Tumor necrosis factor α-induced vascular leakage involves PECAM1 phosphorylation

Cancer Research

Volumn 56, Issue 14, 1996, Pages 3211-3215

  Ferrero, Elisabetta ^a   Villa, Antonello ^b   Ferrero, Maria Elena ^c   Toninelli, Elisabetta ^a   Bender, Jeffrey R ^d   Pardi, Ruggero ^a,c   Zocchi, Maria Raffaella ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; PROTEIN TYROSINE KINASE;

ARTICLE; BLOOD VESSEL PERMEABILITY; CYTOSKELETON; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RNA TRANSCRIPTION; UMBILICAL VEIN;

ALKALOIDS; ANTIGENS, CD31; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BENZOQUINONES; CAPILLARY PERMEABILITY; CELL ADHESION MOLECULES; CELL COMPARTMENTATION; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION; HUMANS; LACTAMS, MACROCYCLIC; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; QUINONES; RNA, MESSENGER; STAUROSPORINE; TUMOR NECROSIS FACTOR-ALPHA; UMBILICAL VEINS;

EID: 0029982830     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Tracey, K J., and Cerami, A. Tumor necrosis factor, other cytokines and disease Annu Rev. Cell Biol., 9: 317-343, 1993.
2. Waldmann, T. A The IL-2/IL-2 receptor system, a target for rationale immune intervention Immunol. Today, 14: 264-270, 1993
3. Goldblum, S. E , Ding, X., and Campbell-Washington, J TNF-α induces EC F-actin depolymerization, new actin synthesis, and barrier disfunction Am Cell. Physiol., 264: C894-C905, 1993.
4. Romer, L. H , McLean, N. V., Yan H-C., Daise, M , Sun, J., and DeLisser, H M. IFN-γ and TNF-α induce redistribution of PECAM-1 (CD31) on human ECs. J Immunol , 154: 6582-6592, 1995.
5. Stewart, R J., Kashour, T. S , and Marsden, P. A. Vascular platelet EC adhesion molecule-1 (PECAM-1) expression is decreased by TNF and IFN evidence for cytokine-induced destabilization of messenger ribonucleic acid transcript in bovine ECs. J. Immunol., 156: 1221-1230, 1996
6. DeLisser, H M., Newman, P. J , and Albelda, S. M. Molecular and functional aspects of PECAM-1/CD31. Immunol. Today, 15: 490-495, 1994
7. Victor, I., Schwenger, P., Li, W , Schlessinger, J., and Vilcek, J Tumor necrosis factor-induced activation and increased tyrosine phosphorylation of mitogen activated protein (MAP) kinase in human fibroblasts. J. Biol. Chem., 268: 18994-18999, 1993.
8. Volberg, T., Zick, Y., Dror, R., Sabanay, L., Gilon, C , Levitzki, A , and Geiger, B. The effect of tyrosine-specific phosphorylation on the assembly of adherens-type junctions EMBO J , 11: 1733-1742, 1992.
9. Denisenko, N , Burighel, P., and Citi, S Different effects of protein kinase inhibitors on the localization of junctional proteins at cell-cell contact sites. J. Cell Sci., 107: 969-981, 1994.
10. Hamaguchi, H , Matsuyoshi, N., Ohnishi, Y., Gotoh, B., Takeichi, M., and Nagai, Y. p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system. EMBO J., 12: 307-314, 1993.
11. Levitzki, A , and Gazit, A. Tyrosine kinase inhibition: an approach to drug development. Science (Washington DC), 267: 1782-1788, 1995.
12. Ferrero, E., Ferrero, M. E., Pardi, R., and Zocchi, M. R. The platelet EC adhesion molecule-1 (PECAM1) contributes to endothelial barrier function. FEBS Lett., 374: 323-326, 1995.
13. Renkin, E. M. Transport Pathways and Processes. In: N. Simionescu and M. Simionescu (eds.), Endothelial Cell Biology, pp. 51-66. New York: Plenum Publishing Corp , 1988.
14. Branster, M V , and Morton, R. K Isolation of intact liver cells. Nature (Lond.), 180: 1283-1284, 1957
15. Zehnder, J. L , Hirai, K., Shatsky, M , McGregoe, J. L , Levitt, L. J., and Leung, L L K. The cell adhesion molecule CD31 is phosphorylated after cell activation. Down-regulation of CD31in activated T lymphocytes J. Biol. Chem., 267: 5243-5249, 1992.
16. Bender, J. R , Sadeghi, M. M., Watson, C., Pfau, S , and Pardi, R Heterogeneous activation thresholds to cytokines in genetically distinct ECs: evidence for diverse transcriptional responses. Proc Natl. Acad. Sci USA, 91: 3994-3998, 1994.
17. Newman, P. J., Hillery, C. A., Albrecht, R , Parise, L V., Berndt, M C., Mazurov, A. V , Dunlop, L C , Zhang, L. and Rittenhouse, S. E Activation-dependent changes in human platelet PECAM-1: phosporylation, cytoskeletal association and surface membrane redistribution J. Cell Biol., 119: 239-246, 1992.
18. Bluethmann, H., Rothe, J , Schultze, N., Tkachuk, M., and Koebel, P. Establishment of the role of IL-6 and TNF receptor 1 using gene knockout mice. J. Leukocyte Biol., 56: 565-570, 1994.
19. Loetscher, H , Pan, Y C. E., Lahm, H W , Gentz, R , Brockhaus, M., Tabuchi, H., and Lesslauer, W. Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor. Cell, 61: 351-359, 1990.