Ablation of colorectal xenografts with combined radioimmunotherapy and tumor blood flow-modifying agents

Cancer Research

Volumn 56, Issue 14, 1996, Pages 3293-3300

  Pedley, R Barbara ^a   Boden, Joan A ^a   Boden, Robert ^a   Boxer, Geoffrey M ^a   Flynn, Aiden A ^a   Keep, Patricia A ^a   Begent, Richard H J ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5,6 DIMETHYLXANTHENONE 4 ACETIC ACID; CYTOKINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLORECTAL CARCINOMA; CONTROLLED STUDY; DOSE RESPONSE; IMMUNOMODULATION; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; MULTIMODALITY CANCER THERAPY; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOTHERAPY; TUMOR BLOOD FLOW; TUMOR NECROSIS; XENOGRAFT;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEOPLASM; CARCINOEMBRYONIC ANTIGEN; COLORECTAL NEOPLASMS; COMBINED MODALITY THERAPY; FLAVONOIDS; HUMANS; MICE; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; RADIOIMMUNOTHERAPY; REGIONAL BLOOD FLOW; SEROTONIN; TISSUE DISTRIBUTION; TRANSPLANTATION, HETEROLOGOUS; XANTHENES; XANTHONES;

EID: 0030002174     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. 131I-labeled monoclonal antibodies. Cancer Res., 52: 6036-6044, 1992.
2. 131I anti-CEA antibody in a colonie xenograft model. Br. J. Cancer, 68: 69-73, 1993
3. Press, O. W., Eary, J. F., Applebaum, F. R., Martin, P. J., Badger, C. C , Nelp, W. B., Glenn, S., Butchko, G., Fisher, D , Porter, B., Matthews, D. C., Fisher, L. D , and Bernstein, I. D Radiolabeled-antibody therapy of B-cell lymphoma with autologous bone marrow support. N. Engl. J Med., 329: 1219-1224, 1993.
4. 2 antibodies Br. J. Cancer. 70: 521-525, 1994.
5. Dvorak, H F , Nagy, J A , and Dvorak, A. M Structure of solid tumours and their vasculature: implications for therapy with monoclonal antibodies. Cancer Cell, 3: 77-85, 1991.
6. Jain, R , K. Delivery of novel therapeutic agents in tumours, physiological barriers and strategies J. Natl. Cancer Inst., 81 570-576, 1989.
7. Chaplin, D. J., Peters, C. E., Horsman, M. R., and Trotter M. J. Drug induced perturbations in tumour blood flow: therapeutic potential and possible limitations Radiother. Oncol. Suppl , 20 93-101, 1991.
8. Zwi, L. J., Baguley, B. C., Gavin, J. B., and Wilson, W. R. The morphological effects of the anti-tumour agents flavone acetic acid and 5,6-dimethyl xanthenone acetic acid on the colon 38 mouse tumour. Pathology, 24: 161-169, 1994.
9. Pedley, R. B., Begent, R. H J , Boden, J A , Boxer, G. M., Boden, R., and Keep, P. A. Enhancement of radioimmunotherapy by drugs modifying tumour blood flow in a colonic xenograft model Int J. Cancer, 57: 830-835, 1994.
10. Ching, L-M , Joseph, W R , Zhuang, L., and Baguley, B. C. Interaction between endotoxin and the antitumour agent 5,6-dimethylxanthenone-4-acetic acid in the induction of tumour necrosis factor and haemorrhagic necrosis of colon 38 tumours. Cancer Chemother. Pharmacol , 35: 153-160, 1994
11. Ching, L-M , Joseph, W R , and Baguley, B. C. Antitumour responses to flavone-8-acetic acid and 5,6-dimethylxanthenone-4-acetic acid in immune deficient mice. Br. J. Cancer, 66: 128-130, 1992.
12. Pratesi, G., Manzotti, C., Tortoretto, M., Audisto, R. A., and Zunino, F Differential efficacy of flavone acetic acid against liver versus lung metastases in a human tumour xenograft. Br. J. Cancer, 63: 71-74, 1991.
13. Siegenthaler, P., Kaye, S. B., Monfardini, S., and Renard, J. Phase II trial with flavone acetic acid (NSC.347512. LM975) in patients with non-small cell lung cancer. Ann. Oncol , 3: 169-170, 1992.
14. O'Reilly, S M., Rustin, G. J. S., Farmer, K., Burke, M., Hill, S , and Denekamp, J. Flavone acetic acid (FAA) with recombinant interleukin-2 (rIL-2) in advanced malignant melanoma. 1. Clinical and vascular studies. Br J Cancer, 67: 1342-1345, 1993.
15. Laws, A. L., Matthew, A. M , Double, J A., and Bibby, M. C. Preclinical in vitro and in vivo activity of 5,6-dimethylxanthenone-4-acetic acid. Br. J. Cancer, 71: 1204-1209, 1995.
16. Ching, L-M., Joseph, W. R., Crosier, K E , and Baguley, B. C. Induction of tumour necrosis factor-α in human and murine cells by the flavone acetic acid analogue 5,6-dimethylxanthenone-4-acetic acid (NSC 640488). Cancer Res , 54: 870-872, 1994.
17. Farber, H W., and Beer, D J Restricted secretion of a T-lymphocyte chemotactic cytokine by serotonin-stimulated cultured aortic endothelium cells. Circ. Res., 69: 257-265, 1991.
18. Manda, T., Nishigaki, F., Mori, J., and Shimomura, K. Important role of serotonin in the antitumour effects of recombinant tumour necrosis factor-α in mice Cancer Res , 48: 4250-4255, 1988
19. Peters, C. E , and Chaplin, D. J. Blood flow modification in the SCVII tumour, effects of 5-hydroxytryptamine, hydralazine, and propanolol. Int. J. Radiat Oncol. Biol. Phys , 22: 463-465, 1992.
20. Okuyama, M., Hatori, Y., and Shigematsu, A. Autoradioluminography, a novel quantitative method of TLC-autoradiography Biol Pharmaceutical Bull., 17: 559-563, 1994.
21. Pedley, R B., Boden, J , Keep, P. A., Harwood, P. A., Green, A. J., and Rogers, G T. Relationship between tumour size and uptake of radiolabelled anti-CEA in a colon tumour xenograft. Eur. J Nucl. Med., 13: 197-202, 1987.
22. Looney, W B , Mayo, A. A., Allen, P. M., Morrow, J. Y., and Morris, H. P A mathematical evaluation of tumour growth curves in rapid, intermediate and slow growing rat hepatoma. Br. J. Cancer, 27: 341-344, 1973.
23. Lee, E., and Desu, M A computer program for comparing K samples with right censored data. Comput. Programs Biomed., 2: 315-321, 1972.
24. Hill, S. A , Williams, K. B , and Denekamp, J A comparison of vascular-mediated tumour cell death by the necrotizing agent GR63178 and flavone acetic acid. Int J. Radiat Oncol. Biol Phys., 22: 437-441, 1992.
25. Stratford, I. J., Adams, G. E., Godden, J., Nolan, J., Howells, N , and Timpson, N. Potentiation of the anti-tumour effect of of melphalan by the vasoactive agent hydralazine. Br. J. Cancer, 58: 122-127, 1988
26. Folli, S., Pelegrin, A., Chalandon, Y., Yao, X , Buchegger, F., Lienard, D., Lejeune, F , and Mach, J-P Tumour-necrosis factor can enhance radio-antibody uptake in human colon carcinoma xenografts by increasing vascular permeability Int. J Cancer, 53: 829-836, 1993
27. 2 conjugate. Eur J. Cancer, 29A: 1177-1183, 1993.
28. Rowlinson-Busza, G , Maraveyas, A , and Epenetos, A. A. Effect of tumour necrosis factor on the uptake of specific and control monoclonal antibodies in a human tumour xenograft model. Br. J Cancer, 71: 660-665, 1993.
29. Khawli, L. A , Miller, G. K., and Epstein, A. L Effect of seven new vasoactive immunoconjugates on the enhancement of monoclonal antibody uptake in tumors. Cancer (Phila), 73: 824-831, 1994.
30. Baguley, B. C., Cole, G , Thomsen, L. L., and Zhuang, L Serotonin involvement in the anti-tumour and host effects of flavone-8-acetic acid and 5,6-dimethylxanthenone-4-acetic acid. Cancer Chemother. Pharmacol , 33 77-81, 1993.
31. Buist, M R., Kenemans, P , Molthoff, C F. M , Roos, J. C., Hollander, W. D , Brinkhuis, M., and Baak, J. P A. Tumour uptake of intravenously administered radiolabeled antibodies in ovarian carcinoma patients in relation to antigen expression and other tumour characteristics. Int. J Cancer, 64: 92-98, 1995
32. Jenkins, D. C., Wilkinson, J., Lindon, J. C., Farrant, R. D , Carpenter, T. A., Stables, J N., Topley, P., Lindstead, D. J . and Holmes, L. S. Anti-tumour effects of 5-hydroxytryptamine (5-HT) are not entirely attributable to its effects on tumour vasculature. Int J. Radiat. Biol., 60: 243-248, 1991.
33. Sersa, G., Willingham, V., and Milas, L. Anti-tumour effects of tumour necrosis factor alone or combined with radiotherapy. Int. J. Cancer, 42 129-134, 1988.
34. Hellman, S., and Weichselbaum, R. R. Radiation oncology and the new biology. Cancer J. Sci Am , 1: 174-179, 1995.
35. Bartch, H. H , Pfizenmaier, K., Schroeder, M., and Nagel, G. A Intralesional application of recombinant human tumour necrosis factor alpha induces local tumour regression in patients with advanced malignancies. Eur. J. Oncol., 25: 287-291, 1989
36. de Kossodo, S., Moore, R., Gschmeissner, S , East, N., Upton, C., and Balkwill, F R. Changes in endogenous cytokines, adhesion molecules and platelets during cytokine-induced tumour necrosis. Br. J. Cancer, 72: 1165-1172, 1995