Combination of angiogenesis inhibitor TNP-470 with cytotoxic drugs in experimental therapy of nasopharyngeal carcinoma

Annals of Otology, Rhinology and Laryngology

Volumn 109, Issue 7, 2000, Pages 641-645

  Qian, Chao Nan ^a   Lin, Han Liang ^a   Min, Hua Qing ^a   Hong, Ming Huang ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

AGM 1470; Angiogenesis inhibitor; Antiangiogenic therapy; Nasopharyngeal carcinoma; TNP 470

Indexed keywords

ANGIOGENESIS INHIBITOR; CISPLATIN; CYTOTOXIC AGENT; FLUOROURACIL; FUMAGILLOL CHLOROACETYLCARBAMATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DIARRHEA; DRUG EFFECT; DRUG POTENTIATION; HUMAN; HUMAN CELL; MALE; MOUSE; NASOPHARYNX CARCINOMA; NONHUMAN; PRIORITY JOURNAL;

EID: 0343953078     PISSN: 00034894     EISSN: None     Source Type: Journal    
DOI: 10.1177/000348940010900705     Document Type: Article

References (18)

1. Fandi A, Altun M, Azli N, Armand JP, Cvitkovic E. Nasopharyngeal cancer: epidemiology, staging and treatment. Semin Oncol 1994;21:382-97.
2. Geara FB, Glisson BS, Sanguineti G, et al. Induction chemotherapy followed by radiotherapy versus radiotherapy alone in patients with advanced nasopharyngeal carcinoma. Cancer 1997;79:1279-86.
3. Al-Sarraf M, McLaughlin PW. Nasopharyngeal carcinoma: choice of treatment. Int J Radiat Oncol Biol Phys 1995;33: 761-3.
4. Folkman J. What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 1990;82:4-6.
5. Qian CN, Min HQ, Liang XM, Zheng SS, Lin HL. Primary study of neovasculature correlating with metastatic nasopharyngeal carcinoma using computer image analysis. J Cancer Res Clin Oncol 1997;123:645-51.
6. Folkman J. Clinical applications of research on angiogenesis. N Engl J Med 1995;333:1757-63.
7. Brem H, Folkman J. Analysis of experimental antiangiogenic therapy. J Pediatr Surg 1993;28:445-51.
8. Fujioka T, Hasegawa M, Ogiu K, Matsushita Y, Sato M, Kubo T. Antitumor effects of angiogenesis inhibitor O-(chloro-acetyl-carbamoyl)-fumagillol (TNP-470) against murine renal cell carcinoma. J Urol 1996;155:1775-8.
9. Yanase T, Tamura M, Fujita K, Kodama S, Tanaka K. Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo. Cancer Res 1993;53:2566-70.
10. Qian CN, Min HQ, Lin HL, Hong MH, Ye YL. Primary study in experimental antiangiogenic therapy of nasopharyngeal carcinoma with AGM-1470 (TNP-470). J Laryngol Otol 1998;112:849-53.
11. Brem H, Goto F, Budson A, Saunders L, Folkman J. Minimal drug resistance after prolonged anti-angiogenic therapy with AGM-1470. Surg Forum 1994;45:674-7.
12. Zhang SZH, Gao XK, Zeng Y. Cytogenetic study on an epithelial cell line derived from poorly differentiated nasopharyngeal carcinoma. Int J Cancer 1983;31:587-90.
13. Al-Sarraf M, Pajak TF, Cooper JS, Mohiuddin M, Herskovic A, Ager PJ. Chemo-radiotherapy in patients with locally advanced nasopharyngeal carcinoma: a radiation therapy oncology group study. J Clin Oncol 1990;8:1342-51.
14. Folkman J. Tumor angiogenesis. Adv Cancer Res 1985; 43:175-203.
15. Kusaka M, Sudo K, Matsutani E, et al. Cytostatic inhibition of endothelial cell growth by the angiogenesis inhibitor TNP-470 (AGM-1470). Br J Cancer 1994;69:212-6.
16. Kato T, Sato K, Kakinuma H, Matsuda Y. Enhanced suppression of tumor growth by combination of angiogenesis inhibitor O-(chloroacctyl-carbamoyl)-fumagillol (TNP-470) and cytotoxic agents in mice. Cancer Res 1994;54:5143-7.
17. Teicher BA, Dupuis NP, Robinson MF, Emi Y, Goff DA. Antiangiogenic treatment (TNP-470/minocyclin) increases tissue levels of anticancer drugs in mice bearing Lewis lung carcinoma. Oncol Res 1995;7:237-43.
18. Murata R, Nishimura Y, Hiraoka M. An antiangiogenic agent (TNP-470) inhibited reoxygenation during fractionated radiotherapy of murine mammary carcinoma. Int J Radiat Oncol Biol Phys 1997;37:1107-13.