Tumor necrosis factor α (TNF-α) gene therapy targeted by ionizing radiation selectively damages tumor vasculature

Cancer Research

Volumn 56, Issue 19, 1996, Pages 4311-4314

  Mauceri, Helena J ^a   Hanna, Nader N ^a   Wayne, Jeffrey D ^a   Hallahan, Dennis E ^a   Hellman, Samuel ^a   Weichselbaum, Ralph R ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR NECROSIS FACTOR ALPHA;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; FEMALE; GENE THERAPY; HUMAN CELL; IONIZING RADIATION; IRRADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOSENSITIVITY; SQUAMOUS CELL CARCINOMA; THROMBOSIS; TUMOR NECROSIS; X IRRADIATION;

ANIMALS; CARCINOMA, SQUAMOUS CELL; FEMALE; GENE EXPRESSION REGULATION; GENE THERAPY; GENETIC VECTORS; HUMANS; MICE; MICE, NUDE; NECROSIS; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; RECOMBINANT FUSION PROTEINS; THROMBOSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0029777311     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Avalosse, B, Dupont, F , and Burney, A Gene therapy for cancer Curr Opin Oncol , 7 94-100, 1995
2. Weichselbaum, R R., Hallahan, D E , Beckett, M A., Mauceri, H J , Lee, H., Sukhatme, V P , and Kufe, D. Gene therapy targeted by radiation preferentially radiosensiuzes tumor cells Cancer Res , 54. 4266-4269, 1994
3. Larrick, J. W , and Wright S. C Cytotoxic mechanism of tumor necrosis factor α. FASEB J., 4: 3215-3223, 1994
4. Hallahan, D. E. Spriggs, D R , Beckett, M A., Kufe, D , and Weichselbaum, R R. Increased tumor necrosis factor α mRNA after cellular exposure to ionizing radiation. Proc Natl. Acad Sci USA, 86: 10104-10107, 1989
5. Hallahan, D. E. Beckett, M A , Kufe, D , and Weichselbaum, R R The interaction between human recombinant tumor necrosis factor and radiation in 13 human tumor cell lines Int J Radiat Oncol. Biol Phys , 19. 60-74, 1990
6. Wong, G H , McHugh, T , Weber, R , and Goeddel, D V Tumor necrosis factor selectively sensitizes human immunodeficiency virus-infected cells to heat and radiation Proc Natl Acad Sci USA, 88 4372-4276, 1991
7. Carswell, E A , Old, L. L. Kassel, R L., Greene, S , Fiore, N , and Williamson, B An endotoxin-induced serum factor that causes necrosis of tumors Proc Natl Acad Sci USA. 72 3666-3670, 1975
8. Mahadevan, V., Malik, A. T. A , Meager, A., Fiers, W., Lewis, G. P., and Hart, I R Role of tumor necrosis factor in flavone acetic acid-induced tumor vasculature shutdown. Cancer Res , 50: 5537-5542, 1990
9. Proietti, E., Belardelli, F., Carpinelli, G., DiVito, M., Woodrow, D , Moss., J., Sestili, P., Fiers, W., Gresser, I , and Podo, F. Tumor necrosis factor α induces early morphologic and metabolic alterations in Friend leukemia cell tumors and fibrosarcomas in mice. Int. J Cancer, 42: 582-591, 1988.
10. Ming, W. J , Bersani, L , and Mavtovani, A Tumor necrosis factor is chemotactic for monocytes and polymorphonuclear leukocytes. J. Immumol., 138 1469-1474, 1987.
11. Issekutz, A. C , and Issekutz, T. B Quantification and kinetics of blood monocyte migration to acute inflammatory reactions, and IL-1α, tumor necrosis factor α, and IFN-τ. J. Immunol., 151: 2105-2115, 1993.
12. Korpelamen, E. I , Gamble, J. R , Smith, W. B , Goodall, G. J., Qlyu, S , Woodock, J M., Dottore, M , Vadas, M. A., and Lopez, A F. The receptor for interleukin 3 is selectively induced in human endothelial cells by tumor necrosis factor α and potentiates interleukin 8 secretion and neutrophil transmigration Proc. Natl Acad Sci. USA, 90. 11137-11141, 1993.
13. Pilaro, A. M , Taub, D. D , McCofmick, K. L, Williams, H. M., Sayers, T. J., Foglef, W. E., and Wiltrout, R H. TNF is a principal cytokine involved in the recruitment of NK cells to liver parenchyma. J Immunol., 153: 333-342, 1995.
14. Hallahan, D. E, Mauceri, H. J., Seung, L. P., Dunphy, E J., Wayne, J. D., Hanna, N. N , Toledano, A., Hellman, S., Kufe, D. W., and Weichselbaum, R. R. Spatial and temporal control of gene therapy using ionizing radiation. Nat Med., 1, 786-791, 1995.
15. Old, L. J Tumor necrosis factor. Science (Washington DC), 230: 630-636, 1985
16. Old, L. J. Tumor necrosis factor Sci. Am., 258: 59-75, 1988.
17. Remick, D. G , Kunkel, R. G., Larrick, J. W., and Kunkel, S. L. Acute in vivo effects of human recombinant tumor necrosis factor. Lab Invest., 56: 583-590, 1987.
18. Paleolog, E. M., Delasalle, S-A. J., Buurman, W. A., and Feldman, M Functional activities of receptors for tumor necrosis factor α on human vascular endothelial cells. Blood, 84: 2578-2590, 1994
19. Zucchella, M., Pacchiarini, L., Meloni, F., Ballabio, P., Saporitti, A., Brocchien, A., and Grignani, G Effect of interferon α, interferon τ, and tumor necrosis factor on the procoagulant activity of human cancer cells. Haematologica, 78: 282-286, 1993.
20. Bevilacqua, M. P , Pober, J S., Majeau, G. R , Fiers, W., Cotran, R. S., and Gimbrone, M. A. Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium characterization and comparison with the actions of interleukin 1. Proc. Natl. Acad. Sci. USA, 83: 4533-4537, 1986.
21. Nawroth, P , Handley, D , Matsueda, G., DeWaal, R , Gerlach, H., Blohm, D., and Stern, D. Tumor necrosis factor/cachectin-induced intravascular fibrin formation in meth A fibrosarcomas J. Esp. Med., 168: 637-647, 1988
22. Kirchhofer, D , Tschopp, T. B., Hadvary, P., and Baumgartner, H. R. Endothelial cells stimulated with tumor necrosis factor a express varying amounts of tissue factor resulting in homogenous fibrin deposition in a native blood flow system. J. Clin Invest , 93: 2073-2083, 1994.
23. Koga, S. Morris, S., Ogawa, S., Llao, H , Bilezikian, J. P., Chen, G., Thompson, W. J , Ashikaga, T , Brett, J , Stern, D. M , and Pinsky, D J. TNF modulates endothelial properties by decreasing cAMP. Am. J. Physiol., 268: C1104-C1113, 1995.
24. Shimomura, K , Manda, T., Mukumoto, S , Kobayashi, K., Nakano, K., and Mori, J. Recombinant human tumor necrosis factor α: thrombus formation is a cause of antitumor activity. Int J. Cancer, 41: 243-247, 1988.
25. Jourdan, A., Aguejouf, O , Imbault, P., Doutremepuich, F., Inamo, J., and Doutremepuich, C Experimental thrombosis model induced by free radicals. Application to aspirin and other different substances. Thomb. Res., 79, 109-123, 1995.
26. Hill, S , Fawcett, W. J , Sheldon, J., Soni, N., Williams, T., and Thomas, J. M. Low-dose tumour necrosis factor a and melphalan in hyperthermic isolated limb perfusion. Br. J. Surg., 80: 995-997, 1993
27. Thom, A. K., Alexander, R , Andrich, M. P., Barker, W. C , Rosenberg, S. A , and Fraker, D. L. Cytokine levels and systemic toxicity in patients undergoing isolated limb perfusion with high-dose tumor necrosis factor, interferon τ, and melphalan. J Clin. Oncol., 13: 264-273, 1995.
28. Havell, E. A., Fiers, W., and North, R. J. The antitumor function of tumor necrosis factor (TNF). J. Exp. Med., 167: 1067-1085, 1988.
29. McIntosh, J. K., Mule, J. J., Travis, W. D., and Rosenberg, S. A. Studies of effects of recombinant human tumor necrosis factor on autochthonous tumor and transplanted normal tissue in mice. Cancer Res., 50: 2463-2469, 1990.
30. Holmgren, L., O'Reilly, M. S , and Folkman, J. Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat Med., 1, 149-153, 1995.
31. O'Reilly, M. S , Holmgren, L., Shing, Y., Chen, C., Rosenthal, R. A., Moses, M., Lane, W. S., Cao, Y., Sage, E. H., and Folkman, J. Angiostatin a novel angiogenesis inhibitor that mediated the suppression of metastases by a Lewis lung sarcoma. Cell, 79: 315-328, 1994.
32. Fisher, D. E. Apoptosis in cancer therapy crossing the threshold. Cell, 78: 539-542, 1994.