The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites

Journal of Biological Chemistry

Volumn 278, Issue 38, 2003, Pages 35869-35877

  Kisselev, Alexei F ^a   Garcia Calvo, Margarita ^b   Overkleeft, Herman S ^a,d   Peterson, Erin ^a   Pennington, Michael W ^c   Ploegh, Hidde L ^d   Thornberry, Nancy A ^a   Goldberg, Alfred L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c Bachem Holding AG   (Switzerland)

^d LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITION; ENZYMES; POLYPEPTIDES; YEAST;

PROTEASOMES;

PROTEINS;

ASPARTIC ACID; CASPASE; CHYMOTRYPSIN; ENZYME INHIBITOR; GLUTAMIC ACID; HYDROLASE; PEPTIDE; POSTGLUTAMYL PEPTIDE HYDROLASE; PROTEASOME; TRYPSIN; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING SITE; CHEMICAL INTERACTION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME SPECIFICITY; ENZYME SYNTHESIS; MAMMAL CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; RECEPTOR OCCUPANCY; YEAST;

NON-PROGRAMMATIC;

ALDEHYDES; ALLOSTERIC SITE; ANIMALS; ASPARTIC ACID; BINDING SITES; CASPASES; CATALYTIC DOMAIN; CHYMOTRYPSIN; CYSTEINE ENDOPEPTIDASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GENE LIBRARY; GLUTAMIC ACID; HUMANS; KETONES; KINETICS; MULTIENZYME COMPLEXES; MUTATION; PEPTIDE HYDROLASES; PEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; RABBITS; SACCHAROMYCES CEREVISIAE; SUBSTRATE SPECIFICITY; TIME FACTORS; TRYPSIN;

MAMMALIA;

EID: 0141704418     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M303725200     Document Type: Article

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