Mitochondrial dysfunction, oxidative stress and neurodegeneration

Journal of Alzheimer's Disease

Volumn 10, Issue 1, 2006, Pages 59-73

  Mancuso, Michelangelo ^a   Coppede, Fabio ^a   Migliore, Lucia ^a   Siciliano, Gabriele ^a   Murri, Luigi ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

Alzheimer's disease; Amyotrophic lateral sclerosis; Friedreich's ataxia; Huntington's disease; Mitochondria; mtDNA; Neurodegeneration; Oxidative stress; Parkinson's disease; ROS

Indexed keywords

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; CELL FUNCTION; CLINICAL FEATURE; COGNITION; DEGENERATIVE DISEASE; DISEASE COURSE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FRIEDREICH ATAXIA; HUMAN; HUNTINGTON CHOREA; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; RISK FACTOR;

EID: 33748757300     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2006-10110     Document Type: Review

References (160)

1. A.K. Afifi, F.P. Aleu, J. Goodgold and B. MacKay, Ultrastructure of atrophic muscle in amyotrophic lateral sclerosis, Neurology 16 (1966), 475-481.
2. N. Aguirre, M.F. Beal, W.R. Matson and M.B. Bogdanov, Increased oxidative damage to DNA in an animal model of amyotrophic lateral sclerosis, Free Radic Res 39 (2005), 383-388.
3. M.Y. Aksenov, M.V. Aksenova, D.A. Butterfield, J.W. Geddes and W.R. Markesbery, Protein oxidation in the brain in Alzheimer's disease, Neuroscience 103 (2001), 373-383.
4. Z.I. Alam, S.E. Daniel, A.J. Lees, D.C. Marsden, P. Jenner and B. Halliwell, A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease, J Neurochem 69 (1997), 1326-1329.
5. Z.I. Alam, B. Halliwell and P. Jenner, No evidence for increased oxidative damage to lipids, proteins, or DNA in Huntington's disease, J Neurochem 75 (2000), 840-846.
6. T. Atsumi, The ultrastructure of intramuscular nerves in amyotrophic lateral sclerosis, Acta Neuropathol (Berl) 55 (1981), 193-198.
7. J. Autere, J. Autere, J.S. Moilanen, S. Finnila, H. Soininen, A. Mannermaa, P. Hartikainen, M. Hallikainen and K. Majamaa, Mitochondrial DNA polymorphisms as risk factors for Parkinson's disease and Parkinson's disease dementia, Hum Genet 115 (2004), 29-35.
8. J.S. Bains and C.A. Shaw, Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death, Brain Res Brain Res Rev 25 (1997), 335-358.
9. M.F. Beal, R.J. Ferrante, S.E. Browne, R.T. Matthews, N.W. Kowall and R.H. Brown Jr, Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis, Ann Neurol 42 (1997), 644-654.
10. M.F. Beal, Mitochondria take center stage in aging and neurodegeneration, Ann Neurol 58 (2005), 495-505.
11. M.F. Beal, Aging, energy, and oxidative stress in neurodegenerative diseases, Ann Neurol 38 (1995), 357-366.
12. J.S. Beckman, M. Carson, C.D. Smith and W.H. Koppenol, ALS, SOD and peroxynitrite, Nature 364 (1993), 584.
13. A. Bender, K.J. Krishnan, C.M. Morris, G.A. Taylor, A.K. Reeve, R.H. Perry, E. Jaros, J.S. Hersheson, J. Betts, T. Klopstock, R.W. Taylor and D.M. Turnbull, High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease, Nat Gene 38 (2006), 515-517.
14. L.A. Bindoff, M. Birch-Machin, N.E. Cartlidge, W.D. Parker Jr and D.M. Turnbull, Mitochondrial function in Parkinson's disease, Lancet 2 (1989), 49.
15. M. Bogdanov, R.H. Brown, W. Matson, R. Smart, D. Hayden, H. O'Donnell, M. Flint Beal and M. Cudkowicz, Increased oxidative damage to DNA in ALS patients, Free Radic Biol Med 29 (2000), 652-658.
16. M.B. Bogdanov, O.A. Andreassen, A. Dedeoglu, R.J. Ferrante and M.F. Beal, Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease, J Neurochem 79 (2001), 1246-1249.
17. V. Bonifati, P. Rizzu, M.J. Van Baren, O. Schaap, G.J. Breedveld, E. Krieger, M.C. Dekker, F. Squitieri, P. Ibanez, M. Joosse, J.W. Van Dongen, N. Vanacore, J.C. Van Swieten, A. Brice, G. Meco, C.M. Van Duijn, B.A. Oostra and P. Heutink, Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism, Science 299 (2003), 256-259.
18. G.M. Borthwick, M.A. Johnson, P.G. Ince, P.J. Shaw and D.M. Turnbull, Mitochondrial enzyme activity in amyotrophic lateral sclerosis: implications for the role of mitochondria in neuronal cell death, Ann Neurol 46 (1999), 787-790.
19. G.M. Borthwick, R.W. Taylor, T.J. Walls, K. Tonska, G.A. Taylor, P.J. Shaw, P.G. Ince and D.M. Turnbull, Motor neuron disease in a patient with a mitochondrial tRNAIle mutation, Ann Neurol 59 (2006), 570-574.
20. A.C. Bowling, J.B. Schulz, R.H. Brown Jr and M.F. Beal, Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis, J Neurochem 61 (1993), 2322-2325.
21. J.L. Bradley, J.C. Blake, S. Chamberlain, P.K. Thomas, J.M. Cooper and A.H. Schapira, Clinical, biochemical and molecular genetic correlations in Friedreich's ataxia, Hum Mol Genet 9 (2000), 275-282.
22. S.E. Browne, A.C. Bowling, U. MacGarvey, M.J. Baik, S.C. Berger, M.M. Muqit, E.D. Bird and M.F. Beal, Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia, Ann Neurol 41 (1997), 646-653.
23. S.E. Browne, R.J. Ferrante and M.F. Beal, Oxidative stress in Huntington's disease, Brain Pathol 9 (1999), 147-163.
24. C. Buhmann, S. Arlt, A. Kontush, T. Moller-Bertram, S. Sperber, M. Oechsner, H.J. Stuerenburg and U. Beisiegel, Plasma and CSF markers of oxidative stress are increased in Parkinson's disease and influenced by antiparkinsonian medication, Neurobiol Dis 15 (2004), 160-170.
25. A.I. Bush, Metals and neuroscience, Curr Opin Chem Biol 4 (2000), 184-191.
26. D.A. Butterfield, B. Howard and M.A. LaFontaine, Brain oxidative stress in animal models of accelerated aging and the age-related neurodegenerative disorders, Alzheimer's disease and Huntington's disease, Curr Med Chem 8 (2001), 815-828.
27. D.A. Butterfield, H.F. Poon, D. St Clair, J.N. Keller, W.M. Pierce, J.B. Klein and W.R. Markesbery, Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: Insights into the development of Alzheimer's disease, Neurobiol Dis (2006), in press.
28. D.A. Butterfield and E.R. Stadtman, Protein oxidation processes in aging brain, Adv. Cell Aging Gerontol 2 (1997), 161-191.
29. D.A. Butterfield, Proteomics: a new approach to investigate oxidative stress in Alzheimer's disease brain, Brain Res 1000 (2004), 1-7.
30. N.Y. Calingasan, J. Chen, M. Kiaei and M.F. Beal, Beta-amyloid 42 accumulation in the lumbar spinal cord motor neurons of amyotrophic lateral sclerosis patients, Neurobiol Dis 19 (2005), 340-347.
31. C. Casali, V. Bonifati, F.M. santorelli, G. Casan, D. Fortini, A. Patrignani, G. Fabbrini, R. Carrozzo, G. D'Amati, N. Locuratolo, N. Vanacore, M. Damiano, A. Pierallini, F. Pierelli, G.A. Amabile and G. Meco, Mitochondrial myopathy, parkinsonism, and multiple mtDNA deletions in a Sephardic Jewish familt, Neurology 56 (2001), 802-805.
32. A. Castegna, V. Thongboonkerd, J.B. Klein, B. Lynn, W.R. Markesbery and D.A. Butterfield, Proteomic identification of nitrated proteins in Alzheimer's disease brain, J Neurochem 85 (2003), 1394-1401.
33. C. Cecchi, C. Fiorillo, S. Sorbi, S. Latorraca, B. Nacmias, S. Bagnoli, P. Nassi and G. Liguri, Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer's patients, Free Radic Biol Med 33 (2002), 1372-1379.
34. P.E. Chabrier, C. Demerle-Pallardy and M. Auguet, Nitric oxide synthases: targets for therapeutic strategies in neurological diseases, Cell Mol Life Sci 55 (1999), 1029-1035.
35. R.M. Chalmers, M. Brockington, R.S. Howard, B.R. Lecky, J.A. Morgan-Hughes and A.E. Harding, Mitochondrial et al., Mitochondrial encephalopathy with multiple mitochondrial DNA deletions: A report of two families and two sporadic cases with unusual clinical and neuropathological features, J Neurol Sci 143 (1996), 41-45.
36. R.A. Cherny, J.T. Legg, C.A. McLean, D.P. Fairlie, X. Huang, C.S. Atwood, K. Beyreuther, R.E. Tanzi, C.L. Masters and A.I. Bush, Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion, J Biol Chem 274 (1999), 23223-23228.
37. J. Choi, A.I. Levey, S.T. Weintraub, H.D. Rees, M. Gearing, L.S. Chin and L. Li, Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases, J Biol Chem 279 (2004), 13256-13264.
38. J. Choi, H.D. Rees, S.T. Weintraub, A.I. Levey, L.S. Chin and L. Li, Oxidative modifications and aggregation of Cu,Zn-superoxide dismutase associated with Alzheimer and Parkinson diseases, J Biol Chem 280 (2005), 11648-14655.
39. G.P. Comi, A. Bordoni, S. Salani, L. Franceschina, M. Sciacco, A. Prelle, F. Fortunato, M. Zeviani, L. Napoli, N. Bresolin, M. Moggio, C.D. Ausenda, J.W. Taanman and G. Scarlato, Cytochrome c oxidase subunit I microdeletion in a patient with motor neuron disease, Ann Neurol 43 (1998), 110-116.
40. C.C. Conrad, P.L. Marshall, J.M. Talent, C.A. Malakowsky, J. Choi and R.W. Gracy, Oxidized proteins in Alzheimer's plasma, Biochem Biophys Res Commun 275 (2000), 678-681.
41. J.M. Cooper, S.E. Daniel, C.D. Marsden and A.H. Schapira, L-dihydroxyphenylalanine and complex I deficiency in Parkinson's disease brain, Mov Disord 10 (1995), 295-297.
42. G. Davidzon, P. Greene, M. Mancuso, K.J. Klos, J.E. Ahlskog, M. Hirano and S. Dimauro, Early-onset familial parkinsonism due to POLG mutations, Ann Neurol 59 (2006), 859-862.
43. S. Davies and D.B. Ramsden, Huntington's disease, Mol Pathol 54 (2001), 409-413.
44. T.M. Dawson and V.L. Dawson, Molecular pathways of neurodegeneration in Parkinson's disease, Science 302 (2003), 819-822.
45. I.F. De Coo, W.O. Renier, W. Ruitenbeek, H.J. Ter Laak, M. Bakker, H. Schagger, B.A. Van Oost and H.J. Smeets, A 4-base pair deletion in the mitochondrial cytochrome b gene associated with Parkinsonism/MELAS overlap syndrome, Ann Neurol 45 (1999), 130-133.
46. D.T. Dexter, C.J. Carter, F.R. Wells, F. Javoy-Agid, Y. Agid, A. Lees, P. Jenner and C.D. Marsden, Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease, J Neurochem 52 (1989), 381-389.
47. D.T. Dexter, A.E. Holley, W.D. Flitter, T.F. Slater, F.R. Wells, S.E. Daniel, A.J. Lees, P. Jenner and C.D. Marsden, Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: an HPLC and ESR study, Mov Disord 9 (1994), 92-97.
48. G.K. Dhaliwal and R.P. Grewal, Mitochondrial DNA deletion mutation levels are elevated in ALS brains, Neuroreport 11 (2000), 2507-2509.
49. Q. Ding, W.R. Markesbery, Q. Chen, F. Li and J.N. Keller, Ribosome dysfunction is an early event in Alzheimer's disease, J Neurosci 25 (2005), 9171-9175.
50. A. Echaniz-Laguna, J. Zoll, E. Ponsot, B. N'guessan, C. Tranchant, J.P. Loeffler and E. Lampert, Muscular mitochondrial function in amyotrophic lateral sclerosis is progressively altered as the disease develops: a temporal study in man, Exp Neurol 198 (2006), 25-30.
51. R.J. Ferrante, S.E. Browne, L.A. Shinobu, A.C. Bowling, M.J. Baik, U. MacGarvey, N.W. Kowall, R.H. Brown Jr and M.F. Beal, Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis, J Neurochem 69 (1997), 2064-2074.
52. M. Emond, G. Lepage, M. Vanasse and M. Pandolfo, Increased levels of plasma malondialdehyde in Friedreich ataxia, Neurology 55 (2000), 1752-1753.
53. C.D. Gajewski, M.T. Lin, M.E. Cudkowicz, M.F. Beal and G. Manfredi, Mitochondrial DNA from platelets of sporadic ALS patients restores normal respiratory functions in rho(0) cells, Exp Neurol 179 (2003), 229-235.
54. O. Gakh, S. Park, G. Liu, L. Macomber, J.A. Imlay, G.C. Ferreira and G. Isaya, Mitochondrial iron detoxification is a primary function of frataxin that limits oxidative damage and preserves cell longevity, Hum Mol Genet 15 (2006), 467-479.
55. G. Gardian and L. Vecsei, Huntington's disease: pathomechanism and therapeutic perspectives, J Neural Transm 111 (2004), 1485-1494.
56. D. Ghezzi, C. Marelli, A. Achilli, S. Goldwurm, G. Pezzoli, P. Barone, M.T. Pellecchia, P. Stanzione, L. Brusa, A.R. Bentivoglio, U. Bonuccelli, L. Petrozzi, G. Abbruzzese, R. Marchese, P. Cortelli, D. Grimaldi, P. Martinelli, C. Ferrarese, B. Garavaglia, S. Sangiorgi, V. Carelli, A. Torroni, A. Albanese and M. Zeviani, Mitochondrial DNA haplogroup K is associated with a lower risk of Parkinson's disease in Italians, Eur J Hum Genet 13 (2005), 748-752.
57. M. Gu, J.M. Cooper, J.W. Taanman and A.H. Schapira, Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease, Ann Neurol 44 (1998), 177-186.
58. F.X. Guix, I. Uribesalgo, M. Coma and F.J. Munoz, The physiology and pathophysiology of nitric oxide in the brain, Prog Neurobiol 76 (2005), 126-152.
59. J.F. Gusella and M.E. MacDonald, Huntington's disease, Semin Cell Biol 6 (1995), 21-28.
60. J.F. Gusella, N.S. Wexler, P.M. Conneally, S.L. Naylor, M.A. Anderson, R.E. Tanzi, P.C. Watkins, K. Ottina, M.R. Wallace, A.Y. Sakaguchi et al., A polymorphic DNA marker genetically linked to Huntington's disease, Nature 306 (1983), 234-238.
61. A. Hald and J. Lotharius, Oxidative stress and inflammation in Parkinson's disease: is there a causal link? Exp Neurol 193 (2005), 279-290.
62. B. Halliwell, Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment, Drugs Aging 18 (2001), 685-716.
63. N. Hattori, M. Tanaka, T. Ozawa and Y. Mizuno, Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in Parkinson's disease, Ann Neurol 30 (1991), 563-571.
64. K. Hensley, M.L. Maidt, Z. Yu, H. Sang, W.R. Markesbery and R.A. Floyd, Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation, J Neurosci 18 (1998), 8126-8132.
65. A. Hirano, H. Donnenfeld, S. Sasaki and I. Nakano, Fine structural observations of neurofilamentous changes in amyotrophic lateral sclerosis, J Neuropathol Exp Neurol 43 (1984), 461-470.
66. K. Honda, M.A. Smith, X. Zhu, D. Baus, W.C. Merrick, A.M. Tartakoff, T. Hattier, P.L. Harris, S.L. Siedlak, H. Fujioka, Q. Liu, P.I. Moreira, F.P. Miller, A. Nunomura, S. Shimohama and G. Perry, Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron, J Biol Chem 280 (2005), 20978-20986.
67. C. Huerta, M.G. Castro, E. Coto, M. Blazquez, R. Ribacoba, L.M. Guisasola, C. Salvador, C. Martinez, C.H. Lahoz and V. Alvarez, Mitochondrial DNA polymorphisms and risk of Parkinson's disease in Spanish population, J Neurol Sci 236 (2005), 49-54.
68. Y. Ihara, K. Nobukuni, H. Takata and T. Hayabara, Oxidative stress and metal content in blood and cerebrospinal fluid of amyotrophic lateral sclerosis patients with and without a Cu, Zn-superoxide dismutase mutation, Neurol Res 27 (2005), 105-108.
69. T.V. Ilic, M. Jovanovic, A. Jovicic and M. Tomovic, Oxidative stress indicators are elevated in de novo Parkinson's disease patients, Funct Neurol 14 (1999), 141-147.
70. K. Jellinger, W. Paulus, I. Grundke-Iqbal, P. Riederer and M.B. Youdim, Brain iron and ferritin in Parkinson's and Alzheimer's diseases, J Neural Transm Park Dis Dement Sect 2 (1990), 327-340.
71. E. Kadioglu, S. Sardas, S. Aslan, E. Isik and A. Esat Karakaya, Detection of oxidative DNA damage in lymphocytes of patients with Alzheimer's disease, Biomarkers 9 (2004), 203-209.
72. J. Kalra, A.H. Rajput, S.V. Mantha, A.K. Chaudhary and K. Prasad, Oxygen free radical producing activity of polymorphonuclear leukocytes in patients with Parkinson's disease, Mol Cell Biochem 112 (1992), 181-186.
73. J.N. Keller, F.A. Schmitt, S.W. Scheff, Q. Ding, Q. Chen, D.A. Butterfield and W.R. Markesbery, Evidence of increased oxidative damage in subjects with mild cognitive impairment, Neurology 64 (2005), 1152-1156.
74. A. Khan, J.P. Dobson and C. Exley, Redox cycling of iron by Abeta(42), Free Radic Biol Med 40 (2006), 557-569.
75. P.M. Kidd, Parkinson's disease as multifactorial oxidative neurodegeneration: implications for integrative management, Altern Med Rev 5 (2000), 502-529.
76. A. Kikuchi, A. Takeda, H. Onodera, T. Kimpara, K. Hisanaga, N. Sato, A. Nunomura, R.J. Castellani, G. Perry, M.A. Smith and Y. Itoyama, Systemic increase of oxidative nucleic acid damage in Parkinson's disease and multiple system atrophy, Neurobiol Dis 9 (2002), 244-248.
77. M.P. King and G. Attardi, Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation, Science 246 (1989), 500-503.
78. W.J. Koroshetz, B.G. Jenkins, B.R. Rosen and M.F. Beal, Energy metabolism defects in Huntington's disease and effects of coenzyme Q10, Ann Neurol 41 (1997), 160-165.
79. S. Kosel, E.M. Grasbon-Frodl, U. Mautsch, R. Egensperger, U. Von Eitzen, D. Frishman, S. Hofmann, K.D. Gerbitz, P. Mehraein and M.B. Graeber, Novel mutations of mitochondrial complex I in pathologically proven Parkinson disease, Neurogenetics 1 (1998), 197-204.
80. H. Koutnikova, V. Campuzano, F. Foury, P. Dolle, O. Cazzalini and M. Koenig, Studies Studies of human, mouse and yeast homologues indicate a mitochondrial function for frataxin, Nat Genet 16 (1997), 345-351.
81. Y. Kraytsberg, E. Kudryavtseva, A.C. McKee, C. Geula, N.W. Kowall and K. Khrapko, Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons, Nat Genet 38 (2006), 518-520.
82. J.W. Langston, L.S. Forno, J. Tetrud, A.G. Reeves, J.A. Kaplan and D. Karluk, Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure, Ann Neurol 46 (1999), 598-605.
83. H.G. Lee, X. Zhu, A. Nunomura, G. Perry and M.A. Smith, Amyloid Beta: the alternate hypothesis, Curr Alzheimer Res 3 (2006), 75-80.
84. Y.J. Li, S.A. Oliveira, P. Xu, E.R. Martin, J.E. Stenger, C.R. Scherzer, M.A. Hauser, W.K. Scott, G.W. Small, M.A. Nance, R.L. Watts, J.P. Hubble, W.C. Koller, R. Pahwa, M.B. Stern, B.C. Hiner, J. Jankovic, C.G. Goetz, F. Mastaglia, L.T. Middleton, A.D. Roses, A.M. Saunders, D.E. Schmechel, S.R. Gullans, J.L. Haines, J.R. Gilbert, J.M. Vance, M.A. Pencak-Vance, C. Hulette and K.A. Welsh-Bohmer, Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease, Hum Mol Genet 12 (2003), 3259-3267.
85. Y.J. Li, W.K. Scott, L. Zhang, P.I. Lin, S.A. Oliveira, T. Skelly, M.P. Doraiswamy, K.A. Welsh-Bohmer, E.R. Martin, J.L. Haines, M.A. Pericak-Vance and J.M. Vance, Revealing the role of glutathione S-transferase omega in age-at-onset of Alzheimer and Parkinson diseases, Neurobiol Aging (2005), in press.
86. R. Lodi, J.M. Cooper, J.L. Bradley, D. Manners, P. Styles, D.J. Taylor and A.H. Schapira, Deficit of mitochondrial respiration in patients with Friedreich's ataxia shown by in vivo 31P magnetic resonance spectroscopy, Proc Natl Acad Sci USA 96 (1999), 11492-11495.
87. M.A. Lovell, W.D. Ehmann, M.P. Mattson and W.R. Markesbery, Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease, Neurobiol Aging 18 (1997), 457-461.
88. P. Luoma, A. Melberg, J.O. Rinne, J.A. Kaukonen, N.N. Nupponen, R.M. Chalmers, A. Oldfors, I. Rautakorpi, L. Peltonen, K. Majamaa, H. Somer and A. Suomalainen, Parkisnsonism, premature menopause, and mitochondrial DNA polymerase mutations: clinical and molecular genetic study, Lancet 364 (2004), 875-882.
89. K.A. Maguire-Zeiss and H.J. Federoff, Convergent pathobiologic model of Parkinson's disease, Ann N Y Acad Sci 991 (2003), 152-166.
90. M. Mancuso, F.L. Conforti, A. Rocchi, A. Tessitore, M. Muglia, G. Tedeschi, D. Panza, M.R. Monsurrò, P. Sola, J. Mandrioli, A. Choub, A. DelCorona, M.L. Manca, R. Mazzei, T. Sprovieri, M. Filosto, A. Salviati, P. Valentino, F. Bono, M. Caracciolo, I.L. Simone, V. La Bella, G. Majorana, G. Siciliano, L. Murri and A. Quattrone, Could mitochondrial haplogroups play a role in sporadic amyotrophic lateral sclerosis? Neurosci Lett 371 (2004), 158-162.
91. M. Mancuso, M. Filosto, S.J. Oh and S. DiMauro, A novel POLG mutation in a family with ophtalmoplegia, neuropathy, and parkinsonism, Arch Neurol 61 (2004), 1777-1779.
92. M. Mancuso, G. Siciliano, M. Filosto, L. Murri, Mitochondrial dysfunction and Alzheimer's disease: new developments, J Alz Dis 9 (2006), 111-117.
93. G. Manfredi and Z. Xu, Mitochondrial dysfunction and its role in motor neuron degeneration in ALS, Mitochondrion 5 (2005), 77-87.
94. V.M. Mann, J.M. Cooper, D. Krige, S.E. Daniel, A.H. Schapira and C.D. Marsden, Brain, skeletal muscle and platelet homogenate mitochondrial function in Parkinson's disease, Brain 115 (1992), 333-342.
95. E. Mariani, M.C. Polidori, A. Cherubini and P. Mecocci, Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview, J Chromatogr B Analyt Technol Biomed Life Sci 827 (2005), 65-75.
96. W.R. Markesbery and M.A. Lovell, Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease, Neurobiol Aging 19 (1998), 33-36.
97. L.T. McGrath, B.M. McGleenon, S. Brennan, D. McColl, S. McILroy and A.P. Passmore, Increased oxidative stress in Alzheimer's disease as assessed with 4-hydroxynonenal but not malondialdehyde, QJM 94 (2001), 485-490.
98. P. Mecocci, U. MacGarvey and M.F. Beal, Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease, Ann Neurol 36 (1994), 747-751.
99. P. Mecocci, M.C. Polidori, A. Cherubini, T. Ingegni, P. Mattioli, M. Catani, P. Rinaldi, R. Cecchetti, W. Stahl, U. Senin and M.F. Beal, Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer disease, Arch Neurol 59 (2002), 794-798.
100. S. Melov, P. Coskun, M. Patel, R. Tuinstra, B. Cottrell, A.S. Jun, T.H. Zastawny, M. Dizdaroglu, S.I. Goodman, T.T. Huang, H. Miziorko, C.J. Epstein and D.C. Wallace, Mitochondrial disease in superoxide dismutase 2 mutant mice, Proc Natl Acad Sci USA 96 (1999), 846-851.
101. A. Menegon, P.G. Board, A.C. Blackburn, G.D. Mellick and D.G. Le Couteur, Parkinson's disease, pesticides, and glutathione transferase polymorphisms, Lancet 352 (1998), 1344-1346.
102. L. Migliore, I. Fontana, F. Trippi, R. Colognato, F. Coppedè, G. Tognoni, B. Nucciarone and G. Siciliano, Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients, Neurobiol Aging 26 (2005), 567-573.
103. L. Migliore, I. Fontana, R. Colognato, F. Coppedè, G. Siciliano and L. Murri, Searching for the role and the most suitable biomarkers of oxidative stress in Alzheimer's disease and in other neurodegenerative diseases, Neurobiol Aging 26 (2005), 587-595.
104. L. Migliore, R. Scarpato, F. Coppedè, L. Petrozzi, U. Bonuccelli and V. Rodilla, Chromosome and oxidative damage biomarkers in lymphocytes of Parkinson's disease patients, Int J Hyg Environ Health 204 (2001), 61-66.
105. L. Migliore, L. Petrozzi, C. Lucetti, G. Gambaccini, S. Bernardini, R. Scarpato, F. Trippi, R. Barale, G. Frenzilli, V. Rodilla and U. Bonuccelli, Oxidative damage and cytogenetic analysis in leukocytes of Parkinson's disease patients, Neurology 58 (2002), 1809-1815.
106. S. Miranda, C. Opazo, L.F. Larrondo, F.J. Munoz, F. Ruiz, F. Leighton and N.C. Inestrosa, The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer's disease, Prog Neurobiol 62 (2000), 633-648.
107. Y. Mizuno, K. Suzuki and S. Ohta, Postmortem changes in mitochondrial respiratory enzymes in brain and a preliminary observation in Parkinson's disease, J Neurol Sci 96 (1990), 49-57.
108. Y. Mizuno, S. Matuda, H. Yoshino, H. Mori, N. Hattori and S. Ikebe, An immunohistochemical study on alpha-ketoglutarate dehydrogenase complex in Parkinson's disease, Ann Neurol 35 (1994), 204-210.
109. T.J. Montine, M.F. Beal, M.E. Cudkowicz, H. O'Donnell, R.A. Margolin, L. McFarland, A.F. Bachrach, W.E. Zackert, L.J. Roberts and J.D. Morrow, Increased CSF F2-isoprostane concentration in probable AD, Neurology 52 (1999), 562-565.
110. T.J. Montine, M.F. Beal, D. Robertson, M.E. Cudkowicz, I. Biaggioni, H. O'Donnell, W.E. Zackert, L.J. Roberts and J.D. Morrow, Cerebrospinal fluid F2-isoprostanes are elevated in Huntington's disease, Neurology 52 (1999), 1104-1105.
111. P.I. Moreira, K. Honda, X. Zhu, A. Nunomura, G. Casadesus, M.A. Smith and G. Perry, Brain and brawn: parallels in oxidative strength, Neurology 66 (2006), 97-101.
112. A. Nunomura, G. Perry, M.A. Pappolla, R. Wade, K. Hirai, S. Chiba and M.A. Smith, RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease, J Neurosci 19 (1999), 1959-1964.
113. R. Pamplona, E. Dalfo, V. Ayala, M.J. Bellmunt, J. Prat, I. Ferrer and M. Portero-Otin, Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation. Effects of Alzheimer disease and identification of lipoxidation targets, J Biol Chem 280 (2005), 21522-21530.
114. H. Peluffo, J.J. Shacka, K. Ricart, C.G. Bisig, L. Martinez-Palma, O. Pritsch, A. Kamaid, J.P. Eiserich, J.P. Crow, L. Barbeito and A.G. Estevez, Induction of motor neuron apoptosis by free 3-nitro-L-tyrosine, J Neurochem 89 (2004), 602-612.
115. M. Perluigi, H. Fai Poon, K. Hensley, W.M. Pierce, J.B. Klein, V. Calabrese, C. De Marco and D.A. Butterfield, Proteomic analysis of 4-hydroxy-2-nonenal-modified proteins in G93A-SOD1 transgenic mice-a model of familial amyotrophic lateral sclerosis, Free Radic Biol Med 38 (2005), 960-968.
116. G. Perry, A. Nunomura, K. Hirai, X. Zhu, M. Perez, J. Avila, R.J. Castellani, C.S. Atwood, G. Aliev, L.M. Sayre, A. Takeda and M.A. Smith, Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases, Free Radic Biol Med 33 (2002), 1475-1479.
117. R.C. Petersen, G.E. Smith, S.C. Waring, R.J. Ivnik, E.G. Tangalos and E. Kokmen, Mild cognitive impairment: clinical characterization and outcome, Arch Neurol 56 (1999), 303-308.
118. F. Piemonte, A. Pastore, G. Tozzi, D. Tagliacozzi, F.M. Santorelli, R. Carrozzo, C. Casali, M. Damiano, G. Federici and E. Bertini, Glutathione in blood of patients with Friedreich's ataxia, Eur J Clin Invest 31 (2001), 1007-1011.
119. M.C. Polidori, P. Mecocci, S.E. Browne, U. Senin and M.F. Beal, Oxidative damage to mitochondrial DNA in Huntington's disease parietal cortex, Neurosci Lett 272 (1999), 53-56.
120. H.F. Poon, K. Hensley, V. Thongboonkerd, M.L. Merchant, B.C. Lynn, W.M. Pierce, J.B. Klein, V. Calabrese and D.A. Butterfield, Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice-a model of familial amyotrophic lateral sclerosis, Free Radic Biol Med 39 (2005), 453-462.
121. D. Pratico, C.M. Clark, F. Liun, J. Rokach, V.Y. Lee and J.Q. Trojanowski, Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease, Arch Neurol 59 (2002), 972-976.
122. A. Pyle, T. Foltynie, W. Tiangyou et al., Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD, Ann Neurol 57 (2005), 564-567.
123. P.H. Reddy, Amyloid precursor protein-mediated free radicals and oxidative damage: implications for the development and progression of Alzheimer's disease, J Neurochem 96 (2006), 1-13.
124. P. Riederer, E. Sofie, W.D. Rausch, B. Schmidt, G.P. Reynolds, K. Jellinger and M.B. Youdim, Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains, J Neurochem 52 (1989), 515-520.
125. P. Rinaldi, M.C. Polidon, A. Metastasio, E. Mariani, P. Mattioli, A. Cherubini, M. Catani, R. Cecchetti, U. Senin and P. Mecocci, Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease, Neurobiol Aging 24 (2003), 915-919.
126. L.S. Ro, S.L. Lai, C.M. Chen and S.T. Chen, Deleted 4977-bp mitochondrial DNA mutation is associated with sporadic amyotrophic lateral sclerosis: a hospital-based case-control study, Muscle Nerve 28 (2003), 737-743.
127. D.R. Rosen, T. Siddique, D. Patterson, D.A. Figlewicz, P. Sapp, A. Hentati, D. Donaldson, J. Goto, J.P. O'Regan, H.X. Deng et al., Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis, Nature 362 (1993), 59-62.
128. A. Rötig, P. De Lonlay, D. Chretien et al., Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia, Nat Genet 17 (1997), 215-217.
129. P. Rustin, A. Rotig, A. Munnich and D. Sidi, Heart hypertrophy and function are improved by idebenone in Friedreich's ataxia, Free Radic Res 36 (2002), 467-469.
130. S. Sasaki and M. Iwata, Impairment of fast axonal transport in the proximal axons of anterior horn neurons in amyotrophic lateral sclerosis, Neurology 47 (1996), 535-540.
131. L.M. Sayre, P.I. Moreira, M.A. Smith and G. Perry, Metal ions and oxidative protein modification in neurological disease, Ann Ist Super Sanita 41 (2005), 143-164.
132. A.H.V. Schapira, V.M. Mann, J.M. Cooper, D. Dexter, S.E. Daniel, P. Jenner, J.B. Clark and C.D. Marsden, Anatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's disease, J Neurochem 55 (1990), 2142-2145.
133. A.H. Schapira, Evidence for mitochondrial dysfunction in Parkinson's disease-a critical appraisal. Evidence for mitochondrial dysfunction in Parkinson's disease-a critical appraisal, Mov Disord 9 (1994), 125-138.
134. J.B. Schulz, J. Lindenau, J. Seyfried and J. Dichgans, Glutathione, oxidative stress and neurodegeneration, Eur J Biochem 267 (2000), 4904-4911.
135. J.B. Schulz, T. Dehmer, L. Schols, H. Mende, C. Hardt, M. Vorgerd, K. Burk, W. Matson, J. Dichgans, M.F. Beal and M.B. Bogdanov, Oxidative stress in patients with Friedreich ataxia, Neurology 55 (2000), 1719-1721.
136. J.A. Serra, R.O. Dominguez, E.S. de Lustig, E.M. Guareschi, A.L. Famulari, E.L. Bartolome and E.R. Marschoff, Parkinson's disease is associated with oxidative stress: comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients, J Neural Transm 108 (2001), 1135-1148.
137. N. Shibata, R. Nagai, S. Miyata, T. Jono, S. Horiuchi, A. Hirano, S. Kato, S. Sasaki, K. Asayama and M. Kobayashi, Nonoxidative protein glycation is implicated in familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutation, Acta Neuropathol 100 (2000), 275-284.
138. N. Shibata, R. Nagai, K. Uchida, S. Horiuchi, S. Yamada, A. Hirano, M. Kawaguchi, T. Yamamoto, S. Sasaki and M. Kobayashi, Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients, Brain Res 917 (2001), 97-104.
139. G. Siciliano, M. Mancuso, R. Ceravolo, V. Lombardi, A. Iudice and U. Bonuccelli, Mitochondrial DNA rearrangements in young onset parkinsonism: Two case reports, J Neurol Neurosurg Psychiat 71 (2001), 685-687.
140. S. Song, S.Y. Kim, Y.M. Hong, D.G. Jo, J.Y. Lee, S.M. Shim, C.W. Chung, S.J. Seo, Y.J. Yoo, J.Y. Koh, M.C. Lee, A.J. Yates, H. Ichijo and Y.K. Jung, Essential role of E2-25K/Hip-2 in mediating amyloid-beta neurotoxicity, Mol Cell 12 (2003), 553-563.
141. I.G. Stavrovskaya and B.S. Kristal, The powerhouse takes control of the cell: is the mitochondrial permeability transition a viable therapeutic target against neuronal dysfunction and death? Free Radic Biol Med 38 (2005), 687-697.
142. A.H. Stokes, T.G. Hastings and K.E. Vrana, Cytotoxic and genotoxic potential of dopamine, J Neurosci Res 55 (1999), 659-665.
143. R.H. Swerdlow, J.K. Parks, D.S. Cassarino, P.A. Trimmer, S.W. Miller, D.J. Maguire, J.P. Sheehan, R.S. Maguire, G. Pattee, V.C. Juel, L.H. Phillips, J.B. Tuttle, J.P. Bennett Jr, R.E. Davis and W.D. Parker Jr., Mitochondria in sporadic amyotrophic lateral sclerosis, Exp Neurol 153 (1998), 135-142.
144. D. Thyagarajan, S. Bressman, C. Bruno, S. Przedborski, S. Shanske, T. Lynch, S. Fahn and S. DiMauro, A novel mitochondrial 12S rRNA point mutation in Parkinsonism, deafness and neuropathy, Ann Neurol 48 (2000), 730-736.
145. H. Tohgi, T. Abe, K. Yamazaki, T. Murata, E. Ishizaki and C. Isobe, Alterations of 3-nitrotyrosine concentration in the cerebrospinal fluid during aging and in patients with Alzheimer's disease, Neurosci Lett 269 (1999), 52-54.
146. H. Tohgi, T. Abe, K. Yamazaki, T. Murata, E. Ishizaki and C. Isobe, Remarkable increase in cerebrospinal fluid 3-nitrotyrosine in patients with sporadic amyotrophic lateral sclerosis, Ann Neurol 46 (1999), 129-131.
147. F. Torreilles, S. Salman-Tabcheh, M. Guerin and J. Torreilles, Neurodegenerative disorders: the role of peroxynitrite, Brain Res Brain Res Rev 30 (1999), 153-163.
148. E.E. Tuppo, L.J. Forman, B.W. Spur, R.E. Cheng-Ting, A. Chopra and A. Cavalieri, Sign of lipid peroxidation as mesured in the urine of patients with probable Alzheimer's disease, Brain Res Bull 54 (2001), 565-568.
149. J.S. Valentine, Do oxidatively modified proteins cause ALS? Free Radic Biol Med 33 (2002), 1314-1320.
150. J.M. Van der Walt, K.K. Nicodemus, E.R. Martin, W.K. Scott, M.A. Nance, R.L. Watts, J.P. Hubble, J.L. Haines, W.C. Koller, K. Lyons, R. Pahwa, M.B. Stern, A. Colcher, B.C. Hiner, J. Jankovic, W.G. Ondo, F.H. Allen Jr, C.G. Goetz, G.W. Small, F. Mastaglia, J.M. Stajich, A.C. McLaurin, L.T. Middleton, B.L. Scott, D.E. Schmechel, M.A. Pericak-Vance and J.M. Vance, Mitochondrial polymorphisms significantly reduce the risk of Parkinson's disease, Am J Hum Genet 72 (2003), 804-811.
151. S. Vielhaber, D. Kunz, K. Winkler, F.R. Wiedemann, E. Kirches, H. Feistner, H.J. Heinze, C.E. Elger, W. Schubert and W.S. Kunz, Mitochondrial DNA abnormalities in skeletal muscle of patients with sporadic amyotrophic lateral sclerosis, Brain 123 (2000), 1339-1348.
152. E. Waddington, K. Croft and R. Clarnette, Artins, Plasma F2-isoprostane levels are inareased in Alzheimer's disease: evidence of increased oxidative stress in vivo, Alzheimers' Rep 2 (1999), 227-282.
153. J. Wang, S. Xiong, C. Xie, W.R. Markesbery and M.A. Lovell, Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease, J Neurochem 93 (2005), 953-962.
154. A.J. Whitworth, D.A. Theodore, J.C. Greene, H. Benes, P.D. Wes and L.J. Pallanck, Increased glutathione S-transferase activity rescues dopaminergic
155. F.R. Wiedemann, G. Manfredi, C. Mawrin, M.F. Beal and E.A. Schon, Mitochondrial DNA and respiratory chain function in spinal cords of ALS patients, J Neurochem 80 (2002), 616-625.
156. F.R. Wiedemann, K. Winkler, A.V. Kuznetsov, C. Bartels, S. Vielhaber, H. Feistner and W.S. Kunz, Impairment of mitochondrial function in skeletal muscle of patients with amyotrophic lateral sclerosis, J Neurol Sci 156 (1998), 65-72.
157. T.I. Williams, B.C. Lynn, W.R. Markesbery and M.A. Lovell, Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease, Neurobiol Aging in press.
158. R.B. Wilson and D.M. Roof, Respiratory deficiency due to loss of mitochondrial DNA in yeast lacking the frataxin homologue, Nat Genet 16 (1997), 352-357.
159. A. Yontaka, N. Hatton, K. Uchida, M. Tanaka, E.R. Stadtman and Y. Mizuno, Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease, Proc Natl Acad Sci USA 93 (1996), 2696-2701.
160. W. Zhou and C.R. Freed, DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity, J Biol Chem 280 (2005), 43150-43158.