Oleandrin suppresses activation of nuclear transcription factor-κB, activator protein-1, and c-Jun NH2-terminal kinase

Cancer Research

Volumn 60, Issue 14, 2000, Pages 3838-3847

  Manna, S K ^a   Sah, N K ^a   Newman, R A ^a   Cisneros, A ^a   Aggarwal, B B ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIAC GLYCOSIDE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; OLEANDRIN; PHORBOL ESTER; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN L 929; CONTROLLED STUDY; ENZYME INHIBITION; GENE REPRESSION; HELA CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; REPORTER GENE;

ANIMALS; BLOTTING, WESTERN; CARDENOLIDES; CELL LINE; CERAMIDES; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HELA CELLS; HUMANS; HYDROGEN PEROXIDE; I-KAPPA B PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPID PEROXIDATION; LIPOPOLYSACCHARIDES; MAP KINASE KINASE 4; MAP KINASE KINASE KINASE 1; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NA(+)-K(+)-EXCHANGING ATPASE; NF-KAPPA B; PHORBOL ESTERS; PLANT EXTRACTS; PROTEIN-SERINE-THREONINE KINASES; TIME FACTORS; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA; U937 CELLS;

EID: 0034660871     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. The NF-κB and IκB proteins: New discoveries and insights
2. NF-κ B as a frequent target for immunosuppressive and anti-inflammatory molecules
3. Apoptosis: Activate NF-κ B or die?
4. Nuclear factor κB: Important transcription factor and therapeutic target
5. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-κB
6. Suppression of TNF-α-induced apoptosis by NF-κB
7. Constitutive activation of NF-κB causes resistance to apoptosis in human cutaneous T cell lymphoma HLT-78 cells: Autocrine role of tumor necrosis factor and reactive oxygen intermediates
8. Constitutive activation of NF-κB during progression of breast cancer to hormone-independent growth
9. The host environment promotes the constitutive activation of nuclear factor-κB and proinflammatory cytokine expression during metastatic tumor progression of murine squamous cell carcinoma
10. Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB
11. NF-κB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis
12. Innovative treatment programs against cancer. II Nuclear factor-κB (NF-κB) as a molecular target
13. AP-1 function and regulation
14. Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: Structure-activity relationship and mechanisms involved
15. Inhibition of carcinogenesis by naturally occurring and synthetic compounds
16. Cross-resistance and biochemical studies with two classes of HeLa cell mutants resistant to cardiac glycosides: The unusual behavior of cardenolide SC4453
17. Cellular basis for the species differences in sensitivity to cardiac glycosides (digitalis)
18. Human cell mutants affected in the interaction of the 12 β-OH group of cardiac glycosides with the digitalis receptor
19. α-melanocyte stimulating hormone inhibits the nuclear transcription factor NF-κB activation induced by various inflammatory agents
20. Silymarin suppresses TNF-induced activation of nuclear transcription factor-κB, c-Jun N terminal kinase, and apoptosis
21. Activation of NF-κB by RANK requires TRAF6 and NF-κB-inducing kinase (NIK): Identification of a novel TRAF6 interaction motif
22. MAP3K- related kinase involved in NF-κB induction by TNF, CD95 and IL-1
23. Tumor necrosis factor and lymphotoxin: Qualitative and quantitative differences in the mediation of early and late cellular responses
24. Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-κB activation, IκBa phosphorylation, and degradation
25. Assay for redox sensitive kinases
26. 2 in NF-κB activation by either cytokine in both primary and transformed endothelial cells
27. Distinct signal transduction pathways mediate nuclear factor-κB induction by IL-1β in epithelial and lymphoid cells
28. Inhibition of Na, K-ATPase by oleandrin and oleandrigenin, and their detection by digoxin immunoassays
29. The sodium-potassium adenosine triphosphatase: Pharmacological, physiological and biochemical aspects
30. Membrane adenosine triphosphatase: A digitalis receptor?
31. Ionizing radiation and short wavelength UV activate NF-κB through two distinct mechanisms
32. A role for phosphorylation and degradation in the control of NF-κ B activity
33. N- and C-terminal sequences control degradation of MAD3/I κ B α in response to inducers of NF-κ B activity
34. Differential IκB kinase activation and IκBα degradation by interleukin-1β and tumor necrosis factor-α in human U937 monocytic cells: Evidence for additional regulatory steps in κB-dependent transcription
35. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
36. Mechanisms by which IκB proteins control NF-κB activity
37. The regulation of AP-I activity by mitogen-activated protein kinases
38. JNK or IKK, AP-I or NF-κB, which are the targets for MEK kinase 1 action?
39. Activation of the IκBα kinase complex by MEKKI, a kinase of the JNK pathway
40. Overexpression of Mn-superoxide dismutase suppresses TNF induced apoptosis and activation of nuclear transcription factor-κB and activated protein-1
41. Overexpression of γ-glutamylcysteine synthetase abolishes tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-κB and activator protein-1
42. Is NF-κB the sensor of oxidative stress?
43. Inducible phosphorylation of IκBα is not sufficient for its dissociation from NF-κB and is inhibited by protease inhibitors
44. Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation
45. IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IκB kinases
46. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
47. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation
48. MEK kinase is involved in tumor necrosis factor α-induced NF-κB activation and degradation of IκB-α
49. Activation of IκB kinase β by protein kinase C isoforms
50. The 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of IκBα and stimulates its degradation in vitro
51. Double-stranded RNA- dependent protein kinase activates transcription factor NF-κB by phosphorylating IκB
52. The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-κB acting through the NF-κB-inducing kinase and IκB kinases
53. Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-κB p65/Re1A subunit
54. The kinase TAK1 can activate the N1K-IκB as well as the MAP kinase cascade in the IL-1 signaling pathway
55. Multiple signals converging on NF-κB
56. Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-κB through IκB kinase-α and IκB kinase-β
57. 2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells
58. Inhibition of NF-κ B by sodium salicylate and aspirin