Importance of VEGF for breast cancer angiogenesis in vivo: Implications from intravital microscopy of combination treatments with an anti-VEGF neutralizing monoclonal antibody and doxorubicin

Anticancer Research

Volumn 19, Issue 5 B, 1999, Pages 4203-4214

  Borgström, Per ^a,c   Gold, Daniel P ^c   Hillan, Kenneth J ^b   Ferrara, Napoleone ^b  

^a La Jolla Institute for Experimental Medicine   (United States)

^b GENENTECH INC   (United States)

^c SIDNEY KIMMEL CANCER CENTER   (United States)

Author keywords

Angiostatic; Anti angiogenic; Breast carcinoma; Combination; Cytotoxic; Human; Intravital microscopy; MCF 7; Skinfold; Tumor spheroid; Vascular endothelial growth factor

Indexed keywords

ANTINEOPLASTIC AGENT; DOXORUBICIN; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; FLUORESCENT DYE; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CELL VIABILITY; CONTROLLED STUDY; GROWTH RATE; HISTOLOGY; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MICROSCOPY; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; TUMOR GROWTH;

EID: 0032806309     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Folkman J: What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 82: 4-6, 1990.
2. Ferrara N: The role of vascular endothelial growth factor in pathological angiogenesis. Breast Cancer Res Treat 36(2): 127-37, 1995.
3. Borgström P, Hillan KJ, Sriramarao P, Ferrara F: Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: Novel concepts of angiostatic therapy from intravital video microscopy. Cancer Res 56: 4032-39, 1996.
4. Borgström P, Mario A, Bourdon Hillan KJ, Sriramarao P, Ferrara F:Neutralizing anti-vascular growth factor antibody completely inhibits angiogenesis and growth of human prostate carcinoma micro tumors in vivo. The Prostate, In Press, 1998.
5. Relf M, LeJeune S, Scott PAE, Fox S, Smith K, Leek R, Moghaddam A, Whitehouse R, Bicknell R, Harris AL: Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor 8-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res 57: 963-969, 1997.
6. Conn G, Soderman D, Schaeffer MT, Wile M, Hatcher VB and Thomas KA: Purification of a glycoprotein vascular endothelial cell mitogen from a rat glioma cell line. Proc Natl Acad Sci U.S.A. 87: 1323, 1990.
7. Levy AP, Tamargo R, Brem H and Nathans D: An endothelial cell growth factor from the mouse neuroblastoma cell line NB41. Growth Factors 2(1): 9, 1989.
8. Rosenthal RA, Megyesi JF, Henzel WJ, Ferrara N and Folkman J: Conditioned media from mouse sarcoma 180 cells contain vascular endothelial growth factor. Growth Factors 4: 53-59, 1990.
9. Toi M, Kashitani J and Tominaga T: Tumor angiogenesis is an independent prognostic indicator in primary breast carcinoma. Int J Cancer 55(3): 371-4, 1993.
10. Weidner N, Semple J and Folkman J: Tumor angiogenesis correlates with metastasis in invasive breast carcinoma. New Engl J Med 324: 1-8, 1991.
11. Brown LF, Berse B, Jackman RW, Tognazzi K et al: Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer. Hum Pathol 1995 26(1): 86-91, 1995.
12. Toi M, Hoshina S, Takayanagi T and Tominaga T: Association of vascular endothelial growth factor expression with tumor angiogenesis and with early relapse in primary breast cancer. Jpn J Cancer Res 85(10): 1045-9, 1994.
13. O'Reilly MS, Holmgren L, Chen C, Folkman J: Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat Med 2(6): 689-92, 1996.
14. Torres Filho IP, Hartley-Asp B and Borgström P: Quantitative angiogenesis in a syngeneic tumor spheroid model. Microvasc Res 49: 212-226, 1995.
15. Lehr H, Leunig M, Menger MD, Messmer K: Dorsal skinfold chamber technique for intravital microscopy on striated muscle in nude mice. Am J Pathol 143: 1055-1062, 1993.
16. Leunig M, Yuan F, Menger MD, Boucher Y, Goetz AE, Messmer K and Jain RK: Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. Cancer Res 52: 6553-6560, 1992.
17. Teicher BA, Holden SA, Ara G, Sotomayor EA, Huang ZD, Chen YN, Brem H: Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other anti-angiogenic agents. Int J Cancer 57(6): 920-5, 1994.