
-
0036850176
-
Molecular mechanisms of sulfasalazine-induced T-cell apoptosis
-
Liptay S., Fulda S., Schanbacher M., Bourteele S., Ferri K.F., Kroemer G., et al. Molecular mechanisms of sulfasalazine-induced T-cell apoptosis. Br J Pharmacol 137 (2002) 608-620
-
(2002)
Br J Pharmacol
, vol.137
, pp. 608-620
-
-
Liptay, S.1
Fulda, S.2
Schanbacher, M.3
Bourteele, S.4
Ferri, K.F.5
Kroemer, G.6
-
56
-
-
0036826735
-
Dissociated ROS production and ceramide generation in sulfasalazine-induced cell death in Raw 264, 7 cells
-
Salh B., Assi K., Huang S., O'Brien L., Steinbrecher U., and Gomez-Munoz A. Dissociated ROS production and ceramide generation in sulfasalazine-induced cell death in Raw 264, 7 cells. J Leukoc Biol 72 (2002) 790-799
-
(2002)
J Leukoc Biol
, vol.72
, pp. 790-799
-
-
Salh, B.1
Assi, K.2
Huang, S.3
O'Brien, L.4
Steinbrecher, U.5
Gomez-Munoz, A.6
-
57
-
-
0037457422
-
Usage of the NF-kappaB inhibitor sulfasalazine as sensitizing agent in combined chemotherapy of pancreatic cancer
-
Muerkoster S., Arlt A., Witt M., Gehrz A., Haye S., March C., et al. Usage of the NF-kappaB inhibitor sulfasalazine as sensitizing agent in combined chemotherapy of pancreatic cancer. Int J Cancer 104 (2003) 469-476
-
(2003)
Int J Cancer
, vol.104
, pp. 469-476
-
-
Muerkoster, S.1
Arlt, A.2
Witt, M.3
Gehrz, A.4
Haye, S.5
March, C.6
-
58
-
-
0035864344
-
Inhibition of NF-kappaB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin
-
Arlt A., Vorndamm J., Breitenbroich M., Folsch U.R., Kalthoff H., Schmidt W.E., et al. Inhibition of NF-kappaB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin. Oncogene 20 (2001) 859-868
-
(2001)
Oncogene
, vol.20
, pp. 859-868
-
-
Arlt, A.1
Vorndamm, J.2
Breitenbroich, M.3
Folsch, U.R.4
Kalthoff, H.5
Schmidt, W.E.6
-
59
-
-
0042914310
-
NF-kappaB-independent actions of sulfasalazine dissociate the CD95L- and Apo2L/TRAIL-dependent death signaling pathways in human malignant glioma cells
-
Hermisson M., and Weller M. NF-kappaB-independent actions of sulfasalazine dissociate the CD95L- and Apo2L/TRAIL-dependent death signaling pathways in human malignant glioma cells. Cell Death Differ 10 (2003) 1078-1089
-
(2003)
Cell Death Differ
, vol.10
, pp. 1078-1089
-
-
Hermisson, M.1
Weller, M.2
-
60
-
-
18244372933
-
Combination gene therapy for glioblastoma involving herpes simplex virus vector-mediated codelivery of mutant IkappaBalpha and HSV thymidine kinase
-
Moriuchi S., Glorioso J.C., Maruno M., Izumoto S., Wolfe D., Huang S., et al. Combination gene therapy for glioblastoma involving herpes simplex virus vector-mediated codelivery of mutant IkappaBalpha and HSV thymidine kinase. Cancer Gene Ther 12 (2005) 487-496
-
(2005)
Cancer Gene Ther
, vol.12
, pp. 487-496
-
-
Moriuchi, S.1
Glorioso, J.C.2
Maruno, M.3
Izumoto, S.4
Wolfe, D.5
Huang, S.6
-
61
-
-
0028945261
-
Activity of melphalan in combination with the glutathione transferase inhibitor sulfasalazine
-
Gupta V., Jani J.P., Jacobs S., Levitt M., Fields L., Awasthi S., et al. Activity of melphalan in combination with the glutathione transferase inhibitor sulfasalazine. Cancer Chemother Pharmacol 36 (1995) 13-19
-
(1995)
Cancer Chemother Pharmacol
, vol.36
, pp. 13-19
-
-
Gupta, V.1
Jani, J.P.2
Jacobs, S.3
Levitt, M.4
Fields, L.5
Awasthi, S.6
-
62
-
-
0036235624
-
Aberrant nuclear factor-kappaB activity and its participation in the growth of human malignant astrocytoma
-
Nagai S., Washiyama K., Kurimoto M., Takaku A., Endo S., and Kumanishi T. Aberrant nuclear factor-kappaB activity and its participation in the growth of human malignant astrocytoma. J Neurosurg 96 (2002) 909-917
-
(2002)
J Neurosurg
, vol.96
, pp. 909-917
-
-
Nagai, S.1
Washiyama, K.2
Kurimoto, M.3
Takaku, A.4
Endo, S.5
Kumanishi, T.6
-
63
-
-
33144461875
-
A phase 1-2, prospective, double blind, randomized study of the safety and efficacy of sulfasalazine for the treatment of progressing malignant gliomas: study protocol of [ISRCTN45828668]
-
Robe P.A., Martin D., Albert A., Deprez M., Chariot A., and Bours V. A phase 1-2, prospective, double blind, randomized study of the safety and efficacy of sulfasalazine for the treatment of progressing malignant gliomas: study protocol of [ISRCTN45828668]. BMC Cancer 6 (2006) 29
-
(2006)
BMC Cancer
, vol.6
, pp. 29
-
-
Robe, P.A.1
Martin, D.2
Albert, A.3
Deprez, M.4
Chariot, A.5
Bours, V.6
-
64
-
-
0041324898
-
The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression
-
De Bosscher K., Vanden Berghe W., and Haegeman G. The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression. Endocr Rev 24 (2003) 488-522
-
(2003)
Endocr Rev
, vol.24
, pp. 488-522
-
-
De Bosscher, K.1
Vanden Berghe, W.2
Haegeman, G.3
-
65
-
-
0028867899
-
Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis
-
Auphan N., DiDonato J.A., Rosette C., Helmberg A., and Karin M. Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science 270 (1995) 286-290
-
(1995)
Science
, vol.270
, pp. 286-290
-
-
Auphan, N.1
DiDonato, J.A.2
Rosette, C.3
Helmberg, A.4
Karin, M.5
-
66
-
-
0028879819
-
Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids
-
Scheinman R.I., Cogswell P.C., Lofquist A.K., and Baldwin Jr. A.S. Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids. Science 270 (1995) 283-286
-
(1995)
Science
, vol.270
, pp. 283-286
-
-
Scheinman, R.I.1
Cogswell, P.C.2
Lofquist, A.K.3
Baldwin Jr., A.S.4
-
67
-
-
0029778179
-
Glucocorticoid-mediated repression of NFkappaB activity in endothelial cells does not involve induction of IkappaBalpha synthesis
-
Brostjan C., Anrather J., Csizmadia V., Stroka D., Soares M., Bach F.H., et al. Glucocorticoid-mediated repression of NFkappaB activity in endothelial cells does not involve induction of IkappaBalpha synthesis. J Biol Chem 271 (1996) 19612-19616
-
(1996)
J Biol Chem
, vol.271
, pp. 19612-19616
-
-
Brostjan, C.1
Anrather, J.2
Csizmadia, V.3
Stroka, D.4
Soares, M.5
Bach, F.H.6
-
68
-
-
0031459881
-
Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation
-
De Bosscher K., Schmitz M.L., Vanden Berghe W., Plaisance S., Fiers W., and Haegeman G. Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation. Proc Natl Acad Sci USA 94 (1997) 13504-13509
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 13504-13509
-
-
De Bosscher, K.1
Schmitz, M.L.2
Vanden Berghe, W.3
Plaisance, S.4
Fiers, W.5
Haegeman, G.6
-
69
-
-
0028107237
-
Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor
-
Ray A., and Prefontaine K.E. Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor. Proc Natl Acad Sci USA 91 (1994) 752-756
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 752-756
-
-
Ray, A.1
Prefontaine, K.E.2
-
70
-
-
0034647929
-
Glucocorticoid effects on NF-kappaB binding in the transcription of the ICAM-1 gene
-
Liden J., Rafter I., Truss M., Gustafsson J.A., and Okret S. Glucocorticoid effects on NF-kappaB binding in the transcription of the ICAM-1 gene. Biochem Biophys Res Commun 273 (2000) 1008-1014
-
(2000)
Biochem Biophys Res Commun
, vol.273
, pp. 1008-1014
-
-
Liden, J.1
Rafter, I.2
Truss, M.3
Gustafsson, J.A.4
Okret, S.5
-
71
-
-
0035840839
-
Glucocorticoid-mediated transrepression is regulated by histone acetylation and DNA methylation
-
Kagoshima M., Wilcke T., Ito K., Tsaprouni L., Barnes P.J., Punchard N., et al. Glucocorticoid-mediated transrepression is regulated by histone acetylation and DNA methylation. Eur J Pharmacol 429 (2001) 327-334
-
(2001)
Eur J Pharmacol
, vol.429
, pp. 327-334
-
-
Kagoshima, M.1
Wilcke, T.2
Ito, K.3
Tsaprouni, L.4
Barnes, P.J.5
Punchard, N.6
-
72
-
-
0034665748
-
The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain
-
Nissen R.M., and Yamamoto K.R. The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain. Genes Dev 14 (2000) 2314-2329
-
(2000)
Genes Dev
, vol.14
, pp. 2314-2329
-
-
Nissen, R.M.1
Yamamoto, K.R.2
-
73
-
-
13944252475
-
Transcription factor cross-talk: the estrogen receptor and NF-kappaB
-
Kalaitzidis D., and Gilmore T.D. Transcription factor cross-talk: the estrogen receptor and NF-kappaB. Trends Endocrinol Metab 16 (2005) 46-52
-
(2005)
Trends Endocrinol Metab
, vol.16
, pp. 46-52
-
-
Kalaitzidis, D.1
Gilmore, T.D.2
-
74
-
-
33645825623
-
Raloxifene-induced myeloma cell apoptosis: a study of nuclear factor-{kappa}B inhibition and gene expression signature
-
Olivier S., Close P., Castermans E., de Leval L., Tabruyn S., Chariot A., et al. Raloxifene-induced myeloma cell apoptosis: a study of nuclear factor-{kappa}B inhibition and gene expression signature. Mol Pharmacol 69 (2006) 1615-1623
-
(2006)
Mol Pharmacol
, vol.69
, pp. 1615-1623
-
-
Olivier, S.1
Close, P.2
Castermans, E.3
de Leval, L.4
Tabruyn, S.5
Chariot, A.6
-
75
-
-
2342477960
-
Multicenter phase II feasibility trial of high-dose tamoxifen in patients with refractory or relapsed multiple myeloma
-
Decaudin D., Etienne M.C., De Cremoux P., Maciorowski Z., Vantelon J.M., Voog E., et al. Multicenter phase II feasibility trial of high-dose tamoxifen in patients with refractory or relapsed multiple myeloma. J Natl Cancer Inst 96 (2004) 636-637
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 636-637
-
-
Decaudin, D.1
Etienne, M.C.2
De Cremoux, P.3
Maciorowski, Z.4
Vantelon, J.M.5
Voog, E.6
-
76
-
-
0035691625
-
Tamoxifen-based treatment induces clinically meaningful responses in multiple myeloma patients with relapsing disease after autotransplantation
-
Fassas A.B., Rapoport A.P., Bolanos-Meade J., Shanholtz C., Cottler-Fox M., and Tricot G. Tamoxifen-based treatment induces clinically meaningful responses in multiple myeloma patients with relapsing disease after autotransplantation. Leuk Lymphoma 42 (2001) 1323-1328
-
(2001)
Leuk Lymphoma
, vol.42
, pp. 1323-1328
-
-
Fassas, A.B.1
Rapoport, A.P.2
Bolanos-Meade, J.3
Shanholtz, C.4
Cottler-Fox, M.5
Tricot, G.6
-
77
-
-
15444369546
-
CD40 engagement prevents peroxisome proliferator-activated receptor gamma agonist-induced apoptosis of B lymphocytes and B lymphoma cells by an NF-kappaB-dependent mechanism
-
Ray D.M., Akbiyik F., Bernstein S.H., and Phipps R.P. CD40 engagement prevents peroxisome proliferator-activated receptor gamma agonist-induced apoptosis of B lymphocytes and B lymphoma cells by an NF-kappaB-dependent mechanism. J Immunol 174 (2005) 4060-4069
-
(2005)
J Immunol
, vol.174
, pp. 4060-4069
-
-
Ray, D.M.1
Akbiyik, F.2
Bernstein, S.H.3
Phipps, R.P.4
-
78
-
-
0242526756
-
Phosphorylation of PPARgamma via active ERK1/2 leads to its physical association with p65 and inhibition of NF-kappabeta
-
Chen F., Wang M., O'Connor J.P., He M., Tripathi T., and Harrison L.E. Phosphorylation of PPARgamma via active ERK1/2 leads to its physical association with p65 and inhibition of NF-kappabeta. J Cell Biochem 90 (2003) 732-744
-
(2003)
J Cell Biochem
, vol.90
, pp. 732-744
-
-
Chen, F.1
Wang, M.2
O'Connor, J.P.3
He, M.4
Tripathi, T.5
Harrison, L.E.6
-
79
-
-
0032746173
-
A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response
-
Su C.G., Wen X., Bailey S.T., Jiang W., Rangwala S.M., Keilbaugh S.A., et al. A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response. J Clin Invest 104 (1999) 383-389
-
(1999)
J Clin Invest
, vol.104
, pp. 383-389
-
-
Su, C.G.1
Wen, X.2
Bailey, S.T.3
Jiang, W.4
Rangwala, S.M.5
Keilbaugh, S.A.6
-
80
-
-
0034610759
-
Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase
-
Rossi A., Kapahi P., Natoli G., Takahashi T., Chen Y., Karin M., et al. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature 403 (2000) 103-108
-
(2000)
Nature
, vol.403
, pp. 103-108
-
-
Rossi, A.1
Kapahi, P.2
Natoli, G.3
Takahashi, T.4
Chen, Y.5
Karin, M.6
-
81
-
-
15744396059
-
PPAR-gamma activation inhibits angiogenesis by blocking ELR + CXC chemokine production in non-small cell lung cancer
-
Keshamouni V.G., Arenberg D.A., Reddy R.C., Newstead M.J., Anthwal S., and Standiford T.J. PPAR-gamma activation inhibits angiogenesis by blocking ELR + CXC chemokine production in non-small cell lung cancer. Neoplasia 7 (2005) 294-301
-
(2005)
Neoplasia
, vol.7
, pp. 294-301
-
-
Keshamouni, V.G.1
Arenberg, D.A.2
Reddy, R.C.3
Newstead, M.J.4
Anthwal, S.5
Standiford, T.J.6
-
82
-
-
0032748385
-
Antitumor activity of thalidomide in refractory multiple myeloma
-
Singhal S., Mehta J., Desikan R., Ayers D., Roberson P., Eddlemon P., et al. Antitumor activity of thalidomide in refractory multiple myeloma. N Engl J Med 341 (1999) 1565-1571
-
(1999)
N Engl J Med
, vol.341
, pp. 1565-1571
-
-
Singhal, S.1
Mehta, J.2
Desikan, R.3
Ayers, D.4
Roberson, P.5
Eddlemon, P.6
-
83
-
-
0035933772
-
Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity
-
Keifer J.A., Guttridge D.C., Ashburner B.P., and Baldwin Jr. A.S. Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity. J Biol Chem 276 (2001) 22382-22387
-
(2001)
J Biol Chem
, vol.276
, pp. 22382-22387
-
-
Keifer, J.A.1
Guttridge, D.C.2
Ashburner, B.P.3
Baldwin Jr., A.S.4
-
84
-
-
0037097595
-
Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications
-
Mitsiades N., Mitsiades C.S., Poulaki V., Chauhan D., Richardson P.G., Hideshima T., et al. Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications. Blood 99 (2002) 4525-4530
-
(2002)
Blood
, vol.99
, pp. 4525-4530
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Poulaki, V.3
Chauhan, D.4
Richardson, P.G.5
Hideshima, T.6
-
85
-
-
0035195019
-
Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications
-
Gupta D., Treon S.P., Shima Y., Hideshima T., Podar K., Tai Y.T., et al. Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications. Leukemia 15 (2001) 1950-1961
-
(2001)
Leukemia
, vol.15
, pp. 1950-1961
-
-
Gupta, D.1
Treon, S.P.2
Shima, Y.3
Hideshima, T.4
Podar, K.5
Tai, Y.T.6
-
86
-
-
0034331194
-
Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy
-
Hideshima T., Chauhan D., Shima Y., Raje N., Davies F.E., Tai Y.T., et al. Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy. Blood 96 (2000) 2943-2950
-
(2000)
Blood
, vol.96
, pp. 2943-2950
-
-
Hideshima, T.1
Chauhan, D.2
Shima, Y.3
Raje, N.4
Davies, F.E.5
Tai, Y.T.6
-
87
-
-
0035412366
-
Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma
-
Davies F.E., Raje N., Hideshima T., Lentzsch S., Young G., Tai Y.T., et al. Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma. Blood 98 (2001) 210-216
-
(2001)
Blood
, vol.98
, pp. 210-216
-
-
Davies, F.E.1
Raje, N.2
Hideshima, T.3
Lentzsch, S.4
Young, G.5
Tai, Y.T.6
-
88
-
-
0036839013
-
Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma
-
Richardson P.G., Schlossman R.L., Weller E., Hideshima T., Mitsiades C., Davies F., et al. Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma. Blood 100 (2002) 3063-3067
-
(2002)
Blood
, vol.100
, pp. 3063-3067
-
-
Richardson, P.G.1
Schlossman, R.L.2
Weller, E.3
Hideshima, T.4
Mitsiades, C.5
Davies, F.6
-
89
-
-
1942534043
-
The evolution of thalidomide and its IMiD derivatives as anticancer agents
-
Bartlett J.B., Dredge K., and Dalgleish A.G. The evolution of thalidomide and its IMiD derivatives as anticancer agents. Nat Rev Cancer 4 (2004) 314-322
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 314-322
-
-
Bartlett, J.B.1
Dredge, K.2
Dalgleish, A.G.3
-
90
-
-
23944453915
-
A rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein {beta} and NF-{kappa}B activity in Hodgkin and anaplastic large cell lymphomas
-
Jundt F., Raetzel N., Muller C., Calkhoven C.F., Kley K., Mathas S., et al. A rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein {beta} and NF-{kappa}B activity in Hodgkin and anaplastic large cell lymphomas. Blood 106 (2005) 1801-1807
-
(2005)
Blood
, vol.106
, pp. 1801-1807
-
-
Jundt, F.1
Raetzel, N.2
Muller, C.3
Calkhoven, C.F.4
Kley, K.5
Mathas, S.6
-
91
-
-
0036776168
-
A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling
-
Chen J., and Fang Y. A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling. Biochem Pharmacol 64 (2002) 1071-1077
-
(2002)
Biochem Pharmacol
, vol.64
, pp. 1071-1077
-
-
Chen, J.1
Fang, Y.2
-
92
-
-
9644252848
-
Rapamycin inhibits doxorubicin-induced NF-kappaB/Rel nuclear activity and enhances the apoptosis of melanoma cells
-
Romano M.F., Avellino R., Petrella A., Bisogni R., Romano S., and Venuta S. Rapamycin inhibits doxorubicin-induced NF-kappaB/Rel nuclear activity and enhances the apoptosis of melanoma cells. Eur J Cancer 40 (2004) 2829-2836
-
(2004)
Eur J Cancer
, vol.40
, pp. 2829-2836
-
-
Romano, M.F.1
Avellino, R.2
Petrella, A.3
Bisogni, R.4
Romano, S.5
Venuta, S.6
-
93
-
-
23044434574
-
Roxithromycin inhibits constitutive activation of nuclear factor {kappa}B by diminishing oxidative stress in a rat model of hepatocellular carcinoma
-
Ueno S., Aoki D., Kubo F., Hiwatashi K., Matsushita K., Oyama T., et al. Roxithromycin inhibits constitutive activation of nuclear factor {kappa}B by diminishing oxidative stress in a rat model of hepatocellular carcinoma. Clin Cancer Res 11 (2005) 5645-5650
-
(2005)
Clin Cancer Res
, vol.11
, pp. 5645-5650
-
-
Ueno, S.1
Aoki, D.2
Kubo, F.3
Hiwatashi, K.4
Matsushita, K.5
Oyama, T.6
-
94
-
-
0035165393
-
Clarithromycin inhibits NF-kappaB activation in human peripheral blood mononuclear cells and pulmonary epithelial cells
-
Ichiyama T., Nishikawa M., Yoshitomi T., Hasegawa S., Matsubara T., Hayashi T., et al. Clarithromycin inhibits NF-kappaB activation in human peripheral blood mononuclear cells and pulmonary epithelial cells. Antimicrob Agents Chemother 45 (2001) 44-47
-
(2001)
Antimicrob Agents Chemother
, vol.45
, pp. 44-47
-
-
Ichiyama, T.1
Nishikawa, M.2
Yoshitomi, T.3
Hasegawa, S.4
Matsubara, T.5
Hayashi, T.6
-
95
-
-
0034660871
-
Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase
-
Manna S.K., Sah N.K., Newman R.A., Cisneros A., and Aggarwal B.B. Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase. Cancer Res 60 (2000) 3838-3847
-
(2000)
Cancer Res
, vol.60
, pp. 3838-3847
-
-
Manna, S.K.1
Sah, N.K.2
Newman, R.A.3
Cisneros, A.4
Aggarwal, B.B.5
-
96
-
-
22144480948
-
Cardiac glycosides inhibit TNF-alpha/NF-kappaB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor
-
Yang Q., Huang W., Jozwik C., Lin Y., Glasman M., Caohuy H., et al. Cardiac glycosides inhibit TNF-alpha/NF-kappaB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor. Proc Natl Acad Sci USA 102 (2005) 9631-9636
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 9631-9636
-
-
Yang, Q.1
Huang, W.2
Jozwik, C.3
Lin, Y.4
Glasman, M.5
Caohuy, H.6
-
97
-
-
0242408772
-
Oleandrin suppresses activation of nuclear transcription factor-kappa B and activator protein-1 and potentiates apoptosis induced by ceramide
-
Sreenivasan Y., Sarkar A., and Manna S.K. Oleandrin suppresses activation of nuclear transcription factor-kappa B and activator protein-1 and potentiates apoptosis induced by ceramide. Biochem Pharmacol 66 (2003) 2223-2239
-
(2003)
Biochem Pharmacol
, vol.66
, pp. 2223-2239
-
-
Sreenivasan, Y.1
Sarkar, A.2
Manna, S.K.3
-
98
-
-
33644974357
-
The cardenolide UNBS1450 is able to deactivate nuclear factor kappaB-mediated cytoprotective effects in human non-small cell lung cancer cells
-
Mijatovic T., Op De Beeck A., Van Quaquebeke E., Dewelle J., Darro F., de Launoit Y., et al. The cardenolide UNBS1450 is able to deactivate nuclear factor kappaB-mediated cytoprotective effects in human non-small cell lung cancer cells. Mol Cancer Ther 5 (2006) 391-399
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 391-399
-
-
Mijatovic, T.1
Op De Beeck, A.2
Van Quaquebeke, E.3
Dewelle, J.4
Darro, F.5
de Launoit, Y.6
-
99
-
-
0346505340
-
The IKK NF-kappa B system: a treasure trove for drug development
-
Karin M., Yamamoto Y., and Wang Q.M. The IKK NF-kappa B system: a treasure trove for drug development. Nat Rev Drug Discov 3 (2004) 17-26
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 17-26
-
-
Karin, M.1
Yamamoto, Y.2
Wang, Q.M.3
-
100
-
-
16844366650
-
Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs
-
Nakanishi C., and Toi M. Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs. Nat Rev Cancer 5 (2005) 297-309
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 297-309
-
-
Nakanishi, C.1
Toi, M.2
-
101
-
-
0036217332
-
Proteasome inhibition: a novel approach to cancer therapy
-
Adams J. Proteasome inhibition: a novel approach to cancer therapy. Trends Mol Med 8 (2002) S49-S54
-
(2002)
Trends Mol Med
, vol.8
-
-
Adams, J.1
-
102
-
-
0141704418
-
The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites
-
Kisselev A.F., Garcia-Calvo M., Overkleeft H.S., Peterson E., Pennington M.W., Ploegh H.L., et al. The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites. J Biol Chem 278 (2003) 35869-35877
-
(2003)
J Biol Chem
, vol.278
, pp. 35869-35877
-
-
Kisselev, A.F.1
Garcia-Calvo, M.2
Overkleeft, H.S.3
Peterson, E.4
Pennington, M.W.5
Ploegh, H.L.6
-
103
-
-
0032476030
-
Contribution of proteasomal beta-subunits to the cleavage of peptide substrates analyzed with yeast mutants
-
Dick T.P., Nussbaum A.K., Deeg M., Heinemeyer W., Groll M., Schirle M., et al. Contribution of proteasomal beta-subunits to the cleavage of peptide substrates analyzed with yeast mutants. J Biol Chem 273 (1998) 25637-25646
-
(1998)
J Biol Chem
, vol.273
, pp. 25637-25646
-
-
Dick, T.P.1
Nussbaum, A.K.2
Deeg, M.3
Heinemeyer, W.4
Groll, M.5
Schirle, M.6
-
104
-
-
18144425142
-
Identification of the ubiquitin-proteasome pathway in the regulation of the stability of eukaryotic elongation factor-2 kinase
-
Arora S., Yang J.M., and Hait W.N. Identification of the ubiquitin-proteasome pathway in the regulation of the stability of eukaryotic elongation factor-2 kinase. Cancer Res 65 (2005) 3806-3810
-
(2005)
Cancer Res
, vol.65
, pp. 3806-3810
-
-
Arora, S.1
Yang, J.M.2
Hait, W.N.3
-
106
-
-
0034647563
-
Ubiquitin-mediated degradation of the proapoptotic active form of bid. A functional consequence on apoptosis induction
-
Breitschopf K., Zeiher A.M., and Dimmeler S. Ubiquitin-mediated degradation of the proapoptotic active form of bid. A functional consequence on apoptosis induction. J Biol Chem 275 (2000) 21648-21652
-
(2000)
J Biol Chem
, vol.275
, pp. 21648-21652
-
-
Breitschopf, K.1
Zeiher, A.M.2
Dimmeler, S.3
-
107
-
-
31544457877
-
p53 ubiquitination: Mdm2 and beyond
-
Brooks C.L., and Gu W. p53 ubiquitination: Mdm2 and beyond. Mol Cell 21 (2006) 307-315
-
(2006)
Mol Cell
, vol.21
, pp. 307-315
-
-
Brooks, C.L.1
Gu, W.2
-
108
-
-
1242317030
-
Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP)
-
Dan H.C., Sun M., Kaneko S., Feldman R.I., Nicosia S.V., Wang H.G., et al. Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). J Biol Chem 279 (2004) 5405-5412
-
(2004)
J Biol Chem
, vol.279
, pp. 5405-5412
-
-
Dan, H.C.1
Sun, M.2
Kaneko, S.3
Feldman, R.I.4
Nicosia, S.V.5
Wang, H.G.6
-
109
-
-
0037053375
-
Ubiquitin/proteasome-dependent degradation of D-type cyclins is linked to tumor necrosis factor-induced cell cycle arrest
-
Hu X., Bryington M., Fisher A.B., Liang X., Zhang X., Cui D., et al. Ubiquitin/proteasome-dependent degradation of D-type cyclins is linked to tumor necrosis factor-induced cell cycle arrest. J Biol Chem 277 (2002) 16528-16537
-
(2002)
J Biol Chem
, vol.277
, pp. 16528-16537
-
-
Hu, X.1
Bryington, M.2
Fisher, A.B.3
Liang, X.4
Zhang, X.5
Cui, D.6
-
110
-
-
0033038942
-
Proteasome inhibitors induce mitochondria-independent apoptosis in human glioma cells
-
Kitagawa H., Tani E., Ikemoto H., Ozaki I., Nakano A., and Omura S. Proteasome inhibitors induce mitochondria-independent apoptosis in human glioma cells. FEBS Lett 443 (1999) 181-186
-
(1999)
FEBS Lett
, vol.443
, pp. 181-186
-
-
Kitagawa, H.1
Tani, E.2
Ikemoto, H.3
Ozaki, I.4
Nakano, A.5
Omura, S.6
-
111
-
-
3543078617
-
Associations among beta-TrCP, an E3 ubiquitin ligase receptor, beta-catenin, and NF-kappaB in colorectal cancer
-
Ougolkov A., Zhang B., Yamashita K., Bilim V., Mai M., Fuchs S.Y., et al. Associations among beta-TrCP, an E3 ubiquitin ligase receptor, beta-catenin, and NF-kappaB in colorectal cancer. J Natl Cancer Inst 96 (2004) 1161-1170
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 1161-1170
-
-
Ougolkov, A.1
Zhang, B.2
Yamashita, K.3
Bilim, V.4
Mai, M.5
Fuchs, S.Y.6
-
112
-
-
0034712842
-
A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination
-
Podust V.N., Brownell J.E., Gladysheva T.B., Luo R.S., Wang C., Coggins M.B., et al. A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination. Proc Natl Acad Sci USA 97 (2000) 4579-4584
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 4579-4584
-
-
Podust, V.N.1
Brownell, J.E.2
Gladysheva, T.B.3
Luo, R.S.4
Wang, C.5
Coggins, M.B.6
-
113
-
-
6944227551
-
A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size
-
Welcker M., Orian A., Grim J.E., Eisenman R.N., and Clurman B.E. A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size. Curr Biol 14 (2004) 1852-1857
-
(2004)
Curr Biol
, vol.14
, pp. 1852-1857
-
-
Welcker, M.1
Orian, A.2
Grim, J.E.3
Eisenman, R.N.4
Clurman, B.E.5
-
114
-
-
7544234764
-
Cell cycle, proteolysis and cancer
-
Yamasaki L., and Pagano M. Cell cycle, proteolysis and cancer. Curr Opin Cell Biol 16 (2004) 623-628
-
(2004)
Curr Opin Cell Biol
, vol.16
, pp. 623-628
-
-
Yamasaki, L.1
Pagano, M.2
-
115
-
-
22344442683
-
Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341 Velcade) and other proteasome inhibitors
-
Zhu H., Zhang L., Dong F., Guo W., Wu S., Teraishi F., et al. Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341 Velcade) and other proteasome inhibitors. Oncogene 24 (2005) 4993-4999
-
(2005)
Oncogene
, vol.24
, pp. 4993-4999
-
-
Zhu, H.1
Zhang, L.2
Dong, F.3
Guo, W.4
Wu, S.5
Teraishi, F.6
-
116
-
-
31544433927
-
Bortezomib mediates antiangiogenesis in multiple myeloma via direct and indirect effects on endothelial cells
-
Roccaro A.M., Hideshima T., Raje N., Kumar S., Ishitsuka K., Yasui H., et al. Bortezomib mediates antiangiogenesis in multiple myeloma via direct and indirect effects on endothelial cells. Cancer Res 66 (2006) 184-191
-
(2006)
Cancer Res
, vol.66
, pp. 184-191
-
-
Roccaro, A.M.1
Hideshima, T.2
Raje, N.3
Kumar, S.4
Ishitsuka, K.5
Yasui, H.6
-
117
-
-
0642349188
-
Differential effects of the proteasome inhibitor bortezomib on apoptosis and angiogenesis in human prostate tumor xenografts
-
Williams S., Pettaway C., Song R., Papandreou C., Logothetis C., and McConkey D.J. Differential effects of the proteasome inhibitor bortezomib on apoptosis and angiogenesis in human prostate tumor xenografts. Mol Cancer Ther 2 (2003) 835-843
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 835-843
-
-
Williams, S.1
Pettaway, C.2
Song, R.3
Papandreou, C.4
Logothetis, C.5
McConkey, D.J.6
-
118
-
-
0035887436
-
Akt1 induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells
-
Park B.K., Zeng X., and Glazer R.I. Akt1 induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells. Cancer Res 61 (2001) 7647-7653
-
(2001)
Cancer Res
, vol.61
, pp. 7647-7653
-
-
Park, B.K.1
Zeng, X.2
Glazer, R.I.3
-
119
-
-
5644225628
-
Caveolin-1 is required for vascular endothelial growth factor-triggered multiple myeloma cell migration and is targeted by bortezomib
-
Podar K., Shringarpure R., Tai Y.T., Simoncini M., Sattler M., Ishitsuka K., et al. Caveolin-1 is required for vascular endothelial growth factor-triggered multiple myeloma cell migration and is targeted by bortezomib. Cancer Res 64 (2004) 7500-7506
-
(2004)
Cancer Res
, vol.64
, pp. 7500-7506
-
-
Podar, K.1
Shringarpure, R.2
Tai, Y.T.3
Simoncini, M.4
Sattler, M.5
Ishitsuka, K.6
-
120
-
-
0037529368
-
Tumors acquire inhibitor of apoptosis protein (IAP)-mediated apoptosis resistance through altered specificity of cytosolic proteolysis
-
Hong X., Lei L., and Glas R. Tumors acquire inhibitor of apoptosis protein (IAP)-mediated apoptosis resistance through altered specificity of cytosolic proteolysis. J Exp Med 197 (2003) 1731-1743
-
(2003)
J Exp Med
, vol.197
, pp. 1731-1743
-
-
Hong, X.1
Lei, L.2
Glas, R.3
-
121
-
-
31544464685
-
Inefficient proteasomal-degradation pathway stabilizes AP-2alpha and activates HER-2/neu gene in breast cancer
-
Li M., Wang Y., Hung M.C., and Kannan P. Inefficient proteasomal-degradation pathway stabilizes AP-2alpha and activates HER-2/neu gene in breast cancer. Int J Cancer 118 (2006) 802-811
-
(2006)
Int J Cancer
, vol.118
, pp. 802-811
-
-
Li, M.1
Wang, Y.2
Hung, M.C.3
Kannan, P.4
-
122
-
-
12944283204
-
Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma
-
Chiarle R., Budel L.M., Skolnik J., Frizzera G., Chilosi M., Corato A., et al. Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma. Blood 95 (2000) 619-626
-
(2000)
Blood
, vol.95
, pp. 619-626
-
-
Chiarle, R.1
Budel, L.M.2
Skolnik, J.3
Frizzera, G.4
Chilosi, M.5
Corato, A.6
-
123
-
-
17144389347
-
Growth factor regulation of a 26S proteasomal subunit in breast cancer
-
Barnes C.J., Li F., Talukder A.H., and Kumar R. Growth factor regulation of a 26S proteasomal subunit in breast cancer. Clin Cancer Res 11 (2005) 2868-2874
-
(2005)
Clin Cancer Res
, vol.11
, pp. 2868-2874
-
-
Barnes, C.J.1
Li, F.2
Talukder, A.H.3
Kumar, R.4
-
124
-
-
0038404847
-
Gene expression profiling detects gene amplification and differentiates tumor types in breast cancer
-
Dressman M.A., Baras A., Malinowski R., Alvis L.B., Kwon I., Walz T.M., et al. Gene expression profiling detects gene amplification and differentiates tumor types in breast cancer. Cancer Res 63 (2003) 2194-2199
-
(2003)
Cancer Res
, vol.63
, pp. 2194-2199
-
-
Dressman, M.A.1
Baras, A.2
Malinowski, R.3
Alvis, L.B.4
Kwon, I.5
Walz, T.M.6
-
125
-
-
0037994340
-
Brody JP. p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells
-
Thompson H.G., Harris J.W., Wold B.J., and Lin F. Brody JP. p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells. Oncogene 22 (2003) 2322-2333
-
(2003)
Oncogene
, vol.22
, pp. 2322-2333
-
-
Thompson, H.G.1
Harris, J.W.2
Wold, B.J.3
Lin, F.4
-
126
-
-
0033059459
-
Increased sensitivity of CLL-derived lymphocytes to apoptotic death activation by the proteasome-specific inhibitor lactacystin
-
Masdehors P., Omura S., Merle-Beral H., Mentz F., Cosset J.M., Dumont J., et al. Increased sensitivity of CLL-derived lymphocytes to apoptotic death activation by the proteasome-specific inhibitor lactacystin. Br J Haematol 105 (1999) 752-757
-
(1999)
Br J Haematol
, vol.105
, pp. 752-757
-
-
Masdehors, P.1
Omura, S.2
Merle-Beral, H.3
Mentz, F.4
Cosset, J.M.5
Dumont, J.6
-
127
-
-
0025134078
-
Characterization of the active site of human multicatalytic proteinase
-
Mason R.W. Characterization of the active site of human multicatalytic proteinase. Biochem J 265 (1990) 479-484
-
(1990)
Biochem J
, vol.265
, pp. 479-484
-
-
Mason, R.W.1
-
128
-
-
0027707470
-
Synthetic inhibitors of the multicatalytic proteinase complex (proteasome)
-
Wilk S., and Figueiredo-Pereira M.E. Synthetic inhibitors of the multicatalytic proteinase complex (proteasome). Enzyme Protein 47 (1993) 306-313
-
(1993)
Enzyme Protein
, vol.47
, pp. 306-313
-
-
Wilk, S.1
Figueiredo-Pereira, M.E.2
-
129
-
-
0030926777
-
Lactacystin and clasto-lactacystin beta-lactone modify multiple proteasome beta-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation
-
Craiu A., Gaczynska M., Akopian T., Gramm C.F., Fenteany G., Goldberg A.L., et al. Lactacystin and clasto-lactacystin beta-lactone modify multiple proteasome beta-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation. J Biol Chem 272 (1997) 13437-13445
-
(1997)
J Biol Chem
, vol.272
, pp. 13437-13445
-
-
Craiu, A.1
Gaczynska, M.2
Akopian, T.3
Gramm, C.F.4
Fenteany, G.5
Goldberg, A.L.6
-
130
-
-
0026011974
-
Structure of lactacystin, a new microbial metabolite which induces differentiation of neuroblastoma cells
-
Omura S., Matsuzaki K., Fujimoto T., Kosuge K., Furuya T., Fujita S., et al. Structure of lactacystin, a new microbial metabolite which induces differentiation of neuroblastoma cells. J Antibiot (Tokyo) 44 (1991) 117-118
-
(1991)
J Antibiot (Tokyo)
, vol.44
, pp. 117-118
-
-
Omura, S.1
Matsuzaki, K.2
Fujimoto, T.3
Kosuge, K.4
Furuya, T.5
Fujita, S.6
-
131
-
-
0032530241
-
Formation of proteasome-PA700 complexes directly correlates with activation of peptidase activity
-
Adams G.M., Crotchett B., Slaughter C.A., DeMartino G.N., and Gogol E.P. Formation of proteasome-PA700 complexes directly correlates with activation of peptidase activity. Biochemistry 37 (1998) 12927-12932
-
(1998)
Biochemistry
, vol.37
, pp. 12927-12932
-
-
Adams, G.M.1
Crotchett, B.2
Slaughter, C.A.3
DeMartino, G.N.4
Gogol, E.P.5
-
132
-
-
0029012388
-
Potent inhibitors of proteasome
-
Iqbal M., Chatterjee S., Kauer J.C., Das M., Messina P., Freed B., et al. Potent inhibitors of proteasome. J Med Chem 38 (1995) 2276-2277
-
(1995)
J Med Chem
, vol.38
, pp. 2276-2277
-
-
Iqbal, M.1
Chatterjee, S.2
Kauer, J.C.3
Das, M.4
Messina, P.5
Freed, B.6
-
133
-
-
0042848726
-
Proline- and arginine-rich peptides constitute a novel class of allosteric inhibitors of proteasome activity
-
Gaczynska M., Osmulski P.A., Gao Y., Post M.J., and Simons M. Proline- and arginine-rich peptides constitute a novel class of allosteric inhibitors of proteasome activity. Biochemistry 42 (2003) 8663-8670
-
(2003)
Biochemistry
, vol.42
, pp. 8663-8670
-
-
Gaczynska, M.1
Osmulski, P.A.2
Gao, Y.3
Post, M.J.4
Simons, M.5
-
134
-
-
0034864799
-
Proteasome inhibitors: from research tools to drug candidates
-
Kisselev A.F., and Goldberg A.L. Proteasome inhibitors: from research tools to drug candidates. Chem Biol 8 (2001) 739-758
-
(2001)
Chem Biol
, vol.8
, pp. 739-758
-
-
Kisselev, A.F.1
Goldberg, A.L.2
-
135
-
-
24944585018
-
A novel carbohydrate-based therapeutic GCS-100 overcomes bortezomib resistance and enhances dexamethasone-induced apoptosis in multiple myeloma cells
-
Chauhan D., Li G., Podar K., Hideshima T., Neri P., He D., et al. A novel carbohydrate-based therapeutic GCS-100 overcomes bortezomib resistance and enhances dexamethasone-induced apoptosis in multiple myeloma cells. Cancer Res 65 (2005) 8350-8358
-
(2005)
Cancer Res
, vol.65
, pp. 8350-8358
-
-
Chauhan, D.1
Li, G.2
Podar, K.3
Hideshima, T.4
Neri, P.5
He, D.6
-
136
-
-
17644379385
-
Pharmacology, pharmacokinetics, and practical applications of bortezomib
-
Schwartz R., and Davidson T. Pharmacology, pharmacokinetics, and practical applications of bortezomib. Oncology (Williston Park) 18 (2004) 14-21
-
(2004)
Oncology (Williston Park)
, vol.18
, pp. 14-21
-
-
Schwartz, R.1
Davidson, T.2
-
137
-
-
0034037622
-
Proteasome inhibition measurements: clinical application
-
Lightcap E.S., McCormack T.A., Pien C.S., Chau V., Adams J., and Elliott P.J. Proteasome inhibition measurements: clinical application. Clin Chem 46 (2000) 673-683
-
(2000)
Clin Chem
, vol.46
, pp. 673-683
-
-
Lightcap, E.S.1
McCormack, T.A.2
Pien, C.S.3
Chau, V.4
Adams, J.5
Elliott, P.J.6
-
138
-
-
15444369226
-
Intracellular inhibitory effects of Velcade correlate with morphoproteomic expression of phosphorylated-nuclear factor-kappaB and p53 in breast cancer cell lines
-
Lun M., Zhang P.L., Siegelmann-Danieli N., Blasick T.M., and Brown R.E. Intracellular inhibitory effects of Velcade correlate with morphoproteomic expression of phosphorylated-nuclear factor-kappaB and p53 in breast cancer cell lines. Ann Clin Lab Sci 35 (2005) 15-24
-
(2005)
Ann Clin Lab Sci
, vol.35
, pp. 15-24
-
-
Lun, M.1
Zhang, P.L.2
Siegelmann-Danieli, N.3
Blasick, T.M.4
Brown, R.E.5
-
139
-
-
2542616162
-
Synergistic effect of histone deacetylase inhibitors FK228 and m-carboxycinnamic acid bis-hydroxamide with proteasome inhibitors PSI and PS-341 against gastrointestinal adenocarcinoma cells
-
Adachi M., Zhang Y., Zhao X., Minami T., Kawamura R., Hinoda Y., et al. Synergistic effect of histone deacetylase inhibitors FK228 and m-carboxycinnamic acid bis-hydroxamide with proteasome inhibitors PSI and PS-341 against gastrointestinal adenocarcinoma cells. Clin Cancer Res 10 (2004) 3853-3862
-
(2004)
Clin Cancer Res
, vol.10
, pp. 3853-3862
-
-
Adachi, M.1
Zhang, Y.2
Zhao, X.3
Minami, T.4
Kawamura, R.5
Hinoda, Y.6
-
140
-
-
3042673073
-
The potential role of proteasome inhibitors in the treatment of lung cancer
-
Bunn Jr. P.A. The potential role of proteasome inhibitors in the treatment of lung cancer. Clin Cancer Res 10 (2004) 4263s-4265s
-
(2004)
Clin Cancer Res
, vol.10
-
-
Bunn Jr., P.A.1
-
141
-
-
0034902354
-
Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma
-
Sunwoo J.B., Chen Z., Dong G., Yeh N., Crowl Bancroft C., Sausville E., et al. Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma. Clin Cancer Res 7 (2001) 1419-1428
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1419-1428
-
-
Sunwoo, J.B.1
Chen, Z.2
Dong, G.3
Yeh, N.4
Crowl Bancroft, C.5
Sausville, E.6
-
142
-
-
26844452967
-
Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy
-
Boccadoro M., Morgan G., and Cavenagh J. Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy. Cancer Cell Int 5 (2005) 18
-
(2005)
Cancer Cell Int
, vol.5
, pp. 18
-
-
Boccadoro, M.1
Morgan, G.2
Cavenagh, J.3
-
143
-
-
33645737411
-
Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells
-
Nawrocki S.T., Carew J.S., Pino M.S., Highshaw R.A., Andtbacka R.H., Dunner Jr. K., et al. Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells. Cancer Res 66 (2006) 3773-3781
-
(2006)
Cancer Res
, vol.66
, pp. 3773-3781
-
-
Nawrocki, S.T.1
Carew, J.S.2
Pino, M.S.3
Highshaw, R.A.4
Andtbacka, R.H.5
Dunner Jr., K.6
-
144
-
-
13244262655
-
Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM)
-
Yin D., Zhou H., Kumagai T., Liu G., Ong J.M., Black K.L., et al. Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM). Oncogene 24 (2005) 344-354
-
(2005)
Oncogene
, vol.24
, pp. 344-354
-
-
Yin, D.1
Zhou, H.2
Kumagai, T.3
Liu, G.4
Ong, J.M.5
Black, K.L.6
-
145
-
-
33646789993
-
Anti-cancer effects of bortezomib against chemoresistant neuroblastoma cell lines in vitro and in vivo
-
Michaelis M., Fichtner I., Behrens D., Haider W., Rothweiler F., Mack A., et al. Anti-cancer effects of bortezomib against chemoresistant neuroblastoma cell lines in vitro and in vivo. Int J Oncol 28 (2006) 439-446
-
(2006)
Int J Oncol
, vol.28
, pp. 439-446
-
-
Michaelis, M.1
Fichtner, I.2
Behrens, D.3
Haider, W.4
Rothweiler, F.5
Mack, A.6
-
146
-
-
2442549643
-
Induction of cell cycle arrest and apoptosis by the proteasome inhibitor PS-341 in Hodgkin disease cell lines is independent of inhibitor of nuclear factor-kappaB mutations or activation of the CD30, CD40, and RANK receptors
-
Zheng B., Georgakis G.V., Li Y., Bharti A., McConkey D., Aggarwal B.B., et al. Induction of cell cycle arrest and apoptosis by the proteasome inhibitor PS-341 in Hodgkin disease cell lines is independent of inhibitor of nuclear factor-kappaB mutations or activation of the CD30, CD40, and RANK receptors. Clin Cancer Res 10 (2004) 3207-3215
-
(2004)
Clin Cancer Res
, vol.10
, pp. 3207-3215
-
-
Zheng, B.1
Georgakis, G.V.2
Li, Y.3
Bharti, A.4
McConkey, D.5
Aggarwal, B.B.6
-
147
-
-
0242468166
-
Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-kappaB-dependent process
-
Dai Y., Rahmani M., and Grant S. Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-kappaB-dependent process. Oncogene 22 (2003) 7108-7122
-
(2003)
Oncogene
, vol.22
, pp. 7108-7122
-
-
Dai, Y.1
Rahmani, M.2
Grant, S.3
-
148
-
-
4344643781
-
Proteasome inhibitor, bortezomib, potently inhibits the growth of adult T-cell leukemia cells both in vivo and in vitro
-
Satou Y., Nosaka K., Koya Y., Yasunaga J.I., Toyokuni S., and Matsuoka M. Proteasome inhibitor, bortezomib, potently inhibits the growth of adult T-cell leukemia cells both in vivo and in vitro. Leukemia 18 (2004) 1357-1363
-
(2004)
Leukemia
, vol.18
, pp. 1357-1363
-
-
Satou, Y.1
Nosaka, K.2
Koya, Y.3
Yasunaga, J.I.4
Toyokuni, S.5
Matsuoka, M.6
-
149
-
-
27744515028
-
Inhibition of nuclear factor-kappaB and target genes during combined therapy with proteasome inhibitor bortezomib and reirradiation in patients with recurrent head-and-neck squamous cell carcinoma
-
Van Waes C., Chang A.A., Lebowitz P.F., Druzgal C.H., Chen Z., Elsayed Y.A., et al. Inhibition of nuclear factor-kappaB and target genes during combined therapy with proteasome inhibitor bortezomib and reirradiation in patients with recurrent head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys 63 (2005) 1400-1412
-
(2005)
Int J Radiat Oncol Biol Phys
, vol.63
, pp. 1400-1412
-
-
Van Waes, C.1
Chang, A.A.2
Lebowitz, P.F.3
Druzgal, C.H.4
Chen, Z.5
Elsayed, Y.A.6
-
150
-
-
18544367201
-
NF-kappa B as a therapeutic target in multiple myeloma
-
Hideshima T., Chauhan D., Richardson P., Mitsiades C., Mitsiades N., Hayashi T., et al. NF-kappa B as a therapeutic target in multiple myeloma. J Biol Chem 277 (2002) 16639-16647
-
(2002)
J Biol Chem
, vol.277
, pp. 16639-16647
-
-
Hideshima, T.1
Chauhan, D.2
Richardson, P.3
Mitsiades, C.4
Mitsiades, N.5
Hayashi, T.6
-
151
-
-
0037441760
-
Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341
-
Hideshima T., Mitsiades C., Akiyama M., Hayashi T., Chauhan D., Richardson P., et al. Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341. Blood 101 (2003) 1530-1534
-
(2003)
Blood
, vol.101
, pp. 1530-1534
-
-
Hideshima, T.1
Mitsiades, C.2
Akiyama, M.3
Hayashi, T.4
Chauhan, D.5
Richardson, P.6
-
152
-
-
0034237661
-
Apoptosis and radiosensitization of hodgkin cells by proteasome inhibition
-
Pajonk F., Pajonk K., and McBride W.H. Apoptosis and radiosensitization of hodgkin cells by proteasome inhibition. Int J Radiat Oncol Biol Phys 47 (2000) 1025-1032
-
(2000)
Int J Radiat Oncol Biol Phys
, vol.47
, pp. 1025-1032
-
-
Pajonk, F.1
Pajonk, K.2
McBride, W.H.3
-
153
-
-
23044431754
-
A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer
-
Mackay H., Hedley D., Major P., Townsley C., Mackenzie M., Vincent M., et al. A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer. Clin Cancer Res 11 (2005) 5526-5533
-
(2005)
Clin Cancer Res
, vol.11
, pp. 5526-5533
-
-
Mackay, H.1
Hedley, D.2
Major, P.3
Townsley, C.4
Mackenzie, M.5
Vincent, M.6
-
154
-
-
33746840548
-
Proteasome inhibitors induce death but activate NF-kappa B on endometrial carcinoma cell lines and primary culture explants
-
Dolcet X., Llobet D., Encinas M., Pallares J., Cabero A., Schoenenberger J.A., et al. Proteasome inhibitors induce death but activate NF-kappa B on endometrial carcinoma cell lines and primary culture explants. J Biol Chem (2006)
-
(2006)
J Biol Chem
-
-
Dolcet, X.1
Llobet, D.2
Encinas, M.3
Pallares, J.4
Cabero, A.5
Schoenenberger, J.A.6
-
155
-
-
30444458109
-
NF-kappaB as a target for the prevention of graft-versus-host disease: comparative efficacy of bortezomib and PS-1145
-
Vodanovic-Jankovic S., Hari P., Jacobs P., Komorowski R., and Drobyski W.R. NF-kappaB as a target for the prevention of graft-versus-host disease: comparative efficacy of bortezomib and PS-1145. Blood 107 (2006) 827-834
-
(2006)
Blood
, vol.107
, pp. 827-834
-
-
Vodanovic-Jankovic, S.1
Hari, P.2
Jacobs, P.3
Komorowski, R.4
Drobyski, W.R.5
-
156
-
-
0035300479
-
The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
-
Hideshima T., Richardson P., Chauhan D., Palombella V.J., Elliott P.J., Adams J., et al. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res 61 (2001) 3071-3076
-
(2001)
Cancer Res
, vol.61
, pp. 3071-3076
-
-
Hideshima, T.1
Richardson, P.2
Chauhan, D.3
Palombella, V.J.4
Elliott, P.J.5
Adams, J.6
-
157
-
-
0037342894
-
The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents
-
Ma M.H., Yang H.H., Parker K., Manyak S., Friedman J.M., Altamirano C., et al. The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents. Clin Cancer Res 9 (2003) 1136-1144
-
(2003)
Clin Cancer Res
, vol.9
, pp. 1136-1144
-
-
Ma, M.H.1
Yang, H.H.2
Parker, K.3
Manyak, S.4
Friedman, J.M.5
Altamirano, C.6
-
158
-
-
0037443551
-
The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications
-
Mitsiades N., Mitsiades C.S., Richardson P.G., Poulaki V., Tai Y.T., Chauhan D., et al. The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications. Blood 101 (2003) 2377-2380
-
(2003)
Blood
, vol.101
, pp. 2377-2380
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Richardson, P.G.3
Poulaki, V.4
Tai, Y.T.5
Chauhan, D.6
-
159
-
-
20344393387
-
Cooperative cytotoxicity of proteasome inhibitors and tumor necrosis factor-related apoptosis-inducing ligand in chemoresistant Bcl-2-overexpressing cells
-
Nencioni A., Wille L., Dal Bello G., Boy D., Cirmena G., Wesselborg S., et al. Cooperative cytotoxicity of proteasome inhibitors and tumor necrosis factor-related apoptosis-inducing ligand in chemoresistant Bcl-2-overexpressing cells. Clin Cancer Res 11 (2005) 4259-4265
-
(2005)
Clin Cancer Res
, vol.11
, pp. 4259-4265
-
-
Nencioni, A.1
Wille, L.2
Dal Bello, G.3
Boy, D.4
Cirmena, G.5
Wesselborg, S.6
-
160
-
-
31544482800
-
Tipifarnib and bortezomib are synergistic and overcome cell adhesion-mediated drug resistance in multiple myeloma and acute myeloid leukemia
-
Yanamandra N., Colaco N.M., Parquet N.A., Buzzeo R.W., Boulware D., Wright G., et al. Tipifarnib and bortezomib are synergistic and overcome cell adhesion-mediated drug resistance in multiple myeloma and acute myeloid leukemia. Clin Cancer Res 12 (2006) 591-599
-
(2006)
Clin Cancer Res
, vol.12
, pp. 591-599
-
-
Yanamandra, N.1
Colaco, N.M.2
Parquet, N.A.3
Buzzeo, R.W.4
Boulware, D.5
Wright, G.6
-
161
-
-
0032923624
-
Proteasome inhibition leads to significant reduction of Bcr-Abl expression and subsequent induction of apoptosis in K562 human chronic myelogenous leukemia cells
-
Dou Q.P., McGuire T.F., Peng Y., and An B. Proteasome inhibition leads to significant reduction of Bcr-Abl expression and subsequent induction of apoptosis in K562 human chronic myelogenous leukemia cells. J Pharmacol Exp Ther 289 (1999) 781-790
-
(1999)
J Pharmacol Exp Ther
, vol.289
, pp. 781-790
-
-
Dou, Q.P.1
McGuire, T.F.2
Peng, Y.3
An, B.4
-
162
-
-
0141953292
-
Blockade of Hsp27 overcomes bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells
-
Chauhan D., Li G., Shringarpure R., Podar K., Ohtake Y., Hideshima T., et al. Blockade of Hsp27 overcomes bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells. Cancer Res 63 (2003) 6174-6177
-
(2003)
Cancer Res
, vol.63
, pp. 6174-6177
-
-
Chauhan, D.1
Li, G.2
Shringarpure, R.3
Podar, K.4
Ohtake, Y.5
Hideshima, T.6
-
163
-
-
20444433230
-
Bortezomib or high-dose dexamethasone for relapsed multiple myeloma
-
Richardson P.G., Sonneveld P., Schuster M.W., Irwin D., Stadtmauer E.A., Facon T., et al. Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. N Engl J Med 352 (2005) 2487-2498
-
(2005)
N Engl J Med
, vol.352
, pp. 2487-2498
-
-
Richardson, P.G.1
Sonneveld, P.2
Schuster, M.W.3
Irwin, D.4
Stadtmauer, E.A.5
Facon, T.6
-
164
-
-
20444455939
-
Bortezomib for myeloma-much ado about something
-
Dispenzieri A. Bortezomib for myeloma-much ado about something. N Engl J Med 352 (2005) 2546-2548
-
(2005)
N Engl J Med
, vol.352
, pp. 2546-2548
-
-
Dispenzieri, A.1
-
165
-
-
0037973279
-
A phase 2 study of bortezomib in relapsed, refractory myeloma
-
Richardson P.G., Barlogie B., Berenson J., Singhal S., Jagannath S., Irwin D., et al. A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med 348 (2003) 2609-2617
-
(2003)
N Engl J Med
, vol.348
, pp. 2609-2617
-
-
Richardson, P.G.1
Barlogie, B.2
Berenson, J.3
Singhal, S.4
Jagannath, S.5
Irwin, D.6
-
166
-
-
33644844108
-
Extended follow-up of a phase II trial in relapsed, refractory multiple myeloma: final time-to-event results from the SUMMIT trial
-
Richardson P.G., Barlogie B., Berenson J., Singhal S., Jagannath S., Irwin D.H., et al. Extended follow-up of a phase II trial in relapsed, refractory multiple myeloma: final time-to-event results from the SUMMIT trial. Cancer 106 (2006) 1316-1319
-
(2006)
Cancer
, vol.106
, pp. 1316-1319
-
-
Richardson, P.G.1
Barlogie, B.2
Berenson, J.3
Singhal, S.4
Jagannath, S.5
Irwin, D.H.6
-
167
-
-
33644916110
-
Phase I/II trial assessing bortezomib and melphalan combination therapy for the treatment of patients with relapsed or refractory multiple myeloma
-
Berenson J.R., Yang H.H., Sadler K., Jarutirasarn S.G., Vescio R.A., Mapes R., et al. Phase I/II trial assessing bortezomib and melphalan combination therapy for the treatment of patients with relapsed or refractory multiple myeloma. J Clin Oncol 24 (2006) 937-944
-
(2006)
J Clin Oncol
, vol.24
, pp. 937-944
-
-
Berenson, J.R.1
Yang, H.H.2
Sadler, K.3
Jarutirasarn, S.G.4
Vescio, R.A.5
Mapes, R.6
-
168
-
-
30844443713
-
Low dose Velcade, thalidomide and dexamethasone (LD-VTD): an effective regimen for relapsed and refractory multiple myeloma patients
-
Ciolli S., Leoni F., Gigli F., Rigacci L., and Bosi A. Low dose Velcade, thalidomide and dexamethasone (LD-VTD): an effective regimen for relapsed and refractory multiple myeloma patients. Leuk Lymphoma 47 (2006) 171-173
-
(2006)
Leuk Lymphoma
, vol.47
, pp. 171-173
-
-
Ciolli, S.1
Leoni, F.2
Gigli, F.3
Rigacci, L.4
Bosi, A.5
-
169
-
-
21344435052
-
PAD combination therapy (PS-341/bortezomib, doxorubicin and dexamethasone) for previously untreated patients with multiple myeloma
-
Oakervee H.E., Popat R., Curry N., Smith P., Morris C., Drake M., et al. PAD combination therapy (PS-341/bortezomib, doxorubicin and dexamethasone) for previously untreated patients with multiple myeloma. Br J Haematol 129 (2005) 755-762
-
(2005)
Br J Haematol
, vol.129
, pp. 755-762
-
-
Oakervee, H.E.1
Popat, R.2
Curry, N.3
Smith, P.4
Morris, C.5
Drake, M.6
-
170
-
-
0036023407
-
A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies
-
Aghajanian C., Soignet S., Dizon D.S., Pien C.S., Adams J., Elliott P.J., et al. A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies. Clin Cancer Res 8 (2002) 2505-2511
-
(2002)
Clin Cancer Res
, vol.8
, pp. 2505-2511
-
-
Aghajanian, C.1
Soignet, S.2
Dizon, D.S.3
Pien, C.S.4
Adams, J.5
Elliott, P.J.6
-
172
-
-
20044396543
-
Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin's lymphoma
-
Goy A., Younes A., McLaughlin P., Pro B., Romaguera J.E., Hagemeister F., et al. Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin's lymphoma. J Clin Oncol 23 (2005) 667-675
-
(2005)
J Clin Oncol
, vol.23
, pp. 667-675
-
-
Goy, A.1
Younes, A.2
McLaughlin, P.3
Pro, B.4
Romaguera, J.E.5
Hagemeister, F.6
-
173
-
-
27144435616
-
PS-341 and gemcitabine in patients with metastatic pancreatic adenocarcinoma: a North Central Cancer Treatment Group (NCCTG) randomized phase II study
-
Alberts S.R., Foster N.R., Morton R.F., Kugler J., Schaefer P., Wiesenfeld M., et al. PS-341 and gemcitabine in patients with metastatic pancreatic adenocarcinoma: a North Central Cancer Treatment Group (NCCTG) randomized phase II study. Ann Oncol 16 (2005) 1654-1661
-
(2005)
Ann Oncol
, vol.16
, pp. 1654-1661
-
-
Alberts, S.R.1
Foster, N.R.2
Morton, R.F.3
Kugler, J.4
Schaefer, P.5
Wiesenfeld, M.6
-
174
-
-
2442510143
-
Phase II trial of PS-341 in patients with renal cell cancer: a University of Chicago phase II consortium study
-
Davis N.B., Taber D.A., Ansari R.H., Ryan C.W., George C., Vokes E.E., et al. Phase II trial of PS-341 in patients with renal cell cancer: a University of Chicago phase II consortium study. J Clin Oncol 22 (2004) 115-119
-
(2004)
J Clin Oncol
, vol.22
, pp. 115-119
-
-
Davis, N.B.1
Taber, D.A.2
Ansari, R.H.3
Ryan, C.W.4
George, C.5
Vokes, E.E.6
-
175
-
-
20444364475
-
A phase II study of bortezomib in the treatment of metastatic malignant melanoma
-
Markovic S.N., Geyer S.M., Dawkins F., Sharfman W., Albertini M., Maples W., et al. A phase II study of bortezomib in the treatment of metastatic malignant melanoma. Cancer 103 (2005) 2584-2589
-
(2005)
Cancer
, vol.103
, pp. 2584-2589
-
-
Markovic, S.N.1
Geyer, S.M.2
Dawkins, F.3
Sharfman, W.4
Albertini, M.5
Maples, W.6
-
176
-
-
0038147060
-
Gold compound auranofin inhibits IkappaB kinase (IKK) by modifying Cys-179 of IKKbeta subunit
-
Jeon K.I., Byun M.S., and Jue D.M. Gold compound auranofin inhibits IkappaB kinase (IKK) by modifying Cys-179 of IKKbeta subunit. Exp Mol Med 35 (2003) 61-66
-
(2003)
Exp Mol Med
, vol.35
, pp. 61-66
-
-
Jeon, K.I.1
Byun, M.S.2
Jue, D.M.3
-
177
-
-
0042744800
-
Inhibition of NF-kappaB essentially contributes to arsenic-induced apoptosis
-
Mathas S., Lietz A., Janz M., Hinz M., Jundt F., Scheidereit C., et al. Inhibition of NF-kappaB essentially contributes to arsenic-induced apoptosis. Blood 102 (2003) 1028-1034
-
(2003)
Blood
, vol.102
, pp. 1028-1034
-
-
Mathas, S.1
Lietz, A.2
Janz, M.3
Hinz, M.4
Jundt, F.5
Scheidereit, C.6
-
178
-
-
26444590898
-
A phase II trial of arsenic trioxide in patients with metastatic melanoma
-
Kim K.B., Bedikian A.Y., Camacho L.H., Papadopoulos N.E., and McCullough C. A phase II trial of arsenic trioxide in patients with metastatic melanoma. Cancer 104 (2005) 1687-1692
-
(2005)
Cancer
, vol.104
, pp. 1687-1692
-
-
Kim, K.B.1
Bedikian, A.Y.2
Camacho, L.H.3
Papadopoulos, N.E.4
McCullough, C.5
-
179
-
-
33645498328
-
Single-agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: durable remissions with minimal toxicity
-
Mathews V., George B., Lakshmi K.M., Viswabandya A., Bajel A., Balasubramanian P., et al. Single-agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: durable remissions with minimal toxicity. Blood 107 (2006) 2627-2632
-
(2006)
Blood
, vol.107
, pp. 2627-2632
-
-
Mathews, V.1
George, B.2
Lakshmi, K.M.3
Viswabandya, A.4
Bajel, A.5
Balasubramanian, P.6
-
180
-
-
0035041127
-
Clinical trials of arsenic trioxide in hematologic and solid tumors: overview of the National Cancer Institute Cooperative Research and Development Studies
-
Murgo A.J. Clinical trials of arsenic trioxide in hematologic and solid tumors: overview of the National Cancer Institute Cooperative Research and Development Studies. Oncologist 6 Suppl 2 (2001) 22-28
-
(2001)
Oncologist
, vol.6
, Issue.SUPPL. 2
, pp. 22-28
-
-
Murgo, A.J.1
-
181
-
-
33644846409
-
Arsenic trioxide inhibits cell growth in SH-SY5Y and SK-N-AS neuroblastoma cell lines by a different mechanism
-
Woo S.Y., Lee M.Y., Jung Y.J., Yoo E.S., Seoh J.Y., Shin H.Y., et al. Arsenic trioxide inhibits cell growth in SH-SY5Y and SK-N-AS neuroblastoma cell lines by a different mechanism. Pediatr Hematol Oncol 23 (2006) 231-243
-
(2006)
Pediatr Hematol Oncol
, vol.23
, pp. 231-243
-
-
Woo, S.Y.1
Lee, M.Y.2
Jung, Y.J.3
Yoo, E.S.4
Seoh, J.Y.5
Shin, H.Y.6
-
182
-
-
3242772761
-
Auranofin induces apoptosis and when combined with retinoic acid enhances differentiation of acute promyelocytic leukaemia cells in vitro
-
Kim I.S., Jin J.Y., Lee I.H., and Park S.J. Auranofin induces apoptosis and when combined with retinoic acid enhances differentiation of acute promyelocytic leukaemia cells in vitro. Br J Pharmacol 142 (2004) 749-755
-
(2004)
Br J Pharmacol
, vol.142
, pp. 749-755
-
-
Kim, I.S.1
Jin, J.Y.2
Lee, I.H.3
Park, S.J.4
-
183
-
-
33646341242
-
Binding of manumycin A inhibits IkappaB kinase beta activity
-
Bernier M., Kwon Y.K., Pandey S.K., Zhu T.N., Zhao R.J., Maciuk A., et al. Binding of manumycin A inhibits IkappaB kinase beta activity. J Biol Chem 281 (2006) 2551-2561
-
(2006)
J Biol Chem
, vol.281
, pp. 2551-2561
-
-
Bernier, M.1
Kwon, Y.K.2
Pandey, S.K.3
Zhu, T.N.4
Zhao, R.J.5
Maciuk, A.6
-
184
-
-
0038237037
-
Jesterone dimer, a synthetic derivative of the fungal metabolite jesterone, blocks activation of transcription factor nuclear factor kappaB by inhibiting the inhibitor of kappaB kinase
-
Liang M.C., Bardhan S., Li C., Pace E.A., Porco Jr. J.A., and Gilmore T.D. Jesterone dimer, a synthetic derivative of the fungal metabolite jesterone, blocks activation of transcription factor nuclear factor kappaB by inhibiting the inhibitor of kappaB kinase. Mol Pharmacol 64 (2003) 123-131
-
(2003)
Mol Pharmacol
, vol.64
, pp. 123-131
-
-
Liang, M.C.1
Bardhan, S.2
Li, C.3
Pace, E.A.4
Porco Jr., J.A.5
Gilmore, T.D.6
-
185
-
-
0033041695
-
Apoptosis of medulloblastoma cells in vitro follows inhibition of farnesylation using manumycin A
-
Wang W., and Macaulay R.J. Apoptosis of medulloblastoma cells in vitro follows inhibition of farnesylation using manumycin A. Int J Cancer 82 (1999) 430-434
-
(1999)
Int J Cancer
, vol.82
, pp. 430-434
-
-
Wang, W.1
Macaulay, R.J.2
-
186
-
-
16844380491
-
Manumycin induces apoptosis in human hepatocellular carcinoma HepG2 cells
-
Zhou J.M., Zhu X.F., Pan Q.C., Liao D.F., Li Z.M., and Liu Z.C. Manumycin induces apoptosis in human hepatocellular carcinoma HepG2 cells. Int J Mol Med 12 (2003) 955-959
-
(2003)
Int J Mol Med
, vol.12
, pp. 955-959
-
-
Zhou, J.M.1
Zhu, X.F.2
Pan, Q.C.3
Liao, D.F.4
Li, Z.M.5
Liu, Z.C.6
-
187
-
-
0034284715
-
Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex
-
May M.J., D'Acquisto F., Madge L.A., Glockner J., Pober J.S., and Ghosh S. Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex. Science 289 (2000) 1550-1554
-
(2000)
Science
, vol.289
, pp. 1550-1554
-
-
May, M.J.1
D'Acquisto, F.2
Madge, L.A.3
Glockner, J.4
Pober, J.S.5
Ghosh, S.6
-
188
-
-
3042716638
-
NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis
-
Biswas D.K., Shi Q., Baily S., Strickland I., Ghosh S., Pardee A.B., et al. NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis. Proc Natl Acad Sci USA 101 (2004) 10137-10142
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 10137-10142
-
-
Biswas, D.K.1
Shi, Q.2
Baily, S.3
Strickland, I.4
Ghosh, S.5
Pardee, A.B.6
-
189
-
-
14944353807
-
Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-kappaB activation
-
di Meglio P., Ianaro A., and Ghosh S. Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-kappaB activation. Arthritis Rheum 52 (2005) 951-958
-
(2005)
Arthritis Rheum
, vol.52
, pp. 951-958
-
-
di Meglio, P.1
Ianaro, A.2
Ghosh, S.3
-
190
-
-
70350545937
-
Local treatment with the selective IkappaB kinase beta inhibitor NEMO-binding domain peptide ameliorates synovial inflammation
-
Tas S.W., Vervoordeldonk M.J., Hajji N., May M.J., Ghosh S., and Tak P.P. Local treatment with the selective IkappaB kinase beta inhibitor NEMO-binding domain peptide ameliorates synovial inflammation. Arthritis Res Ther 8 (2006) R86
-
(2006)
Arthritis Res Ther
, vol.8
-
-
Tas, S.W.1
Vervoordeldonk, M.J.2
Hajji, N.3
May, M.J.4
Ghosh, S.5
Tak, P.P.6
-
191
-
-
12444296120
-
Novel IKK inhibitors: beta-carbolines
-
Castro A.C., Dang L.C., Soucy F., Grenier L., Mazdiyasni H., Hottelet M., et al. Novel IKK inhibitors: beta-carbolines. Bioorg Med Chem Lett 13 (2003) 2419-2422
-
(2003)
Bioorg Med Chem Lett
, vol.13
, pp. 2419-2422
-
-
Castro, A.C.1
Dang, L.C.2
Soucy, F.3
Grenier, L.4
Mazdiyasni, H.5
Hottelet, M.6
-
192
-
-
0037449711
-
BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice
-
Burke J.R., Pattoli M.A., Gregor K.R., Brassil P.J., MacMaster J.F., McIntyre K.W., et al. BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. J Biol Chem 278 (2003) 1450-1456
-
(2003)
J Biol Chem
, vol.278
, pp. 1450-1456
-
-
Burke, J.R.1
Pattoli, M.A.2
Gregor, K.R.3
Brassil, P.J.4
MacMaster, J.F.5
McIntyre, K.W.6
-
193
-
-
32944468414
-
BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways
-
Yang J., Amiri K.I., Burke J.R., Schmid J.A., and Richmond A. BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways. Clin Cancer Res 12 (2006) 950-960
-
(2006)
Clin Cancer Res
, vol.12
, pp. 950-960
-
-
Yang, J.1
Amiri, K.I.2
Burke, J.R.3
Schmid, J.A.4
Richmond, A.5
-
194
-
-
33646527980
-
Antitumoural effects of the pyridyl cyanoguanidine CHS 828 on three different types of neuroendocrine tumours xenografted to nude mice
-
Johanson V., Arvidsson Y., Kolby L., Bernhardt P., Sward C., Nilsson O., et al. Antitumoural effects of the pyridyl cyanoguanidine CHS 828 on three different types of neuroendocrine tumours xenografted to nude mice. Neuroendocrinology 82 (2006) 171-176
-
(2006)
Neuroendocrinology
, vol.82
, pp. 171-176
-
-
Johanson, V.1
Arvidsson, Y.2
Kolby, L.3
Bernhardt, P.4
Sward, C.5
Nilsson, O.6
-
195
-
-
0035917672
-
Cellular pharmacodynamics of the cytotoxic guanidino-containing drug CHS 828. Comparison with methylglyoxal-bis(guanylhydrazone)
-
Ekelund S., Sjoholm A., Nygren P., Binderup L., and Larsson R. Cellular pharmacodynamics of the cytotoxic guanidino-containing drug CHS 828. Comparison with methylglyoxal-bis(guanylhydrazone). Eur J Pharmacol 418 (2001) 39-45
-
(2001)
Eur J Pharmacol
, vol.418
, pp. 39-45
-
-
Ekelund, S.1
Sjoholm, A.2
Nygren, P.3
Binderup, L.4
Larsson, R.5
-
196
-
-
0033571407
-
CHS, 828 a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo
-
Hjarnaa P.J., Jonsson E., Latini S., Dhar S., Larsson R., Bramm E., et al. CHS, 828 a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo. Cancer Res 59 (1999) 5751-5757
-
(1999)
Cancer Res
, vol.59
, pp. 5751-5757
-
-
Hjarnaa, P.J.1
Jonsson, E.2
Latini, S.3
Dhar, S.4
Larsson, R.5
Bramm, E.6
-
197
-
-
14844291424
-
Phase I study and pharmacokinetic of CHS-828, a guanidino-containing compound, administered orally as a single dose every 3 weeks in solid tumours: an ECSG/EORTC study
-
Ravaud A., Cerny T., Terret C., Wanders J., Bui B.N., Hess D., et al. Phase I study and pharmacokinetic of CHS-828, a guanidino-containing compound, administered orally as a single dose every 3 weeks in solid tumours: an ECSG/EORTC study. Eur J Cancer 41 (2005) 702-707
-
(2005)
Eur J Cancer
, vol.41
, pp. 702-707
-
-
Ravaud, A.1
Cerny, T.2
Terret, C.3
Wanders, J.4
Bui, B.N.5
Hess, D.6
-
198
-
-
3042642760
-
Synthesis and structure-activity relationships of novel IKK-beta inhibitors. Part 3. Orally active anti-inflammatory agents
-
Murata T., Shimada M., Sakakibara S., Yoshino T., Masuda T., Shintani T., et al. Synthesis and structure-activity relationships of novel IKK-beta inhibitors. Part 3. Orally active anti-inflammatory agents. Bioorg Med Chem Lett 14 (2004) 4019-4022
-
(2004)
Bioorg Med Chem Lett
, vol.14
, pp. 4019-4022
-
-
Murata, T.1
Shimada, M.2
Sakakibara, S.3
Yoshino, T.4
Masuda, T.5
Shintani, T.6
-
199
-
-
16344362279
-
Growth inhibition of multiple myeloma cells by a novel IkappaB kinase inhibitor
-
Sanda T., Iida S., Ogura H., Asamitsu K., Murata T., Bacon K.B., et al. Growth inhibition of multiple myeloma cells by a novel IkappaB kinase inhibitor. Clin Cancer Res 11 (2005) 1974-1982
-
(2005)
Clin Cancer Res
, vol.11
, pp. 1974-1982
-
-
Sanda, T.1
Iida, S.2
Ogura, H.3
Asamitsu, K.4
Murata, T.5
Bacon, K.B.6
-
200
-
-
33646490131
-
Induction of cell death in adult T-cell leukemia cells by a novel IkappaB kinase inhibitor
-
Sanda T., Asamitsu K., Ogura H., Iida S., Utsunomiya A., Ueda R., et al. Induction of cell death in adult T-cell leukemia cells by a novel IkappaB kinase inhibitor. Leukemia 20 (2006) 590-598
-
(2006)
Leukemia
, vol.20
, pp. 590-598
-
-
Sanda, T.1
Asamitsu, K.2
Ogura, H.3
Iida, S.4
Utsunomiya, A.5
Ueda, R.6
-
201
-
-
0344825070
-
AS602868, a pharmacological inhibitor of IKK2, reveals the apoptotic potential of TNF-alpha in Jurkat leukemic cells
-
Frelin C., Imbert V., Griessinger E., Loubat A., Dreano M., and Peyron J.F. AS602868, a pharmacological inhibitor of IKK2, reveals the apoptotic potential of TNF-alpha in Jurkat leukemic cells. Oncogene 22 (2003) 8187-8194
-
(2003)
Oncogene
, vol.22
, pp. 8187-8194
-
-
Frelin, C.1
Imbert, V.2
Griessinger, E.3
Loubat, A.4
Dreano, M.5
Peyron, J.F.6
-
202
-
-
6544264325
-
Intratumoral injection of oligonucleotides to the NF kappa B binding site inhibits cachexia in a mouse tumor model
-
Kawamura I., Morishita R., Tomita N., Lacey E., Aketa M., Tsujimoto S., et al. Intratumoral injection of oligonucleotides to the NF kappa B binding site inhibits cachexia in a mouse tumor model. Gene Ther 6 (1999) 91-97
-
(1999)
Gene Ther
, vol.6
, pp. 91-97
-
-
Kawamura, I.1
Morishita, R.2
Tomita, N.3
Lacey, E.4
Aketa, M.5
Tsujimoto, S.6
-
203
-
-
0034949959
-
Intravenous injection of oligodeoxynucleotides to the NF-kappaB binding site inhibits hepatic metastasis of M5076 reticulosarcoma in mice
-
Kawamura I., Morishita R., Tsujimoto S., Manda T., Tomoi M., Tomita N., et al. Intravenous injection of oligodeoxynucleotides to the NF-kappaB binding site inhibits hepatic metastasis of M5076 reticulosarcoma in mice. Gene Ther 8 (2001) 905-912
-
(2001)
Gene Ther
, vol.8
, pp. 905-912
-
-
Kawamura, I.1
Morishita, R.2
Tsujimoto, S.3
Manda, T.4
Tomoi, M.5
Tomita, N.6
-
204
-
-
2542449068
-
Enhanced chemosensitivity to irinotecan by RNA interference-mediated down-regulation of the nuclear factor-kappaB p65 subunit
-
Guo J., Verma U.N., Gaynor R.B., Frenkel E.P., and Becerra C.R. Enhanced chemosensitivity to irinotecan by RNA interference-mediated down-regulation of the nuclear factor-kappaB p65 subunit. Clin Cancer Res 10 (2004) 3333-3341
-
(2004)
Clin Cancer Res
, vol.10
, pp. 3333-3341
-
-
Guo, J.1
Verma, U.N.2
Gaynor, R.B.3
Frenkel, E.P.4
Becerra, C.R.5
-
205
-
-
0037119628
-
IkappaB kinase signaling is essential for maintenance of mature B cells
-
Pasparakis M., Schmidt-Supprian M., and Rajewsky K. IkappaB kinase signaling is essential for maintenance of mature B cells. J Exp Med 196 (2002) 743-752
-
(2002)
J Exp Med
, vol.196
, pp. 743-752
-
-
Pasparakis, M.1
Schmidt-Supprian, M.2
Rajewsky, K.3
-
206
-
-
20644455960
-
Control of lymphocyte development by nuclear factor-kappaB
-
Siebenlist U., Brown K., and Claudio E. Control of lymphocyte development by nuclear factor-kappaB. Nat Rev Immunol 5 (2005) 435-445
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 435-445
-
-
Siebenlist, U.1
Brown, K.2
Claudio, E.3
-
207
-
-
30944468153
-
Expression of the Bcl-3 proto-oncogene suppresses p53 activation
-
Kashatus D., Cogswell P., and Baldwin A.S. Expression of the Bcl-3 proto-oncogene suppresses p53 activation. Genes Dev 20 (2006) 225-235
-
(2006)
Genes Dev
, vol.20
, pp. 225-235
-
-
Kashatus, D.1
Cogswell, P.2
Baldwin, A.S.3
-
208
-
-
0036599406
-
Verma I. p53 stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapy
-
Tergaonkar V., Pando M., Vafa O., and Wahl G. Verma I. p53 stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapy. Cancer Cell 1 (2002) 493-503
-
(2002)
Cancer Cell
, vol.1
, pp. 493-503
-
-
Tergaonkar, V.1
Pando, M.2
Vafa, O.3
Wahl, G.4
-
209
-
-
0033558155
-
Stable inhibition of nuclear factor kappaB in cancer cells does not increase sensitivity to cytotoxic drugs
-
Bentires-Alj M., Hellin A.C., Ameyar M., Chouaib S., Merville M.P., and Bours V. Stable inhibition of nuclear factor kappaB in cancer cells does not increase sensitivity to cytotoxic drugs. Cancer Res 59 (1999) 811-815
-
(1999)
Cancer Res
, vol.59
, pp. 811-815
-
-
Bentires-Alj, M.1
Hellin, A.C.2
Ameyar, M.3
Chouaib, S.4
Merville, M.P.5
Bours, V.6
|