Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: Intravital microscopy and measurement of vascular permeability

Cancer Research

Volumn 61, Issue 17, 2001, Pages 6413-6422

  Tozer, Gillian M ^a   Prise, Vivien E ^a   Wilso, John ^a   Cemazar, Maja ^a   Shan, Siqing ^b   Dewhirst, Mark W ^b   Barber, Paul R ^a   Vojnovic, Borivoj ^a   Chaplin, David J ^a  

^a MOUNT VERNON HOSPITAL   (United Kingdom)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; COMBRETASTATIN A4; COMBRETASTATIN A4 PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD VESSEL DIAMETER; BLOOD VISCOSITY; CANCER INHIBITION; CELL DEATH; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INHIBITION; ERYTHROCYTE; EXPERIMENTAL NEOPLASM; HEMATOCRIT; MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR BLOOD FLOW; TUMOR VASCULARIZATION;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAPILLARY PERMEABILITY; CARCINOSARCOMA; DRUG SYNERGISM; ENZYME INHIBITORS; MALE; MICROSCOPY, FLUORESCENCE; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROARGININE; RATS; STILBENES;

EID: 0035417875     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Angiogenesis and angiogenesis inhibition: An overview
2. Tumor vasculature as a target for cancer therapy
3. Antivascular approaches to solid tumor therapy: Evaluation of tubulin binding agents
4. Increased plasma serotonin following treatment with flavone-8-acetic acid, 5,6-dimethylxanthenone-4-acetic acid, vinblastine, and colchicine: Relation to vascular effects
5. Vinca alkaloids: Anti-vascular effects in a murine tumor
6. Effect of colchicine on human carcinoma
7. Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A4
8. Antineoplastic agents 322. Synthesis of combretastatin A-4 prodrugs
9. The interaction with tubulin of a series of stilbenes based on combretastatin A-4
10. Combretastatin A-4. An agent that displays potent and selective toxicity toward tumor vasculature
11. 4 prodrug-induced disruption of tumor perfusion and energetic status
12. The effect of combretastatin A-4 disodium phosphate in a C3H mouse mammary carcinoma and a variety of murine spontaneous tumors
13. In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug
14. Anti-vascular approaches to solid tumor therapy: Evaluation of combretastatin A4 phosphate
15. Combretastatin A-4 phosphate as a tumor vasculartargeting agent: Early effects in tumors and normal tissues
16. Ischemia reperfusion injury in tumors: The role of oxygen radicals and nitric oxide
17. Nitric oxide production by tumor tissue: Impact on the response to photodynamic therapy
18. Studies on the mechanism of action of the vascular targeting agent combretastatin A-4 phosphate
19. Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumor vascular targeting activity in vivo
20. Targeting the tumor vasculature with combretastatin A-4 disodium phosphate: Effects on radiation therapy
21. Combination chemotherapy with combretastatin A-4 phosphate and 5-fluorouracil in an experimental murine colon adenocarcinoma
22. A transparent access chamber for the rat dorsal skin fold
23. Temporal effects of 5.0 Gy radiation in healing subcutaneous microvasculature of a dorsal flap window chamber
24. Modification of tumor blood flow using the hypertensive agent, angiotensin II
25. Evaluation of carbocyanine-labeled erythrocytes for microvascular measurements
26. Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma
27. Characterisation of tumor blood flow using a "tissue-isolated" preparation
28. Measurement of brain uptake of radiolabelled substances using a tritiated water internal standard
29. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo
30. Inhibition of nitric oxide synthase induces a selective reduction in tumor blood flow that is reversible with L-arginine
31. Role of nitric oxide in tumor microcirculation: Blood flow, vascular permeability, and leukocyte-endothelial interactions
32. Determinants of anti-vascular action by combretastatin A-4 phosphate: Role of nitric oxide
33. Combretastatin A-4-phosphate (CA-4-P) induces neutrophil recruitment to cultured endothelial cells under flow
34. Effect of red blood cell rigidity on tumor blood flow: Increase in viscous resistance during hyperglycemia
35. Red blood cell behavior at low flow rate in microvessels
36. The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH and lactate treatment
37. Perivascular oxygen tensions in a transplantable mammary tumor growing in a dorsal flap window chamber
38. 2 gradients in window chamber tumors: Impact on tumor hypoxia
39. Interstitial pressure gradients in tissue isolated and subcutaneous tumors: Implications for therapy
40. Eradication of colorectal xenografts by combined radioimmunotherapy and combretastatin A-4 3-O-phosphate