Comparative effects of combretastatin A-4 disodium phosphate and 5,6-dimethylxanthenone-4-acetic acid on blood perfusion in a murine tumour and normal tissues

International Journal of Radiation Biology

Volumn 77, Issue 2, 2001, Pages 195-204

  Murata, R ^a   Overgaard, J ^a   Horsman, M R ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

5,6 DIMETHYLXANTHENONE 4 ACETIC ACID; COMBRETASTATIN A4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER; BLOOD; BREAST CARCINOMA; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; INTESTINE PERFUSION; KIDNEY PERFUSION; LIVER PERFUSION; LUNG PERFUSION; MOUSE; MUSCLE PERFUSION; NONHUMAN; PRIORITY JOURNAL; SPLEEN; TISSUE PERFUSION; TUMOR VASCULARIZATION;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BLOOD; DIGESTIVE SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; KIDNEY; LIVER; LUNG; MICE; MICE, INBRED C3H; MUSCLES; NEOPLASM TRANSPLANTATION; NEOPLASMS; PERFUSION; SKIN; SPLEEN; STILBENES; TIME FACTORS; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED; URINARY BLADDER; XANTHENES; XANTHONES;

ANIMALIA; MURINAE;

EID: 0035131992     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/09553000010007695     Document Type: Article

References (28)

1. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
2. Tumour vasculature as a target for cancer therapy
3. Anti-vascular approaches to solid tumour therapy: Evaluation of combretastatin A4 phosphate
4. Antivascular approaches to solid tumour therapy: Evaluation of tubulin binding agents
5. Induction of tumor necrosis factor-α messenger RNA in human and routine cells by the flavone acetic acid analogue 5,6-dimethylxanthenone-4-acetic acid (NSC 640488)
6. Combining bioreductive drugs (SR 4233 or SN 23862) with the vasoactive agents flavone acetic acid or 5,6-dimethylxanthenone acetic acid
7. Combretastatin A-4, an agent that displays potent and selective toxicity toward tumour vasculature
8. Angiogenic attack as a therapeutic strategy, for cancer
9. Vascular occlusion and tumour cell death
10. Antiangiogenic Therapy
11. In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug
12. Hydralazine-induced enhancement of hyperthermic damage in a C3H mammary carcinoma in vivo
13. The effect of combretastatin A-4 disodium phosphate in a C3H mouse mammary carcinoma and a variety of marine spontaneous tumors
14. Combretastatins: Novel vascular targeting drugs for improving anti-cancer therapy
15. The in vivo interaction between flavone acetic acid and hyperthermia
16. Induction of apoptosis in proliferating human endothelial cells by the tumor-specific antiangiogenesis agent combretastatin A-4
17. Stimulation of tumors to synthesize tumor necrosis factor-alpha in situ using 5,6-dimethylxanthenone-4-acetic acid: A novel approach to cancer therapy
18. Enhancement of the anti-tumour effects of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by combination with 5-hydroxytryptamine and bioreductive drugs
19. Preclinical in vitro and in vivo activity of 5,6-dimethylxanthenone-4-acetic acid
20. Targeting the tumor vasculature with combretastatin A-4 disodium phosphate: Effects on radiation therapy
21. 1H MRI
22. Simultaneous and sequential hyperthermia and radiation treatment of an experimental tumor and its surrounding normal tissue in vivo
23. Production of tumour necrosis factor-α by cultured human peripheral blood leucocytes in response to the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid (NSC 640488)
24. Potential antitumor agents 61. Structure-activity relationships for in vivo colon 38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids
25. Regional blood flow by fractional distribution of indicators
26. Combretastatin A-4 phosphate as a tumor vascular-targeting agent: Early effects in tumors and normal tissues
27. Enhancement of tumor radiation response by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid
28. Necrosis in non-tumour tissues caused by flavone acetic acid and 5,6-dimethylxanthenone acetic acid